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INTRODUCTION HEPAMERZ INFUSION contains L-Ornithine L-Aspartate which belongs to the group of medicines called Amino Acids. It is used to treat latent and prominent hepatic encephalopathy (decline in brain function as a result of liver failure) and liver cirrhosis (condition in which your live...
HEPAMERZ INFUSION contains L-Ornithine L-Aspartate which belongs to the group of medicines called Amino Acids. It is used to treat latent and prominent hepatic encephalopathy (decline in brain function as a result of liver failure) and liver cirrhosis (condition in which your liver is scarred and permanently damaged).
During treatment with HEPAMERZ INFUSION, your doctor might advise you to undertake blood investigations before and during treatment such as kidney and liver function test to prevent the risk of any unusual effects.
Avoid consuming alcohol while receiving HEPAMERZ INFUSION. It is not recommended for use in patients with severe kidney function impairment (renal failure). Consult your doctor before receiving it.
HEPAMERZ INFUSION should be used with caution in patients suffering from severe liver damage. HEPAMERZ INFUSION is not recommended for use in pregnant and breast-feeding women unless clearly advised by the doctor.
The common side effects of receiving HEPAMERZ INFUSION are nausea, vomiting, cough, muscle cramps and diarrhoea. Inform your doctor immediately if any of the side effect worsens or persist for a long period of time.
HEPAMERZ INFUSION helps in improving liver function by helping in urea synthesis in liver (important metabolic process in the body), reduces levels of ammonia from liver, muscles and brain, helps in normalizing the levels of liver enzymes. It also protects the liver from further damage by drugs, alcohol and promotes liver regeneration by increasing liver energy balance.
HEPAMERZ INFUSION will be given to you only by a doctor or a nurse into a vein as an intravenous infusion. Your doctor will decide the correct dosage and treatment duration depending upon your age, body weight and disease condition.
Drink lot of fluids such as water to keep yourself hydrated. Avoid eating high-fat or spicy foods. Inform your doctor if the symptom gets worse.
Stick to simple meals while receiving HEPAMERZ INFUSION. Avoid eating oily rich, fried or spicy foods. Do not lie down or sleep immediately after eating. Inform your doctor if the symptom does not improve.
HEPAMERZ INFUSION is generally not recommended for use during pregnancy unless considered clearly necessary. Consult your doctor before receiving it.
HEPAMERZ INFUSION should be used in breast-feeding women only if considered clearly necessary. Consult your doctor before receiving it.
Avoid driving or operating machines after receiving HEPAMERZ INFUSION.
Avoid consumption of alcohol while receiving HEPAMERZ INFUSION.
HEPAMERZ INFUSION is not recommended for use in patients suffering from severe kidney function impairment (renal failure). Consult your doctor before receiving it.
HEPAMERZ INFUSION should be used with caution in patients suffering from severe liver damage. Consult your doctor before receiving it.
Do not receive HEPAMERZ INFUSION if you are allergic to L-Ornithine L-Aspartate or any other ingredients of this medicine.
There is no proper information regarding the use of HEPAMERZ INFUSION in children. Consult your child’s doctor for advice.
There is no proper information regarding the use of HEPAMERZ INFUSION in elderly patients. Consult your doctor for advice.
A. Drug-Drug interactions:
Before receiving HEPAMERZ INFUSION, inform your doctor if you have taken or taking any medicines including precipitation, non-prescription and herbals or vitamin supplements.
Overdosage:
HEPAMERZ INFUSION will be administered to you only by a doctor or a nurse in a hospital and so it is unlikely to receive an overdose. However, consult your doctor or nurse immediately if you experience any unusual symptoms.
| Drug | : | L-Ornithine L-Aspartate |
| Pharmacological Category | : | Amino Acids |
| Therapeutic Indication | : | Hepatic Encephalopathy, Liver Cirrhosis |
| Dosage Forms | : | Granules, Injection, Infusion, Sachet, Syrup, Tablet |
Q: What is HEPAMERZ INFUSION used for?
A: HEPAMERZ INFUSION is used to treat latent and prominent hepatic encephalopathy (decline in brain function as a result of liver failure) and liver cirrhosis (condition in which your liver is scarred and permanently damaged).
Q: How does HEPAMERZ INFUSION work?
A: HEPAMERZ INFUSION helps in improving liver function by helping in urea synthesis in liver (important metabolic process in the body), reduces levels of ammonia from liver, muscles and brain, helps in normalizing the levels of liver enzymes. It also protects the liver from further damage by drugs, alcohol and promotes liver regeneration by increasing liver energy balance.
Q: Is HEPAMERZ INFUSION safe to use in patients with kidney problems?
A: HEPAMERZ INFUSION is not recommended for use in patients suffering from severe kidney function impairment (renal failure). Your doctor may monitor your kidney function test before and during treatment with this medicine to prevent the risk of any unusual effects. Consult your doctor before receiving it.
Q: What are the common side effects of HEPAMERZ INFUSION?
A: The common side effects of receiving HEPAMERZ INFUSION are nausea, vomiting, cough, muscle cramps and diarrhoea. Inform your doctor immediately if any of the side effect worsens or persist for a long period of time.
Q: Can HEPAMERZ INFUSION be used in pregnant and breast-feeding women?
A: HEPAMERZ INFUSION is not recommended for use in pregnant and breast-feeding women unless clearly advised by the doctor. Consult your doctor before receiving HEPAMERZ INFUSION if you are pregnant, planning to get pregnant or breast-feeding your child.
1. Gerald Kircheis, Stefan Luth. Pharmacokinetic and Pharmacodynamic Properties of l-Ornithine l-Aspartate (LOLA) in Hepatic Encephalopathy. National Centre for Biotechnology. Drugs. January 2019. [Accessed on 20th October 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416235/
2. Roger F. Butterworth, Mark J. W. McPhail. L-Ornithine L-Aspartate (LOLA) for Hepatic Encephalopathy in Cirrhosis: Results of Randomized Controlled Trials and Meta-Analyses. National Centre for Biotechnology. Drugs. January 2019. [Accessed on 20th October 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416237/
3. Polifarma. L-Ornithine L-Aspartate. [Revised in December 2019] [Accessed on 20th October 2022] https://www.polifarma.com.tr/media/2119/hepalornitin_spc_rev01.pdf
4. Merz Pharma GmbH & Co KGaA. L-Ornithine L-Aspartate. [Accessed on 20th October 2022] https://www.liverandbrain.com/wp-content/uploads/2019/06/HM-Patient-Information_Infusion-Concentrate_en-1.pdf
5. Zuventus Healthcare Limited. L-Ornithine L-Aspartate. [Accessed on 20th October 2022] http://www.zuventus.co.in/doctor_wise_products_selected.aspx?Medi_Id=56
6. Leeford. Heplofit Injection. (L-Ornithine L-Aspartate). [Accessed on 20th October 2022] https://www.leeford.in/product/202/heplofit-injection
Written By Dr. R. Dinesh John Rajkumar, Pharm.D
Last updated on 11 Feb 2023 | 04:57 PM(IST)