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INTRODUCTION AMBISOME 50MG INJECTION contains Amphotericin B which belongs to the group of medicines called Anti-fungal agents. AMBISOME 50MG INJECTION is used to treat invasive fungal infections in patients who are resistant/intolerant to conventional Amphotericin B therapy....
AMBISOME 50MG INJECTION contains Amphotericin B which belongs to the group of medicines called Anti-fungal agents. AMBISOME 50MG INJECTION is used to treat invasive fungal infections in patients who are resistant/intolerant to conventional Amphotericin B therapy.
AMBISOME 50MG INJECTION is not recommended for use in patients allergic to Amphotericin B. It is also not recommended for use in patients with common/superficial, clinically inapparent fungal infections (which are detectable only by positive skin/serologic tests).
Before receiving AMBISOME 50MG INJECTION, inform your doctor if you are neutropenic, and/or have liver problems (such as hepatic impairment), and suffer from kidney problems/undergoing dialysis.
AMBISOME 50MG INJECTION should be used with caution in pregnant and breast-feeding women only if it is clearly necessary. It is also used with caution in children and adolescents (aged below 18 years) and in elders (aged above 65 years) after consulting with the doctor.
The most common side effects of receiving AMBISOME 50MG INJECTION are fever, chills, and/or rigors. Consult your doctor if any of these symptoms worsen.
AMBISOME 50MG INJECTION binds to ergosterol (steroid present on the cell membranes of fungi) which leads to the formation of pores and ion leakage on the cell membrane resulting in fungal cell death thus treating invasive fungal infections in affected individuals.
AMBISOME 50MG INJECTION will be given to you only by a doctor or a nurse into a vein as an intravenous infusion. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
AMBISOME 50MG INJECTION should be administered with caution in pregnant women only if it is clearly necessary. Consult your doctor before receiving the medicine.
AMBISOME 50MG INJECTION should be administered with caution in breastfeeding women only if it is clearly necessary. Consult your doctor before receiving the medicine.
AMBISOME 50MG INJECTION is unlikely to affect your ability to drive/operate machines. Consult your doctor before receiving AMBISOME 50MG INJECTION.
AMBISOME 50MG INJECTION should be administered with caution in patients with kidney disease and in patients who are under dialysis. Consult your doctor before receiving the medicine.
AMBISOME 50MG INJECTION should be administered with caution in patients with hepatic impairment, and/or other liver disease. Consult your doctor before receiving AMBISOME 50MG INJECTION.
Do not receive AMBISOME 50MG INJECTION if you are allergic to Amphotericin B, and/or any other ingredients of this medicine.
AMBISOME 50MG INJECTION is not recommended for use if you:
Before receiving AMBISOME 50MG INJECTION, inform your doctor if you:
Use in Pediatrics:
AMBISOME 50MG INJECTION should be used with caution in children and adolescents (aged below 18 years). Consult your doctor before child receives the medicine.
Use in Geriatrics:
AMBISOME 50MG INJECTION should be used with caution in elderly patients (aged above 65 years). Consult your doctor before receiving AMBISOME 50MG INJECTION.
A. Drug–Drug interactions:
Before receiving AMBISOME 50MG INJECTION, inform your doctor if you are taking any of the following medicine:
Overdosage:
AMBISOME 50MG INJECTION will be administered to you only by a doctor or a nurse in a hospital, and so it is unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms.
| Drug | : | Amphotericin B |
| Pharmacological Category | : | Anti-fungal agent |
| Therapeutic Indication | : | Invasive fungal infection |
| Dosage Forms | : | Injection, Infusion, Emulsion, Gel |
What is AMBISOME 50MG INJECTION used for?
AMBISOME 50MG INJECTION is an anti-fungal agent which is used to treat invasive fungal infections in patients who are resistant/intolerant to conventional Amphotericin B therapy.
What are the side effects of AMBISOME 50MG INJECTION?
The most common side effects of receiving AMBISOME 50MG INJECTION are fever, chills, and/or rigors. Consult your doctor if any of these symptoms worsen.
How AMBISOME 50MG INJECTION works:
AMBISOME 50MG INJECTION binds to ergosterol (steroid present on the cell membranes of fungi) which leads to the formation of pores and ion leakage on the cell membrane resulting in fungal cell death thus treating invasive fungal infections in affected individuals.
How AMBISOME 50MG INJECTION is administered?
AMBISOME 50MG INJECTION will be given to you only by a doctor or a nurse into a vein as an intravenous infusion. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Can AMBISOME 50MG INJECTION be used in pregnant and breast-feeding women?
Yes, AMBISOME 50MG INJECTION can be administered but with caution in pregnant and breastfeeding women. Consult your doctor before receiving the medicine.
1. KD. Tripathi. Anti-Fungal Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 787.
2. Neil RH Stone, Tihana Bicanic, Rahuman Salim and William Hope. Liposomal Amphotericin B (AmBisome®): A review of the pharmacokinetics, pharmacodynamics, clinical experience and future directions. NIH National Library of Medicine. National Center for Biotechnology Information. PMC PubMed Central. March 2017. [Accessed on 12th May 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4856207/
3. Satomi Ueda, Shunichi Miyamoto, Kosuke Kaida, Aki Chizuka, Rie Kojima, Junichiro Takano, Toshie Ogasawara, Ko Miyamoto, Shigesaburo Miyakoshi, Yoshinobu Kanda. Safety and efficacy of treatment with liposomal amphotericin B in elderly patients at least 65 years old with hematological diseases. NIH National Library of Medicine. National Center for Biotechnology Information. PubMed.gov. May 2016. [Accessed on 12th May 2022] https://pubmed.ncbi.nlm.nih.gov/26908230/
4. Bharat Serums and Vaccines Limited. Ampholip. [Accessed on 12th May 2022] https://bsvgroup.com/assets/pdf/products/AMPHOLIP-Common-Pack-Insert-Export-for-Domestic.pdf
Written By Dr. K .AZEEM HUSSAIN, B.D.S
Last updated on 22 Nov 2022 | 05:12 PM(IST)