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INTRODUCTION EPOCEPT 4000IU INJECTION contains Epoetin Alfa which belongs to the group of medicines called Erythropoiesis-stimulating agents. It is used to treat anemia caused due to chronic kidney disease (CKD), chemotherapy, anti-viral therapy (Ex. zidovudine), blood donation or due to any b...
EPOCEPT 4000IU INJECTION contains Epoetin Alfa which belongs to the group of medicines called Erythropoiesis-stimulating agents. It is used to treat anemia caused due to chronic kidney disease (CKD), chemotherapy, anti-viral therapy (Ex. zidovudine), blood donation or due to any bone marrow disorders/cancers (such as myelodysplastic syndromes).
It can also be used to prevent or manage anemia in patients who are planning to undergo any major bone surgery (such as hip or knee replacement operations). It may also reduce the potential need for blood transfusion in cancer patients and in patients undergoing bone surgery or chemotherapy.
EPOCEPT 4000IU INJECTION is suitable for use both in adults and in children. During treatment with EPOCEPT 4000IU INJECTION your doctor will constantly monitor your blood pressure and iron levels in blood and will adjust the dose accordingly to avoid the risk of unwanted side effects.
Before receiving EPOCEPT 4000IU INJECTION inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have high blood pressure, diabetes, obesity, breast cancer, head and neck cancer, fits, previous history of blood clots or if you are undergoing dialysis or any surgery as a precaution.
EPOCEPT 4000IU INJECTION is not recommended for use in patients with recent heart attack or stroke. It is also not suitable for use in patients having severe uncontrollable high blood pressure and pure red aplastic anemia (a condition in which the bone marrow cannot produce RBC).
Inform your doctor before receiving EPOCEPT 4000IU INJECTION if you are pregnant or breastfeeding as a precaution. The most common side effects of receiving EPOCEPT 4000IU INJECTION are diarrhea, nausea, vomiting, fever, stuffy nose and sore throat. Contact your doctor if any of these side effect worsens.
It is used in adults and in children to treat:
EPOCEPT 4000IU INJECTION is an Erythropoiesis-stimulating agent. Following administration, it stimulates the bone marrow to produce red blood cells. It contains a medicine called Epoetin Alfa which acts similar to the endogenous human protein called erythropoietin (a substance that stimulates bone marrow to produce red blood cells).
Therefore, it replaces the lost red blood cells (RBC) in the body of anaemic patients and in patients who are at risk of developing anemia due to chemotherapy, anti-viral therapy or bone marrow disorders.
EPOCEPT 4000IU INJECTION will be given to you only by a doctor or a nurse into the vein (intravenously) or under the skin (subcutaneously). It can also be self-administered by the patient if instructed by the doctor. Carefully follow the instructions given by your doctor in case of self-administration.
Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
Consult your doctor immediately if you experience any of the following side effects after receiving EPOCEPT 4000IU INJECTION:
Injection site reactions:
Place an ice pack on the affected area. Do not frequently move the injection site. Consult your doctor if the symptom did not improve.
Feeling dizzy:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
Nausea and Vomiting:
Stick to simple meals. Avoid eating oil rich or spicy foods. Consult your doctor if your symptom worsens.
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
It is not known whether the use of EPOCEPT 4000IU INJECTION can harm the growing baby. Therefore, it should be used in pregnant women and in women planning to become pregnant only if considered necessary by the physician.
It is not known whether EPOCEPT 4000IU INJECTION can pass through breast milk or not. Therefore, it should be used in breastfeeding women only if considered necessary by the physician.
Do not drive or handle any heavy tools or machines if your ability is affected by EPOCEPT 4000IU INJECTION.
Avoid consumption of alcohol before receiving EPOCEPT 4000IU INJECTION.
EPOCEPT 4000IU INJECTION should be used with caution in patients undergoing dialysis. Therefore, consult your doctor before receiving it.
EPOCEPT 4000IU INJECTION should be used with caution in patients suffering from liver diseases. Therefore, consult your doctor before receiving it.
Talk to your doctor before receiving EPOCEPT 4000IU INJECTION if you are allergic to Epoetin Alfa.
EPOCEPT 4000IU INJECTION is not recommended for use in patients with severe heart diseases (including recent heart attack). It should be used with caution in patients with other mild heart problems. Therefore, consult your doctor before receiving it.
EPOCEPT 4000IU INJECTION is not recommended for use if you:
Before receiving EPOCEPT 4000IU INJECTION inform your doctor if you have:
Use in paediatrics:
EPOCEPT 4000IU INJECTION should be used in children and in adolescents (aged below 18 years) only if prescribed by the physician. It is not suitable for use in young babies (aged below 1 year). Therefore, consult your doctor for advice before administration.
Use in geriatrics:
EPOCEPT 4000IU INJECTION should be used with caution in elderly patients. Therefore, consult your doctor before receiving it.
