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INTRODUCTION AF 400MG TABLET contains Fluconazole which belongs to the group of medicines called Anti-fungal agents. It is used to treat various fungal infections such as systemic candidiasis (fungal infection affecting the blood, brain, heart, eyes or other parts of the body), mucosal candidi...
AF 400MG TABLET contains Fluconazole which belongs to the group of medicines called Anti-fungal agents. It is used to treat various fungal infections such as systemic candidiasis (fungal infection affecting the blood, brain, heart, eyes or other parts of the body), mucosal candidiasis (fungal infection affecting the mouth, throat or denture sore mouth), cryptococcosis (fungal infection mainly affecting the lungs and brain), vaginal candidiasis (fungal infection of the vagina and tissues at the opening of vagina (vulva)).
Also, it prevents fungal infections in immunocompromised patients considered at risk as a consequence of HIV infection or low white blood cell count after cytotoxic chemotherapy, radiotherapy or bone marrow transplant.
Before taking AF 400MG TABLET, inform your doctor if you have liver, kidney or heart problems, abnormal levels of potassium, calcium, or magnesium in your blood, are prone to develop severe skin reactions and have a history of adrenal insufficiency.
AF 400MG TABLET is not recommended for use in pregnant and breast-feeding women unless clearly advised by the doctor. AF 400MG TABLET should be used with caution in children and adolescents (from birth to 17 years of age). It should be used with caution in elderly patients particularly with renal impairment.
The most common side effects of taking AF 400MG TABLET are headache, nausea, vomiting diarrhea, abdominal pain, and indigestion. Consult your doctor if any of the side effect gets worse.
AF 400MG TABLET works by stopping the action of an enzyme called ergosterol, which is an integral part of the fungal cell membrane to increase its cellular permeability. Thereby, making the cell membrane more permeable and stops the fungal growth. This type of action is useful in treating and preventing various fungal infections.
Take AF 400MG TABLET as advised by your physician. Swallow AF 400MG TABLET with a glass of water and do not chew or crush the medicine. The correct dose and duration for you will be decide by the doctor depending upon your age, body weight and type of infection.
Stop taking AF 400MG TABLET and contact your doctor immediately if you experience any of the following side effects:
Drink lot of fluids, such as water or fruit juice to keep yourself hydrated. Do not take any medicine on your own to treat diarrhea without consulting your doctor.
Lie down until dizziness is gone, then get up slowly. Move slowly and carefully, do not hurry. Get adequate rest. Drink plenty of water and other fluids. Avoid coffee, cigarettes, alcohol, and drugs. Consult your doctor if the symptom gets worse.
Drink ample amount of water and avoid skipping meals. Get adequate rest. Try to be relaxed and stress free. Apply pain relieving balm on your forehead if necessary. Consult your doctor if the symptom does not improve.
Stick to simple meals while receiving this medicine. Avoid eating oily rich, fried or spicy foods. Do not lie down or sleep immediately after eating. Consult your doctor if the symptom does not improve.
Try to take rest and relax. Eat and drink slowly or try to have smaller and frequent meals. Keep a heat pad on your stomach. If the symptom does not improve, contact your doctor.
AF 400MG TABLET is not recommended for use during pregnancy unless considered clearly necessary. Consult your doctor before taking AF 400MG TABLET.
AF 400MG TABLET is not recommended for use in breastfeeding women after repeated use or after high dose of this medicine. You may continue breast-feeding after single dose of AF 400MG TABLET. Consult your doctor before taking AF 400MG TABLET.
Do not drive or operate any machines if you experience dizziness or fits after taking AF 400MG TABLET.
AF 400MG TABLET should be used with caution in patients with kidney dysfunction. Consult your doctor before taking AF 400MG TABLET.
AF 400MG TABLET should be used with caution in patients with liver dysfunction. Consult your doctor before taking AF 400MG TABLET.
AF 400MG TABLET is not recommended for use if you are allergic to fluconazole or other azole anti-fungals (such as itraconazole or posaconazole).
