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INTRODUCTION PANSEC L CAPSULE is a combination of Levosulpiride and Pantoprazole which belongs to the group of medicines called Dopamine D2 antagonists and Proton-pump inhibitors respectively. PANSEC L CAPSULE is indicated for the short-term treatment of gastro-esophageal reflux disease (GERD)...
PANSEC L CAPSULE is a combination of Levosulpiride and Pantoprazole which belongs to the group of medicines called Dopamine D2 antagonists and Proton-pump inhibitors respectively. PANSEC L CAPSULE is indicated for the short-term treatment of gastro-esophageal reflux disease (GERD) among patients who do not respond adequately to proton-pump inhibitors (Ex. pantoprazole, omeprazole, rabeprazole) alone.
GERD is a chronic digestive disease in which the stomach acid frequently flows into the esophagus leading to irritation and inflammation of lining of food pipe. Symptoms include heartburn, chest pain, nausea, sensation of lump in throat and stomach discomfort.
PANSEC L CAPSULE can also be used to treat peptic ulcer (painful sores in the gut) caused by H. pylori infection or NSAIDs use and Zollinger-Ellison syndrome (tumors in pancreas causing the stomach to secrete more acid).
Take PANSEC L CAPSULE preferably one hour before meals. Avoid consumption of alcohol while taking PANSEC L CAPSULE as it could potentiate the CNS depressive side effects.
Patients receiving long-term treatment with PANSEC L CAPSULE should be kept on regular surveillance to rule out the risk of hypomagnesaemia (decreased magnesium levels in blood) and bone fracture, predominantly in the elderly patients and in patients with other recognized risk factors like osteoporosis.
Before taking PANSEC L CAPSULE inform your doctor if you have any liver, kidney or heart problems. PANSEC L CAPSULE is generally not recommended for use in pregnant or breastfeeding women and in children or adolescents (below 18 years of age).
PANSEC L CAPSULE should be used with caution in elderly patients (aged 65 years or above) due to increased risk of postural hypotension, sedation and extrapyramidal effects (such as involuntary muscle movements, restless, muscle stiffness).
The most common side effects of taking PANSEC L CAPSULE are nausea, vomiting, headache, dizziness, polyps in the stomach gut and flatulence. Consult your doctor if any of the side effects worsen during or after treatment with PANSEC L CAPSULE.
PANSEC L CAPSULE reduces stomach ulcers and acid reflux, where pantoprazole acts by inhibiting the secretions of stomach acid by blocking the proton pump (H+ K+ ATPase) at the secretory surface of gastric parietal cells and levosulpiride acts by facilitating gastric emptying and bowel movements by blocking the dopamine D2 receptors in the gut, thus reducing acid reflux and healing of stomach ulcers and esophageal lesions.
Take PANSEC L CAPSULE as advised by your physician. Swallow PANSEC L CAPSULE with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of PANSEC L CAPSULE for you depending upon your age, body weight and disease condition. Do not stop taking PANSEC L CAPSULE without informing your doctor.
Stop taking PANSEC L CAPSULE and contact your doctor immediately if you experience any of the following side effects:
Nausea and vomiting:
Stick to simple meals while taking PANSEC L CAPSULE. Avoid eating oily, fried or spicy foods. Eat meals slowly and smaller and avoid doing activities immediately after eating. Consult your doctor if the symptom did not improve.
Diarrhea:
Drink lot of fluids such as water or fruit juices to keep yourself hydrated. Avoid taking any medicine on your own for treating diarrhea. Consult your doctor if the symptom did not improve.
Headache:
Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the forehead if required. Do not consume too much of alcohol. Consult your doctor if the symptom did not improve.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines while you are feeling dizzy. Do not consume too much of alcohol, as it can aggravate your dizziness. Consult your doctor if the symptom did not improve.
Constipation :
Eat fiber rich foods such as fresh fruits, vegetables, cereals and drink plenty of water. Try to exercise more regularly. Consult your doctor if the symptom did not improve on its own.
Stomach pain:
Rest and relax. Eat and drink slowly or try to have smaller and frequent meals. Keep a heat pad on your stomach. Do not self-treat on your own and consult your doctor if the symptom did not improve on its own.
PANSEC L CAPSULE is not recommended for use in pregnant women. Consult your doctor before taking PANSEC L CAPSULE.
PANSEC L CAPSULE is not recommended for use in breastfeeding women. Consult your doctor before taking PANSEC L CAPSULE.
Do not drive or operate any heavy tools or machines if you experience dizziness, drowsiness, involuntary muscle movements or blurred vision after taking PANSEC L CAPSULE.
Avoid consumption of alcohol while taking PANSEC L CAPSULE, as it may cause additive sedative effects.
PANSEC L CAPSULE is not recommended for use in patients with severe impaired kidney function consult your doctor before taking PANSEC L CAPSULE.
