INTRODUCTION

ALCROS SB 130 CAPSULE contains Itraconazole which belongs to the group of medicines called Anti-fungals. It is used to treat infections of the mouth or vagina (causing thrush), skin infections and infections affecting other parts of the body.

Fungal infections also known as mycosis is a disease caused by fungus, which can affect people of all age groups. People with injuries and suppressed immune system are more susceptible to fungal infections.

ALCROS SB 130 CAPSULE should be used with caution in patients with kidney or liver problems and heart problems such as heart failure. ALCROS SB 130 CAPSULE is not recommended for use in patients when the immune system is not functioning well or have acquired immunodeficiency syndrome (AIDS).

Do not take any medicine without consulting your doctor while on treatment with ALCROS SB 130 CAPSULE especially medicines given to treat indigestion or stomach ulcers. If the duration of the treatment with ALCROS SB 130 CAPSULE is more than a month your doctor will advise you to take some blood tests to monitor your liver function.

ALCROS SB 130 CAPSULE is not recommended for use in pregnant women unless advised by the doctor and it is not recommended for use in breast-feeding women. ALCROS SB 130 CAPSULE is not recommended for use in children less than 12 years of age, however your child’s doctor may advise them in special cases.

ALCROS SB 130 CAPSULE is normally not recommended for use in elderly patients, however, your doctor may prescribe them in special cases. The common side effects of taking ALCROS SB 130 CAPSULE are stomach pain, nausea and headache. Consult your doctor if any of the side effects worsen.

USES OF ALCROS SB 130 CAPSULE

Treats:

• Infections of the mouth or vagina (causing thrush)
• Skin infections and infections affecting other parts of the body

HOW ALCROS SB 130 CAPSULE WORKS

ALCROS SB 130 CAPSULE works by preventing the fungal growth by blocking the production of enzymes responsible for the growth of fungal cell. This inhibition results in breakage of cell membranes and fungal cell abnormalities, finally leading to alterations in membrane-based activity of fungus. These leads to fungal cell death and prevention of further fungal growth.

DIRECTIONS FOR USE

Take ALCROS SB 130 CAPSULE as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of ALCROS SB 130 CAPSULE for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF ALCROS SB 130 CAPSULE

HOW TO MANAGE SIDE EFFECTS

Diarrhea

Drink lot of fluids, such as water to keep yourself hydrated. Avoid eating high-fat or spicy foods. Try to avoid taking any medicine on your own to treat diarrhea and consult your doctor if the symptom gets worse.

Headache

Drink ample amount of water and avoid skipping meals. Get adequate rest. Try to be relaxed and stress free. Apply pain relieving balm on your forehead if necessary. Consult your doctor if the symptom does not improve.

Nausea And Vomiting

Stick to simple meals while taking this medicine. Avoid eating oily rich, fried or spicy foods. Do not lie down or sleep immediately after eating. Consult your doctor if the symptom does not improve.

Stomach Pain

Try to rest and relax. Eat and drink slowly or try to have smaller meals more frequently. Keep a heat pad on your stomach. If the symptom does not improve, consult your doctor.

WARNING & PRECAUTIONS

PREGNANCY

Monitoring required

ALCROS SB 130 CAPSULE is not recommended for use in pregnant women unless advised by the doctor. You should use contraception to make sure that you do not become pregnant during treatment with this medicine. Consult your doctor before taking ALCROS SB 130 CAPSULE.

BREASTFEEDING

Contraindicated

ALCROS SB 130 CAPSULE is not recommended for use in breast-feeding women as small amount of this medicine passes into breast milk. Consult your doctor before taking ALCROS SB 130 CAPSULE.

DRIVING AND USING MACHINES

Use with Caution

Do not drive or handle heavy machines if you experience dizziness, blurred/double vision or hearing loss while taking ALCROS SB 130 CAPSULE.

ALCOHOL

Contraindicated

Consumption of alcohol is not recommended during treatment with ALCROS SB 130 CAPSULE.

KIDNEY

Use with Caution

ALCROS SB 130 CAPSULE should be used with caution in patients with kidney problems. Consult your doctor before taking ALCROS SB 130 CAPSULE.

