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INTRODUCTION DEPOPRED INJECTION contains Methylprednisolone which belongs to the group of medicines called Corticosteroids. It is used to treat problematic conditions of the adrenal glands (such as adrenal insufficiency, congenital adrenal hyperplasia and nonsuppurative thyroiditis)....
DEPOPRED INJECTION contains Methylprednisolone which belongs to the group of medicines called Corticosteroids. It is used to treat problematic conditions of the adrenal glands (such as adrenal insufficiency, congenital adrenal hyperplasia and nonsuppurative thyroiditis).
It can also be used to treat various inflammatory auto-immune disease conditions affecting the bones and joints (Ex. rheumatoid arthritis, ankylosing spondylitis), skin and collagen (Ex. severe erythema multiforme), eyes (Ex. optic neuritis, uveitis or iritis), respiratory tract (Ex. asthma, tuberculosis), blood or blood vessels (Ex. leukemia), bowel and gut (Ex. Crohn’s disease and ulcerative colitis) and brain (Ex. tuberculous meningitis).
It is also indicated in the treatment of drug induced hypersensitivity reactions and in other allergic conditions (such as atopic dermatitis, allergic conjunctivitis and allergic rhinitis). It also helps in the prevention of graft rejection following organ transplantation, reduce flare-ups of multiple sclerosis and reduces protein loss in urine among patients having kidney problems (such as nephrotic syndrome).
Before receiving DEPOPRED INJECTION inform your doctor if you any viral infections, or any liver, kidney or heart problems. You must also inform your doctor if you have hypertension, diabetes, thyroid deficiency, glaucoma, skin problem, gut inflammation, muscle problems, osteoporosis, any types of tumors or cancer in the body, depression or any other forms of mental illness.
DEPOPRED INJECTION is not recommended for use in patients with severe fungal infections, brain swelling due to malaria, or brain injury or stroke. It should be used in pregnant or breastfeeding women only if it is considered necessary by the physician. Avoid drinking grapefruit juice or eating grapefruit while receiving DEPOPRED INJECTION as it may lead to unwanted side effects.
The most common side effects of receiving DEPOPRED INJECTION are high blood pressure, swelling of body parts, muscle cramps or weakness, skin thinning, feeling sad or depressed and slowed growth in children. Consult your doctor if any of these side effect worsens.
You must also inform your doctor if you experience severe depression with suicidal thoughts or severe stomach pain with blood-stained stools or vomit after receiving DEPOPRED INJECTION.
It is used to treat the following disease conditions:
It can also:
DEPOPRED INJECTION is a corticosteroid medicine with anti-inflammatory and immune suppressant properties. It boosts your body with sufficient corticosteroid levels (cortisol, aldosterone) during deficient conditions and helps your body to function properly.
It also reduces the release of certain chemicals (prostaglandins) in the body that causes pain, swelling and inflammation. It prevents graft rejection by suppressing the immune functions and protects your kidney from damage in patients with kidney problems.
DEPOPRED INJECTION will be given to you only by a doctor or a nurse into the muscle (intramuscularly) or into the vein (intravenously). Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
Contact your doctor immediately if you experience any of the following side effects while undergoing therapy with DEPOPRED INJECTION:
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
DEPOPRED INJECTION should be used in pregnant women only if it is considered necessary by the physician. Therefore, inform your doctor before receiving DEPOPRED INJECTION if you are pregnant, think you may be pregnant or planning to have a baby.
DEPOPRED INJECTION should be used in breastfeeding women only if it is considered necessary by the physician. Therefore, inform your doctor before receiving it.
Do not drive or operate any heavy tools or machines if you experience dizziness after receiving DEPOPRED INJECTION.
Avoid consumption of alcohol while receiving DEPOPRED INJECTION as it may make you feel drowsier.
DEPOPRED INJECTION should be used with caution in patients with kidney diseases. Therefore, consult your doctor before receiving it.
DEPOPRED INJECTION should be used with caution in patients with liver diseases. Therefore, consult your doctor before receiving it.
Talk to your doctor before receiving DEPOPRED INJECTION if you are allergic to Methylprednisolone.
DEPOPRED INJECTION is not recommended for use in patients with fungal infection of the lungs. Therefore, consult your doctor before receiving it.
DEPOPRED INJECTION should be used with caution in patients with heart problems (such as recent heart attack or heart failure). Therefore, consult your doctor before receiving it.
DEPOPRED INJECTION is not recommended for use if you:
Before receiving DEPOPRED INJECTION, inform your doctor if you:
Use in pediatrics:
DEPOPRED INJECTION should be used in infants, children and adolescents (aged below 18 years) only if prescribed by the physician. Therefore, consult your doctor for advice before receiving it.
Use in geriatrics:
DEPOPRED INJECTION should be used with caution in elderly patients (aged 65 years or above). Therefore, consult your doctor before receiving it.
A. Drug - Drug interactions:
Before receiving DEPOPRED INJECTION, inform your doctor if you are taking any of the following medicines such as:
B. Drug - Food interaction:
Avoid drinking grapefruit juice or eating grapefruit while undergoing therapy with DEPOPRED INJECTION as it may lead to unwanted side effects.
Overdosage:
DEPOPRED INJECTION will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms.
| Drug | : | Methylprednisolone |
| Pharmacological Category | : | Synthetic Glucocorticoids |
| Therapeutic Indication | : | Adrenal insufficiency, Auto Immune Disease, Allergic reactions, Prevent graft rejection, Proteinuria |
| Dosage Forms | : | Tablet, Injection, Cream, Lotion |
What is DEPOPRED INJECTION used for?
