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INTRODUCTION ANGELOVA TABLET is a combination of Clomiphene Citrate and Melatonin, which belong to the groups of medicines called Ovarian stimulants and Nutraceutical products, respectively. It is used in the treatment of female infertility, which means not being able to get pregnant after at...
ANGELOVA TABLET is a combination of Clomiphene Citrate and Melatonin, which belong to the groups of medicines called Ovarian stimulants and Nutraceutical products, respectively. It is used in the treatment of female infertility, which means not being able to get pregnant after at least one year of trying (or 6 months if the woman is over age 35) or a woman who keeps having miscarriages.
It can result from age, physical problems, hormone problems and lifestyle or environmental factors and present as abnormal periods, heavy menstrual bleeding or lighter than usual, irregular periods, the number of days in between each period varying each month, painful periods or periods that suddenly stop.
Before starting ANGELOVA TABLET, your doctor should check for any other causes of fertility problems. ANGELOVA TABLET is not recommended for use in patients with liver disease, unusual menstrual bleeding where the cause is not known, hormone-dependent cancers or ovarian cysts.
Before taking ANGELOVA TABLET, inform your doctor if you have early menopause or stopped having periods because you are underweight, have uterine fibroids, polycystic ovaries or swollen ovaries, hypertriglyceridemia, epilepsy, autoimmune disease, diabetes or smoking habit.
ANGELOVA TABLET is generally not recommended for use in pregnant women, breastfeeding women, children, adolescents (below 18 years of age) and post-menopausal women. The common side effects of ANGELOVA TABLET are flushing, pelvic discomfort or abdominal distention or bloating, nausea and vomiting, painful breasts and headaches. If any of these become worse, contact your doctor.
ANGELOVA TABLET is a combination of Clomiphene citrate that selectively binds to estrogen hormone receptors in the brain, ovary, endometrium and cervix to increase the secretion of the luteinizing hormone as well as a follicle-stimulating hormone for the release of a mature egg from ovaries and Melatonin improves egg quality by reducing the damage, which in turn leads to higher fertilization rate. This collective action is useful in treating female infertility.
Take ANGELOVA TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. The correct dose and duration for you will be decided by your doctor, depending on your age, body weight and disease condition.
Stop taking ANGELOVA TABLET and contact your doctor immediately if you experience any of the following side effects:
Nausea or vomiting:
Take this medicine with meals or just after meals. Stick to simple meals and avoid eating oil-rich or spicy foods. In case of no improvement, consult your doctor.
Bloating:
Eat smaller and more frequent meals, drink a lot of water and go for small walks after each meal. In the event of no improvement, consult your doctor.
Stomach pain:
Take a break for relaxation. Eat and drink slowly or try to have smaller and more frequent meals. Keep a heating pad on your stomach. In the event of no improvement, consult your doctor.
Headache:
Try to relax and rest yourself. Apply pain balm to the head to ease the pain. Sip on some hot water or ginger tea. In case of no improvement, contact your doctor for advice.
ANGELOVA TABLET is not recommended for use in pregnant women or in women who think they may be pregnant. You should take a pregnancy test before taking the medicine. Consult your doctor for advice.
ANGELOVA TABLET is not recommended for breastfeeding women as it is excreted in human milk and poses a risk to the sucking child. Therefore, consult your doctor for advice.
Do not drive or operate any machines if you feel drowsy or blurred vision after taking ANGELOVA TABLET.
Avoid consuming alcohol while taking ANGELOVA TABLET as it can impair sleep and concentration and potentially worsen side effects such as headache and tiredness.
ANGELOVA TABLET should be used cautiously in patients having impaired kidney function. Consult your doctor for advice.
ANGELOVA TABLET is not recommended for use in patients having or ever had liver disease. Consult your doctor for advice.
Do not take ANGELOVA TABLET if you are allergic to Clomiphene citrate or Melatonin.
ANGELOVA TABLET is not recommended for use if you:
Before taking ANGELOVA TABLET, inform your doctor if you:
Use in Pediatrics:
ANGELOVA TABLET is generally not recommended for use in children and adolescents (under 18 years of age). Consult your doctor for advice.
