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INTRODUCTION BINAPREX ER 500 TABLET contains Divalproex, which belongs to the group of medicines called Anti-epileptic drugs. It is used to treat manic episodes related to bipolar disorder. It is also used in adults and children (10 years and above) to treat complex partial seizures, with or w...
BINAPREX ER 500 TABLET contains Divalproex, which belongs to the group of medicines called Anti-epileptic drugs. It is used to treat manic episodes related to bipolar disorder. It is also used in adults and children (10 years and above) to treat complex partial seizures, with or without other seizure types and to prevent migraine headaches.
Epilepsy (fits or seizures) is a condition that occurs as a result of the abnormal electrical activity of the brain, which may lead to loss of consciousness, abnormal muscle movements or behaviour, etc. Partial seizures involve a specific area of the brain but may spread to the entire brain and cause a generalized tonic-clonic seizure. Before the treatment, your physician may want you to take relevant tests to understand your existing condition. Avoid consumption of alcohol BINAPREX ER 500 TABLET, as it may make you feel drowsy.
BINAPREX ER 500 TABLET is not recommended for use in patients with liver disease or significant liver dysfunction or urea cycle disorders. Before taking BINAPREX ER 500 TABLET, inform your physician if you have kidney problems, systemic lupus erythematosus and porphyria. BINAPREX ER 500 TABLET should be used with caution by pregnant and breastfeeding women. BINAPREX ER 500 TABLET is not recommended for use by children (aged 10 years or younger).
The most common side effects of taking BINAPREX ER 500 TABLET are nausea, vomiting, dizziness, double vision, weight gain, problems with walking or coordination, headache, weakness, stomach pain, diarrhoea, hair loss, sleepiness, tremors, blurry vision, increased appetite, loss of appetite, etc. Contact your physician if any of the side effects worsen or if you have thoughts of harming yourself.
BINAPREX ER 500 TABLET helps to control abnormal electrical activity in the brain (by binding to sodium channels), thus reducing the chances of having fits or seizures.
Take BINAPREX ER 500 TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your physician will decide the correct dose and duration for you depending on your age, body weight and disease condition.
Stop taking BINAPREX ER 500 TABLET and contact your physician immediately if you experience any of the following side effects:
Nausea:
Take BINAPREX ER 500 TABLET with or immediately after meals. Stick to simple meals. Avoid eating oily or spicy foods. Consult your doctor if your symptom gets worse or persist.
Vomiting:
Take adequate rest and drink sufficient amount of water. Do not take spicy or oily foods. Consult your doctor if your symptom gets worse or persist.
Headache:
Drink an ample amount of water. Get adequate rest. Try to be relaxed and stress-free. Ask your physician before taking any medicine for headaches. Consult your doctor if your symptom gets worse or persist.
Dizziness:
Lie down till the dizziness is gone, then get up slowly. Move slowly and carefully, do not hurry. Get adequate rest. Drink plenty of water and other fluids. Avoid coffee, cigarettes, alcohol and drugs. Consult your doctor if your symptom gets worse or persist.
Diarrhoea:
Drink more fluids, such as water or fruit juice to keep yourself hydrated. Do not consume any medicine on your own without consulting your physician. Consult your doctor if your symptom gets worse or persist.
Stomach pain:
Try to rest and relax. Eat and drink slowly or try to have smaller meals more frequently. Keep a heating pad on your stomach. If the symptom does not improve, contact your physician. Consult your doctor if your symptom gets worse or persist.
Loss of appetite:
Eat when you are hungry. Eat smaller meals more often than usual. Snack only when you're hungry. Eat a nutritious snack that is rich in calories and protein, such as dried fruit and nuts. Consult your doctor if your symptom gets worse or persist.
BINAPREX ER 500 TABLET should be used with caution in pregnant women as it can cause developmental defects and decreased IQ level of the baby. Consult your physician before taking it.
BINAPREX ER 500 TABLET should be used with caution in breastfeeding women only if recommended by your doctor, as it passes through the breast milk and can affect breastfeeding babies. Consult your physician before taking BINAPREX ER 500 TABLET.
Do not drive or operate any machines after taking BINAPREX ER 500 TABLET if you experience dizziness, drowsiness, balance or coordination problems, eye problems like double or blurred vision, low blood levels of sodium causing muscle weakness, or decreased consciousness.
Avoid consumption of alcohol while taking BINAPREX ER 500 TABLET as it might make you feel sleepy or drowsy. Consult your physician for advice.
Do not take BINAPREX ER 500 TABLET if you are allergic to Divalproex or any of the other ingredients of this medicine.