PANSEC L CAPSULE is not recommended for use in patients with severe impaired liver function and it should be used with caution in patients with mild to moderate severe hepatic cirrhosis. Consult your doctor before taking PANSEC L CAPSULE.
Do not take PANSEC L CAPSULE if you are allergic to Levosulpiride or Pantoprazole. Consult your doctor before taking PANSEC L CAPSULE.
PANSEC L CAPSULE should be taken with caution in patients with cardiovascular disease or a family history of prolonged QT interval. Consult your doctor before taking PANSEC L CAPSULE.
PANSEC L CAPSULE is not recommended for use if you:
Before taking PANSEC L CAPSULE, inform your physician if you:
Use in pediatrics:
PANSEC L CAPSULE is not recommended for use in children and adolescents (aged below 18 years) due to lack of safety and efficacy data. Consult your child’s doctor for advice.
Use in geriatrics:
PANSEC L CAPSULE should be used with caution in elderly patients (aged 65 years or above) due to increased risk of postural hypotension, sedation and extrapyramidal effects (such as involuntary muscle movements, restless, muscle stiffness). Consult your doctor before taking PANSEC L CAPSULE. Dose should be adjusted in patients with evidence of impaired kidney function.
A. Drug-Drug interactions:
Before taking PANSEC L CAPSULE inform to your doctor, if you are taking any of these medicines:
Overdosage:
If you or anyone else accidentally take too much of PANSEC L CAPSULE, contact your doctor immediately or go to a hospital straight away. Overdosage symptoms of PANSEC L CAPSULE might include extrapyramidal reactions (such as rigidity, tremor, drooling etc.) or sleep disturbances.
| Drug | : | Levosulpiride, Pantoprazole |
| Pharmacological Category | : | Dopamine D2 antagonists, Proton pump inhibitors |
| Therapeutic Indication | : | GERD, Peptic ulcer, Zollinger-Ellison syndrome |
| Dosage Forms | : | Tablet, Capsule |
Can PANSEC L CAPSULE be used to treat depression?
No, PANSEC L CAPSULE is only used to treat gastrointestinal disorders such as GERD, peptic ulcer and Zollinger-Ellison syndrome. Although levosulpiride is an antipsychotic medicine, at this recommended dosage, it is only used to treat acid reflux and to improve gastric motility. For more queries, please consult your doctor before taking PANSEC L CAPSULE.
Can PANSEC L CAPSULE cause constipation?
Yes, PANSEC L CAPSULE can cause constipation in some individuals which is nothing to worry about. Eat fiber rich diet with lots of fresh vegetables, fruits, cereals and drink plenty of water. Try to exercise more regularly (such as walking). Consult your doctor if the symptom did not improve on its own during treatment with PANSEC L CAPSULE.
Can PANSEC L CAPSULE be used in elderly patients?
PANSEC L CAPSULE should be used with caution in elderly patients (aged 65 years or above) due to increased risk of postural hypotension, sedation and extrapyramidal effects (such as involuntary muscle movements, restless, muscle stiffness). Consult your doctor before taking PANSEC L CAPSULE. Dose should be adjusted in patients with evidence of impaired kidney function.
Is PANSEC L CAPSULE safe to use in patients with liver problems?
PANSEC L CAPSULE is not recommended for use in patients with severe impaired liver function and it should be used with caution in patients with mild to moderate severe hepatic cirrhosis. Consult your doctor before taking PANSEC L CAPSULE.
Can I drive or operate machines after taking PANSEC L CAPSULE?
Do not drive or operate any heavy tools or machines if you experience dizziness, drowsiness, involuntary muscle movements or blurred vision after taking PANSEC L CAPSULE. Consult your doctor for advice before taking PANSEC L CAPSULE.
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2. Keith A. Sharkey and John L. Wallace. Pharmacotherapy of gastric acidity, peptic ulcer and gastroesophageal reflux disease. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 1311-1313.
3. Gerald G. Briggs and Roger K. Freeman. P. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 2960 & -2775.
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6. D. C. Metz, G. M. Comer, E. Soffer, C. E. Forsmark, B. Cryer, W. Chey and J. R. Pisegna. Three-year oral pantoprazole administration is effective for patients with Zollinger–Ellison syndrome and other hypersecretory conditions. NCBI; PMC US National Library of Medicine, National Institute of Health. September 2019. [Accessed on 1st November 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6736592/
7. Jordi Serra. [Levosulpiride in the management of functional dyspepsia and delayed gastric emptying]. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. October 2010. [Accessed on 1st November 2021] https://pubmed.ncbi.nlm.nih.gov/20850200/
8. Cipla Ltd. Pansec L Capsules (Hetero Labs) (Pantoprazole + Levosulpiride). Ciplamed.com. [Revised in July 2020]. [Accessed on 1st November 2021] https://www.ciplamed.com/content/pansec-l-capsules-hetero-labs
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Written By Dr. R. Dinesh John Rajkumar, Pharm.D
Last updated on 02 Dec 2022 | 11:19 AM(IST)