Use in Geriatrics:
ANGELOVA TABLET is not recommended for use in women who have already gone through menopause (post-menopausal).
A. Drug-Drug interactions:
Before taking ANGELOVA TABLET, inform your doctor if you are taking any of the following medicine:
Overdosage:
If you or anyone else accidentally take too much of ANGELOVA TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are pelvic or stomach pain, bloating, drowsiness, headache, dizziness and nausea.
| Drug | : | Clomiphene citrate, Melatonin |
| Pharmacological Category | : | Estrogen receptor modulators, Hormones |
| Therapeutic Indication | : | Female infertility |
| Dosage Forms | : | Tablet, Capsule, Softgel Capsule |
Q. What is the use of ANGELOVA TABLET?
A. ANGELOVA TABLET is a medicine used to treat female infertility. It increases the chances of pregnancy in women who have a problem with ovulation (the release of an egg) or have a condition called polycystic ovary syndrome (PCOS).
Q. How long should I take ANGELOVA TABLET?
A. Take ANGELOVA TABLET as advised by your doctor during your menstrual cycle. First, take one tablet a day for five days and then increase the dose. Usually, there won’t be more than three courses of treatment.
Q. What does ANGELOVA TABLET do?
A. ANGELOVA TABLET is a combination of Clomiphene citrate that selectively binds to oestrogen hormone receptors in the brain, ovary, endometrium and cervix to increase the secretion of the luteinizing hormone as well as a follicle-stimulating hormone for the release of a mature egg from the ovaries. Melatonin improves egg quality by reducing the damage, which in turn leads to a higher fertilisation rate. This collective action is useful in treating female infertility.
Q. Can this medicine be taken during pregnancy?
A. No, ANGELOVA TABLET is not recommended for use in pregnant women or in women who think they may be pregnant. You should take a pregnancy test before taking the medicine. Consult your doctor for advice.
Q. How long does it take to get pregnant on ANGELOVA TABLET?
A. Women under 35 years of age with the polycystic ovarian syndrome (PCOS) should have about a 15% chance of pregnancy per month with ANGELOVA TABLET (for about 3–4 months) if they start to ovulate after taking the medicine (assuming the sperm and fallopian tubes are normal).
1. KD Tripathi. Hormones and Related Drugs. Essentials of medical pharmacology. Eighth edition. 2019. Page – 336,337,436.
2. Singh, Monika and Shipra Kumari. Comparison of fertility rates of a combination of clomiphene citrate and melatonin with fertility rates of plain clomiphene citrate in cases of dysovulatory infertility. International Journal of Reproduction, Contraception, Obstetrics and Gynecology. April 2020. [Accessed on 24th June 2022] https://search.bvsalud.org/gim/resource/en/sea-207624
3. Chaudhary, Anjali, Aditi Agarwal, Meenakshi Tanwar, Parul Singh and Priyanka Negi. Effect of melatonin addition in ovulation induction protocols with clomiphene citrate in management of infertility. International Journal of Reproduction, Contraception, Obstetrics and Gynecology. December 2021. [Accessed on 24th June 2022] https://go.gale.com/ps/i.do?id=GALE%7CA688228983&sid=googleScholar&v=2.1&it=r&linkaccess=abs&issn=23201770&p=AONE&sw=w&userGroupName=anon%7Edbb86023
4. UHL Pharma. Clomipreg-M. http://uhlpharma.co.in/UHL_Gynaecological_CLOMIPREG.html
5. Zentiva k.s. Electronic Medicines Compendium (EMC). [Revised in June 2021] [Accessed on 24th June 2022] https://www.medicines.org.uk/emc/files/pil.961.pdf
6. RAFARM SA. Electronic Medicines Compendium (EMC). [Revised in June 2021] [Accessed on 24th June 2022] https://www.medicines.org.uk/emc/files/pil.10405.pdf
Written By Dr. Dhivakaran R, BDS
Last updated on 20 Feb 2023 | 04:53 PM(IST)