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INTRODUCTION COLCHIGOUT 0.5 TABLET contains Colchicine which belongs to a group of medicines called Antigout agents. COLCHIGOUT 0.5 TABLET is used in adults, in the short-term treatment of gout attacks and to prevent gout recurrence. It is also indicated in familial mediterranean fever (FMF) t...
COLCHIGOUT 0.5 TABLET contains Colchicine which belongs to a group of medicines called Antigout agents. COLCHIGOUT 0.5 TABLET is used in adults, in the short-term treatment of gout attacks and to prevent gout recurrence. It is also indicated in familial mediterranean fever (FMF) to prevent fever attacks and amyloidosis (a rare protein disorder that interferes with normal functioning of organs). Gout is a common and complex form of arthritis (joint pain) which is characterized by sudden, severe attacks of pain, swelling, redness and tenderness in one or more joints which most often occurs in the big toe. Familial mediterranean fever is a genetic disorder that causes recurrent fevers and painful inflammation of the abdomen, chest and joints.
Colchicine is an antigout agent which works by lessening the buildup of hard uric acid crystals in the joints by reducing the uric acid level in the blood which are needed for the formation of hard uric acid crystals that cause pain in joints resulting in the decreased swelling and relief from pain in the joints. It also works by preventing the occurrence of pain in the abdomen, chest or joints in patients suffering from familial mediterranean fever by decreasing the production of amyloid protein which is an abnormal protein that forms due to a rare protein disease called amyloidosis which causes interference in the normal functioning of an organ. Along with this treatment, your doctor might advise regular blood tests to check for any occurence of blood disorders.
Before taking COLCHIGOUT 0.5 TABLET, inform your doctor if you are allergic to Colchicine, and or have blood disorders, heart, kidney, or liver disease which is not recommended for use in patients with severe liver or kidney disease. COLCHIGOUT 0.5 TABLET is not recommended for use in pregnant women when indicated for gout treatment and used with caution in familial mediterranean fever (FMF) only if it’s clearly necessary in pregnant and childbearing potential women who should use effective contraception during and for at least 3 months following the termination of treatment with COLCHIGOUT 0.5 TABLET when indicated for gout treatment. COLCHIGOUT 0.5 TABLET is not recommended for use to treat gout in children and adolescents (below 18 years of age) which is indicated for use in children less than 5 years of age and adolescents (from 10 to 18 years of age) in the treatment of familial mediterranean fever (FMF) after consulting the doctor for an advice. The most common side effects of taking COLCHIGOUT 0.5 TABLET are nausea, vomiting, abdominal cramps and diarrhea. Contact your doctor if any of the symptoms worsen.
COLCHIGOUT 0.5 TABLET is an antigout agent which works by lessening the buildup of hard uric acid crystals in the joints by reducing the uric acid level in the blood. In familial mediterranean fever it works by decreasing the production of amyloid protein which is an abnormal protein that forms due to a rare protein disease called amyloidosis which causes interference in the normal functioning of an organ.
Take COLCHIGOUT 0.5 TABLET as advised by your physician. Swallow COLCHIGOUT 0.5 TABLET with a glass of water and do not chew or crush the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Stop taking COLCHIGOUT 0.5 TABLET and contact your doctor if you experience any of the following side effects:
Drink lots of fluids, such as water to keep yourself hydrated. Try to avoid taking any medicine on your own to treat diarrhea and consult your doctor if the symptom gets worse.
Try to take COLCHIGOUT 0.5 TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if the symptom gets worse.
COLCHIGOUT 0.5 TABLET is not recommended for use in pregnant women when indicated for gout treatment and is used with caution in familial mediterranean fever (FMF) only if it’s clearly necessary in pregnant and childbearing potential women. Women with childbearing potential should use effective contraception during and for at least 3 months following the termination of treatment with COLCHIGOUT 0.5 TABLET when indicated for gout treatment who should consult doctor before taking COLCHIGOUT 0.5 TABLET.
COLCHIGOUT 0.5 TABLET is not recommended for use in breastfeeding women when indicated for the treatment of gout which is advised to be used with caution for familial mediterranean fever (FMF) only if it is clearly necessary. Consult your doctor before taking COLCHIGOUT 0.5 TABLET.
COLCHIGOUT 0.5 TABLET may cause drowsiness and dizziness which could affect your ability to drive or operate machines. Consult your doctor before taking COLCHIGOUT 0.5 TABLET.
Avoid consumption of alcohol while taking COLCHIGOUT 0.5 TABLET. Consult your doctor before taking COLCHIGOUT 0.5 TABLET.
COLCHIGOUT 0.5 TABLET should be used with caution in patients with kidney problems which would be carefully monitored by your doctor. It is not recommended for use in patients with severe renal impairment. Consult your doctor for advice before taking COLCHIGOUT 0.5 TABLET.
COLCHIGOUT 0.5 TABLET should be used with caution in patients with liver problems which would be carefully monitored by your doctor. It is not recommended for use in patients with severely impaired liver disease or severe liver impairment. Consult your doctor for advice before taking COLCHIGOUT 0.5 TABLET.
COLCHIGOUT 0.5 TABLET is not recommended for use if you are allergic to colchicine or any of the other ingredients of this medicine.
COLCHIGOUT 0.5 TABLET should be used with caution in patients with heart or vascular disease. Consult your doctor before taking COLCHIGOUT 0.5 TABLET.
COLCHIGOUT 0.5 TABLET is not recommended for use to treat gout in children and adolescents (below 18 years of age). COLCHIGOUT 0.5 TABLET is used when indicated for familial mediterranean fever (FMF) in children less than 5 years of age and adolescents (from 10 to 18 years of age) after consulting the doctor for an advice.
