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INTRODUCTION BIOVAL 500 CR TABLET contains Sodium Valproate which belongs to the group of medicines called Mood stabilizers. It is used to manage or control mania (feeling very excited, enthusiastic, over-active and easily irritated or distracted) caused by bipolar disorder. Bipolar disorder i...
BIOVAL 500 CR TABLET contains Sodium Valproate which belongs to the group of medicines called Mood stabilizers. It is used to manage or control mania (feeling very excited, enthusiastic, over-active and easily irritated or distracted) caused by bipolar disorder. Bipolar disorder is when the mood fluctuates between feeling very high (mania) and very low (depression).
BIOVAL 500 CR TABLET can be used when lithium cannot be used. BIOVAL 500 CR TABLET is also used to treat complex partial seizures (in adults and children 10 years of age and older) and simple and complex absence seizures, with or without other types of seizures.
A seizure results from an excessive discharge of specific nerve cells and is characterized by changes in electrical activity. BIOVAL 500 CR TABLET can also be used to prevent migraine headaches (episodes of moderate to severe headache, mostly unilateral, generally associated with nausea and hypersensitivity to light and sound).
Before taking BIOVAL 500 CR TABLET, inform your doctor if you have fits, porphyria, liver, kidney, or pancreatic problems, diabetes, systemic lupus erythematosus, or any genetic diseases. Patients should be monitored for signs of suicidal ideation and behaviour and advised to seek medical advice if any such signs occur.
Avoid consumption of alcohol while taking BIOVAL 500 CR TABLET. BIOVAL 500 CR TABLET is not recommended for use in pregnant or breastfeeding women or children (younger than 2 years) who are at a considerably increased risk of developing liver toxicity.
The most common side effects of taking BIOVAL 500 CR TABLET are nausea, vomiting, headache, sleepiness, blurry or double vision, weight gain, hair loss, problems with walking, etc. Consult your doctor if any of the symptoms get worse.
BIOVAL 500 CR TABLET is used:
BIOVAL 500 CR TABLET works by acting on GABA (γ aminobutyric acid) levels in the CNS, whose inhibitory activity is impaired in seizures and also in migraine headaches. It may also exert antiepileptic effects by reducing the high-frequency firing (excessive discharge) of nerve cells. BIOVAL 500 CR TABLET stabilizes mood by stabilizing the levels of chemicals in your brain that are responsible to affect your mood.
Take BIOVAL 500 CR TABLET as advised by your physician. Swallow it with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of BIOVAL 500 CR TABLET for you based upon your age, body weight and disease condition. Do not stop taking BIOVAL 500 CR TABLET unless your doctor advises you to stop.
Stop taking BIOVAL 500 CR TABLET and contact your doctor immediately if you experience any of the following side effects:
Drink lots of fluids, like water or fruit juice, to keep yourself hydrated. Check with your doctor before taking any medicine for diarrhoea. If the diarrhoea does not get better, contact your doctor.
Lie down until the dizziness is resolved, then get up slowly. Do not hurry and move slowly and carefully. Get adequate rest. Drink plenty of water and other fluids. Avoid coffee, cigarettes, alcohol, and drugs. If dizziness does not get better, consult your doctor.
Drink plenty of water and get adequate rest. Try to be relaxed and stress-free. Check with your doctor before taking any medicine for a headache. If your headache does not get better, consult your doctor.
Eat when you are hungry. Eat smaller meals more often than usual. Snack only when you're hungry. Eat a nutritious snack rich in calories and protein, such as dried fruit and nuts. If your appetite does not improve, contact your doctor.
Take BIOVAL 500 CR TABLET with, or just after, meals. Stick to simple meals. Avoid eating oily or spicy foods. If you still feel nauseous, contact your doctor. Get adequate rest. Drink lots of fluids, especially water. Have small sips if you feel sick. Eat when you feel like eating; you don't have to eat or avoid any specific foods. Do not take any medicine for vomiting without your doctor's consultation. If vomiting does not get better, contact your doctor.
Try to rest and relax. Eat and drink slowly, or try to eat smaller meals more frequently. Keep a heating pad on your stomach. If your stomach still aches, contact your doctor.
Avoid driving or going outside on your own if you have blurred eyesight. Close your eyes for some time until your eyesight gets clear. Contact your doctor if your vision remains blurred for a long period.
BIOVAL 500 CR TABLET is not recommended for use in pregnant women, especially if you are taking it to prevent migraine headaches. Females of child-bearing capability must use effective contraception. Consult your doctor before taking it.
BIOVAL 500 CR TABLET should be used with caution in breastfeeding women as a little amount may pass through the breast milk. Consult your doctor before taking it.
Do not drive or operate any machines if you feel sleepy, confused or dizzy after taking BIOVAL 500 CR TABLET.
Alcohol consumption is not recommended while taking BIOVAL 500 CR TABLET as it may cause sleepiness or dizziness or make these worse.
BIOVAL 500 CR TABLET should be taken with caution in patients with kidney problems. Consult your doctor before taking it.
BIOVAL 500 CR TABLET is not recommended in patients with liver problems or a family history of liver problems caused by taking medicine. Consult your doctor before taking it.
Do not take BIOVAL 500 CR TABLET if you are allergic to Valproic acid, divalproex sodium, sodium valproate, aspirin or any of the other ingredients of this medicine.
BIOVAL 500 CR TABLET is not recommended for use in children (younger than two years) who are at a considerably increased risk of developing liver toxicity. Consult your doctor before taking it.
