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INTRODUCTION ACOSITA M SR 100/1000MG TABLET is a combination of Metformin and Sitagliptin, which belongs to the group of medicines called Antidiabetic agents. It is used to control blood sugar levels in patients with type II diabetes mellitus, along with proper diet and exercise....
ACOSITA M SR 100/1000MG TABLET is a combination of Metformin and Sitagliptin, which belongs to the group of medicines called Antidiabetic agents. It is used to control blood sugar levels in patients with type II diabetes mellitus, along with proper diet and exercise.
Type II diabetes mellitus is a chronic disease characterized by abnormally high levels of glucose in the blood. It is caused by inadequate production of a hormone called insulin (produced by the pancreas to metabolize glucose) in the body or by inadequate sensitivity of body cells to the actions of insulin.
Before taking ACOSITA M SR 100/1000MG TABLET, inform your doctor if you have any liver, kidney, or heart problems. You must also inform your doctor if you have high blood cholesterol levels, severe systemic infections, or are severely dehydrated due to excessive vomiting or diarrhea recently.
During therapy with ACOSITA M SR 100/1000MG TABLET, your doctor might regularly monitor your blood sugar levels and kidney functions to avoid the risk of unwanted side effects. He might also ask you to make certain lifestyle changes, such as following a healthy diet, regular physical exercise, and quitting alcohol consumption, to achieve better results.
ACOSITA M SR 100/1000MG TABLET is not recommended for use in patients with severe, uncontrollable diabetes. It is also not suitable for use in patients with alcoholism, shock, or problems with breathing or blood circulation.
Consult your doctor before taking ACOSITA M SR 100/1000MG TABLET if you are pregnant or breastfeeding. The most common side effects of taking ACOSITA M SR 100/1000MG TABLET are low blood sugar levels, stomach upset, constipation, flatulence, metallic taste in the mouth, sore throat, stuffy nose, and joint pain. Consult your doctor if they bother you.
ACOSITA M SR 100/1000MG TABLET is an antidiabetic medicine. It contains two medicines, namely metformin and sitagliptin. Metformin makes the body more sensitive to insulin (a hormone involved in glucose metabolism). This helps our body cells utilize more of the circulating blood glucose. Additionally, it can stop glucose production by the liver and reduce its absorption in the body.
Teneligliptin controls blood sugar levels by blocking the actions of an enzyme called dipeptidyl peptidase (DPP)-4 that reduces insulin secretion in the body. Collectively, ACOSITA M SR 100/1000MG TABLET controls blood sugar levels and improves glycemic control in patients with type II diabetes.
Take ACOSITA M SR 100/1000MG TABLET, preferably after meals or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.
Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight, and disease condition. Do not stop taking ACOSITA M SR 100/1000MG TABLET unless your doctor advises you to stop.
Stop taking ACOSITA M SR 100/1000MG TABLET and consult your doctor immediately if you experience any of the following side effects:
Taking ACOSITA M SR 100/1000MG TABLET with meals may reduce the chances of constipation. However, if you experience constipation, eat plenty of fiber-rich foods, such as fresh fruits, vegetables, and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
Rest and relax. Keep yourself hydrated by drinking plenty of fluids, such as water or electrolytes. Applying a pain-relieving balm to your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Have foods rich in sugars, such as fruit juices, glucose drinks, candies, honey, or biscuits. Check your blood sugar after 10 minutes. If you have not reached your optimum level, take another sugary snack or drink and check your blood sugar levels once again. Contact your doctor if there is no improvement in your condition.
ACOSITA M SR 100/1000MG TABLET is not recommended for use by pregnant women. Therefore, inform your doctor before taking ACOSITA M SR 100/1000MG TABLET if you are pregnant, think you may be pregnant, or are planning to have a baby.
ACOSITA M SR 100/1000MG TABLET is not recommended for use by breastfeeding women. However, consult your doctor before taking it.
Do not drive or operate any machines if you feel dizzy after taking ACOSITA M SR 100/1000MG TABLET.
Avoid consumption of alcohol while taking ACOSITA M SR 100/1000MG TABLET, as it may increase the risk of unwanted side effects.
ACOSITA M SR 100/1000MG TABLET is not recommended for use in patients with severely reduced kidney functions. Therefore, consult your doctor before taking it.
ACOSITA M SR 100/1000MG TABLET is not recommended for use in patients with severe liver problems. It should be used with caution in patients with gallstones. Therefore, consult your doctor before taking it.
Do not take ACOSITA M SR 100/1000MG TABLET if you are allergic to metformin or sitagliptin.
ACOSITA M SR 100/1000MG TABLET is not recommended for use in patients with severe heart problems (such as acute heart failure or a recent heart attack). Therefore, consult your doctor before taking it.
ACOSITA M SR 100/1000MG TABLET is not recommended for use in children and adolescents (aged below 18 years). However, consult your doctor before taking it.
ACOSITA M SR 100/1000MG TABLET should be used with caution in elderly patients (aged above 65 years). Therefore, consult your doctor before taking it.
ACOSITA M SR 100/1000MG TABLET is not recommended for use if you:
Before taking ACOSITA M SR 100/1000MG TABLET, inform your doctor if you:
A. Drug-Drug interactions:
Before taking ACOSITA M SR 100/1000MG TABLET, inform your doctor if you are taking any of the following medicines, such as:
Overdosage:
If you or anyone else accidentally took more ACOSITA M SR 100/1000MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of an overdose are feeling cold or uncomfortable, severe nausea or vomiting, stomach pain, unexplained weight loss, muscular cramps, and fast breathing.
| Drug | : | Metformin, Sitagliptin |
| Pharmacological Category | : | Biguanides, DPP-4 Inhibitors |
| Therapeutic Indication | : | Type II diabetes mellitus |
| Dosage Forms | : | Tablet, Capsule, Combi pack |
A: ACOSITA M SR 100/1000MG TABLET is an antidiabetic medicine used as an adjunct to diet and exercise to control blood sugar levels in patients with type II diabetes mellitus.
