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INTRODUCTION ARPIMUNE O 50MG CAPSULE contains Cyclosporine which belongs to the group of medicines called Immunosuppressants. It is used to prevent graft rejection in patients undergoing transplantation of any organ, bone marrow or stem cells. It can also be used to treat...
ARPIMUNE O 50MG CAPSULE contains Cyclosporine which belongs to the group of medicines called Immunosuppressants. It is used to prevent graft rejection in patients undergoing transplantation of any organ, bone marrow or stem cells.
It can also be used to treat various auto-immune disease conditions such as psoriasis, atopic dermatitis (or eczema), rheumatoid arthritis (joint inflammation), nephrotic syndrome (a kidney disease) or eye inflammation (such as endogenous uveitis, including Behçet's uveitis). It is mostly used in combination with other immune suppressants (such as azathioprine) to achieve maximum benefits.
Take ARPIMUNE O 50MG CAPSULE regularly as instructed by your doctor. While undergoing therapy with ARPIMUNE O 50MG CAPSULE your doctor will periodically monitor your blood pressure, blood cholesterol levels, liver and kidney functions to avoid the risk of side effects.
Your doctor may also prescribe you blood tests and urine tests at regular intervals to access the improvement in your health conditions. During treatment with ARPIMUNE O 50MG CAPSULE, avoid exposing your skin towards direct sunlight. Wear protective loose-fitting clothes and apply sunscreen while going outdoors.
Before taking ARPIMUNE O 50MG CAPSULE inform your doctor if you have any liver problems or any signs of infections (such as fever or sore throat). You must also inform your doctor if you have hepatitis C infection, fits, low blood magnesium levels, gout, alcohol dependence or if you are about to receive any vaccinations as a precaution.
ARPIMUNE O 50MG CAPSULE is not recommended for use in patients with severe uncontrollable infections, any types of cancer or severe high blood pressure. Do not take ARPIMUNE O 50MG CAPSULE without consulting your doctor if you are pregnant or breastfeeding.
Avoid consuming grapefruit or drinking grapefruit juice while taking ARPIMUNE O 50MG CAPSULE as it may increase the risk of side effects. The most common side effects of taking ARPIMUNE O 50MG CAPSULE are increase in blood sugar levels, increase in blood cholesterol levels, increased blood potassium levels, high blood pressure, headache, loss of appetite, acne, hot flushes, tiredness, excessive facial hair and low blood magnesium levels in blood. Consult your doctor if any of these side effects worsen.
ARPIMUNE O 50MG CAPSULE is an immunosuppressive agent. It works by blocking the release of certain chemicals in the body (such as T-cells, interleukins and cytokines) that triggers the immune response. This action suppresses your body’s immune functions and enables your body to accept the newly transplanted organ. It also stops the abnormal immune response in the body and prevents your body from attacking its own cells.
Take ARPIMUNE O 50MG CAPSULE as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. Do not stop taking ARPIMUNE O 50MG CAPSULE without consulting your doctor.
Stop taking ARPIMUNE O 50MG CAPSULE and contact your doctor immediately if you experience any of the following side effects:
Nausea or vomiting:
Try to take ARPIMUNE O 50MG CAPSULE with or just after meals. Stick to simple meals and avoid oil rich or spicy foods. Consult your doctor if nausea worsens.
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
ARPIMUNE O 50MG CAPSULE is not recommended for use in pregnant women unless considered necessary by the physician. Therefore, consult your doctor before taking it.
ARPIMUNE O 50MG CAPSULE may pass through the breast milk. Therefore, it is not recommended for use in breastfeeding woman. However, consult your doctor before taking it.
Do not drive or operate any heavy tools or machines if your ability is affected by ARPIMUNE O 50MG CAPSULE.
Avoid consumption of alcohol while taking ARPIMUNE O 50MG CAPSULE as it might worsen your condition.
ARPIMUNE O 50MG CAPSULE is not recommended for use in patients with other kidney problems (except for nephrotic syndrome). Therefore, consult your doctor before taking it.
ARPIMUNE O 50MG CAPSULE should be used with caution in patients with liver problems (including Hepatitis C infection). Therefore, consult your doctor before taking it.
