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INTRODUCTION ZILAST 50MG TABLET contains Cilostazol which belongs to the group of medicines called Phosphodiesterase type 3 inhibitors. It is used in the treatment of intermittent claudication, which is defined as the cramp-like pain in the legs while walking caused by insufficient blood suppl...
ZILAST 50MG TABLET contains Cilostazol which belongs to the group of medicines called Phosphodiesterase type 3 inhibitors. It is used in the treatment of intermittent claudication, which is defined as the cramp-like pain in the legs while walking caused by insufficient blood supply in the legs. Symptoms include pain, ache, discomfort or fatigue in muscles every time, when those muscles are used (usually the calves, thighs, buttocks, hips or feet).
Along with this treatment your doctor might advise you to make lifestyle modifications like increasing regular exercise and stop smoking. Prior to the treatment, your doctor may want you to take ankle-brachial index test to understand your existing condition.
ZILAST 50MG TABLET is not recommended for use in patients having severe heart problems (such as heart failure, heart attack), uncontrolled blood pressure, kidney or liver disease, active stomach ulcer and stroke.
Do not drink large amounts of grapefruit juice while taking ZILAST 50MG TABLET as it may reduce the effect of this medicine. ZILAST 50MG TABLET is not recommended for use among pregnant or breastfeeding women, therefore consult your doctor before taking it. This medicine is not recommended for use in children and adolescents.
The most common side effects of taking ZILAST 50MG TABLET are headache, abnormal stools, diarrhea, abdominal discomfort, dizziness, nausea and loss of appetite. Consult your doctor if any of the side effects worsen over the time.
ZILAST 50MG TABLET acts by inhibiting the activity of certain enzymes (phosphodiesterase) which helps in the increase in the level of cAMP (cellular messengers to initiate certain actions) in platelets and blood vessels. The cAMP helps in widening of some blood vessels and reducing the clotting activity of platelets inside the blood vessels. Hence increasing the blood circulation to the legs making it easier and less painful to walk.
Take ZILAST 50MG TABLET as advised by your physician. Swallow ZILAST 50MG TABLET with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Stop taking ZILAST 50MG TABLET and contact your doctor immediately if you experience any of the following side effects:
Drink lot of fluids such as water to keep yourself hydrated. Avoid eating high-fat or spicy foods. Avoid taking any medicine on your own for treating diarrhea. Consult your doctor if the symptom does not improve.
Lie down until dizziness goes away and then move slowly and carefully. Take sufficient rest and drink plenty of fluids. Rise slowly after sitting or lying down. Be careful while going up and down stairs. Consult your doctor if the symptom worsens.
Drink ample amount of water and avoid skipping meals. Get adequate rest. Try to be relaxed and stress free. Apply pain relieving balm on your forehead if necessary. Consult your doctor if the symptom does not improve.
Stick to simple meals while taking this medicine. Avoid eating oily, fried and spicy foods. Do not perform any strenuous activities immediately after eating. Consult your doctor if the symptom does not improve.
Try to rest and relax. Eat and drink slowly or try to eat smaller meals more frequently. Keep a heat pad on your stomach. Consult your doctor if the symptom does not improve.
ZILAST 50MG TABLET is not recommended for use in pregnant women. Consult your doctor before taking ZILAST 50MG TABLET.
ZILAST 50MG TABLET is not recommended for use in breastfeeding women. Consult your doctor before taking ZILAST 50MG TABLET.
Do not drive or operate heavy machines if you experience dizziness while taking ZILAST 50MG TABLET.
ZILAST 50MG TABLET is not recommended for use in patients with severe kidney disease. Consult your doctor before taking ZILAST 50MG TABLET.
ZILAST 50MG TABLET is not recommended for use in patients with moderate or severe liver disease. Consult your doctor before taking ZILAST 50MG TABLET.
Do not take ZILAST 50MG TABLET if you are allergic to Cilostazol or any other ingredients of this medicine.
ZILAST 50MG TABLET is not recommended for use in patients with heart failure, had heart attack, persistent chest pain at rest, any heart surgery in the last 6 months, suffered from blackouts due to heart disease or any severe disturbances of the heartbeat. It should be taken with caution in patients with severe heart problem or any other problems with your heart beat and high blood pressure. Consult your doctor before taking ZILAST 50MG TABLET.
