INTRODUCTION

MOZA 5MG contains Mosapride which belongs to the group of medicines called Gastrointestinal Agents. It is used in the treatment of heartburn, nausea and vomiting caused by chronic gastritis (condition that occurs when your stomach lining becomes inflamed) and disorders associated with reduced gastrointestinal motility (digestive problems that occurs when the nerves or muscles of the gut do not work in a coordinated way). It is also used as an adjuvant therapy with oral gastrointestinal lavage solution for barium enema x-ray examination.

A barium enema x-ray (examination) is a special type of X-ray that takes images of the large intestine (colon, rectum and anus) which helps the healthcare providers to diagnose certain gastrointestinal tract conditions or understand its associated symptoms.

MOZA 5MG is not recommended for use if you are allergic to mosapride. It is also not recommended for use if you have any haemorrhage (bleeding problems) or digestive blockage. It should be used with caution in patients with liver disease (like non-alcoholic steatohepatitis) and patients with kidney disease who are undergoing dialysis. Consult your doctor before taking this medicine.

MOZA 5MG is not recommended for use in pregnant and breastfeeding women. It should be used with caution in children and adolescents (aged 5 to 18 years). The common side effects associated with the use of MOZA 5MG are abdominal pain, diarrhoea, dry mouth, rash, itchy welts, nausea, or feeling fullness. Consult your doctor if any of the symptom worsens.

USES OF MOZA 5MG

• Treats heartburn, nausea and vomiting caused by chronic gastritis and disorders associated with reduced gastrointestinal motility
• Used as adjuvant therapy with oral gastrointestinal lavage solution for barium enema x-ray examination

HOW MOZA 5MG WORKS

MOZA 5MG works by stimulating selective receptors in the gastrointestinal region which releases certain chemical messengers that enhances gastrointestinal motility and gastric emptying thus provides relief from the symptoms of chronic gastritis and disorders associated with reduced gastrointestinal motility.

DIRECTIONS FOR USE

Take MOZA 5MG as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF MOZA 5MG

HOW TO MANAGE SIDE EFFECTS

Diarrhoea:

Drink lot of fluids, such as water to keep yourself hydrated. Try to avoid taking any medicine on your own to treat diarrhoea and consult your doctor if the symptom gets worse.

Nausea:

Try to take MOZA 5MG with or just after a meal or a snack. Stick to simple meals. Avoid eating oily, fried or spicy foods. Consult your doctor if the symptom gets worse.

Dry mouth:

Try to drink plenty of cold water. Sip on cold unsweetened drinks and use lip balm if your lips are dry. Try to brush your teeth twice a day and use mouthwash. Consult your doctor if the symptom does not improve.

Stomach pain:

Try to take rest and relax. Eat and drink slowly or try to have smaller and frequent meals. Keep a heat pad on your stomach. If the symptom does not improve, consult your doctor.

Loss of appetite:

Eat when you feel hungry. Eat smaller meals frequently than usual. Snack only when you're hungry. Eat a nutritious snack which is rich in calories and protein, such as dried fruit and nuts. Consult your doctor if the symptom does not improve.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug Interactions

Before taking MOZA 5MG, inform your doctor, if you are taking any of the following medicines:

• anti-cholinergic agents such as butylscopolamine (used to treat abdominal pain)
• medicines used to treat fungal infections (Ex. ketoconazole, itraconazole)
• macrolide antibiotics such as azithromycin, erythromycin (used to treat bacterial infections)
• HIV protease inhibitors such as ritonavir, nelfinavir (used to treat HIV infection)

Overdosage:

If you or anyone else accidentally takes too much of MOZA 5MG, consult your doctor immediately or visit the nearby hospital if you experience any unusual symptoms.

SYNOPSIS

MORE INFORMATION

• Keep the medicine out of reach of children
• Store MOZA 5MG at room temperature

FAQs ABOUT MOZA 5MG

What is MOZA 5MG used for?

MOZA 5MG is used in the treatment of heartburn, nausea, and vomiting caused by chronic gastritis and disorders associated with reduced gastrointestinal motility in affected individuals. It is also used as an adjuvant therapy with oral gastrointestinal lavage solution in affected individuals for barium enema x-ray examination. Consult your doctor before taking MOZA 5MG.

Is MOZA 5MG a laxative?

No, MOZA 5MG is a gastrointestinal agent which stimulates selective receptors in the gastrointestinal region that releases certain chemical messengers that enhances gastrointestinal motility and gastric emptying thus provides relief from the symptoms of chronic gastritis and disorders associated with reduced gastrointestinal motility.