Do not take BINAPREX ER 500 TABLET, if you have:
Before taking BINAPREX ER 500 TABLET, inform your physician if you have:
Use in pediatrics:
BINAPREX ER 500 TABLET is not recommended for use in children (under 10 years of age) as it has not been shown to be safe and effective in this age group. It should be used with caution in children (10 years and older). Consult your physician before taking BINAPREX ER 500 TABLET.
Use in geriatrics:
BINAPREX ER 500 TABLET should be used with caution in elderly patients (aged above 65 years) with kidney impairment. Consult your physician before taking BINAPREX ER 500 TABLET.
A. Drug-Drug interactions:
Before taking BINAPREX ER 500 TABLET, inform your physician if you are taking any of the following medicine:
Overdosage:
If you or anyone else accidentally take too much of BINAPREX ER 500 TABLET, consult your physician immediately or visit the nearby hospital. Symptoms of overdose are drowsiness, heart block and deep coma.
| Drug | : | Divalproex |
| Pharmacological Category | : | Antiepileptics |
| Therapeutic Indication | : |
Mania, bipolar disorder, seizure disorder, migraine |
| Dosage Forms | : |
Tablet, Capsule, Oral Solution, Solution |
Can taking BINAPREX ER 500 TABLET lead to suicidal thoughts?
Thoughts of harming or killing self are seen in a small number of patients being treated with BINAPREX ER 500 TABLET. If you have such thoughts at any time, immediately contact your physician or go to the nearby hospital.
Can I continue taking my contraceptive pill with BINAPREX ER 500 TABLET?
No. BINAPREX ER 500 TABLET can stop hormonal contraceptives from working properly. Another form of contraception should also be used to help prevent unwanted pregnancy while taking BINAPREX ER 500 TABLET. Inform your physician immediately if you have irregular vaginal bleeding or spotting. If you have any doubts about this, discuss it with your physician.
Can I crush BINAPREX ER 500 TABLET if I cannot swallow it whole?
No. Swallow BINAPREX ER 500 TABLET with a glass of water. If you cannot swallow it whole, do not crush or chew it. Instead, break the medicine with the help of the score line. Consult your, physician, for other forms of BINAPREX ER 500 TABLET that you can take.
What if I forget to take a dose of BINAPREX ER 500 TABLET?
If you forget to take a dose of BINAPREX ER 500 TABLET, take it as soon as you remember. However, omit the missed dose if it is almost time for the next dose. Do not take BINAPREX ER 500 TABLET twice to make up for a forgotten dose.
Can I stop taking BINAPREX ER 500 TABLET?
Do not stop taking BINAPREX ER 500 TABLET without consulting your physician, as it can lead to a sudden increase in fits. If you have any more doubts about using BINAPREX ER 500 TABLET, ask your physician.
Can BINAPREX ER 500 TABLET be used in pregnancy?
BINAPREX ER 500 TABLET should be used with caution in pregnancy as there may be a risk to your baby. However, it is important to control epileptic fits during pregnancy. Your physician will help you decide whether you should take BINAPREX ER 500 TABLET by discussing the benefits and risks involved. Do not stop your treatment with BINAPREX ER 500 TABLET during pregnancy without asking your physician.
1. KD Tripathi. Antiepileptic Drugs. Essentials of medical pharmacology. Eighth Edition. 2019. Page 411– 424.
2. Steven C Stoner and Megan M Dahmen. Extended-release divalproex in bipolar and other psychiatric disorders: A comprehensive review. Journal of Neuropsychiatric Disease and Treatment. December 2007. [Accessed on 21st July 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2656326/
3. Nilesh Shah, M.S.Reddy, Sandeep Vohra, Uday Chaudhuri, Senthilnathan Mohanasundaram. Safety and effectiveness of divalproex sodium extended release containing regimen in Indian patients with bipolar I disorder in continuation phase: Results of EASED registry. Asian Journal of Psychiatry. April 2016. [Accessed on 21st July 2022] https://www.sciencedirect.com/science/article/abs/pii/S1876201815002816
4. Epilepsy Foundation. Divalproex Sodium. [Accessed on 21st July 2022] https://www.epilepsy.com/tools-resources/seizure-medication-list/divalproex-sodium
5. AbbVie Inc. U.S. Food and Drug Administration. [Revised in February 2016] [Accessed on 21st July 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/018723s056lbl.pdf
6. Abbott Laboratories. Food and Drug Administration. [Revised in February 2016] [Accessed on 21st July 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/18081s44,18082s27,18723s33,19680s22,20593s15,21168s14lbl.pdf
7. AbbVie Inc. Depakote. [Revised in February 2016] [Accessed on 21st July 2022] https://www.depakote.com/
Written By Dr. Dhivakaran R, BDS
Last updated on 08 Oct 2022 | 01:14 PM(IST)