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INTRODUCTION DURAPLUS 10/30MG TABLET is a combination of Dapoxetine and Tadalafil, which belong to the group of medicines called Selective serotonin reuptake inhibitors and Phosphodiesterase type 5 (PDE5) inhibitors, respectively. It is used in adult men to help improve blood flow to the penis...
DURAPLUS 10/30MG TABLET is a combination of Dapoxetine and Tadalafil, which belong to the group of medicines called Selective serotonin reuptake inhibitors and Phosphodiesterase type 5 (PDE5) inhibitors, respectively. It is used in adult men to help improve blood flow to the penis and to manage early ejaculation by balancing certain chemicals in the brain.
Before taking DURAPLUS 10/30MG TABLET, inform your doctor if you have any previous history of fainting or dizziness due to low blood pressure. You must also inform your doctor if you have epilepsy, lung problems, mental health problems, or bleeding disorders before taking DURAPLUS 10/30MG TABLET as a precaution. DURAPLUS 10/30MG TABLET is not recommended for use in patients with liver or heart problems. It is also not suitable for use with children under the age of 18. Avoid taking DURAPLUS 10/30MG TABLET with grapefruit juice.
The most common side effects of taking DURAPLUS 10/30MG TABLET are flushing, headache, dizziness, blurred vision, muscle pain, nausea, tiredness, increased sweating, restlessness, and a decrease in sex drive. Consult your doctor if any of these side effects trouble you.
Also, inform your doctor immediately if you experience any prolonged painful penile erections without sexual stimulation (priapism), experience dizziness upon standing up suddenly, or if you have sudden mood changes or suicidal thoughts after taking DURAPLUS 10/30MG TABLET.
It is used by adult men to:
DURAPLUS 10/30MG TABLET contains two medicines called dapoxetine and tadalafil. Dapoxetine delays ejaculation by blocking the reuptake of a chemical messenger called serotonin between the nerve cells. This increases the activity of serotonin within the brain, which therefore increases the time taken to release the semen (ejaculate) during sexual intercourse.
Tadalafil works by improving the blood supply to the penis. It works by blocking the effects of certain enzymes (PDE5) in the body that limit blood flow to the penis. As a result, it relaxes the blood vessels supplying the penis and improves blood flow.
Take DURAPLUS 10/30MG TABLET as advised by your physician. Swallow DURAPLUS 10/30MG TABLET with a glass of water. Do not chew or crush the medicine. DURAPLUS 10/30MG TABLET can be taken with or without meals. Take DURAPLUS 10/30MG TABLET at least 30 minutes to 1 hour before planning to have sexual intercourse. Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight, and health condition.
Stop taking DURAPLUS 10/30MG TABLET and contact your doctor if you experience any of the following side effects:
Hydrate yourself by drinking plenty of fluids, such as water or fruit juices. Consuming ORS can also be beneficial. Do not self-treat diarrhea on your own. Consult your doctor if your diarrhea becomes uncontrollable.
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens or if you feel dizzy upon standing up suddenly.
Rest and relax. Keep yourself hydrated by drinking plenty of fluids, such as water or electrolytes. Applying a pain-relieving balm to your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Take DURAPLUS 10/30MG TABLET with or just after meals. Stick to simple meals. Avoid eating oil-rich or spicy foods. Consult your doctor if your vomiting worsens.
DURAPLUS 10/30MG TABLET is not intended for use by women.
DURAPLUS 10/30MG TABLET is not intended for use by women.
Do not drive or operate any machines if you experience dizziness or blurred vision after taking DURAPLUS 10/30MG TABLET.
Avoid consumption of alcohol while taking DURAPLUS 10/30MG TABLET, as it may cause dizziness or sleepiness.
DURAPLUS 10/30MG TABLET should be used with caution in patients with kidney problems. Therefore, consult your doctor before taking it.
DURAPLUS 10/30MG TABLET is not recommended for use in patients with moderate or severe liver diseases. Therefore, consult your doctor before taking it.