LIVER

Use with Caution

ALCROS SB 130 CAPSULE should be used with caution in patients with kidney problems. Consult your doctor before taking ALCROS SB 130 CAPSULE.

ALLERGY

Contraindicated

Do not take ALCROS SB 130 CAPSULE if you are allergic to itraconazole or any other ingredients of this medicine.

HEART DISEASE

Use with Caution

ALCROS SB 130 CAPSULE should be used with caution in patients with heart problem such as heart failure. Consult your doctor before taking ALCROS SB 130 CAPSULE.

USE IN PEDIATRICS

Monitoring required

ALCROS SB 130 CAPSULE is not recommended for use in children less than 12 years of age. However, your child’s doctor may advise them in special cases. Consult your child’s doctor for advice before giving ALCROS SB 130 CAPSULE to your child.

USE IN GERIATRICS

Monitoring required

ALCROS SB 130 CAPSULE is not recommended for use in elderly patients. However, your doctor may prescribe them in special cases. Consult your doctor before taking ALCROS SB 130 CAPSULE.

INTERACTIONS

A. Drug - Drug interactions:

Before taking ALCROS SB 130 CAPSULE, inform your doctor if you are taking any of the following medicines:

• medicines used to treat allergies or hay fever Ex. terfenadine, astemizole, ebastine, mizolastine
• medicines used to lower blood cholesterol levels Ex. atorvastatin, lovastatin, simvastatin
• medicines used to treat irregular heartbeat Ex. quinidine, disopyramide, dronedarone or dofetilide
• medicines used to treat chest pain and high blood pressure Ex. bepridil, , lercanidipine, ivabradine, ranolazine, nisoldipine, aliskiren, nadolol, digoxin, cilostazol dihydropyridines such as amlodipine, felodipine, verapamil
• medicines used to treat migraine headaches Ex. dihydroergotamine, eletriptan, ergotamine
• medicines used to treat drug abuse Ex. levacetylmethadol and methadone
• medicines used to treat digestive problems Ex. cisapride
• colchicine (used to treat gout)
• medicines used to treat fluid accumulation Ex. Eplerenone
• medicines used after labour Ex. ergometrine, methylergometrine
• medicine used to treat malaria Ex. halofantrine
• medicines used to treat cancer Ex. irinotecan, bortezomib, busulphan, docetaxel, erlotinib, ixabepilone, trimetrexate, axitinib, dabrafenib, dasatinib, ibrutinib, lapatinib, nilotinib, sunitinib and trabectedin
• medicines used as blood thinners Ex. dabigatran, ticagrelor, rivaroxaban, warfarin
• medicines used to treat mental illness Ex. quetiapine, pimozide, lurasidone, aripiprazole, haloperidol, perospirone, ramelteon, risperidone, reboxetine, and sertindole
• medicines used to treat urinary bladder disorders Ex. darifenacin, tamsulosin, fesoterodine, imidafenacin, solifenacin, tolterodine
• medicines used to treat anxiety Ex. midazolam, triazolam, buspirone, alprazolam, brotizolam
• medicines used after an organ transplant Ex. everolimus, ciclesonide, temsirolimus, ciclosporin, tacrolimus, sirolimus
• medicines used to relive pain Ex. fentanyl, alfentanil, buprenorphine, oxycodone
• medicines used to treat inflammation or asthma Ex. salmeterol, methylprednisolone, fluticasone, budesonide, dexamethasone
• medicines used to treat erection problems Ex. vardenafil, sildenafil and tadalafil
• medicines used to treat indigestion, stomach ulcers or heartburn Ex. Pantoprazole, omeprazole
• medicines used to treat HIV infection Ex. ritonavir, darunavir, indinavir, fosamprenavir, saquinivir
• medicines used to treat bacterial infections Ex. ciprofloxacin, clarithromycin, erythromycin
• medicines used to treat tuberculosis Ex. rifampicin, rifabutin or isoniazid
• medicines used to treat epilepsy Ex. phenytoin, carbamazepine or phenobarbital
• st. john’s wort (used to treat depression)
• medicines used to treat eczema Ex. alitretioin
• medicines used to treat vomiting Ex. aprepitant, domperidone
• medicines used to treat excess thyroid hormone secretion Ex. cinacalcet
• medicines used to treat low sodium blood levels Ex. mozavaptan or tolvaptan
• medicines used to treat worms Ex. praziquantel
• medicines used to treat high blood sugar Ex. Repaglinide, saxagliptin
• medicines used to relive inflammation and pain Ex. meloxicam

Overdosage:

If you or anyone else accidentally takes too much of ALCROS SB 130 CAPSULE, consult your doctor immediately or visit the nearby hospital.