A. Drug-Drug interactions:
Before receiving EPOCEPT 4000IU INJECTION, inform your doctor if you are taking any of the following medicines such as:
Overdosage:
EPOCEPT 4000IU INJECTION will be administered to you only by a doctor or a nurse in a hospital and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms. Symptoms of overdose might include fits and high blood pressure.
| Drug | : | Erythropoietin Alfa |
| Pharmacological Category | : | Erythropoiesis-stimulating agents |
| Therapeutic Indication | : | Anaemia |
| Dosage Forms | : | Injection, Pre-filled syringe |
What is the use of EPOCEPT 4000IU INJECTION?
EPOCEPT 4000IU INJECTION is used to treat anemia caused due to chronic kidney disease (CKD), chemotherapy, anti-viral therapy (Ex. zidovudine), blood donation or due to any bone marrow disorders/cancers (such as myelodysplastic syndromes). It can also be used to prevent or manage anemia in patients who are planning to undergo any major bone surgery (such as hip or knee replacement operations). It may also reduce the potential need for blood transfusion in cancer patients and in patients undergoing bone surgery or chemotherapy.
How EPOCEPT 4000IU INJECTION works?
EPOCEPT 4000IU INJECTION stimulates the bone marrow to produce red blood cells. Therefore, it replaces the lost red blood cells (RBC) in the body of anaemic patients and in patients who are at risk of developing anemia due to chemotherapy, anti-viral therapy or bone marrow disorders.
How EPOCEPT 4000IU INJECTION is administered?
EPOCEPT 4000IU INJECTION will be given to you only by a doctor or a nurse into the vein (intravenously) or under the skin (subcutaneously). It can also be self-administered by the patients if advised by the physician. Carefully, follow the instructions given by the doctor in case of self-administration.
What precautions must be followed while receiving EPOCEPT 4000IU INJECTION?
Before receiving EPOCEPT 4000IU INJECTION inform your doctor if you have any liver, kidney or heart problems. You must also inform your doctor if you have high blood pressure, diabetes, obesity, breast cancer, head and neck cancer, fits, previous history of blood clots or if you are undergoing dialysis or any surgery as a precaution. EPOCEPT 4000IU INJECTION is not recommended for use in patients with recent heart attack or stroke. It is also not suitable for use in patients having severe uncontrollable high blood pressure and pure red aplastic anemia (bone marrow cannot produce RBC). Inform your doctor before receiving EPOCEPT 4000IU INJECTION if you are pregnant or breastfeeding as a precaution. Regularly visit your doctor and perform all blood tests and ultrasounds recommended by him/her without fail.
Is EPOCEPT 4000IU INJECTION safe?
EPOCEPT 4000IU INJECTION is considered safe at the doses administered by the physician. However, consult your doctor if you experience any unusual side effects.
What are the common side effects of receiving EPOCEPT 4000IU INJECTION?
The most common side effects of receiving EPOCEPT 4000IU INJECTION are diarrhea, nausea, vomiting, fever, stuffy nose and sore throat. Contact your doctor if any of these side effect worsens.
Can I stop receiving EPOCEPT 4000IU INJECTION once my symptoms subside?
Do not stop receiving EPOCEPT 4000IU INJECTION without consulting your doctor. You need to receive EPOCEPT 4000IU INJECTION for the duration recommended by your doctor to achieve better results.
Can I use EPOCEPT 4000IU INJECTION during pregnancy?
It is not known whether the use of EPOCEPT 4000IU INJECTION can harm the growing baby. Therefore, it should be used in pregnant women and in women planning to become pregnant only if considered necessary by the physician.
Can EPOCEPT 4000IU INJECTION be used in children?
EPOCEPT 4000IU INJECTION should be used in children and in adolescents (aged below 18 years) only if prescribed by the physician. It is not suitable for use in young babies (aged below 1 year). Therefore, consult your doctor for advice before administration.
1. KD Tripathi. Drugs Affecting Blood and Blood Formation. Essentials of Medical Pharmacology. 7th edition. 2013. Page - 611.
2. Saumil Patel, Jayesh B. Patel. Epoetin Alfa. Statpearls. NIH. National Library of Medicine, National center for biotechnology information. May 2022. [Accessed on 15th November 2022] https://www.ncbi.nlm.nih.gov/books/NBK554547/#article-21266.s3
3. R Provenzano, L Garcia-Mayol, P Suchinda, B Von Hartitzsch, S B Woollen, R Zabaneh, J C Fink, POWER Study Group. Once-weekly epoetin alfa for treating the anemia of chronic kidney disease. NIH. National Library of Medicine, National center for biotechnology information. Pubmed.gov. June 2004. [Accessed on 15th November 2022] https://pubmed.ncbi.nlm.nih.gov/15224803/
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7. Biocon Biologics India Limited. Erythropoietin Alfa. [Revised in December 2019] [Accessed on 15th November 2022] https://www.biocon.com/docs/domestic-market-pi/onco/ERYPRO%20SAFE%20PI.pdf
8. Janssen Products, LP. Erythropoietin Alfa. [Revised in September 2017] [Accessed on 15th November 2022] https://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/PROCRIT-pi.pdf
Written By Srilekha. R, B.Pharm
Last updated on 18 Nov 2022 | 11:58 AM(IST)