INTRODUCTION

PANTOP HP KIT is a combination of Clarithromycin, Pantoprazole and Amoxicillin which belongs to the group of medicines called Antibiotics and Antiulcer agents. It is used to eradicate a bacteria called Helicobacter pylori in patients with active chronic gastritis, stomach and intestinal ulcers.

Along treatment with PANTOP HP KIT your doctor might want you to make some lifestyle changes such as eating less spicy foods. Before starting the treatment with PANTOP HP KIT your doctor might ask you to take some diagnostic tests to understand the existing condition.

Before taking PANTOP HP KIT inform your doctor if you have liver, kidney or heart disease. PANTOP HP KIT should be taken with caution in patients having fungal infections, glandular fever, problems in urinating, joint pains and due to take Chromogranin A test.

PANTOP HP KIT should be used with caution in pregnant and breast-feeding women. The most common side effects of taking PANTOP HP KIT are nausea, vomiting, diarrhea, vomiting, indigestion and dry mouth. Talk to your doctor if any of these worsen or doesn’t improve.

USES OF PANTOP HP KIT

• Eradicates Helicobacter pylori in patients with active chronic gastritis, stomach and intestinal ulcers

HOW PANTOP HP KIT WORKS

PANTOP HP KIT effectively eradicates H. Pylori and treats ulcers, where Clarithromycin which belongs to a group of medicine called macrolide antibiotics which enters the bacteria and stop its growth thus relieving the infection. Amoxicillin is a penicillin antibiotic which interferes with the important life cycle of the bacteria leading to its destruction. Pantoprazole is a selective proton pump inhibitor, which acts on the cells present in the lining of the stomach and reduces the amount of acid produced in the stomach.

DIRECTIONS FOR USE

Take PANTOP HP KIT as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of PANTOP HP KIT for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF PANTOP HP KIT

HOW TO MANAGE SIDE EFFECTS

Headache:

Drink ample amount of water and avoid skipping meals. Get adequate rest. Try to be relaxed and stress free. Apply pain relieving balm on your forehead if necessary. Consult your doctor if the symptom does not improve.

Stomach pain:

Try to rest and relax. Eat and drink slow or try to have smaller and frequent meals. Keep a heat pad on your stomach. If the symptom does not improve, contact your doctor.

Constipation:

Try to eat more high-fiber foods such as fresh fruit, vegetables, cereals and drink plenty of water. If this does not help, inform your doctor for receiving alternate treatment for constipation.

Diarrhoea:

Drink lot of fluids such as water to keep yourself hydrated. Avoid eating high-fat or spicy foods. Inform your doctor if the symptom gets worse.

Dry mouth:

Sip water regularly and other sugar free liquids. Do not use mouthwashes that contain alcohol because they can make your mouth dry, use mouthwash that is used only for dry mouth. Limit your caffeine intake. Avoid smoking or using tobacco products. Consult your doctor if the symptom does not improve.

WARNING & PRECAUTIONS

PREGNANCY

PANTOP HP KIT should be used with caution in pregnant women. Consult your doctor before taking it.

BREASTFEEDING

PANTOP HP KIT should be used with caution in breastfeeding women. Consult your doctor before taking it.

DRIVING AND USING MACHINES

Do not drive or operate any machines if you feel dizzy or disturbed vision after taking PANTOP HP KIT.

KIDNEY

PANTOP HP KIT should be used with caution in patients with kidney problems. Consult your doctor before taking PANTOP HP KIT.

LIVER

PANTOP HP KIT is not recommended for use in patients with severe liver disease. It should be used with caution in patients with other liver disease. Consult your doctor before taking PANTOP HP KIT.

ALLERGY

Do not take PANTOP HP KIT if you are allergic to Clarithromycin, Pantoprazole or Amoxicillin.

HEART DISEASE

PANTOP HP KIT is not recommended for use in patients having heart rhythm disorders. It should be used with caution in patients with heart problems such as heart failure, an unusually slow heart rate. Consult your doctor before taking PANTOP HP KIT.

INTERACTIONS

A. Drug – Drug Interactions:

Before taking PANTOP HP KIT, inform your doctor if you are taking any of the following medicines:

