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INTRODUCTION HEPAVION SOFTGEL is a combination of Metadoxine, Silymarin and L Ornithine L Aspartate which belongs to the group of medicines called Antioxidants, Flavonolignans and Amino acid salts respectively. It is used as supportive treatment in chronic liver disease...
HEPAVION SOFTGEL is a combination of Metadoxine, Silymarin and L Ornithine L Aspartate which belongs to the group of medicines called Antioxidants, Flavonolignans and Amino acid salts respectively. It is used as supportive treatment in chronic liver disease and cirrhosis.
Chronic liver disease (CLD) is a continuous process of inflammation, destruction and regeneration of functional liver cells, which leads to cirrhosis (disruption of liver structure and function). Symptoms include fluid build-up in the belly, itching, yellow skin and eyes, muscle loss, loss of appetite, easy bruising, low energy and weakness, weight loss and confusion.
Consult your doctor before giving HEPAVION SOFTGEL to your child. Before taking HEPAVION SOFTGEL, inform your doctor if you have any pre-existing conditions or allergies. HEPAVION SOFTGEL is not recommended for use in pregnant and breastfeeding women unless considered clearly necessary by your doctor.
The most common side effects of taking HEPAVION SOFTGEL are gastrointestinal disturbances (such as indigestion, diarrhoea), nausea and headache. Consult your doctor if any of the side effects worsen.
HEPAVION SOFTGEL improves liver function where metadoxine exerts a protective effect against the damage done by free radicals, silymarin acts as a rejuvenating agent which helps in regenerating the damaged liver cells and in liver decongestion and L-Ornithine L-Aspartate converts ammonia to urea, leading to reduced burden of the liver and thus increases functional capacity of the liver.
Take HEPAVION SOFTGEL as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the appropriate dose and duration for you based upon your age, body weight and disease condition.
Nausea:
Take HEPAVION SOFTGEL with or just after meals. Stick to simple meals. Avoid eating oily, fried or spicy foods. Do not lie down or sleep immediately after eating. If you still feel nauseous, consult your doctor.
Headache:
Drink plenty of water and get adequate rest. Try to be relaxed and stress free. Check with your doctor before taking any medicine for headache. If headache does not get better, consult your doctor.
Skin itching:
Avoid hot showers because hot water can irritate your skin further. Do not scratch the affected area. Avoid sun exposure or UV rays as it may sensitize your skin. Use sunscreen and protective clothing when going outdoor. Regularly moisturize your skin after consulting the doctor. Consult your doctor if the symptom does not improve.
HEPAVION SOFTGEL is not recommended for use in pregnant women unless considered clearly necessary. Consult your doctor before taking it.
HEPAVION SOFTGEL is not recommended for use in breastfeeding women unless considered clearly necessary. Consult your doctor before taking it.
Consult your doctor if you feel any side effect during treatment with HEPAVION SOFTGEL that may stop you from driving or using machines.
Avoid consumption of alcohol during treatment with HEPAVION SOFTGEL.
Do not take HEPAVION SOFTGEL if you are allergic to Metadoxine, Silymarin, L Ornithine L Aspartate or any other ingredients of this medicine.
Before taking HEPAVION SOFTGEL, inform your doctor if you have:
Use in pediatrics:
There are no adequate and well-controlled studies of HEPAVION SOFTGEL in infants. Consult your child’s doctor before giving it to them.
A. Drug-Drug interactions:
Before taking HEPAVION SOFTGEL, inform your doctor if you are taking, have taken or might take any other medicine including prescription, non-prescription or any herbal medicine.
Overdosage:
If you or anyone else accidentally takes too much of HEPAVION SOFTGEL, consult your doctor immediately or visit the nearby hospital.
| Drug | : | Metadoxine, Silymarin, L Ornithine L Aspartate |
| Pharmacological Category | : | Antioxidants, Flavonolignans, Amino acid salts |
| Therapeutic Indication | : | Supportive treatment in chronic liver disease and cirrhosis |
| Dosage Forms | : | Tablet, Softgel |
Q: Can HEPAVION SOFTGEL make me feel nauseous?
A: HEPAVION SOFTGEL may cause nausea in some individuals. If you feel nauseous, take HEPAVION SOFTGEL with or just after meals and stick to simple meals. Avoid eating oily, fried or spicy foods. Do not lie down or sleep immediately after eating. If you still feel nauseous, contact your doctor.
Q: What if I forget to take a dose of HEPAVION SOFTGEL?
A: If you forget to take a dose of HEPAVION SOFTGEL, take it as soon as you remember. However, omit the missed dose if it's almost time for the next one. Do not take the medicine two times to make up for the missed dose.
Q: Can HEPAVION SOFTGEL be stopped on my own?
A: Continue taking HEPAVION SOFTGEL until your doctor tells you to stop, unless you experience any unwanted effects, worsening of your condition or any new symptoms. Contact your doctor in such cases.
Q: What should I tell my doctor before taking HEPAVION SOFTGEL?
A: Patients taking HEPAVION SOFTGEL must inform their doctor about their pre-existing conditions. Patients should also tell if they are pregnant, breast-feeding or allergic to anything. Consult your doctor if you experience any unusual effects.
Q: Can I take other medicines with HEPAVION SOFTGEL?
A: Before taking HEPAVION SOFTGEL, inform your doctor if you are taking, have taken or might take any other medicine, including prescription, over the counter or any herbal medicine as these might cause serious side effects by interacting with each other.
1. Sean C Sweetman. Chelators Antidotes and Antagonists. Nutritional Agents and Vitamins. Martindale The Complete Drug Reference. 36th edition. Page- 1452, 1978.
2. Vali L, Blazovics A, Feher J. A metadoxin teraipias hatasanak osszehasonlitasa alkoholos es nem alkoholos zsirmajban. The therapeutic effect of metadoxine on alcoholic and non-alcoholic steatohepatitis. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. November 2005. [Accessed on 19th August 2022] https://pubmed.ncbi.nlm.nih.gov/16398154/
3. Gillessen A, Schmidt HH. Silymarin as Supportive Treatment in Liver Diseases: A Narrative Review. NIH National Library of Medicine, National center for biotechnology information. PubMed Central. April 2020. [Accessed on 19th August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7140758/
4. Aga Khan University. Efficacy of L-Ornithine-L-Aspartate in Cirrhotics With Hepatic Encephalopathy. NIH U.S. National Library of Medicine. ClinicalTrials.gov. [Revised in February 2007] [Accessed on 19th August 2022] https://clinicaltrials.gov/ct2/show/NCT00433368?term=l-ornithine+l-aspartate&draw=2&rank=6
5. Micro Labs Ltd. Metadoxine + Silymarin + L Ornithine L Aspartate. [Accessed on 19th August 2022] http://www.microlabsltd.com/elibrary/node/1570
Written By Dr. R. Dinesh John Rajkumar, Pharm.D
Last updated on 17 Jan 2023 | 05:34 PM(IST)