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INTRODUCTION COMBITHER AT 120MG INJECTION contains Artesunate which belongs to the group of medicines called Antimalarials. It is used for the treatment of severe malaria including cerebral malaria in adult and paediatric patients. Also, it can also be used against quinine resistance....
COMBITHER AT 120MG INJECTION contains Artesunate which belongs to the group of medicines called Antimalarials. It is used for the treatment of severe malaria including cerebral malaria in adult and paediatric patients. Also, it can also be used against quinine resistance.
Malaria is mosquito-borne acute febrile disease caused by a protozoan named Plasmodium falciparum. It is characterized by symptoms such as high fever, chills, sweating, headache, muscle pain, nausea, vomiting, body aches, weakness, agitation, confusion, fainting on standing up and anaemia (reduced red blood cell count). Cerebral malaria is the most severe neurological complication of Plasmodium falciparum malaria which may also cause coma.
COMBITHER AT 120MG INJECTION is not recommended for use if you have previous history of allergic reactions to artesunate or artemisinin derivatives. Before receiving COMBITHER AT 120MG INJECTION inform your doctor if you liver or kidney problems or any other problems.
COMBITHER AT 120MG INJECTION is not recommended for use during first trimester of pregnancy. It should be used with caution in breastfeeding women. Consult your doctor before receiving COMBITHER AT 120MG INJECTION.
COMBITHER AT 120MG INJECTION should be used with caution in children. Consult your child’s doctor for advice before administration of COMBITHER AT 120MG INJECTION to your child.
The most common side effects associated with the use of COMBITHER AT 120MG INJECTION are dizziness, light-headedness, headache, rash, hair loss, taste alteration (metallic/bitter taste), nausea, vomiting, abdominal pain and diarrhoea. Inform your doctor if any of these side effects bothers you.
COMBITHER AT 120MG INJECTION helps in treating malaria where Artesunate works by transforming into a metabolite and binds with iron component of blood and forms free radicals which inhibit the synthesis of protein and nucleic acid in Plasmodium parasites and prevents it from invading red blood cells, thus treating the malaria effectively.
COMBITHER AT 120MG INJECTION will be given to you only by a doctor or a nurse intravenously (into the vein) or intramuscularly (into the muscle). Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Stop receiving COMBITHER AT 120MG INJECTION and inform your doctor if you experience any of the following side effects:
Nausea or vomiting:
Stick to simple meals while receiving this medicine. Avoid eating oily, fried or spicy foods. Do not lie down or sleep immediately after eating. If the symptom does not improve, inform your doctor.
Stomach pain:
Take rest to relax yourself. Try to have smaller and frequent meals. Keep a heat pad on your stomach. In case of no improvement, inform your doctor.
Diarrhoea:
Drink lot of fluids such as water or fruit juices to keep yourself hydrated. Inform your doctor if the symptom does not improve.
Headache:
Rest and relax. Consume plenty of fluids such as water and electrolytes. Apply a pain-relieving balm on the forehead if necessary. Inform your doctor if the symptom worsens.
Skin rash:
Avoid hot showers because hot water can irritate the skin. Do not scratch the affected area. Use moisturizers to relax and hydrate the affected skin area. Inform your doctor if the symptom worsens.
COMBITHER AT 120MG INJECTION is not recommended for use during first trimester of pregnancy. Consult your doctor before receiving COMBITHER AT 120MG INJECTION.
COMBITHER AT 120MG INJECTION should be used with caution in breastfeeding women. Consult your doctor before receiving COMBITHER AT 120MG INJECTION.
No dose adjustment is needed for patients with kidney impairment. Consult your doctor before receiving COMBITHER AT 120MG INJECTION.
No dose adjustment is needed for patients with liver impairment. Consult your doctor before receiving COMBITHER AT 120MG INJECTION.
Do not receive COMBITHER AT 120MG INJECTION if you are allergic to artesunate or artemisinin derivatives or any other ingredients of this medicine.
Use in Paediatrics
COMBITHER AT 120MG INJECTION should be used with caution in children. Consult your child’s doctor for advice before administration of COMBITHER AT 120MG INJECTION to your child.
