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INTRODUCTION ARNOZA 50 TABLET is a combination of Sacubitril and Valsartan which belongs to the group of medicines called Angiotensin receptor neprilysin inhibitors. ARNOZA 50 TABLET is indicated to reduce the risk of cardiovascular death and hospitalization for heart failure in patients with...
ARNOZA 50 TABLET is a combination of Sacubitril and Valsartan which belongs to the group of medicines called Angiotensin receptor neprilysin inhibitors. ARNOZA 50 TABLET is indicated to reduce the risk of cardiovascular death and hospitalization for heart failure in patients with chronic heart failure (New York Heart Association Class II-IV) and reduced ejection fraction.
Heart failure occurs when the heart is weak and cannot pump enough blood to the lungs and to the rest of the body and it is characterized by symptoms such as breathlessness, fatigue, tiredness and ankle swelling. Before taking ARNOZA 50 TABLET inform your doctor if you have liver, kidney or heart problems.
ARNOZA 50 TABLET is not recommended for use in pregnant and breast-feeding women. It is not suitable for use in children and adolescents under 18 years of age and it should be used with caution in elderly patients (65 years of age and above).
Before taking ARNOZA 50 TABLET inform your doctor about previous allergy and medication history to prevent any serious effect.
The most common side effects of taking ARNOZA 50 TABLET are dizziness, cough, headache, tiredness, nausea and weakness. Consult your doctor if any of the side effects worsen.
ARNOZA 50 TABLET helps to treat long-term heart failure, where sacubitril works by relaxing and widening the blood vessels and makes it easier for the heart to pump blood throughout the body and valsartan works by relaxing the blood vessels by blocking a substance called angiotensin-II (causing blood vessels to tighten) which is produced in the body and thus lowers the blood pressure.
Take ARNOZA 50 TABLET as advised by your physician. Swallow ARNOZA 50 TABLET with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Stop taking ARNOZA 50 TABLET and contact your doctor immediately if you experience any of the following side effects:
Drink lot of fluids such as water or fruit juices to keep yourself hydrated. Avoid taking any medicine on your own for treating diarrhea. Consult your doctor if the symptom did not improve.
Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the forehead if required. Do not consume too much of alcohol. Consult your doctor if the symptom did not improve.
Stick to simple meals. Avoid eating oily, fried and spicy foods. Do not perform any strenuous activities immediately after eating. Consult your doctor if the symptom did not improve.
Drink plenty of fluids and eat balanced diet and frequent meals. Do regular minimal exercise and follow regular sleep schedule. Consult your doctor if your symptom did not improve.
ARNOZA 50 TABLET is not recommended for use in early pregnancy and must not be used in pregnant women when more than 3 months pregnant, as it may cause serious harm to the baby. Consult your doctor before taking ARNOZA 50 TABLET if you think you may be pregnant.
ARNOZA 50 TABLET is not recommended for use in breastfeeding women. Consult your doctor before taking ARNOZA 50 TABLET if you are breast-feeding or about to start breast-feeding.
Avoid driving or handling any machines while taking ARNOZA 50 TABLET because it may cause dizziness or tiredness.
ARNOZA 50 TABLET should be used with caution in patients with severe kidney disease and with narrowed kidney artery. Consult your doctor before taking ARNOZA 50 TABLET.
ARNOZA 50 TABLET is not recommended for use in patients with severe liver disease and it should be used with caution in patients with liver disease. Consult your doctor before taking ARNOZA 50 TABLET.
Do not take ARNOZA 50 TABLET if you are allergic (hypersensitive) to Sacubitril and Valsartan.
ARNOZA 50 TABLET is generally not recommended for use in children and adolescents (under 18 years of age). Consult your child’s doctor for advice.
ARNOZA 50 TABLET should be used with caution in elderly patients (above 65 years of age). Consult your doctor before taking ARNOZA 50 TABLET.
ARNOZA 50 TABLET is not recommended for use, if you have:
Before taking ARNOZA 50 TABLET inform your doctor if you have:
A. Drug-Drug interactions:
Before taking ARNOZA 50 TABLET inform to your doctor, if you are taking any of these medicines:
Overdosage:
If you or anyone else accidentally take too much of ARNOZA 50 TABLET, contact your doctor immediately or go to a nearest hospital straight away. Overdosage symptoms of ARNOZA 50 TABLET includes severe dizziness and fainting.
| Drug | : | Sacubitril and Valsartan |
| Pharmacological Category | : |
Neprilysin Inhibitor, Angiotensin II Receptor Blocker |
| Therapeutic Indication | : | Heart failure |
| Dosage Forms | : | Tablet |
Q: What is ARNOZA 50 TABLET used for?
A: ARNOZA 50 TABLET is indicated to reduce the risk of cardiovascular death and hospitalization for heart failure in patients with chronic heart failure (New York Heart Association Class II-IV) and reduced ejection fraction.
Q: What are the common side effects of taking ARNOZA 50 TABLET?
A: The most common side effects of taking ARNOZA 50 TABLET are dizziness, light-headedness (low blood pressure), signs of high levels of potassium in the blood (irregular heartbeat, muscle weakness), decrease in renal function, cough, diarrhea, signs of low red blood cells (anemia), tiredness, headache, fainting or spinning sensation. Consult your doctor immediately if any of the side effects worsen.
Q: Can ARNOZA 50 TABLET be used in pregnant women?
A: No, ARNOZA 50 TABLET is not recommended for use in early pregnancy and must not be used in pregnant women when more than 3 months pregnant, as it may cause serious harm to the baby. Consult your doctor before taking ARNOZA 50 TABLET if you think you may be pregnant.
Q: Is ARNOZA 50 TABLET safe to use in liver disease patients?
A: ARNOZA 50 TABLET is not recommended for use in patients with severe liver disease and it should be used with caution in patients with liver disease. Consult your doctor before taking ARNOZA 50 TABLET.
Q: What to do If I forget to take ARNOZA 50 TABLET?
A: You should take ARNOZA 50 TABLET immediately when you remember. If it is time for your next dose skip the missed dose and follow your regular dose schedule. Do not double the dose to match up your missed dose.
1. KD Tripathi MD. Cardiovascular drugs. Essentials of Medical Pharmacology. Seventh Edition. New Delhi, May 2013. Page – 508.
2. Loretta Fala. Entresto (Sacubitril/Valsartan): First-in-Class Angiotensin Receptor Neprilysin Inhibitor FDA Approved for Patients with Heart Failure. NCBI; PMC. Pubmed Central. National Library of Medicine, National Institute of Health. September 2018. [Accessed on 1st July 2021] ncbi.nlm.nih.gov/pmc/articles/PMC4636283/
3. Peter Khalil, Ghazal Kabbach, Sarmad Said and Debabrata Mukherje. Entresto, a New Panacea for Heart Failure. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. 2018. [Accessed on 1st July 2021] https://pubmed.ncbi.nlm.nih.gov/29532764/
4. Novartis Pharmaceuticals UK Ltd. Electronic Medicines Compendium (EMC) [Revised in May 2021] [Accessed on 1st July 2021] https://www.medicines.org.uk/emc/files/pil.7751.pdf
5. Cipla Ltd. Azmarda Tablets (Sacubitril/Valsartan). Ciplamed. [Revised in March 2017] [Accessed on 1st July 2021] https://www.ciplamed.com/content/azmarda-tablets
Written By Dr. R. Dinesh John Rajkumar, Pharm.D
Last updated on 20 Mar 2023 | 09:09 AM(IST)