INTRODUCTION

ACMEGLIM MV 2/0.3 TABLET is a combination of Glimepiride, Metformin and Voglibose, which belongs to the group of medicines called Antidiabetic agents. ACMEGLIM MV 2/0.3 TABLET is used in adults to manage type 2 diabetes mellitus when diet, exercise, and single-agent or second-line therapy with two drugs are insufficient to adequately control blood sugar levels.

ACMEGLIM MV 2/0.3 TABLET is not recommended for use in patients allergic to glimepiride, metformin, voglibose, and/or other sulfonylureas or sulphonamides. It is also not recommended for use in patients with acute conditions (such as dehydration or severe infection), severe ketosis (a severe complication of diabetes), severe trauma, lung problems (such as acute or chronic respiratory failure), heart problems (such as acute or chronic cardiac failure or recent myocardial infarction), and/or severe kidney or liver problems.

Before taking ACMEGLIM MV 2/0.3 TABLET, inform your doctor if you recently had trauma and/or have febrile infections, fever, uncontrolled diabetes, hypothyroidism (underactive thyroid), chronic intestinal disease, fever, or other kidney or liver problems.

ACMEGLIM MV 2/0.3 TABLET is not recommended for use in pregnant and breastfeeding women since it may cause harm to the developing foetus or nursing child.

ACMEGLIM MV 2/0.3 TABLET is also not recommended for use in children and adolescents (aged below 18 years) and is advised to be used with caution in elderly patients (aged 75 years or older) after consulting the doctor.

The most common side effects of ACMEGLIM MV 2/0.3 TABLET are nausea and vomiting, diarrhea, abdominal pain, loss of appetite, metallic taste, and/or hypoglycemia (low blood sugar). Consult your doctor if any of these side effects worsen.

USES OF ACMEGLIM MV 2/0.3 TABLET

• To manage type 2 diabetes mellitus in adults when diet, exercise, and a single agent or second line of therapy with two drugs are insufficient to adequately control blood sugar levels

HOW ACMEGLIM MV 2/0.3 TABLET WORKS

ACMEGLIM MV 2/0.3 TABLET is used to manage type 2 diabetes mellitus, where glimepiride lowers blood glucose levels by increasing the amount of insulin released by the pancreas. Metformin works by decreasing glucose production in the liver and the amount of glucose absorbed by the stomach and intestine. It also helps to restore the body’s response to insulin, and voglibose works by inhibiting the alpha-glucosidase enzyme, which breaks down complex carbohydrates into simple sugars. Thus, voglibose slows down the digestion and absorption of carbohydrates in the small intestine. This leads to a reduction in blood glucose levels in individuals with type 2 diabetes mellitus.

DIRECTIONS FOR USE

Take ACMEGLIM MV 2/0.3 TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending on your age, body weight, and disease condition.

SIDE EFFECTS OF ACMEGLIM MV 2/0.3 TABLET

HOW TO MANAGE SIDE EFFECTS

Diarrhea

Drink plenty of water and stay hydrated. Try to avoid taking any medicine on your own to treat diarrhea. Consult and inform your doctor if the symptoms worsen.

Nausea And Vomiting

Take ACMEGLIM MV 2/0.3 TABLET with or just after a meal. Stick to simple meals. Avoid eating oil-rich or spicy foods, sugary snacks, and drinks. Avoid drinking too much liquid along with your meals, drink slowly in between meals. Inform your doctor if the condition worsens.

WARNING & PRECAUTIONS

PREGNANCY

Contraindicated

ACMEGLIM MV 2/0.3 TABLET is not recommended for use during pregnancy since it may cause harm to the foetus. Consult your doctor before taking ACMEGLIM MV 2/0.3 TABLET.

BREASTFEEDING

Contraindicated

ACMEGLIM MV 2/0.3 TABLET is not recommended for use in breastfeeding women since the medicine may pass through breast milk and may cause harm to the nursing child. Consult your doctor before taking ACMEGLIM MV 2/0.3 TABLET.

DRIVING AND USING MACHINES

Use with Caution

Do not drive or operate any machines if you experience impaired alertness or reactions (due to hypoglycemia) while taking ACMEGLIM MV 2/0.3 TABLET.

ALCOHOL

Consult your doctor

Do not consume alcohol while taking ACMEGLIM MV 2/0.3 TABLET since it may reduce your blood sugar level.

KIDNEY

Consult your doctor

ACMEGLIM MV 2/0.3 TABLET is not recommended in patients with severe renal failure. It should be used with caution in patients with other kidney diseases. Consult your doctor before taking the medicine.

LIVER

Consult your doctor

ACMEGLIM MV 2/0.3 TABLET is not recommended for use in patients with severe liver disease. It should be used with caution in patients with other liver diseases. Consult your doctor before taking the medicine.

ALLERGY

Contraindicated

Do not take ACMEGLIM MV 2/0.3 TABLET if you are allergic to glimepiride, metformin, voglibose, other sulfonylureas/sulphonamides, and/or any other ingredients of this medicine.

LUNGS

Contraindicated

ACMEGLIM MV 2/0.3 TABLET is not recommended for use in patients with lung problems such as acute or chronic respiratory failure. Consult your doctor before taking ACMEGLIM MV 2/0.3 TABLET.

HEART DISEASE

Contraindicated

ACMEGLIM MV 2/0.3 TABLET) is not recommended in patients with heart problems such as acute or chronic cardiac failure or recent myocardial infarction. Consult your doctor before taking ACMEGLIM MV 2/0.3 TABLET.