A. Drug-Drug Interactions
Before receiving COMBITHER AT 120MG INJECTION, inform your doctor, if you are taking any of the following medicines:
Overdosage:
COMBITHER AT 120MG INJECTION will be given to you only by a doctor or nurse in a hospital, and so it is unlikely to receive an overdose. In case of overdose you may experience seizures, dark stools, low levels of blood cells and multiorgan failure.
| Drug | : | Artesunate |
| Pharmacological Category | : | Artemisinin derivative |
| Therapeutic Indication | : | Severe malaria including falciparum malaria, cerebral malaria |
| Dosage Forms | : | Injection, Infusion, Tablet |
What is COMBITHER AT 120MG INJECTION used for?
COMBITHER AT 120MG INJECTION is used for the treatment of severe malaria including cerebral malaria in adult and paediatric patients. It can also be used against quinine resistant strains of P. falciparum. Consult your doctor before receiving COMBITHER AT 120MG INJECTION.
Who should avoid receiving COMBITHER AT 120MG INJECTION?
Do not receive COMBITHER AT 120MG INJECTION if you are allergic to artesunate or artemisinin derivatives. It is not recommended for use during first trimester of pregnancy. Consult your doctor before receiving COMBITHER AT 120MG INJECTION.
Is COMBITHER AT 120MG INJECTION safe to use in children?
COMBITHER AT 120MG INJECTION should be used with caution in children and adolescents (aged 18 years or below) as it may cause postartemisinin-delayed hemolysis (PADH). Consult your child’s doctor for advice before administration of COMBITHER AT 120MG INJECTION to your child.
Is COMBITHER AT 120MG INJECTION safe to use in pregnant and breastfeeding women?
COMBITHER AT 120MG INJECTION is not recommended for use during first trimester of pregnancy. It should be used with caution in breastfeeding women as it may pass through milk in very small quantities. Consult your doctor before receiving COMBITHER AT 120MG INJECTION.
How does COMBITHER AT 120MG INJECTION work?
COMBITHER AT 120MG INJECTION helps in treating malaria where Artesunate works by transforming into a metabolite and binds with iron component of blood and forms free radicals which inhibit the synthesis of protein and nucleic acid in Plasmodium parasites and prevents it from invading red blood cells, thus treating the malaria effectively.
What is the method of receiving COMBITHER AT 120MG INJECTION?
COMBITHER AT 120MG INJECTION will be given to you only by a doctor or a nurse intravenously (into the vein) or intramuscularly (into the muscle). Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
1. KD. Tripathi. Antimalarial drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 830.
2. Twomey PS, Smith BL, McDermott C, Novitt-Moreno A, McCarthy W, Kachur SP, Arguin PM. Intravenous Artesunate for the Treatment of Severe and Complicated Malaria in the United States: Clinical Use under an Investigational New Drug Protocol. Annals of Internal Medicine. October 2015. [Accessed on 8th November 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4627466/
3. Michael T Hawkes, Sarah Forgie, Jason Brophy, Maryanne Crockett. Artesunate treatment of severe pediatric malaria: A review of parasite clearance kinetics and clinical implications. NIH. National Library of Medicine. National Centre for Biotechnology Information. PubMed Central (PMC). October 2015. [Accessed on 8th November 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4644001/
4. Bethesda, National Library of Medicine (US). NIH. National Library of Medicine. National Centre for Biotechnology Information. Drugs and Lactation Database (LactMed) [Internet]. March 2021. [Accessed on 8th November 2022] https://www.ncbi.nlm.nih.gov/books/NBK501473/
5. Guilin Pharmaceutical Co., Ltd. Artesunate. [Revised in January 2020] [Accessed on 8th November 2022] https://extranet.who.int/pqweb/sites/default/files/MA090part4.pdf
6. Amivas LLC. U.S. Food & Drug Administration. [Revised in May 2020] [Accessed on 8th November 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/213036s000lbl.pdf
7. Genix Pharma Private Limited. Artesunate. [Accessed on 8th November 2022] https://genixpharma.com/img/Gen_M_Injection-Artesunate.pdf
Written By Dr. R. Dinesh John Rajkumar, Pharm.D
Last updated on 15 Nov 2022 | 03:13 PM(IST)