INTRODUCTION

EVERMIL 10MG TABLET contains Everolimus which belongs to the group of medicines called Anticancer agents. It is used to treat hormone receptor-positive advanced breast cancer in postmenopausal women, in whom other treatments, advanced tumours called neuroendocrine tumours that originate from the stomach, bowels, lung or pancreas, advanced kidney cancer (advanced renal cell carcinoma), where other treatments (VEGF-targeted therapy) have not helped stop your disease.

Before taking EVERMIL 10MG TABLET, inform your doctor if you have or ever had liver problems, diabetes, need to receive a vaccine, high cholesterol, recent major surgery or unhealed wound, an infection, hepatitis B, and are about to receive radiation therapy. EVERMIL 10MG TABLET is not recommended to use in children and adolescents (under 18 years of age). Consult your doctor before taking the medicine.

EVERMIL 10MG TABLET should be used with caution in elder patients (65 years and above). EVERMIL 10MG TABLET is generally not recommended for use among pregnant and breastfeeding women. The most common side effects of taking EVERMIL 10MG TABLET are fever, cough, difficulty breathing, wheezing, swelling, feeling of heaviness or tightness, pain. Contact your doctor for advice if any of the symptoms worsen.

USES OF EVERMIL 10MG TABLET

It is used to treat adult patients with:

• hormone receptor-positive advanced breast cancer in postmenopausal women, in whom other treatments (non-steroidal aromatase inhibitors) no longer keep the disease under control
• advanced tumours called neuroendocrine tumours that originate from the stomach, bowels, lung or pancreas
• advanced kidney cancer (advanced renal cell carcinoma)

HOW EVERMIL 10MG TABLET WORKS

EVERMIL 10MG TABLET reduces the blood supply to the tumour and slows down the growth and spread of cancer cells.

DIRECTIONS FOR USE

Take EVERMIL 10MG TABLET as advised by your physician. Swallow the medicine with enough water. Do not crush or chew the EVERMIL 10MG TABLET. The correct dose and duration will be decided by your physician for you depending on your age, body weight, and disease condition.

SIDE EFFECTS OF EVERMIL 10MG TABLET

HOW TO MANAGE SIDE EFFECTS

Diarrhea

Drink more fluids, such as water or fruit juice to keep yourself hydrated. Do not consume any medicine on your own without taking advice from your doctor.

Nausea And Vomiting

Take this medicine with, or just after meals. Have simple meals. Avoid eating food that is rich in oil or spicy foods.

Stomach Pain

Try to rest and relax. Eat and drink gradually or try to have lesser and more frequent meals. Keep a heating pad on your stomach. Contact your physician if the symptom does not improve.

WARNING & PRECAUTIONS

PREGNANCY

Monitoring required

EVERMIL 10MG TABLET is not recommended for use in pregnant women unless considered clearly necessary. Consult your doctor before taking EVERMIL 10MG TABLET.

BREASTFEEDING

Contraindicated

EVERMIL 10MG TABLET is generally not recommended for use in breastfeeding women as it may pass through breast milk. Consult your doctor before taking EVERMIL 10MG TABLET.

DRIVING AND USING MACHINES

Use with Caution

Do not drive or operate any machines if you feel tired (fatigue) after taking EVERMIL 10MG TABLET.

KIDNEY

Use with Caution

EVERMIL 10MG TABLET should be taken with caution in patients with kidney problems. Consult your doctor before taking EVERMIL 10MG TABLET.

LIVER

Use with Caution

EVERMIL 10MG TABLET should be taken with caution in patients with liver problems. Consult your doctor before taking EVERMIL 10MG TABLET.

ALLERGY

Contraindicated

Do not take EVERMIL 10MG TABLET if you are allergic to Everolimus, or any of the other ingredients of EVERMIL 10MG TABLET.

USE IN PEDIATRICS

Contraindicated

EVERMIL 10MG TABLET is not recommended to use in children and adolescents (under 18 years of age) Consult your doctor before taking [GBKEYWORD].

USE IN GERIATRICS

Use with Caution

EVERMIL 10MG TABLET should be used with caution in elderly patients (above 65 years of age). Consult your doctor before taking EVERMIL 10MG TABLET.

INTERACTIONS

A. Drug-Drug interactions:

Before taking EVERMIL 10MG TABLET, inform your doctor if you are taking any of the following medicine:

• medicine used to treat fungal infections (Ex. voriconazole, ketoconazole, fluconazole, itraconazole, or and other antifungals)
• medicine used to treat bacterial infections (Ex. clarithromycin, telithromycin, or erythromycin)
• medicines used to treat HIV infection/AIDS (Ex. ritonavir, efavirenz or nevirapine, and other antivirals)
• medicine used to treat heart conditions or high blood pressure (Ex. verapamil or diltiazem)
• medicine used to help regulate heartbeat (Ex. dronedarone)
• medicine used to stop the body from rejecting organ transplants (Ex. ciclosporin)
• medicine used to inhibit the growth of abnormal cells (Ex. imatinib)
• medicine used to treat high blood pressure or other cardiovascular problems (Ex. angiotensin-converting enzyme (ACE) inhibitors
• medicine used to treat tuberculosis (Ex. rifampicin)
• medicine used to treat depression and other conditions (Ex. St. John’s wort)
• medicine used to treat a wide variety of conditions including inflammatory or immune problems (Ex. dexamethasone)
• medicine used to treat epilepsy (Ex. phenytoin, carbamazepine or phenobarbital, and other anti-epileptics)

B. Drug-Food interactions:

Avoid having grapefruit or grapefruit juice while taking EVERMIL 10MG TABLET as it may increase the risk of side effects.