DEPOPRED INJECTION is a corticosteroid medicine used to treat adrenal insufficiency. It can also be used to treat drug induced hypersensitivity reactions, allergic reactions and various inflammatory auto-immune disease conditions affecting the skin, collagen, bones and joints, brain, gut, eyes etc. It also helps in prevention of graft rejection following organ transplantation, reduces flare-ups of multiple sclerosis and increases urine output among patients with kidney problems.
How to take DEPOPRED INJECTION?
DEPOPRED INJECTION is not meant for self-administration. It will be given to you only by a doctor or a nurse into the muscle (intramuscularly) or into the vein (intravenously).
Is DEPOPRED INJECTION a steroid?
Yes. DEPOPRED INJECTION is synthetic corticosteroid used to treat problems of adrenal gland and various allergic, hypersensitivity and inflammatory autoimmune disease conditions.
What are the most common side effects of DEPOPRED INJECTION?
The most common side effects of receiving DEPOPRED INJECTION are high blood pressure, swelling of body parts, muscle cramps or weakness, skin thinning, feeling sad or depressed and slowed growth in children. Consult your doctor if any of these side effect worsens.
Can DEPOPRED INJECTION make you feel high?
Yes. DEPOPRED INJECTION may make you feel high. Such symptoms may disappear once the therapy has been stopped. However, consult your doctor if it bothers you.
How does DEPOPRED INJECTION works?
DEPOPRED INJECTION boosts your body with sufficient corticosteroid levels and helps your body to function properly. It also reduces the release of certain chemicals in the body that causes inflammation. It also prevents graft rejection by suppressing the immune functions and protects your kidney from damage in patients with kidney problems.
How long will it take for DEPOPRED INJECTION to control my disease?
The time taken by DEPOPRED INJECTION to control the disease may vary from person-to-person depending upon the dose of methylprednisolone administered and disease severity.
Is DEPOPRED INJECTION safe to use in diabetic patients?
DEPOPRED INJECTION may alter the blood sugar levels in your body. Therefore, it is necessary to inform your doctor if you have diabetes before receiving DEPOPRED INJECTION as a precaution.
Who should not take DEPOPRED INJECTION?
DEPOPRED INJECTION is not recommended for use in patients with serious fungal infections, brain swelling due to malaria or brain injury or stroke. It is also not suitable for use in patients who got vaccinated recently.
Can I receive DEPOPRED INJECTION daily?
Your doctor will evaluate your health condition and suggests whether can you receive DEPOPRED INJECTION every day or not.
Can DEPOPRED INJECTION be used in children?
DEPOPRED INJECTION should be used in children and adolescents (aged below 18 years) only if prescribed by the physician. Therefore, consult your doctor for advice before receiving it.
Will DEPOPRED INJECTION alter the effects of birth control pills?
DEPOPRED INJECTION may reduce the effects of birth control pills. Therefore, try to avoid taking birth control pills along with DEPOPRED INJECTION. Consult your doctor for advice.
Can DEPOPRED INJECTION be used in pregnant women?
DEPOPRED INJECTION should be used in pregnant women only if it is considered necessary by the physician. Therefore, inform your doctor before receiving DEPOPRED INJECTION if you are pregnant, think you may be pregnant or planning to have a baby.
1. KD. Tripathi. Corticosteroids. Essentials of medical pharmacology. Eighth Edition. 2019. Page – 313.
2. Antonio Ocejo, Ricardo Correa. Methylprednisolone. StatPearls. NIH. National Library of Medicine. National Center for Biotechnology Information. [Revised in December 2021]. [Accessed on 12th October 2022] https://www.ncbi.nlm.nih.gov/books/NBK544340/
3. Maryam Edalatifard, Maryam Akhtari, Mohammadreza Salehi, Zohre Naderi, Ahmadreza Jamshidi, Shayan Mostafaei, Seyed Reza Najafizadeh, Elham Farhadi, Nooshin Jalili, Masoud Esfahani, Besharat Rahimi, Hossein Kazemzadeh, Maedeh Mahmoodi Aliabadi, Tooba Ghazanfari, Mohammadreza Sattarian, Hourvash Ebrahimi Louyeh, Seyed Reza Raeeskarami, Saeidreza Jamalimoghadamsiahkali, Nasim Khajavirad, Mahdi Mahmoudi and Abdolrahman Rostamian. Intravenous methylprednisolone pulse as a treatment for hospitalised severe COVID-19 patients: results from a randomised controlled clinical trial. NIH. National Library of Medicine. National Center for Biotechnology Information. December 2020. [Accessed on 12th October 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7758541/
4. Biomendi, S.A. Electronic Medicines Compendium (EMC). [Revised in November 2016] [Accessed on 12th October 2022] https://www.medicines.org.uk/emc/files/pil.5993.pdf
5. Pharmacia NV/SA. Electronic Medicines Compendium (EMC). [Revised in October 2021] [Accessed on 12th October 2022] https://www.medicines.org.uk/emc/files/pil.1550.pdf
6. Pfizer. U.S Food and Drug Administration. [Revised in July 2014] [Accessed on 12th October 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/011757s103lbl.pdf
Written By Srilekha. R, B.Pharm
Last updated on 13 Oct 2022 | 10:20 AM(IST)