AF 400MG TABLET should be used with caution in children and adolescents (from birth to 17 years of age). Consult child’s doctor for advice before administration of AF 400MG TABLET to your child.
AF 400MG TABLET should be used with caution in elderly patients particularly with renal impairment. Your doctor may adjust the dose depending upon kidney function. Consult your doctor for advice before taking AF 400MG TABLET.
AF 400MG TABLET is not recommended for use if you:
Before taking AF 400MG TABLET, inform your doctor if you:
A. Drug-Drug Interactions:
Before taking AF 400MG TABLET, inform your doctor, if you are taking any of the following medicines:
Overdosage:
If you or anyone else accidentally takes too much of AF 400MG TABLET, consult your doctor immediately or visit the nearby hospital. Overdosage symptoms of AF 400MG TABLET are hearing, seeing, feeling and thinking things that are not real (hallucination and paranoid behaviour).
| Drug | : | Fluconazole |
| Pharmacological Category | : | Triazoles |
| Therapeutic Indication | : | Prevents and treats various fungal infections |
| Dosage Forms | : | Tablet, Dispersible tablet, Capsule, Injection, Infusion, Dry syrup, Dusting powder, Gel, Cream, Ear drops, Eye drops,Soap |
Q: How does AF 400MG TABLET work?
A: AF 400MG TABLET works by stopping the action of an enzyme called ergosterol, which is an integral part of the fungal cell membrane to increase its cellular permeability. Thereby, making the cell membrane more permeable and stops the fungal growth. This type of action is useful in treating and preventing various fungal infections.
Q: What if I forget to take a dose of AF 400MG TABLET?
A: If you have missed a dose of AF 400MG TABLET, take it as soon as you remember. However, if it is almost time for your next dose, skip the missed dose and take the next scheduled dose. Do not double the dose of AF 400MG TABLET to make up for the missed one as this may increase the chances of developing side effects.
Q: What are the common side effects of AF 400MG TABLET?
A: The common side effects of taking AF 400MG TABLET are headache, nausea, vomiting, diarrhea, abdominal pain, indigestion and acne. Consult your doctor if any of the symptom gets worse or does not improve over the time
Q: Can AF 400MG TABLET be used in elderly patients?
A: AF 400MG TABLET should be used with caution in elderly patients particularly with renal impairment. Your doctor may adjust the dose depending upon kidney function. Consult your doctor for advice before taking AF 400MG TABLET.
Q: Is AF 400MG TABLET safe to use during pregnancy?
A: AF 400MG TABLET is not recommended for use during pregnancy unless clearly advised by the doctor. Consult your doctor before taking AF 400MG TABLET if you are pregnant or planning to get pregnant.
1. KD. Tripathi. Section, Antifungal Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 787.
2. Ameish Govindarajan; Karlyle G. Bistas; Curtis J. Ingold; Ayham Aboeed. NIH National Library of Medicine, National center for biotechnology information. June 2022. [Accessed on 12th July 2022] https://www.ncbi.nlm.nih.gov/books/NBK537158
3. Josilene Chaves Ruela Corrra & Herida Regina Nunes Salgado. Review of Fluconazole Properties and Analytical Methods for Its Determination, Critical Reviews in Analytical Chemistry. May 2011. [Accessed on 12th July 2022] https://www.tandfonline.com/doi/abs/10.1080/10408347.2011.557980?journalCode=batc20
3. Viatris Ltd. Fluconazole. [Revised in March 2022] [Accessed on 12th July 2022] https://www.medsafe.govt.nz/profs/datasheet/f/fluconazolecapmylan.pdf
4. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in April 2021] [Accessed on 12th July 2022] https://www.medicines.org.uk/emc/files/pil.6086.pdf
5. FDC limited. Zocon (Fluconazole tablets) [Revised in July 2022] [Accessed on 12th July 2022] http://fdcindia.com/PackageInsert/ZoconTablets.pdf
Written By Dr. R. Dinesh John Rajkumar, Pharm.D
Last updated on 23 Feb 2023 | 06:06 PM(IST)