Overdosage:

If you or anyone else accidentally takes too much of EVERMIL 10MG TABLET, consult your doctor immediately or visit the nearby hospital.

SYNOPSIS

MORE INFORMATION

• Keep EVERMIL 10MG TABLET out of reach of children
• Store at a temperature below 25°C

FAQs ABOUT EVERMIL 10MG TABLET

Q: Is there any food to avoid while taking EVERMIL 10MG TABLET?

A: Avoid having grapefruit or grapefruit juice while taking EVERMIL 10MG TABLET as it may increase the risk of side effects. Consult your physician for advice before taking EVERMIL 10MG TABLET.

Q: Can I stop taking EVERMIL 10MG TABLET if I feel my condition is improved?

A: Do not stop taking EVERMIL 10MG TABLET even if you feel improved because the condition may become worsen. Consult your doctor before stopping EVERMIL 10MG TABLET.

Q: How to take EVERMIL 10MG TABLET?

A: Take EVERMIL 10MG TABLET as advised by your physician. Swallow the medicine with enough water. Do not crush or chew the medicine. The correct dose and duration will be decided by your physician for you depending on your age, body weight, and disease condition.

Q: How do EVERMIL 10MG TABLET works?

A: EVERMIL 10MG TABLET reduces the blood supply to the tumour and slows down the growth and spread of cancer cells.

Q: Can I take EVERMIL 10MG TABLET along with antiepileptics?

A: Antiepileptics like phenytoin, phenobarbital, or carbamazepine will affect the efficacy of EVERMIL 10MG TABLET. Consult your doctor before taking EVERMIL 10MG TABLET.

Q: Is it safe to use EVERMIL 10MG TABLET in children?

A: EVERMIL 10MG TABLET is not recommended to use in children and adolescents (under 18 years of age) Consult your doctor before taking EVERMIL 10MG TABLET.

Q: EVERMIL 10MG TABLET is safe for pregnant and breastfeeding women?

A: EVERMIL 10MG TABLET is generally not recommended for use in pregnant and breastfeeding women unless considered clearly necessary. Consult your doctor before taking EVERMIL 10MG TABLET.

REFERENCES

1. Alan M. Krensky, Jamil R. Azzi, and David A. Hafler. Immunosuppressants and Tolerogens. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 13th Edition. New York McGraw Hill Medical 2018. Page – 638-653.

2. David N. Franz, Elena Belousova, Steven Sparagana, E. Martina Bebin, Michael D. Frost, Rachel Kuperman, et.al. Long-Term Use of Everolimus in Patients with Tuberous Sclerosis Complex: Results from the EXIST-1 Study. Journal of Plos one. June 2018. [Accessed on 11th June 2022] https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0158476

3. Katarzyna Bobeff, Karolina Krajewska, Dobromila Baranska, Katarzyna Kotulska, Sergiusz Jozwiak, Wojciech Mlynarski and Joanna Trelinska. Maintenance Therapy With Everolimus for Subependymal Giant Cell Astrocytoma in Patients With Tuberous Sclerosis –Results From the EMINENTS Study. Journal of Frontiers in Neurology. April 2021. [Accessed on 11th June 2022] https://www.frontiersin.org/articles/10.3389/fneur.2021.581102/full

4. Peri M, Fazio N. Clinical Evaluation of Everolimus in the Treatment of Neuroendocrine Tumor of the Lung: Patient Selection and Special Considerations. Systematic and Critical Review of the Literature. Journal of lung cancer: targets and therapy. June 2020. [Accessed on 11th June 2022] https://www.dovepress.com/clinical-evaluation-of-everolimus-in-the-treatment-of-neuroendocrine-t-peer-reviewed-fulltext-article-LCTT

5. Ajay Dhakal, Roby Antony Thomas, Ellis G Levine, Adam Brufsky, Kazuaki Takabe, Matthew G Hanna, et.al. Outcome of Everolimus-Based Therapy in Hormone-Receptor-Positive Metastatic Breast Cancer Patients After Progression on Palbociclib. SAGE Journals (July 2020). [Accessed on 11th June 2022] https://journals.sagepub.com/doi/full/10.1177/1178223420944864

6. Novartis Pharmaceuticals UK Limited. Electronic Medicines Compendium (EMC). [Revised in January 2022] [Accessed 11th June 2022] https://www.medicines.org.uk/emc/files/pil.6658.pdf

7. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in February 2022] [Accessed 11th June 2022] https://www.medicines.org.uk/emc/files/pil.11084.pdf

8. Novartis Pharmaceuticals Corporation. US Food and Drug Administration. [Revised in July 2012] [Accessed on 11th June 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/022334s016lbl.pdf

USEFUL DIAGNOSTIC TESTS

• Complete Blood Count

AUTHOR DETAILS

Written By Dr. Janet.C, Pharm.D
Last updated on 23 Mar 2023 | 06:01 PM(IST)