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INTRODUCTION AMFY V GEL(TOPICAL) contains Amphotericin B which belongs to the group of medicines called Anti-fungal agents. AMFY V GEL(TOPICAL) is used to treat acute, chronic & recurrent fungal infections, vaginal candidiasis, diaper rash, and bed sores in affected individuals....
AMFY V GEL(TOPICAL) contains Amphotericin B which belongs to the group of medicines called Anti-fungal agents. AMFY V GEL(TOPICAL) is used to treat acute, chronic & recurrent fungal infections, vaginal candidiasis, diaper rash, and bed sores in affected individuals.
AMFY V GEL(TOPICAL) is also used in dressing after wound debridement and burns which is also applied around tube and catheters during intubation in intensive care unit.
AMFY V GEL(TOPICAL) is not recommended for use in patients allergic to Amphotericin B. Before applying AMFY V GEL(TOPICAL), inform your doctor if you have kidney problems (such as renal impairment).
AMFY V GEL(TOPICAL) should be used with caution in pregnant and breastfeeding women. The medicine is also advised to be used with caution in children & adolescents (aged below 18 years) and in elderly patients (aged above 65 years) after consulting the doctor.
The most common side-effects of applying AMFY V GEL(TOPICAL) are ulceration and induration (thickened and hardened skin), scarring, and/or swelling at the applied site. Consult your doctor if any of these symptoms worsen.
AMFY V GEL(TOPICAL) binds to ergosterol (steroid present on the cell membranes of fungi) which leads to the formation of pores and ion leakage on the cell membrane resulting in fungal cell death thus treating invasive fungal infections in affected individuals.
Always apply AMFY V GEL(TOPICAL) as directed by your physician. Clean and dry the affected area before application of AMFY V GEL(TOPICAL). It is for external use only. A thin layer of medicine has to be applied on the affected area. Treated areas need not be covered with a plaster/bandage. Wash hands before and after the application AMFY V GEL(TOPICAL). Avoid applying this medicine around your eyes, including eyelids, nose, and mouth.
AMFY V GEL(TOPICAL) should be used with caution in pregnant women. Consult your doctor before using applying the medicine.
AMFY V GEL(TOPICAL) should be used with caution in breastfeeding women as it is not known whether the medicine pass through breast milk. Consult your doctor before applying AMFY V GEL(TOPICAL).
AMFY V GEL(TOPICAL) should be used with caution in patients with kidney problems such as renal impairment. Consult your doctor before applying AMFY V GEL(TOPICAL).
Do not apply AMFY V GEL(TOPICAL) if you are allergic to Amphotericin B, and/or any other ingredients of this medicine.
Use in Pediatrics:
AMFY V GEL(TOPICAL) is safe to use in children and adolescents (below 18 years). Consult your doctor before applying the medicine.
Use in Geriatrics:
AMFY V GEL(TOPICAL) should be used with caution in elderly patients (aged above 65 years). Consult your doctor before applying the medicine.
A.Drug–Drug interactions:
Inform your doctor about all the medicines you use including prescription, non-prescription and herbal medicines.
Overdosage:
If you or anyone else applied too much of AMFY V GEL(TOPICAL) or accidentally swallowed the medicine, consult your doctor immediately or visit the nearby hospital to manage the overdose symptoms.
| Drug | : | Amphotericin B |
| Pharmacological Category | : | Anti-fungal agents |
| Therapeutic Indication | : | Fungal infections, Vaginal candidiasis, Diaper rash, Bed sores, Dressing (after wound debridement and burns) |
| Dosage Forms | : | Injection, Infusion, Emulsion, Gel |
What is AMFY V GEL(TOPICAL) used for?
AMFY V GEL(TOPICAL) is used to treat acute, chronic & recurrent fungal infections, vaginal candidiasis, diaper rash, and bed sores in affected individuals. It is also used in dressing after wound debridement and burns which is also applied around tube and catheters during intubation in intensive care unit.
What are the side effects of AMFY V GEL(TOPICAL)?
