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INTRODUCTION BUXSTAT 40MG TABLET contains Febuxostat, which belongs to a group of medicines called Antigout agents. It is used in the treatment of gout (common and complex form of arthritis that occurs when too much uric acid crystallises and deposits in the joints, resulting in sudden, severe...
BUXSTAT 40MG TABLET contains Febuxostat, which belongs to a group of medicines called Antigout agents. It is used in the treatment of gout (common and complex form of arthritis that occurs when too much uric acid crystallises and deposits in the joints, resulting in sudden, severe attacks of pain, swelling, redness and tenderness in one or more joints, most often in the big toe). It is also used to prevent accumulation of high blood levels of uric acid in the blood.
Before taking BUXSTAT 40MG TABLET inform your doctor if you have any liver, kidney, heart, thyroid problems and undergoing treatment for Lesch-Nyhan syndrome. BUXSTAT 40MG TABLET is not recommended for use by pregnant women, breastfeeding mothers, children, and adolescents. BUXSTAT 40MG TABLET should be used with caution by elderly patients.
The common side effects of taking BUXSTAT 40MG TABLET are abnormal liver test results, diarrhoea, headache, rash, nausea, increase in gout symptoms, localized swelling due to retention of fluids in tissues (oedema). Consult your doctor immediately if any of your symptoms gets worse.
BUXSTAT 40MG TABLET works by blocking the action of enzyme called xanthine oxidase, which is involved in the process of converting hypoxanthine into uric acid (purine metabolism pathway). This type of action reduces high uric acid level in gout and blood cancer patients undergoing chemotherapy treatment.
Take BUXSTAT 40MG TABLET as advised by your physician. Swallow BUXSTAT 40MG TABLET with a glass of water and do not chew or crush the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight.
Stop taking BUXSTAT 40MG TABLET and contact your doctor immediately if you experience any of the following side effects:
Nausea or vomiting:
Take BUXSTAT 40MG TABLET with or just after meals. Stick to simple meals. Avoid eating oil rich or spicy foods. If the symptom does not improve, contact your doctor immediately.
Flatulence:
Eat smaller and more frequent meals. Eat and drink slowly, and exercise regularly. If the symptom does not improve, contact your doctor immediately.
Constipation:
Eat plenty of fiber rich foods such as fresh fruits, vegetables, and cereals and drink plenty of water. Exercise more regularly. If the symptom does not improve, contact your doctor immediately.
Diarrhoea:
Drink lots of fluids, such as water or fruit juice, to keep yourself hydrated. Do not consume any medicine on your own without consulting your doctor.
Stomach pain:
Try to rest and relax. Eat and drink slowly or try to have smaller and more frequent meals. Keep a heating pad on your stomach. If the symptom does not improve, contact your doctor immediately.
BUXSTAT 40MG TABLET is generally not recommended for use by pregnant women. Consult your doctor before taking the medicine.
BUXSTAT 40MG TABLET is generally not recommended for use by breastfeeding women as it may pass through the breast milk. Consult your doctor before taking it.
Do not drive or operate any machines if you feel dizzy, sleepy, blurred vision and numbness or tingling sensation after taking BUXSTAT 40MG TABLET.
BUXSTAT 40MG TABLET should be used with caution in patients with having or have had kidney disease. Consult your doctor for advice before taking BUXSTAT 40MG TABLET.
BUXSTAT 40MG TABLET should be used with caution in patients who have or had liver disease or liver function test abnormalities. Consult your doctor for advice before taking BUXSTAT 40MG TABLET.
BUXSTAT 40MG TABLET is not recommended for use if you are allergic to febuxostat. It should also be used with caution in patients having history of serious allergic reaction to Allopurinol.
BUXSTAT 40MG TABLET should be used with caution in patients having or have had heart failure or heart problems or stroke. Consult your doctor for advice before taking BUXSTAT 40MG TABLET.
Before taking BUXSTAT 40MG TABLET, inform your doctor if you:
Use in Paediatrics:
BUXSTAT 40MG TABLET is generally not recommended for use in children and adolescents (under 18 years of age). Consult your doctor before taking BUXSTAT 40MG TABLET.
Use in Geriatrics:
BUXSTAT 40MG TABLET should be used with caution in elderly patients. Consult your doctor for advice before taking BUXSTAT 40MG TABLET.
A. Drug-Drug Interactions:
Before taking BUXSTAT 40MG TABLET, inform your doctor if you are taking any of the following medicine:
Overdosage:
If you or anyone else accidentally takes too much of BUXSTAT 40MG TABLET, consult your doctor immediately or visit the nearby hospital.
| Drug | : |
Febuxostat |
| Pharmacological Category | : |
Xanthine oxidase inhibitors |
| Therapeutic Indication | : |
Gout, blood cancer patients undergoing chemotherapy |
| Dosage Forms | : |
Tablet |
What is BUXSTAT 40MG TABLET used for?
BUXSTAT 40MG TABLET is used in adults to treat gout (form of arthritis that occur when too much uric acid crystallises and deposits in the joints) and used to prevent high blood levels of uric acid in blood cancer patients receiving chemotherapy.
What are the side effects of BUXSTAT 40MG TABLET?
BUXSTAT 40MG TABLET can commonly cause side effects such as abnormal liver function test results, diarrhea, headache, skin rash, nausea, exaggerated gout symptoms and oedema. If you feel any of these getting worse, please consult your doctor immediately.
Does BUXSTAT 40MG TABLET reduce uric acid levels?
Yes, BUXSTAT 40MG TABLET works by blocking the action of an enzyme called xanthine oxidase, which is involved in the process of converting hypoxanthine into uric acid (purine metabolism pathway). This type of action reduces high uric acid levels in gout and blood cancer patients undergoing chemotherapy treatment.
What happens if I stop taking BUXSTAT 40MG TABLET?
Once you are prescribed BUXSTAT 40MG TABLET it is very important that you do not stop taking it unless advised by your doctor or unless side effects develop. If BUXSTAT 40MG TABLET treatment is stopped, there is a high risk that your gout may worsen. You should continue to take it even if you do not have symptoms.
Is BUXSTAT 40MG TABLET good for kidney?
No, BUXSTAT 40MG TABLET might affect the function of the kidney, resulting in kidney stones, changes in the amount of urine, abnormally frequent urination, and an increased level of proteins in the urine). If you experience any of these symptoms while taking BUXSTAT 40MG TABLET, please consult your doctor immediately.
1. KD Tripathi. Section 11, Antirheumatoid and Antigout Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 210-218.
2. N. Lawrence Edwards, Febuxostat: a new treatment for hyperuricemia in gout, Rheumatology . [Revised in May 2009] [Accessed on 18th July 2022] https://doi.org/10.1093/rheumatology/kep088
3. Schumacher Jr, H. R., M. A. Becker, E. Lloyd, P. A. MacDonald, and C. Lademacher. Febuxostat in the treatment of gout: 5-yr findings of the FOCUS efficacy and safety study. Rheumatology. [Revised in June 2009] [Accessed on 18th July 2022] https://doi.org/10.1093/eurheartj/ehz119
4. MIAS Pharma Limited. Electronic Medicines Compendium (EMC). [Revised in June 2021] [Accessed on 18th July 2022] https://www.medicines.org.uk/emc/files/pil.11500.pdf
5. Takeda Pharmaceuticals Inc. U.S. Food & Drug Administration. [Revised in March 2013] [Accessed on 18th July 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/021856s011lbl.pdf
Written By Dr. Dhivakaran R, BDS
Last updated on 08 Oct 2022 | 05:13 PM(IST)