Can MOZA 5MG cause diarrhoea?

Yes, MOZA 5MG may cause diarrhoea. To manage this side effect, drink lot of fluids, such as water to keep yourself hydrated. Try to avoid taking any medicine on your own to treat diarrhoea and consult your doctor if the symptom gets worse.

What common side effects are seen with MOZA 5MG?

The common side effects associated with the use of MOZA 5MG are abdominal pain, diarrhoea, dry mouth, rash, itchy welts, nausea, or feeling fullness. Consult your doctor if any of the symptom worsens.

Who should avoid taking MOZA 5MG?

MOZA 5MG is not recommended for use if you are allergic to mosapride. It is also not recommended for use in patients with any bleeding problems or digestive blockage. Also, it is not recommended for use in pregnant and breastfeeding women. Consult your doctor before taking MOZA 5MG.

What if I forget to take a dose of MOZA 5MG?

If you forgot to take MOZA 5MG dose, take it as early as possible. Do not double up the dose to make up for the forgotten one. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. If you are not sure, then consult your doctor before taking MOZA 5MG.

Can MOZA 5MG cause dry mouth?

Yes, MOZA 5MG may cause dry mouth in some individuals. If you experience dry mouth, try drinking plenty of cold water. Sip on cold unsweetened drinks and use lip balm if your lips are dry. Try to brush your teeth twice a day and use mouthwash. Consult your doctor if the symptom does not improve.

REFERENCES

1. KD. Tripathi. Antiemetic, Prokinetic and Digestant Drugs. Essentials Of Medical Pharmacology. Seventh edition. 2013. Page – 667.

2. Jin Lee, Su Jin Jeong, Tae Hyung Kim, Yong Eun Park, Joon Hyuk Choi, Nae-Yun Heo, Jongha Park, Seung Ha Park, Young Soo Moon, Tae Oh Kim. Efficacy of mosapride citrate with a split dose of polyethylene glycol plus ascorbic acid for bowel preparation in elderly patients. NIH National Library of Medicine. National Centre for Biotechnology Information. PMC PubMed Central. January 2020. [Accessed on 1st August 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6959869/

3. Hirofumi Okubo, Yusuke Nakatsu, Hideyuki Sakoda, Akifumi Kushiyama, Midori Fujishiro, Toshiaki Fukushima, Yasuka Matsunaga, Haruya Ohno, Masayasu Yoneda, Hideaki Kamata, Takanori Shinjo, Misaki Iwashita, Fusanori Nishimura, Tomoichiro Asano. Mosapride citrate improves nonalcoholic steatohepatitis with increased fecal lactic acid bacteria and plasma glucagon-like peptide-1 level in a rodent model. American Journal of Physiology. Gastrointestinal and Liver Physiology. January 2015. [Accessed on 1st August 2022] https://journals.physiology.org/doi/full/10.1152/ajpgi.00198.2014?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org

4. Kazutaka Kurabayashi, Daizou Henmi, Ken Kayakabe, Takako Nakano, Keiko Kobatake, Satsuki Kobayashi, Shigeo Tamura, Keiju Hiromura, Yoshihisa Nojima, Kazue Ueki. Effects of mosapride citrate, a serotonin 5-hydroxytryptamine type4 agonist, on abdominal symptoms in hemodialysis patients. J Stage. 2008. [Accessed on 1st August 2022] https://www.jstage.jst.go.jp/article/jsdt/41/10/41_10_731/_article/-char/en

5. Yoshimitsu Fujii, Tetsuji Morimoto. Utility of Mosapride Citrate in Pediatric Functional Constipation with Low Bowel Movement Frequency. Mathews Open Access Journals. Mathews Journal of Pediatrics. October 2019. [Accessed on 1st August 2022] https://www.mathewsopenaccess.com/scholarly-articles/utility-of-mosapride-citrate-in-pediatric-functional-constipation-with-low-bowel-movement-frequency.pdf

6. Fouda Pharmacy. Mosapride citrate. [Accessed on 1st August 2022] https://www.fouda.com/sites/default/files/2018/10/03/11246.pdf

7. Gramon Bago. Gastrial (Mosapride). [Accessed on 1st August 2022] https://www.gramonbago.com.uy/english/contenido/Mosapride-Citrate-10-mg--Tablets-4770

USEFUL DIAGNOSTIC TESTS

• Upper GI endoscopy