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INTRODUCTION BETABRIM EYE DROPS is a combination of Brimonidine and Timolol which belongs to the group of medicines called an Alpha-adrenergic receptor agonist and Beta-adrenergic receptor inhibitors respectively. BETABRIM EYE DROPS is used to reduce the elevated intraocular pressure (pressure...
BETABRIM EYE DROPS is a combination of Brimonidine and Timolol which belongs to the group of medicines called an Alpha-adrenergic receptor agonist and Beta-adrenergic receptor inhibitors respectively. BETABRIM EYE DROPS is used to reduce the elevated intraocular pressure (pressure inside the eye) in patients with glaucoma or ocular hypertension who require adjunctive or replacement therapy due to inadequately managed intraocular pressure.
Glaucoma is a disease which damages the optic nerve (nerve in the back of eye) because of excessive pressure inside the eye and may gradually lead to blindness. Ocular hypertension is a condition when pressure inside the eye rises higher than normal. Such conditions are characterized by halos, pain and blurred vision.
BETABRIM EYE DROPS is not recommended for use in patients with reactive airway disease such as bronchial asthma, severe chronic obstructive bronchitis and other severe chronic obstructive pulmonary disease (group of lung diseases causing difficulty in breathing).
It is also not recommended for use in patients having heart diseases such as sinus bradycardia (a type of slow heartbeat), 2nd or 3rd degree heart block, heart failure or cardiogenic shock. BETABRIM EYE DROPS should be used with caution in patients with liver and kidney problems.
BETABRIM EYE DROPS should be used in pregnant women only if clearly advised by the doctor and it is not recommended for use in breastfeeding women and children or adolescents (aged below 17 years).
The common side effects associated with the use of are BETABRIM EYE DROPS are eye redness, eye burning, stinging or pain in eyes, small breaks on the eye surface, inflammation in the eyelids and itching in eyes. Consult your doctor if any of the side effects worsen.
BETABRIM EYE DROPS helps to lower eye pressure due to glaucoma and intraocular hypertension, where Brimonidine works by allowing better fluid drainage from the eye resulting in reduced pressure in the eye and Timolol works by decreasing the amount of fluid formed in the eye which results in reduced intraocular pressure in the eye thereby treating glaucoma and ocular hypertension.
Use BETABRIM EYE DROPS as advised by your physician. It is for ophthalmic use only. Wash your hands before application, tilt your head back slightly and gently pull down the lower eyelid until there is a small pocket. Turn the bottle upside down and squeeze it to release one drop into each eye that needs treatment. Release the lower lid and close your eye. Keep the eye closed and press your finger against the corner of your eye for two minutes. If you miss a drop, try again.
Your doctor will decide the correct dose and duration of BETABRIM EYE DROPS for you depending upon your age and severity of the condition.
Stop using BETABRIM EYE DROPS and contact your doctor immediately if you experience any of the following side effects:
Itchy eyelids:
Clean your eyelids twice a day. Keep a flannel or cotton wool cloth soaked in warm water on your closed eyes for 5 to 10 minutes. Then gently massage your eyelids for few seconds. Do not use eye make up until the problem is resolved.
Eye Pain:
Rest your eyes by closing or sleeping. Avoid bright lights, reading, watching the television, and working on the computer. Keep eyes closed and gently massage your eyes for few seconds to relieve the muscles.
Headache:
Take enough rest and have proper sleep. Do not strain your eyes for long durations such as watching screen. Avoid taking alcohol. Consult your doctor if the symptom persists for long or gets worsened.
[GNBKEYWORD] is not recommended for use in pregnant women unless considered clearly necessary. Consult your doctor before using BETABRIM EYE DROPS.
BETABRIM EYE DROPS is not recommended for use in breastfeeding mothers since it may pass into the milk. Consult your doctor before using BETABRIM EYE DROPS.
Do not drive or operate machines while using BETABRIM EYE DROPS as it may cause drowsiness, tiredness or blurred vision. Consult your doctor before using BETABRIM EYE DROPS.
Avoid or limit consumption of alcohol while using BETABRIM EYE DROPS.
BETABRIM EYE DROPS should be used with caution in patients with kidney problems. Consult your doctor for advice before using BETABRIM EYE DROPS.
BETABRIM EYE DROPS should be used with caution in patient with liver problems. Consult your doctor before using it.
BETABRIM EYE DROPS is not recommended for use if you are allergic to brimonidine, timolol or any other ingredients of this medicine.
BETABRIM EYE DROPS is not recommended for use if you have/had respiratory problems such as bronchial asthma, severe chronic obstructive bronchitis (severe lung disease causing noisy breathing, difficulty in breathing or long- standing cough) and other severe chronic obstructive pulmonary disease (group of lung diseases causing difficulty in breathing). Consult your doctor before using BETABRIM EYE DROPS.
BETABRIM EYE DROPS is not recommended for use in patients with sinus bradycardia (a type of slow heartbeat), 2nd or 3rd degree heart block (delay in electrical conduction that triggers heart pumping), cardiac failure, cardiogenic shock (condition arising when heart is unable to pump enough blood to heart or brain) or heartbeat disorders. It should be used with caution in patients with heart disease such as coronary heart disease (causing chest pain or tightness, breathlessness or choking). Consult your before using BETABRIM EYE DROPS.