• medicines used for the treatment of heart problems (Ex. digoxin, disopyramide, quinidine), lower cholesterol (Ex. atorvastatin, rosuvastatin), high blood pressure (Ex. verapamil, amlodipine, diltiazem)
• medicines used for the treatment of epilepsy (Ex. carbamazepine, valproate, phenobarbital, phenytoin)
• medicines used in patients with breathing difficulties such as asthma (Ex. theophylline)
• sedatives (Ex. triazolam, alprazolam or midazolam)
• medicines used to treat poor circulation (Ex. cilostazol)
• corticosteroid (Ex. methylprednisolone) (used to treat inflammatory condition)
• medicines used for thinning the blood (Ex. warfarin, dabigatran, rivaroxaban, apixaban)
• medicines used to lower blood glucose levels (Ex. nateglinide, pioglitazone, repaglinide, rosiglitazone, gliclazide, glimepiride, insulin)
• medicines used for treatment of cancer (Ex. vinblastine, erlotinib)
• immune suppressants (Ex. ciclosporin, sirolimus, tacrolimus) (used to prevent organ rejection after transplant)
• medicines used in the treatment of HIV (Ex. ritonavir, efavirenz, etravirine, nevirapine, zidovudine, atazanavir, saquinavir)
• medicines used for treatment of certain bacterial infections (Ex. rifampicin, rifapentine, rifabutin, lincomycin)
• fluconazole, itraconazole, clindamycin, ketoconazole, itraconazole, posaconazole (used to treat fungal infections)
• medicines used for treating overactive bladder (Ex. tolterodine)
• medicines used for impotence in adult males or for use in pulmonary arterial hypertension (Ex. sildenafil, vardenafil, tadalafil)
• herbal product used to treat depression (Ex. St John’s Wort)
• medicine used to treat rheumatoid arthritis, psoriasis and cancer (Ex. methotrexate)
• medicine used to treat depression and other psychiatric diseases (Ex. fluvoxamine)
• medicines used to treat gout (Ex. probenecid, allopurinol)

Overdosage:

If you or anyone else accidentally take too much of PANTOP HP KIT, consult your doctor immediately or visit the nearby hospital.

SYNOPSIS

MORE INFORMATION

• Keep PANTOP HP KIT out of reach of children
• Store at room temperature

FAQs ABOUT PANTOP HP KIT

Q: What is PANTOP HP KIT and why is it given?

A: PANTOP HP KIT is a combination of Clarithromycin, Pantoprazole and Amoxicillin which belongs to the group of medicines called Antibiotics and Antiulcer agents. It is used to eradicate a bacteria called Helicobacter pylori in patients with active chronic gastritis, stomach and intestinal ulcers.

Q: Can PANTOP HP KIT cause diarrhoea?

A: Diarrhoea is a common side effect of taking PANTOP HP KIT. For symptomatic relief, drink lot of fluids such as water, squash or fruit juice to keep yourself hydrated. Do not consume any medicine by yourself without consulting your doctor .

Q: Is PANTOP HP KIT safe for pregnant and breast-feeding women?

A: PANTOP HP KIT should be used with caution in pregnant women and breast-feeding mother. Ask for your doctor’s advice before taking PANTOP HP KIT if you are pregnant, planning to get pregnant and breast-feeding your child.

Q: For how long should I take PANTOP HP KIT?

A: Take PANTOP HP KIT for as long as your doctor has prescribed for you. It depends on your specific condition, age and body weight. Do not stop taking without the doctor’s consultation and do not take it for prolonged periods as well.

Q: What should I tell my doctor before taking PANTOP HP KIT?

A: Before taking PANTOP HP KIT inform your doctor if you have any liver, kidney or heart disease, fungal infections, glandular fever (sore throat, fever, swollen glands and extreme tiredness), problems in urination, joint pain, due to have Chromogranin A test or if you have reduced Vitamin B12.

REFERENCES

1. KD. Tripathi. Drugs for Peptic Ulcer and GERD, Antimicrobial Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 653, 754 & 762

2. Imad M Ghazzawi, Walid A Obeidat, Feras A Zuriekat. Triple therapy with pantoprazole, clarithromycin and amoxicillin for eradication in patients with Helicobacter pylori positive duodenal ulcers. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. August 2004. [Accessed on 18th June 2022] https://pubmed.ncbi.nlm.nih.gov/15322588/

3. NIH National Library of Medicine, National center for biotechnology information. Clarithromycin. Pubchem. [Accessed on 18th June 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Clarithromycin#section=Mechanism-of-Action

4. Pantoprazole. NIH National Library of Medicine, National center for biotechnology information. Pubchem. [Accessed on 18th June 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Pantoprazole#section=Mechanism-of-Action

5. Amoxicillin. NIH National Library of Medicine, National center for biotechnology information. Pubchem. [Accessed on 18th June 2022] https://pubchem.ncbi.nlm.nih.gov/compound/Amoxicillin#section=Mechanism-of-Action

6. ARISTO Pharmaceuticals Private Limited. Pantop HP Kit (Combipack of Clarithromycin, Pantoprazole & Amoxicillin Tablets. [Revised in February 2022]. [Accessed on 18th June 2022] https://www.aristopharma.co.in/wp-content/uploads/2022/03/Pantop-HP-Kit.pdf

USEFUL DIAGNOSTIC TESTS

• Endoscopy
• Complete Blood Count

AUTHOR DETAILS

Written By Dr. R. Dinesh John Rajkumar, Pharm.D
Last updated on 17 Jan 2023 | 05:19 PM(IST)