INTRODUCTION

BESIX contains Besifloxacin which belongs to the group of medicines called Fluoroquinolone antibiotics. It is used in patients of age one year and older to treat bacterial conjunctivitis caused by certain susceptible bacteria.

Bacterial conjunctivitis is a type of inflammation of conjunctiva (tissue that covers the white of the eyes and inside part of the eyelids) that occurs due to direct contact with secretions from an infected individual or by contact with contaminated surfaces which is generally characterized by symptoms such as redness of the eye, purulent discharge, irritation or burning sensation, and decreased vision.

BESIX is not recommended for use if you are allergic to besifloxacin, or other quinolones (such as moxifloxacin or ciprofloxacin). Before using BESIX, inform your doctor if you wear contact lens, have hepatic or renal insufficiency. It should be used with caution in pregnant women only if clearly advised by the doctor and it is used with caution in breastfeeding women.

BESIX is recommended for use in children and adolescents (aged above 1 to 18 years). Consult ophthalmologist advice before using BESIX. The common side effects associated with the use of BESIX are redness in the eye, blurred vision, eye pain, eye irritation, eye itching, and headache. Contact your doctor if any of the symptoms worsen.

USES OF BESIX

• Treats bacterial conjunctivitis

HOW BESIX WORKS

BESIX contains besifloxacin, a bactericidal type of antibiotic that acts against bacteria by inhibiting those bacterial enzymes which help in synthesis, replication, and repair of bacterial DNA, thereby limiting bacterial growth, multiplication, and resistance to antibiotic treatment, thus leading to its destruction and effectively works to treat bacterial conjunctivitis.

DIRECTIONS FOR USE

Use BESIX as advised by your physician. It is for ophthalmic use only. Invert the closed bottle (upside down) and shake well before use. Wash your hands prior to using the medicine. Avoid contaminating the applicator tip with material from the eye, fingers or other source. Remove the cap with bottle in the inverted position. Tilt head backwards, and gently squeeze bottle to instil one drop into the affected eye. Close the bottle cap and keep it safe in a place unreachable to children. Your ophthalmologist will decide the correct dose and duration for you depending upon your age and severity of the condition.

SIDE EFFECTS OF BESIX

HOW TO MANAGE SIDE EFFECTS

Eye itching:

Clean your eyelids twice a day. Keep a flannel or cotton wool cloth soaked in warm water on your closed eyes for 5 to 10 minutes. Then gently massage your eyelids for few seconds. Do not use eye make up until the problem is resolved.

Eye Pain:

Rest your eyes by closing or sleeping. Avoid bright lights, reading, watching the television, and working on the computer. Keep eyes closed and gently massage your eyes for few seconds to relieve the muscles.

Headache:

Take rest and drink plenty of water. Avoid taking alcohol and skipping meals. Do not strain your eyes by watching screen for long time. Consult your doctor if the condition persists for long or gets worsened.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug - Drug interactions

Before using BESIX, inform your ophthalmologist if you are taking or using any medicines including prescription, non-prescription, herbals or vitamin supplements.

Overdosage:

If you or anyone else accidentally instils too much of BESIX, consult your ophthalmologist immediately or visit the nearby hospital if you experience any unusual symptoms.

SYNOPSIS

MORE INFORMATION

• Keep BESIX out of reach of children
• Store at 15-25°C

FAQs ABOUT BESIX

What is the use of BESIX?

BESIX is used in patients of age one year and older to treat bacterial conjunctivitis caused by certain susceptible bacteria. Bacterial conjunctivitis is a type of inflammation of conjunctiva that occurs due to direct contact with secretions from an infected individual or by contact with contaminated surfaces, generally characterized by symptoms such as redness of the eye, purulent discharge, irritation or burning sensation.

What common side effects are seen with BESIX?

The common side effects associated with the use of BESIX are redness in the eye, blurred vision, eye pain, eye irritation, eye itching, and headache. Contact your doctor if any of the symptoms worsen.

Is BESIX safe to use in children or elderly patients?

Yes, BESIX should be used with caution in children and adolescents (aged above 1 to 18 years) and in elderly individuals (aged above 60 years) after consulting the doctor.

Is BESIX safe to use in pregnant or breastfeeding women?

Yes, BESIX can be used in pregnant women with caution only if it is clearly advised by the doctor, also caution should be exercised while using in breast-feeding women. Consult your ophthalmologist before using the medicine.

How BESIX works?

BESIX works by inhibiting the bacterial enzymes that help in synthesis, replication, and repair of bacterial DNA which results in limiting the bacterial growth, multiplication, and resistance thus leading to its destruction and preventing the occurrence of bacterial conjunctivitis.

When to stop using BESIX?

Stop using BESIX and consult your ophthalmologist immediately if you experience signs of hypersensitivity (collapse, loss of consciousness, face and throat swelling, airway obstruction, shortage of breath, raised red rashes and itching) or super infections.

REFERENCES

1. Laurence Brunton. Goodman and Gillman’s The Pharmacological Basics of Therapeutics. Twelfth Edition. 2011. Page – 1781.

2. Ranjan Malhotra, Stacey Ackerman, Lynne S. Gearinger, Timothy W. Morris, Catherine Allaire. The Safety of Besifloxacin Ophthalmic Suspension 0.6 % Used Three Times Daily for 7 Days in the Treatment of Bacterial Conjunctivitis. NIH National Library of Medicine. National Centre for Biotechnology Information. PMC PubMed Central. December 2013. [Accessed on 28th July 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3851703/

3. Francis S. Mah and Christine M. Sanfilippo. Besifloxacin: Efficacy and Safety in Treatment and Prevention of Ocular Bacterial Infections. NIH National Library of Medicine. National Centre for Biotechnology Information. PMC PubMed Central. June 2016. [Accessed on 28th July 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4909673/

4. Bausch & Lomb. U.S. Food and Drug Administration (FDA). [Revised in March 2018] [Accessed on 28th July 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/022308s013lbl.pdf

5. Bausch & Lomb. Besivance. [Revised in February 2018] [Accessed on 28th July 2022] https://pdf.hres.ca/dpd_pm/00043976.PDF

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