A: Take ACOSITA M SR 100/1000MG TABLET, preferably after meals or as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight, and disease condition.
A: You need to take ACOSITA M SR 100/1000MG TABLET as long as your doctor or physician prescribes you the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight, and disease condition.
A: ACOSITA M SR 100/1000MG TABLET must be taken with meals to avoid gastrointestinal side effects.
A: If you forgot to take a dose of ACOSITA M SR 100/1000MG TABLET, take it as soon as you remember. However, if it is time for the next dose of ACOSITA M SR 100/1000MG TABLET, skip the missed dose and take the next one regularly. Do not take a double dose of ACOSITA M SR 100/1000MG TABLET to compensate for the missed ones.
A: The most common side effects of taking ACOSITA M SR 100/1000MG TABLET are low blood sugar levels, stomach upset, constipation, flatulence, metallic taste in the mouth, sore throat, stuffy nose, and joint pain. Consult your doctor if they bother you.
A: No. You should not stop taking ACOSITA M SR 100/1000MG TABLET without consulting your doctor because it may lead to a reversal of symptoms. If you feel better after using ACOSITA M SR 100/1000MG TABLET, consult your doctor for advice.
A: No, taking a higher dose of ACOSITA M SR 100/1000MG TABLET will not be effective; rather, it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.
A: Before taking ACOSITA M SR 100/1000MG TABLET, inform your doctor if you have any liver, kidney, or heart problems. You must also inform your doctor if you have high blood cholesterol levels, severe systemic infections, or are severely dehydrated due to excessive vomiting or diarrhea recently. Along with the therapy, follow the diet and lifestyle changes advised by your doctor to achieve better results. Consult your doctor before taking ACOSITA M SR 100/1000MG TABLET if you are pregnant or breastfeeding.
A: It is not advisable to take medicines to control blood pressure while taking ACOSITA M SR 100/1000MG TABLET without consulting your doctor. Therefore, consult your doctor before taking any antihypertensive such as beta blockers (Ex. atenolol, propranolol) along with ACOSITA M SR 100/1000MG TABLET, as they have known interactions with ACOSITA M SR 100/1000MG TABLET.
A: Low blood sugar is a common side effect of taking ACOSITA M SR 100/1000MG TABLET. If you experience any signs of low blood sugar levels (such as increased hunger, sweating, shakiness, weakness, or an irregular heartbeat), consume a sugary snack or sugar drink immediately. Consult your doctor if the symptom does not improve.
A: Co-administration of ACOSITA M SR 100/1000MG TABLET with insulin is considered risky as it increases the chance of hypoglycemia (decreased blood sugar levels). Therefore, consult your doctor before taking it.
A: ACOSITA M SR 100/1000MG TABLET is not recommended for use by pregnant women. Therefore, consult your doctor for advice.
A: You must take ACOSITA M SR 100/1000MG TABLET as advised by your physician. Try to take this medicine, preferably after meals, and swallow it with a glass of water. Do not crush or chew the medicine.
A: ACOSITA M SR 100/1000MG TABLET should be used only under medical supervision. Your doctor will decide the correct dose and duration of therapy for you depending on your age, body condition, and severity of the disease.
A: Yes. Constipation is a common side effect of using ACOSITA M SR 100/1000MG TABLET. Eat plenty of fiber-rich foods, such as fresh fruits, vegetables, and cereals, as well as drink plenty of water and exercise more regularly when taking this medicine. Contact your doctor if this side effect bothers you.
1. KD. Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of medical pharmacology. Seventh edition. 2013. Page – 274 & 275.
2. Erin L. St. Onge, Shannon Miller and Elizabeth Clements. Sitagliptin/Metformin (Janumet) as Combination Therapy in the Treatment of Type-2 Diabetes Mellitus. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. December 2012. [Accessed on 19th January 2024] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3541863/
3. Chitrabhanu Ballav and Stephen C.L. Gough. Safety and Efficacy of Sitagliptin-Metformin in Fixed Combination for the Treatment of Type 2 Diabetes Mellitus. Libertas Academica. 2013. [Accessed on 19th January 2024] https://journals.sagepub.com/doi/pdf/10.4137/CMED.S7314
4. Merck Sharp & Dohme (UK) Limited. Electronic Medicines Compendium (EMC) [Revised in February 2022] [Accessed on 19th January 2024] https://www.medicines.org.uk/emc/files/pil.564.pdf
5. Merck & Co., Inc. JANUMET® (sitagliptin and metformin hydrochloride) tablets, for oral use. [Revised in July 2022] [Accessed on 19th January 2024] https://www.merck.com/product/usa/pi_circulars/j/janumet/janumet_pi.pdf
6. Milpharm Limited. Electronic Medicines Compendium (EMC). [Revised in June 2020] [Accessed on 19th January 2024] https://www.medicines.org.uk/emc/files/pil.594.pdf
7. Rx Farma Limited. Electronic Medicines Compendium (EMC). [Revised in September 2019] [Accessed on 19th January 2024] https://www.medicines.org.uk/emc/files/pil.11951.pdf
8. Organon Pharma (UK) Limited. Electronic Medicines Compendium (EMC). [Revised in November 2021] [Accessed on 19th January 2024] https://www.medicines.org.uk/emc/files/pil.7887.pdf
Written By Dr. N. Sai Swaroop, Pharm.D
Last updated on 20 Jan 2024 | 05:57 PM(IST)