BIOVAL 500 CR TABLET should be used with caution in elderly patients as they may experience drowsiness or sleepiness. Consult your doctor before taking it.
BIOVAL 500 CR TABLET is not recommended for use if you:
Before taking BIOVAL 500 CR TABLET, inform your doctor if you:
A. Drug-Drug interactions:
Before taking BIOVAL 500 CR TABLET, inform your doctor if you are taking any of the following medicines:
Overdosage:
If you or anyone else accidentally take too much of BIOVAL 500 CR TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of GBNKEYWORD] overdose are nausea, vomiting, headache, blurred eyesight, dizziness, poor reflexes, confusion, memory loss, tiredness, weak or ‘floppy’ muscles, fits, loss of consciousness, behavioural changes, fast breathing, shortness of breath or chest pain.
| Drug | : | Valproic acid |
| Pharmacological Category | : | Aliphatic carboxylic acid |
| Therapeutic Indication | : | Mania, Seizures, Migraine headaches |
| Dosage Forms | : | Tablet, Oral solution |
Q: Can BIOVAL 500 CR TABLET be taken during pregnancy?
A: BIOVAL 500 CR TABLET is not recommended for use by pregnant women, especially if you are taking it to prevent migraine headaches. Females of childbearing capability must use effective contraception. Do not stop taking your contraception until your doctor advises you further.
If you are pregnant, think you may be pregnant or are planning to get pregnant, consult your doctor before taking BIOVAL 500 CR TABLET. Inform your doctor immediately if you become pregnant during treatment with BIOVAL 500 CR TABLET.
Q: Can BIOVAL 500 CR TABLET make me feel suicidal?
A: Thoughts of harming or killing oneself are seen in a small number of patients being treated with BIOVAL 500 CR TABLET. Patients taking BIOVAL 500 CR TABLET should be monitored for signs of suicidal ideation and behaviours, especially sudden changes in mood, behaviours, thoughts, or feelings, and advised to seek medical advice if any such signs occur.
Q: Can BIOVAL 500 CR TABLET cause weight gain?
A: Yes. Taking BIOVAL 500 CR TABLET may make you put on weight. Discuss with your doctor for advice before taking BIOVAL 500 CR TABLET.
Q: Can I take other medicines with BIOVAL 500 CR TABLET?
A: Before taking BIOVAL 500 CR TABLET, inform your doctor if you are taking, have taken, or might take any other medicine, including prescription, over-the-counter or herbal medicine, as these might cause serious side effects by interacting with each other.
Q: Can BIOVAL 500 CR TABLET cause erectile dysfunction?
A: According to some studies, men on BIOVAL 500 CR TABLET therapy show irregularities in androgens blood levels, sperm motility, and erectile dysfunction. Consult your physician if you have trouble getting an erection or related symptoms during BIOVAL 500 CR TABLET treatment.
Q: Can BIOVAL 500 CR TABLET cause autism?
A: Autism and related disorders are more often diagnosed in children exposed to BIOVAL 500 CR TABLET during pregnancy. Consult your doctor for further doubts.
Q: Can BIOVAL 500 CR TABLET be given to children?
A: BIOVAL 500 CR TABLET is not recommended for use in children (younger than two years) who are at a considerably increased risk of developing liver toxicity. Your doctor will decide on the correct dose of BIOVAL 500 CR TABLET or select a suitable alternative treatment for your child.
Q: What if I forget to take a dose of BIOVAL 500 CR TABLET?
A: If you forget to take a dose of BIOVAL 500 CR TABLET, take it as soon as you remember. However, omit the missed dose if it's almost time for the next one. Do not take BIOVAL 500 CR TABLET twice to make up for the missed dose.
Q: Can BIOVAL 500 CR TABLET be stopped?
A: Continue taking BIOVAL 500 CR TABLET until your doctor tells you to stop unless you experience any unwanted effects, a worsening of your condition, or any new symptoms. Contact your doctor in such cases.
If you stop taking BIOVAL 500 CR TABLET without your doctor’s advice, your condition may get worse. When your doctor finds it okay to discontinue BIOVAL 500 CR TABLET treatment, your dose will be lowered gradually.
1. Barbara G. Wells, Joseph T. DiPiro, Terry L. Shwinghammer, Cecily V. DiPiro. Epilepsy. Pharmacotherapy Handbook. Ninth edition. Page-518, 530.
2. Rahman M, Nguyen H. Valproic Acid. NIH National Library of Medicine, National center for biotechnology information. StatPearls [Internet]. July 2022. [Accessed on 9th August 2022] https://www.ncbi.nlm.nih.gov/books/NBK559112/
3. Cutrer FM, Limmroth V, Moskowitz MA. Possible mechanisms of valproate in migraine prophylaxis. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. April 1997. [Accessed on 9th August 2022] https://pubmed.ncbi.nlm.nih.gov/9137844/#:~:text=Valproate%20increases%20brain%20GABA%20levels,and%20directly%20attenuates%20nociceptive%20neurotransmission.
4. Sanofi-aventis SA. Electronic Medicines Compendium (EMC). [Revised in January 2022] [Accessed on 9th August 2022] https://www.medicines.org.uk/emc/files/pil.6102.pdf
5. AbbVie Ltd. Valproic Avid. [Revised in October 2021] [Accessed on 9th August 2022] https://www.rxabbvie.com/pdf/depakote.pdf
Written By Dr. Dhivakaran R, BDS
Last updated on 05 Apr 2023 | 05:47 PM(IST)