Talk to your doctor before taking ARPIMUNE O 50MG CAPSULE if you are allergic to cyclosporine.
ARPIMUNE O 50MG CAPSULE is not recommended for use if you:
Before taking ARPIMUNE O 50MG CAPSULE inform your doctor if you:
Use in paediatrics:
ARPIMUNE O 50MG CAPSULE should only be used to treat nephrotic syndrome in children. It is generally not recommended for preventing graft rejection or for treating other auto-immune disease condition apart from nephrotic syndrome in children. Therefore, consult your doctor before taking it.
Use in geriatrics:
ARPIMUNE O 50MG CAPSULE should be used with caution in elderly patients. Therefore, consult your doctor before taking it. Proper dose adjustments and careful monitoring are required in such patients.
A. Drug - Drug interactions:
Before taking ARPIMUNE O 50MG CAPSULE, inform your doctor if you are taking any of the following medicines such as:
B. Drug – food interactions
Avoid consuming grapes or grapefruit juice while taking ARPIMUNE O 50MG CAPSULE as it may increase the risk of side effects.
Overdosage:
If you or anyone else accidentally took more ARPIMUNE O 50MG CAPSULE, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage might include vomiting, drowsiness, headache, fast heartbeat and kidney damage.
| Drug | : | Cyclosporine |
| Pharmacological Category | : | Calcineurin inhibitors |
| Therapeutic Indication | : | Graft rejection, Autoimmune diseases |
| Dosage Forms | : | Tablet, Capsule, Injection, Infusion, Oral Solution, Oral Suspension, Eye Drops, Ophthalmic Emulsion |
What is the use of ARPIMUNE O 50MG CAPSULE?
ARPIMUNE O 50MG CAPSULE is used to prevent graft rejection in patients undergoing transplantation of any organ, bone marrow or stem cells. It can also be used to treat various auto-immune disease conditions such as psoriasis, atopic dermatitis (or eczema), rheumatoid arthritis, nephrotic syndrome or eye inflammation (such as endogenous uveitis, including Behçet's uveitis).
How ARPIMUNE O 50MG CAPSULE works?
ARPIMUNE O 50MG CAPSULE is an immunosuppressive agent. It works by blocking the release of certain chemicals in the body (such as T-cells, interleukins and cytokines) that triggers the immune response. This action suppresses your body’s immune functions and enables your body to accept the newly transplanted organ. It also stops the abnormal immune response in the body and prevents your body from attacking its own cells.
How to take ARPIMUNE O 50MG CAPSULE?
Take ARPIMUNE O 50MG CAPSULE as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.
Is ARPIMUNE O 50MG CAPSULE an antibiotic?
No. ARPIMUNE O 50MG CAPSULE is an immunosuppressive agent. It suppresses your body’s immune functions and enables your body to accept the transplanted organ. It also stops the abnormal immune response in the body and prevents your body from attacking its own cells.
What precautions must be followed while taking ARPIMUNE O 50MG CAPSULE?
Before taking ARPIMUNE O 50MG CAPSULE inform your doctor if you have any liver problems or any signs of infections (such as fever or sore throat). You must also inform your doctor if you have hepatitis C infection, fits, low blood magnesium levels, gout, alcohol dependence, severe uncontrollable infections, any types of cancer, severe high blood pressure or if you are about to receive any vaccinations as a precaution. Inform your doctor before taking ARPIMUNE O 50MG CAPSULE if you are pregnant or breastfeeding.
How long should I take ARPIMUNE O 50MG CAPSULE?
You need to take ARPIMUNE O 50MG CAPSULE for the stipulated duration prescribed by your doctor. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
What to do if I forgot to take a dose of ARPIMUNE O 50MG CAPSULE?
If you forgot to take a dose of ARPIMUNE O 50MG CAPSULE, take it as soon as you remember. However, if it is time for the next dose of ARPIMUNE O 50MG CAPSULE, skip the missed dose and take the next one regularly. Do not take a double dose of ARPIMUNE O 50MG CAPSULE to compensate the missed ones.
