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INTRODUCTION ADVAGRAF 1MG CAPSULE contains Tacrolimus which belongs to the group of medicines called Immunosuppressants. It is used to prevent graft rejection in patients undergoing organ transplantation. It can also be used to treat an ongoing graft rejection of the newly transplanted organ....
ADVAGRAF 1MG CAPSULE contains Tacrolimus which belongs to the group of medicines called Immunosuppressants. It is used to prevent graft rejection in patients undergoing organ transplantation. It can also be used to treat an ongoing graft rejection of the newly transplanted organ. It is mostly used in combination with other immune suppressants to achieve maximum benefits.
Tacrolimus suppresses your body’s immune functions and enables your body to accept the transplanted organ. Take ADVAGRAF 1MG CAPSULE regularly as instructed by your doctor. While undergoing therapy with ADVAGRAF 1MG CAPSULE your doctor will periodically monitor your heart functions and nerve functions to avoid the risk of side effects.
Your doctor may also prescribe you blood tests and urine tests at regular intervals to access the improvement in your health conditions. During treatment with ADVAGRAF 1MG CAPSULE, avoid exposing your skin towards direct sunlight. Wear protective loose-fitting clothes and apply sunscreen while going outdoors.
Before taking ADVAGRAF 1MG CAPSULE inform your doctor if you have any liver, kidney or heart problems. Avoid consuming grapefruit or drinking grapefruit juice while taking ADVAGRAF 1MG CAPSULE as it may increase the risk of side effects.
Do not take ADVAGRAF 1MG CAPSULE without consulting your doctor if you are pregnant or breastfeeding. Both men and women taking ADVAGRAF 1MG CAPSULE must use a suitable contraceptive method (such as condoms or oral contraceptive pills) to avoid pregnancy while undergoing therapy with ADVAGRAF 1MG CAPSULE.
The most common side effects of taking ADVAGRAF 1MG CAPSULE are an increase in blood sugar levels, increased blood cholesterol levels, difficulty in falling asleep, increased blood potassium levels, high blood pressure, headache, dizziness, indigestion, oedema and increased infections. Consult your doctor if any of these side effects worsen.
ADVAGRAF 1MG CAPSULE is an immunosuppressive agent. It works by blocking the release of certain chemicals in the body (such as T-cells) that triggers the immune response. It suppresses your body’s immune functions and enables your body to accept the transplanted organ. As a result, it prevents the risk of graft rejection and increases the survival of the newly transplanted organ.
Take ADVAGRAF 1MG CAPSULE 1 hour before meals or 2-3 hours after meals or as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.
Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight and disease condition. Do not stop taking ADVAGRAF 1MG CAPSULE without consulting your doctor.
Stop taking ADVAGRAF 1MG CAPSULE and contact your doctor immediately if you experience any of the following side effects such as:
Nausea or vomiting:
Try to take ADVAGRAF 1MG CAPSULE with or just after meals. Stick to simple meals and avoid oil-rich or spicy foods. Consult your doctor if the nausea worsens.
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
Constipation:
Taking ADVAGRAF 1MG CAPSULE with meals may reduce the chances of constipation. However, if you experience constipation, eat plenty of fiber-rich foods such as fresh fruits, vegetables and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.
ADVAGRAF 1MG CAPSULE should be used in pregnant women only if it is considered necessary by the physician. Therefore, inform your doctor before taking it. Women of childbearing potential must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with ADVAGRAF 1MG CAPSULE.
ADVAGRAF 1MG CAPSULE may pass through breast milk. Therefore, it is not recommended for use in breastfeeding woman. However, consult your doctor before taking it.
Do not drive or operate any heavy tools or machines if you experience dizziness or sleepiness after taking ADVAGRAF 1MG CAPSULE.
Avoid consumption of alcohol while taking ADVAGRAF 1MG CAPSULE as it might make you feel dizzier or sleepy.
ADVAGRAF 1MG CAPSULE should be used with caution in patients with kidney problems. Therefore, consult your doctor before taking it.
ADVAGRAF 1MG CAPSULE should be used with caution in patients with liver problems. Therefore, consult your doctor before taking it.
Talk to your doctor before taking ADVAGRAF 1MG CAPSULE if you are allergic to Tacrolimus or to any macrolide antibiotics (such as erythromycin, azithromycin).