Do not take DURAPLUS 10/30MG TABLET if you are allergic to dapoxetine or tadalafil.
DURAPLUS 10/30MG TABLET should be used with caution in patients with pulmonary arterial hypertension. Therefore, consult your doctor before taking it.
DURAPLUS 10/30MG TABLET is not recommended for use in patients with heart problems (such as heart failure, low blood pressure, or problems with the heart rhythm). Therefore, consult your doctor before taking it.
DURAPLUS 10/30MG TABLET is not recommended for use in children and adolescents (below 18 years). Therefore, consult your doctor before taking it.
DURAPLUS 10/30MG TABLET is not recommended for use in elderly patients (aged 65 years or older). Therefore, consult your doctor before taking it.
DURAPLUS 10/30MG TABLET is not recommended for use if you:
Before taking DURAPLUS 10/30MG TABLET, inform your doctor if you:
A. Drug-Drug Interactions:
Before taking DURAPLUS 10/30MG TABLET, inform your doctor if you are taking any of the following medicines, such as:
B. Drug-Food Interactions:
Avoid drinking grapefruit juice within 24 hours prior to taking DURAPLUS 10/30MG TABLET, as it may increase the level of DURAPLUS 10/30MG TABLET in the body.
Overdosage:
If you or anyone else accidentally took more DURAPLUS 10/30MG TABLET, consult your doctor immediately or visit the nearby hospital. The symptoms of an overdose are nausea and vomiting.
| Drug | : | Dapoxetine, Tadalafil |
| Pharmacological Category | : | Selective serotonin reuptake inhibitors (SSRI), Phosphodiesterase type 5 inhibitors |
| Therapeutic Indication | : | Problems in erection, to manage early ejaculation |
| Dosage Forms | : | Tablet |
Q: What is DURAPLUS 10/30MG TABLET used for?
A: DURAPLUS 10/30MG TABLET is used in adult men to help improve blood flow to the penis and to manage early ejaculation by balancing certain chemicals in the brain.
Q: How do I take DURAPLUS 10/30MG TABLET?
A: Take DURAPLUS 10/30MG TABLET for at least 30 minutes to 1 hour before having sexual intercourse. Swallow the medicine with a glass of water. Do not crush or chew the medicine.
Q: Can I take DURAPLUS 10/30MG TABLET daily?
A: DURAPLUS 10/30MG TABLET is generally prescribed as one dose per day. However, your doctor will decide whether you can take this medicine daily or not, depending on your health condition. Do not take DURAPLUS 10/30MG TABLET more than once a day without consulting your doctor.
Q: How long does it take for DURAPLUS 10/30MG TABLET to start working?
A: It may take around 30 minutes to 1 hour for DURAPLUS 10/30MG TABLET to start working; therefore, take this medicine at least one hour before planning to have sex. This time may vary from person to person depending upon their health condition.
Q: What happens if I consume a higher dose of DURAPLUS 10/30MG TABLET than prescribed by my doctor?
A: Do not consume a higher dose of DURAPLUS 10/30MG TABLET than the one prescribed by your doctor, as it may lead to unwanted side effects. Your doctor will decide the correct dose for you, depending on your age and disease condition. If the prescribed dose does not help you, contact your doctor.
Q: Can men be taking DURAPLUS 10/30MG TABLET father a child?
A: There is no confirmed proof that DURAPLUS 10/30MG TABLET could affect fertility in men. However, it is better to consult your doctor before taking DURAPLUS 10/30MG TABLET if you are planning to father a child.
Q: Is DURAPLUS 10/30MG TABLET safe?
A: Yes. DURAPLUS 10/30MG TABLET is safe to use. But inform your doctor immediately if you experience painful, prolonged erections or chest pain after taking DURAPLUS 10/30MG TABLET. It can also cause headache dizziness, flushing, or muscle pain in some individuals. Contact your doctor if they bother you.