SYNOPSIS

MORE INFORMATION

• Keep ALCROS SB 130 CAPSULE out of reach of children
• Store ALCROS SB 130 CAPSULE at room temperature

FAQs ABOUT ALCROS SB 130 CAPSULE

Q. What is ALCROS SB 130 CAPSULE used for?

A. ALCROS SB 130 CAPSULE contains itraconazole which belongs to the group of medicines called anti-fungals. It is used to treat infections of the mouth or vagina (causing thrush), skin infections and infections affecting other parts of the body.

Q. How does ALCROS SB 130 CAPSULE work?

A. ALCROS SB 130 CAPSULE works by preventing the fungal growth by blocking the production of enzymes responsible for the growth of fungal cell. This inhibition results in breakage of cell membranes and fungal cell abnormalities, finally leading to alterations in membrane-based activity of fungus. These leads to fungal cell death and prevention of further fungal growth.

Q. Does ALCROS SB 130 CAPSULE cause stomach pain?

A. The most common side effect of ALCROS SB 130 CAPSULE is stomach pain. To manage this effect, try to rest and relax. Eat and drink slowly or try to have smaller meals more frequently. Keep a heat pad on your stomach. If the symptom does not improve, consult your doctor.

Q. Is ALCROS SB 130 CAPSULE safe to use in pregnant women?

A. ALCROS SB 130 CAPSULE is not recommended for use in pregnant women unless advised by the doctor. You should use contraception to make sure that you do not become pregnant during treatment with this medicine. Consult your doctor before taking ALCROS SB 130 CAPSULE.

Q. Can ALCROS SB 130 CAPSULE be used in children?

A. ALCROS SB 130 CAPSULE is not recommended for use in children less than 12 years of age. However, your child’s doctor may advise them in special cases. Consult your child’s doctor for advice

REFERENCES

1. K.D. Tripathi. Antifungal Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page 794

2. Heidi Kurn; Roopma Wadhwa. Itraconazole. NIH National Library of Medicine. National Center for Biotechnology Information. StatPearls [Internet]. April 2022. [Accessed on 7th July 2022] https://www.ncbi.nlm.nih.gov/books/NBK557874/

3. Stiefel, a GSK Company. Itraconazole Tablets Vs. Itraconazole Capsules vs. Placebo in Onychomycosis of the Toenail. NIH. National Library of medicine. Clinical trials.gov. [Revised in February 2017] [Accessed on 7th July 2022] https://clinicaltrials.gov/ct2/show/NCT00356915

4. Laboratorios Liconsa, S.A. Electronic Medicines Compendium (EMC) [Revised in January 2021] [Accessed on 7th July 2022] https://www.medicines.org.uk/emc/files/pil.5914.pdf

5. Janssen Pharmaceutical Companies [Revised in May 2018] [Accessed on 7th July 2022] https://www.janssenlabels.com/package-insert/product-monograph/prescribing-information/SPORANOX-Capsules-pi.pdf

6. Mint Pharmaceuticals Inc Health Canada [Revised in March 2018] [Accessed on 7th July 2022] https://pdf.hres.ca/dpd_pm/00044442.PDF

7. Mayne Pharma International Pty Ltd [Revised in April 2020] [Accessed on 7th July 2022] https://www.nps.org.au/medicine-finder/lozanoc-capsules#product-description

USEFUL DIAGNOSTIC TESTS

• Complete blood count
• Fungal culture test

AUTHOR DETAILS

Written By Dr. R. Dinesh John Rajkumar, Pharm.D
Last updated on 24 Feb 2023 | 10:26 AM(IST)