COLCHIGOUT 0.5 TABLET should be used with caution in elderly patients (aged 70 years or above) especially when you are weak after careful assessment of potential benefits and consequences of therapy. Consult your doctor before taking COLCHIGOUT 0.5 TABLET.
COLCHIGOUT 0.5 TABLET is not recommended for use if you:
Before taking COLCHIGOUT 0.5 TABLET, inform your doctor if you:
A. Drug-Drug Interactions:
Before taking COLCHIGOUT 0.5 TABLET, inform your doctor, if you are taking any of the following medicine:
B. Drug-Food Interactions:
COLCHIGOUT 0.5 TABLET should not be taken with grapefruit juice.
Overdosage:
If you or anyone else accidentally takes too much of COLCHIGOUT 0.5 TABLET, contact your doctor immediately or go to a hospital straight away. Early symptoms of overdose are burning sensation in the throat, stomach and skin, nausea and vomiting, abdominal cramps, bloody diarrhea, dehydration, and lowering of blood pressure and shock. Overdosage symptoms after 24 – 72 hours can result in life-threatening complications such as consciousness disorder with possible delusions, coma, symptoms of paralysis, respiratory depression, fluid retention in the lungs, kidney damage, shortage of blood and cardiac arrest.
| Drug | : | Colchicine |
| Pharmacological Category | : | Antigout agents |
| Therapeutic Indication | : | Gout attacks and Familial Mediterranean Fever (FMF) |
| Dosage Forms | : | Tablet |
Q: What COLCHIGOUT 0.5 TABLET is used for?
A: COLCHIGOUT 0.5 TABLET is used in adults, in the short-term treatment of gout attacks and to prevent gout recurrence. It is also indicated in familial mediterranean fever (FMF) to prevent fever attacks and amyloidosis (a rare protein disorder that interferes with normal functioning of organs). Gout is a common and complex form of arthritis (joint pain) which is characterized by sudden, severe attacks of pain, swelling, redness and tenderness in one or more joints which most often occurs in the big toe. Familial mediterranean fever is a genetic disorder that causes recurrent fevers and painful inflammation of the abdomen, chest and joints.
Q: What happens if you forget to take COLCHIGOUT 0.5 TABLET?
A: If you forget to take COLCHIGOUT 0.5 TABLET, take another dose as soon as you remember. If it is almost time for your next dose, do not take the missed dose at all and continue as per your prescribed dosing regime. Consult your doctor if you are not sure about the missed dose.
Q: What happens if you take more COLCHIGOUT 0.5 TABLET than your required dose?
A: If you or anyone else accidentally takes too much of COLCHIGOUT 0.5 TABLET, contact your doctor immediately or go to a hospital straight away. Early symptoms of overdose are burning sensation in the throat, stomach and skin, nausea and vomiting, abdominal cramps, bloody diarrhea, dehydration, and lowering of blood pressure and shock.
Q: Can COLCHIGOUT 0.5 TABLET be taken with grapefruit juice?
A: No, COLCHIGOUT 0.5 TABLET should not be taken with grapefruit juice since it may increase the risks of side effects and lead to some unwanted complications. Consult your doctor before taking COLCHIGOUT 0.5 TABLET.
Q: Is COLCHIGOUT 0.5 TABLET safe to use in children?
A: COLCHIGOUT 0.5 TABLET is not recommended for use to treat gout in children and adolescents (below 18 years of age). It is used when indicated for familial mediterranean fever (FMF) in children less than 5 years of age and adolescents (from 10 to 18 years of age) after consulting the doctor for an advice.
1. KD. Tripathi. Antirheumatoid and Antigout Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 214.
2. Regeneron Pharmaceuticals. Efficacy and Safety of Colchicine for the Prevention of Gout Flares During the Initiation of Allopurinol. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in May 2014] [Accessed on 4th May 2022] https://clinicaltrials.gov/ct2/show/NCT01451645
3. Nicola Dalbeth, Thomas J Lauterio, Henry R Wolfe. Mechanism of action of colchicine in the treatment of gout. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. [Revised in August 2014] [Accessed on 4th May 2022] https://pubmed.ncbi.nlm.nih.gov/25151572/
4. C Cerquaglia, M Diaco,G Nucera,M La Regina, M Montalto, R Manna.Pharmacological and clinical basis of treatment of Familial Mediterranean Fever (FMF) with colchicine or analogues:an update.NIH National Library of Medicine,National center for biotechnology information.Pubmed.gov. [Revised in February 2005] [Accessed on 4th May 2022] https://pubmed.ncbi.nlm.nih.gov/15720245/
5. Michelle A Fravel, Michael E Ernst. Management of gout in the older adult.NIH National Library of Medicine,National center for biotechnology information.Pubmed.gov.[Revised in August 2017] [Accessed on 4th May 2022] https://pubmed.ncbi.nlm.nih.gov/21849262/
6. A Rambaldi 1, C Gluud. Colchicine for alcoholic and non-alcoholic liver fibrosis and cirrhosis. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. [Revised in April 2014] [Accessed on 4th May 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3991555/
7. Tiofarma B.V. Health Products Regulatory Authority (HPRA). [Revised in July 2021] [Accessed on 4th May 2022] https://www.hpra.ie/img/uploaded/swedocuments/aefb96f2-6bfc-45d9-a8147a9782bf7708.pdf
Written By Dr. R. Dinesh John Rajkumar, Pharm.D
Last updated on 20 Mar 2023 | 08:57 AM(IST)