ADVAGRAF 1MG CAPSULE should be used with caution in patients with heart problems (such as prolonged QT interval). Therefore, consult your doctor before taking it.
Before taking ADVAGRAF 1MG CAPSULE inform your doctor if you:
Use in pediatrics:
The safety and effectiveness of ADVAGRAF 1MG CAPSULE have not been established in children and adolescents (aged below 18 years) undergoing transplantation. Therefore, consult your doctor before taking it.
Use in geriatrics:
ADVAGRAF 1MG CAPSULE should be used with caution in elderly patients. Therefore, consult your doctor before taking it.
A. Drug-Drug interactions :
Before taking ADVAGRAF 1MG CAPSULE inform your doctor if you are taking the following medicines such as:
B. Drug-food interactions :
ADVAGRAF 1MG CAPSULE may interact with food. To avoid this, take ADVAGRAF 1MG CAPSULE 1 hour before meals or 2-3 hours after meals. Avoid consuming grapes or grapefruit juice while taking ADVAGRAF 1MG CAPSULE as it may increase the risk of side effects.
Overdosage:
If you or anyone else accidentally took more ADVAGRAF 1MG CAPSULE, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose might include tremors, abnormal kidney function results in less or no urine output, increased blood pressure, leg swelling and lack of energy.
| Drug | : | Tacrolimus |
| Pharmacological Category | : | Calcineurin Inhibitors |
| Therapeutic Indication | : | Prevents graft rejection |
| Dosage Forms | : | Capsules, Tablets, Ointment, Lotion, solution, Topical Solution, Oral gel, eye ointment |
What is the use of ADVAGRAF 1MG CAPSULE?
ADVAGRAF 1MG CAPSULE is used to prevent graft rejection in patients undergoing organ transplantation. It can also be used to treat an ongoing graft rejection of the newly transplanted organ.
How ADVAGRAF 1MG CAPSULE works?
ADVAGRAF 1MG CAPSULE is an immunosuppressive agent. It works by blocking the release of certain chemicals in the body (such as T-cells) that triggers the immune response. It suppresses your body’s immune functions and enables your body to accept the transplanted organ. As a result, it prevents the risk of graft rejection and increases the survival of the newly transplanted organ.
How to take ADVAGRAF 1MG CAPSULE?
Take ADVAGRAF 1MG CAPSULE 1 hour before meals or 2-3 hour after meals or as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.
What is the best time to take ADVAGRAF 1MG CAPSULE?
Take ADVAGRAF 1MG CAPSULE 1 hour before meals or 2-3 hours after meals or as directed by your physician. It is usually taken twice daily. However, your doctor will decide the correct dose, duration of therapy and time of administration for you depending on your age, body weight and disease condition.
Is ADVAGRAF 1MG CAPSULE an antibiotic?
No. ADVAGRAF 1MG CAPSULE is an immunosuppressive agent. It suppresses your body’s immune functions and enables your body to accept the transplanted organ.
What precautions must be followed while taking ADVAGRAF 1MG CAPSULE?
ADVAGRAF 1MG CAPSULE must be taken 1 hour before meals or 2-3 hour after meals. Avoid drinking grapefruit juice while taking ADVAGRAF 1MG CAPSULE. During treatment with ADVAGRAF 1MG CAPSULE, avoid exposing your skin towards direct sunlight. Wear protective loose-fitting clothes and apply sunscreen while going outdoors. Before taking ADVAGRAF 1MG CAPSULE inform your doctor if you have any liver, kidney or heart problems or if you are pregnant or breastfeeding. Both men and women taking ADVAGRAF 1MG CAPSULE must use a suitable contraceptive method (such as condoms or oral contraceptive pills) to avoid pregnancy while undergoing therapy with ADVAGRAF 1MG CAPSULE.
How long should I take ADVAGRAF 1MG CAPSULE?
You need to take ADVAGRAF 1MG CAPSULE for the stipulated duration prescribed by your doctor. Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight and disease condition.
What to do if I forgot to take a dose of ADVAGRAF 1MG CAPSULE?
If you forgot to take a dose of ADVAGRAF 1MG CAPSULE, take it as soon as you remember. However, if it is time for the next dose of ADVAGRAF 1MG CAPSULE, skip the missed dose and take the next one regularly. Do not take a double dose of ADVAGRAF 1MG CAPSULE to compensate for the missed ones.