ZILAST 50MG TABLET is not recommended for use in children and adolescents. Consult your child’s doctor for advice.
ZILAST 50MG TABLET should be taken with caution in elderly patients. Consult your doctor before taking ZILAST 50MG TABLET.
ZILAST 50MG TABLET is not recommended for use if you:
Before taking ZILAST 50MG TABLET, inform your doctor if you:
A. Drug-Drug interactions:
Before taking ZILAST 50MG TABLET, inform your doctor if you are taking any of the following medicines:
B. Drug-Food interactions:
Do not drink large amounts of grapefruit juice while taking ZILAST 50MG TABLET as it may reduce the effect of this medicine and do not take together with meals as it may affects its absorption and increase the risk of side effects.
Overdosage:
If you or anyone else accidentally take too much of ZILAST 50MG TABLET, consult your doctor immediately or visit the nearby hospital. Overdosage symptoms of ZILAST 50MG TABLET includes severe headache, diarrhea, increase in heart rate and irregularities of the heartbeat.
| Drug | : | Cilostazol |
| Pharmacological Category | : | Platelet aggregation inhibitors |
| Therapeutic Indication | : | Intermittent claudication |
| Dosage Forms | : | Tablet |
Q: How does ZILAST 50MG TABLET work?
A: ZILAST 50MG TABLET acts by inhibiting the activity of certain enzymes (phosphodiesterase) which helps in the increase in the level of cAMP (cellular messengers to initiate certain actions) in platelets and blood vessels. The cAMP helps in widening of some blood vessels and reducing the clotting activity of platelets inside the blood vessels. Hence increasing the blood circulation to the legs making it easier and less painful to walk.
Q: What is ZILAST 50MG TABLET used for?
A: ZILAST 50MG TABLET is used in the treatment of intermittent claudication, which is defined as the cramp-like pain in the legs while walking caused by insufficient blood supply in the legs. Symptoms include pain, ache, discomfort or fatigue in muscles every time, when those muscles are used (usually the calves, thighs, buttocks, hips or feet).
Q: Can I stop taking ZILAST 50MG TABLET on my own?
A: If you stop taking ZILAST 50MG TABLET the pain in your legs may come back or get worse. Therefore, you should only stop taking it if you notice side effects requiring urgent medical attention or if your doctor tells you to.
Q: What to do If I forget to take a dose of ZILAST 50MG TABLET?
A: You should take ZILAST 50MG TABLET immediately when you remember. If it is time for the next dose skip the missed dose and follow the regular dose schedule. Do not double the dose to match up the missed dose.
Q: Can ZILAST 50MG TABLET be used in pregnant or breast-feeding women?
A: ZILAST 50MG TABLET is not recommended for use in pregnant and breast-feeding women. Consult your doctor before taking this medicine if you are pregnant, planning to become pregnant or breast-feeding your child.
1. K.D.Tripathi, Antianginal and Other Anti-ischemic Drugs. Essentials of Medical Pharmacology. Eighth Edition.2019. Page – 601, 602.
2. Alexander M. Balinski; Charles V. Preuss. Cilostazol. NIH National Library of Medicine, National center for biotechnology information. [Revised in September 2021] [Accessed on 3rd May 2022] https://www.ncbi.nlm.nih.gov/books/NBK544363/
3. Tamara Brown, Rachel B Forster, Marcus Cleanthis, Dimitri P Mikhailidis, Gerard Stansby, Marlene Stewart. Cilostazol for intermittent claudication. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. June 2001. [Accessed on 3rd May 2022] https://pubmed.ncbi.nlm.nih.gov/34192807/#:~:text=Authors'%20conclusions%3A%20Cilostazol%20has%20been,higher%20odds%20of%20experiencing%20headache.
4. Adamed Pharma S.A. Electronic Medicines Compendium (EMC). [Revised in February 2020] [Accessed on 3rd May 2022] https://www.medicines.org.uk/emc/files/pil.2590.pdf
Written By Dr. R. Dinesh John Rajkumar, Pharm.D
Last updated on 23 Feb 2023 | 09:20 AM(IST)