The most common side-effects of applying AMFY V GEL(TOPICAL) are ulceration and induration (thickened and hardened skin), scarring, and/or swelling at the applied site. Consult your doctor if any of these symptoms worsen.
How AMFY V GEL(TOPICAL) works:
AMFY V GEL(TOPICAL) binds to ergosterol (steroid present on the cell membranes of fungi) which leads to the formation of pores and ion leakage on the cell membrane resulting in fungal cell death thus treating invasive fungal infections in affected individuals.
How to apply AMFY V GEL(TOPICAL)?
Always apply AMFY V GEL(TOPICAL) as directed by your physician. Clean and dry the affected area before application of AMFY V GEL(TOPICAL). It is for external use only. A thin layer of medicine has to be applied on the affected area. Treated areas need not be covered with a plaster/bandage. Wash hands before and after the application AMFY V GEL(TOPICAL). Avoid applying this medicine around your eyes, including eyelids, nose, and mouth.
Can AMFY V GEL(TOPICAL) be applied in pregnant and breast-feeding women?
Yes, AMFY V GEL(TOPICAL) can be applied but with caution in pregnant women. It is also advised to be used with caution in breastfeeding women as it is unknown whether the medicine pass through breast milk. Consult your doctor before applying AMFY V GEL(TOPICAL).
1. KD. Tripathi. Anti-Fungal Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 787.
2. Neil RH Stone, Tihana Bicanic, Rahuman Salim and William Hope. Liposomal Amphotericin B (AmBisome®): A review of the pharmacokinetics, pharmacodynamics, clinical experience and future directions. NIH National Library of Medicine. National Center for Biotechnology Information. PMC PubMed Central. March 2017. [Accessed on 7th May 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856207/
3. C P Thakur, G P Sinha, V Sharma, D Barat. The treatment of kala-azar during pregnancy. NIH National Library of Medicine. National Center for Biotechnology Information. PubMed.gov. 1993. [Accessed on 7th May 2022] https://pubmed.ncbi.nlm.nih.gov/7950931/
4. Bethesda. Amphotericin B. NIH National Library of Medicine. National Center for Biotechnology Information. March 2021. [Accessed on 7th May 2022] https://www.ncbi.nlm.nih.gov/books/NBK501321/
5. Amir Horev, Orli Sagi, Eyal Zur, Shalom Ben-Shimol. Topical liposomal amphotericin B gel treatment for cutaneous leishmaniasis caused by Leishmania major: a double-blind, randomized, placebo-controlled, pilot study. NIH National Library of Medicine. National Center for Biotechnology Information. PubMed.gov. August 2022. [Accessed on 7th May 2022] https://pubmed.ncbi.nlm.nih.gov/36040071/
6. Patrick T. McKeny; Trevor A. Nessel; Patrick M. Zito. Antifungal Antibiotics.NIH National Library of Medicine. National Center for Biotechnology Information. StatPearls [Internet]. August 2022. [Accessed on 7th May 2022] https://www.ncbi.nlm.nih.gov/books/NBK538168/
7. Satomi Ueda, Shunichi Miyamoto, Kosuke Kaida, Aki Chizuka, Rie Kojima, Junichiro Takano, Toshie Ogasawara, Ko Miyamoto, Shigesaburo Miyakoshi, Yoshinobu Kanda. Safety and efficacy of treatment with liposomal amphotericin B in elderly patients at least 65 years old with hematological diseases. NIH National Library of Medicine. National Center for Biotechnology Information. PubMed.gov. [Revised on May 2016] [Accessed on 7th May 2022] https://pubmed.ncbi.nlm.nih.gov/26908230/
8. Lifecare Innovations Pvt Ltd. Fungisome Gel. [Accessed on 7th May 2022] https://www.lifecareinnovations.com/pdf/FUNGISOME-GEL-for-the-Treatment-of-Mucormycosis.pdf
Written By Dr. K .AZEEM HUSSAIN, B.D.S
Last updated on 22 Nov 2022 | 06:15 PM(IST)