Is ADVAGRAF 1MG CAPSULE safe?
The most common side effects of taking ADVAGRAF 1MG CAPSULE are an increase in blood sugar levels, increased blood cholesterol levels, difficulty in falling asleep, increased blood potassium levels, high blood pressure, headache, dizziness, indigestion, oedema and increased infections. Consult your doctor if any of these side effects worsen.
Can I stop taking ADVAGRAF 1MG CAPSULE without consulting your doctor?
No. You should not stop taking ADVAGRAF 1MG CAPSULE without consulting your doctor because your body’s immune system may once again attempt to reject the newly transplanted organ. Therefore, take ADVAGRAF 1MG CAPSULE for the stipulated duration recommended by your doctor to achieve maximum results.
What happens if I take too more of ADVAGRAF 1MG CAPSULE?
If you or anyone else accidentally took more ADVAGRAF 1MG CAPSULE, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose might include tremors, abnormal kidney function results in less or no urine output, increased blood pressure, leg swelling and lack of energy.
Can I use ADVAGRAF 1MG CAPSULE if I suffer from kidney diseases?
ADVAGRAF 1MG CAPSULE should be used with caution in patients with kidney problems. Therefore, consult your doctor before taking it.
Will taking a higher dose of ADVAGRAF 1MG CAPSULE be more effective?
No, taking a higher dose of ADVAGRAF 1MG CAPSULE will not be effective rather it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.
Can I take medication for high blood pressure along with ADVAGRAF 1MG CAPSULE?
It is not advisable to take medicines to control blood pressure while taking ADVAGRAF 1MG CAPSULE without consulting your doctor as they have known interactions with ADVAGRAF 1MG CAPSULE.
Can ADVAGRAF 1MG CAPSULE be used in pregnant women?
ADVAGRAF 1MG CAPSULE should be used in pregnant women only if it is considered necessary by the physician. Therefore, consult your doctor before taking it.
How much ADVAGRAF 1MG CAPSULE should I take?
ADVAGRAF 1MG CAPSULE should be used only under medical supervision. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body condition and severity of the disease condition.
Can ADVAGRAF 1MG CAPSULE cause constipation?
Yes. Constipation is a common side effect of using ADVAGRAF 1MG CAPSULE. Eat plenty of fiber-rich foods such as fresh fruits, vegetables, cereals as well as drink plenty of water and exercise more regularly when taking this medicine. Contact your doctor if this side effect bothers you.
Can the use of ADVAGRAF 1MG CAPSULE affect fertility?
ADVAGRAF 1MG CAPSULE may affect fertility in both men and women. Therefore, try to avoid pregnancy while undergoing therapy with ADVAGRAF 1MG CAPSULE. Both men and women must use a suitable contraceptive method (such as condoms or oral contraceptive pills) to avoid pregnancy while undergoing therapy with [GBNKEYWORD.
1. KD. Tripathi. Autocoids and related drugs. Essentials of Medical Pharmacology. 8th edition. 2019. Page – 940-941.
2. Mahmoud Kamel, Manish Kadian, Titte Srinivas, David Taber, and Maria Aurora Posadas Salas. Tacrolimus confers lower acute rejection rates and better renal allograft survival compared to cyclosporine. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. December 2016. [Accessed on 26th October 2022]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5175228/
3. Astellas Ireland Co. Ltd. European Medicines Compendium (EMC) [Revised on May 2022] [Accessed on 26th October 2022] https://www.medicines.org.uk/emc/files/pil.6720.pdf
4. Astellas Pharma. U S Food and Drug Administration. [Revised in February 2012]. [Accessed on 26th October 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/050709s031lbl.pdf
5. Astellas Pharma Tech Co. Ltd. Tacrolimus [Revised in July 2021] [Accessed on 26th October 2022] https://www.astellas.com/us/system/files/prografwpi_3.pdf
6. Biocon Ltd. Tacrolimus Capsules. Tacrograf – 0.25/0.5/1/2/3/5mg. [Accessed on 26th October 2022] https://biocon.com/docs/prescribing_informatio/nephrology/tacrograf_pi.pdf
Written By Srilekha. R, B.Pharm
Last updated on 27 Oct 2022 | 06:21 PM(IST)