Q: Can I consume alcohol while taking DURAPLUS 10/30MG TABLET?
A: Avoid consumption of alcohol while taking DURAPLUS 10/30MG TABLET, as it could reduce the effectiveness of DURAPLUS 10/30MG TABLET.
Q: How long will the effects of DURAPLUS 10/30MG TABLET last?
A: The effects of DURAPLUS 10/30MG TABLET would normally last for 4 hours. However, this time may vary from person to person depending on their age and health condition. Consult your doctor if the effects of DURAPLUS 10/30MG TABLET do not last until sexual intercourse.
Q: Can DURAPLUS 10/30MG TABLET make you last longer?
A: Yes. DURAPLUS 10/30MG TABLET delays the release of sperm (ejaculation) in patients suffering from premature ejaculation.
Q: Will taking DURAPLUS 10/30MG TABLET affect my sexual life?
A: Long-term use of DURAPLUS 10/30MG TABLET may negatively impact your sexual life. It may cause sexual problems, such as a decrease in sex drive. Talk to your doctor if you are facing any sexual problems while taking DURAPLUS 10/30MG TABLET.
Q: How does DURAPLUS 10/30MG TABLET work?
A: DURAPLUS 10/30MG TABLET delays the ejaculation (release of semen) by increasing the activity of a particular chemical called serotonin in the brain. This promotes control over ejaculation and helps your body hold sperm for a longer period. It also improves penile functions by improving blood supply to the penis.
Q: Can I stop taking DURAPLUS 10/30MG TABLET on my own without consulting a doctor?
A: Do not stop taking DURAPLUS 10/30MG TABLET without consulting your physician, as sudden discontinuation of DURAPLUS 10/30MG TABLET may cause withdrawal symptoms like sleeping problems or dizziness.
Q: Can DURAPLUS 10/30MG TABLET cause bipolar disorder?
A: DURAPLUS 10/30MG TABLET may cause mood changes in some individuals. Inform your doctor immediately if you experience any sudden changes in mood. Also, it is important to inform you doctor if you already have bipolar disorder as a precaution before starting treatment with DURAPLUS 10/30MG TABLET.
1. KD. Tripathi. Androgens and Drugs for Erectile Dysfunction & Drugs Used in Mental Illness: Antidepressant and Antianxiety Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 304 & 464.
2. Aykut Bugra Sentürk, Ali Haydar Yilmaz, Basri Çakiroglu, Muhammet Yaytokgil, Cemil Aydin, Musa Ekici, Serdar Aykan, Mustafa Sungur. Combination or alone? Which one is the Best in Premature Ejaculation Treatment? HAYDARPASA NUMUNE MEDICAL JOURNAL. October 2018. [Accessed on 7th July 2022]. https://jag.journalagent.com/hnhjournal/pdfs/HNHJ-87699-RESEARCH_ARTICLE-SENTURK.pdf
3. Hamed Mohseni Rad, Telma Zahirian Moghadam, Ali Hosseinkhani and Nima Nima Soluki. Comparison of Dapoxetine /Tadalafil and Paroxetine/Tadalafil Combination Therapies for the Treatment of the Premature Ejaculation: A Randomized Clinical Trial. ScienceDirect. November 2021. [Accessed on 7th July 2022]. https://www.researchgate.net/publication/360618767_Comparison_of_Dapoxetine_Tadalafil_and_ParoxetineTadalafil_Combination_Therapies_for_the_Treatment_of_the_Premature_Ejaculation_A_Randomized_Clinical_Trial
4. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in January 2021] [Accessed 7th July 2022]. https://www.medicines.org.uk/emc/files/pil.8636.pdf
5. Menarini - Von Heyden GmbH. Electronic Medicines Compendium (EMC). [Revised in June 2021] [Accessed 7th July 2022]. https://www.medicines.org.uk/emc/files/pil.1269.pdf
Written By Dr. N. Sai Swaroop, Pharm.D
Last updated on 12 Dec 2023 | 05:33 PM(IST)