Is ARPIMUNE O 50MG CAPSULE safe?
The most common side effects of taking ARPIMUNE O 50MG CAPSULE are increase in blood sugar levels, increase in blood cholesterol levels, increased blood potassium levels, high blood pressure, headache, loss of appetite, acne, hot flushes, tiredness, excessive facial hair and low blood magnesium levels in blood. Consult your doctor if any of these side effects worsen.
Can I stop taking ARPIMUNE O 50MG CAPSULE without consulting your doctor?
No. You should not stop taking ARPIMUNE O 50MG CAPSULE without consulting your doctor because your body’s immune system may once again attempt to reject the newly transplanted organ. Therefore, take ARPIMUNE O 50MG CAPSULE for the stipulated duration recommended by your doctor to achieve maximum results.
What happens if I take too more of ARPIMUNE O 50MG CAPSULE?
If you or anyone else accidentally took more ARPIMUNE O 50MG CAPSULE, consult your doctor immediately or visit the nearby hospital. Symptoms of overdosage might include vomiting, drowsiness, headache, fast heartbeat and kidney damage.
Can I use ARPIMUNE O 50MG CAPSULE if I suffer from kidney diseases?
ARPIMUNE O 50MG CAPSULE is not recommended for use in patients with other kidney problems (except for nephrotic syndrome). Therefore, consult your doctor before taking it.
Will taking a higher dose of ARPIMUNE O 50MG CAPSULE be more effective?
No, taking a higher dose of ARPIMUNE O 50MG CAPSULE will not be effective rather it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.
Can I take medication for high blood pressure along with ARPIMUNE O 50MG CAPSULE?
It is not advisable to take medicines to control blood pressure while taking ARPIMUNE O 50MG CAPSULE without consulting your doctor as they have known interactions with ARPIMUNE O 50MG CAPSULE.
Can ARPIMUNE O 50MG CAPSULE be used in pregnant women?
ARPIMUNE O 50MG CAPSULE is not recommended for use in pregnant women unless considered necessary by the physician. Therefore, consult your doctor before taking it.
How much ARPIMUNE O 50MG CAPSULE should I take?
ARPIMUNE O 50MG CAPSULE should be used only under medical supervision. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body condition and severity of the disease condition.
Is ARPIMUNE O 50MG CAPSULE a steroid?
No. ARPIMUNE O 50MG CAPSULE is an immunosuppressive agent. It suppresses your body’s immune functions and enables your body to accept the transplanted organ. It also stops the abnormal immune response in the body and prevents your body from attacking its own cells.
1. KD. Tripathi. Immunosuppressant Drugs. Essentials of Medical pharmacology. 7th Edition. 2013. Page – 878.
2. Carolina Tapia, Trevor A. Nessel, Patrick M. Zito. Cyclosporine. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. August 2022. [Accessed on 21st November 2022] https://www.ncbi.nlm.nih.gov/books/NBK482450/
3. James F. Burke, Jr., John D. Pirsch, Eleanor L. Ramos, Daniel R. Salomon, Donald M. Stablein, David H. Van Buren, and John C. West. Long-Term Efficacy and Safety of Cyclosporine in Renal-Transplant Recipients. The New England Journal of Medicine. August 1994. [Accessed on 21st November 2022]. https://www.nejm.org/doi/full/10.1056/NEJM199408113310604
4. Novartis Pharmaceuticals UK Limited. Electronic Medicines Compendium (EMC) [Revised in May 2022] [ Accessed on 21st November 2022] https://www.medicines.org.uk/emc/files/pil.1034.pdf
5. Novartis Pharmaceuticals Canada Inc [Revised in August 2022] [ Accessed on 21st November 2022] https://www.ask.novartispharma.ca/download.htm?res=neoral_scrip_e.pdf&resTitleId=691
6. Biocon House, Semicon Park. [Revised in August 2019] [ Accessed on 21st November 2022] https://www.biocon.com/docs/domestic-market-pi/immuno/PSORID-CAPSULES%20PI.pdf
Written By Srilekha. R, B.Pharm
Last updated on 22 Nov 2022 | 11:49 PM(IST)