Before using BETABRIM EYE DROPS, inform your doctor if you:
Use in Paediatrics:
BETABRIM EYE DROPS is not recommended for use in children and adolescents (aged below 17 years). Consult your child’s doctor for advice.
Use in Geriatrics:
BETABRIM EYE DROPS should be used with caution in elderly patients (aged 65 years and above). Consult your doctor before using BETABRIM EYE DROPS.
A. Drug-Drug Interactions:
Before using BETABRIM EYE DROPS, inform your doctor if you are taking any of the following medicines:
Overdosage:
If you or anyone else accidentally use too much of BETABRIM EYE DROPS, consult your doctor immediately or visit the nearby hospital. Overdosage symptoms of BETABRIM EYE DROPS are dizziness, headache, bradycardia (slowing of heartbeats), bronchospasm (tightening of airway muscles causing coughing and noisy breathing), cardiac arrest (sudden loss of heart function) or low blood pressure.
| Drug | : | Brimonidine, Timolol |
| Pharmacological Category | : | Alpha-adrenergic receptor agonist, Beta-adrenergic receptor inhibitors |
| Therapeutic Indication | : | Glaucoma, Ocular hypertension |
| Dosage Forms | : | Eye drops |
What is BETABRIM EYE DROPS used for?
BETABRIM EYE DROPS is used to reduce the elevated intraocular pressure in patients with glaucoma. It is also used to reduce elevated intraocular pressure in patients with ocular hypertension who may require it as an adjunctive or replacement therapy due to uncontrolled intraocular pressure.
What happens if you use more BETABRIM EYE DROPS than your required dose?
If you or anyone else accidentally use too much of BETABRIM EYE DROPS, consult your doctor immediately or visit the nearby hospital. Overdosage symptoms of BETABRIM EYE DROPS are dizziness, headache, bradycardia (slowing of heartbeats), bronchospasm (tightening of airway muscles causing coughing and noisy breathing), cardiac arrest (sudden loss of heart function) or low blood pressure.
Who should avoid using BETABRIM EYE DROPS?
BETABRIM EYE DROPS is not recommended for use if you are allergic to brimonidine and timolol and/or have reactive airway disease such as bronchial asthma, severe chronic obstructive pulmonary disease (group of lung diseases causing difficulty in breathing), sinus bradycardia (a type of slow heartbeat), 2nd or 3rd degree heart block, cardiac failure or cardiogenic shock. It is also not recommended for breast-feeding women including children and adolescents (aged below 17 years). Consult your doctor before using BETABRIM EYE DROPS.
Is BETABRIM EYE DROPS safe to use in children?
BETABRIM EYE DROPS is not recommended for use in children and adolescents (aged below 17 years). If BETABRIM EYE DROPS is accidentally ingested by a child or adolescent, go to the hospital immediately and consult the doctor for further management.
Does BETABRIM EYE DROPS cause damage to lungs?
BETABRIM EYE DROPS may cause damage to your lungs if you are having reactive airway disease including bronchial asthma, a history of bronchial asthma or severe chronic obstructive pulmonary disease (group of lung diseases causing difficulty in breathing). Consult your doctor before using BETABRIM EYE DROPS.
How does BETABRIM EYE DROPS work?
BETABRIM EYE DROPS helps to lower eye pressure due to glaucoma and intraocular hypertension, where Brimonidine works by allowing better fluid drainage from the eye resulting in reduced pressure in the eye and Timolol works by decreasing the amount of fluid formed in the eye which results in reduced intraocular pressure in the eye thereby treating glaucoma and ocular hypertension.
Can BETABRIM EYE DROPS lower the blood pressure?
Yes, BETABRIM EYE DROPS may lower your blood pressure. Before using BETABRIM EYE DROPS inform your doctor if you are suffering from orthostatic hypotension (lowering of blood pressure on changing the posture) or taking blood pressure lowering medicines such as calcium antagonists such as amlodipine or catecholamine-depleting drugs such as reserpine.
1. KD. Tripathi. Antiadrenergic Drugs (Adrenergic Receptor Antagonists) and Drugs for Glaucoma. Seventh edition. 2013. Page – 153, 154.
2. Anne J Lee, Peter McCluskey. Fixed combination of topical brimonidine 0.2% and timolol 0.5% for glaucoma and uncontrolled intraocular pressure. NIH National Library of Medicine. National Centre for Biotechnology Information. PMC PubMed Central. September 2008. [Accessed on 29th June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2694019/
3. HBM Pharma s.r.o. Electronic Medicines Compendium (EMC). [Revised in December 2020] [Accessed on 29th May 2022] https://www.medicines.org.uk/emc/files/pil.12171.pdf
4. Allergan, Inc. U.S. Food & Drug Administration (FDA) [Revised in October 2015] [Accessed on 29th May 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/021398s007lbl.pdf
5. Allergan, Inc. U.S. Food & Drug Administration (FDA). [Revised in May 2010] [Accessed on 29th May 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021262s020,021770s004lbl.pdf
6. Valeant Pharmaceuticals North America LLC. U.S. Food & Drug Administration (FDA). [Revised in April 2016] [Accessed on 29th May 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/018086s076lbl.pdf
Written By Dr. R. Dinesh John Rajkumar, Pharm.D
Last updated on 23 Dec 2022 | 10:45 AM(IST)