USE IN PEDIATRICS

Contraindicated

ACMEGLIM MV 2/0.3 TABLET is not recommended for use in children and adolescents (aged below 18 years) since the safety and effectiveness of the medicine are not established. Consult your doctor before taking ACMEGLIM MV 2/0.3 TABLET.

USE IN GERIATRICS

Use with Caution

ACMEGLIM MV 2/0.3 TABLET should be used with caution in elderly patients (aged 65 years and above). Consult your doctor before taking ACMEGLIM MV 2/0.3 TABLET.

INTERACTIONS

A. Drug-Drug interactions:

Before taking ACMEGLIM MV 2/0.3 TABLET, inform your doctor if you are taking any of the following medicines:

• medicine used to manage bacterial infections (Ex. rifampicin, ciprofloxacin, clarithromycin, sulfacetamide, minocycline, and chloramphenicol)
• medicine used to manage fungal infections (Ex. fluconazole, isavuconazole, and miconazole)
• oral antidiabetics and insulin (medicines used to manage high blood sugar) Ex. glipizide, glyburide diazoxide
• medicines used to manage cancer (Ex. cyclophosphamide, trofosfamide, vandetanib, crizotinib, olaparib)
• disopyramide (medicine used to manage an irregular heartbeat)
• fenyramidol (a medicine used to relax muscles)
• pentoxifylline (a medicine used to improve blood flow through the arteries)
• medicine used to manage joint pain (Ex. phenylbutazone, oxyphenbutazone, and probenecid sulfinpyrazone)
• azapropazone (a medicine used to manage fertility)
• tritoqualine (a medicine used to manage allergies)
• acetazolamide (a medicine used to manage glaucoma)
• corticosteroids (medicines used to manage inflammation) Ex. prednisolone, methylprednisolone
• diuretics (medicine used to manage water retention in the body) Ex. furosemide
• adrenaline (a medicine used to manage serious diseases such as shock)
• glucagon (a medicine used to manage severe low blood sugar)
• laxatives (medicines used to manage constipation): Ex. bisacodyl
• nicotinic acid (medicine used to manage niacin deficiency)
• anabolic steroids (synthetic male sex hormones) Ex. testosterone
• phenothiazines (medicine used to manage mental illness) Ex. chlorpromazine
• phenytoin and fenfluramine (medicines used to manage seizures)
• H2 receptor antagonists (medicine used to manage acidity and heartburn) Ex. cimetidine ranitidine
• trimethoprim (used to manage urinary tract infections)
• ranolazine (medicine used to manage chest pain)
• dolutegravir (a medicine used to manage HIV infection)
• cimetidine (used to manage ulcers)
• verapamil (used to manage irregular heartbeats)
• epinephrine (used in emergencies to manage life-threatening allergic reactions)
• fibrate derivatives (used to lower high triglyceride levels) Ex. clofibrate, fenofibrate
• medicine used to manage depression, such as monoamine oxidase inhibitors (Ex. phenelzine, selegiline)
• salicylates (medicine used to manage pain) Ex. aspirin
• medicine used to manage high blood pressure, such as alpha blockers (Ex. doxazosin, prazosin
• anticoagulants (medicines used to manage the clotting of blood), Ex. warfarin

Overdosage:

If you or anyone else accidentally takes too much of ACMEGLIM MV 2/0.3 TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are hypoglycemia (low blood sugar), lactic acidosis, pancreatitis (inflammation of the pancreas), abdominal discomfort, and/or diarrhea.

SYNOPSIS

MORE INFORMATION

• Keep ACMEGLIM MV 2/0.3 TABLET out of reach of children
• Do not store ACMEGLIM MV 2/0.3 TABLET above 25°C

FAQs ABOUT ACMEGLIM MV 2/0.3 TABLET

Q: What is ACMEGLIM MV 2/0.3 TABLET used for?

A: ACMEGLIM MV 2/0.3 TABLET is used in adults to manage type 2 diabetes mellitus when diet, exercise, and single-agent or second-line therapy with two drugs are insufficient to adequately control blood sugar levels.

Q: How does ACMEGLIM MV 2/0.3 TABLET work?

A: ACMEGLIM MV 2/0.3 TABLET is used to manage type 2 diabetes mellitus, where glimepiride lowers blood glucose levels by increasing the amount of insulin released by the pancreas. Metformin works by decreasing glucose production in the liver and the amount of glucose absorbed by the stomach and intestine. It also helps to restore the body’s response to insulin, and voglibose works by inhibiting the alpha-glucosidase enzyme, which breaks down complex carbohydrates into simple sugars. Thus, voglibose slows down the digestion and absorption of carbohydrates in the small intestine. This leads to a reduction in blood glucose levels in individuals with type 2 diabetes mellitus.

Q: What are the side-effects of ACMEGLIM MV 2/0.3 TABLET?

A: The most common side-effects of ACMEGLIM MV 2/0.3 TABLET are nausea and vomiting, diarrhea, abdominal pain, loss of appetite, metallic taste, and/or hypoglycemia (low blood sugar). Consult your doctor if any of these side effects worsen.

Q: How do I take ACMEGLIM MV 2/0.3 TABLET?

A: Take ACMEGLIM MV 2/0.3 TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending on your age, body weight, and disease condition.

Q: What happens if ACMEGLIM MV 2/0.3 TABLET is taken at more than its required dosage?

A: If you or anyone else accidentally takes too much of ACMEGLIM MV 2/0.3 TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are hypoglycemia (low blood sugar), lactic acidosis, pancreatitis (inflammation of the pancreas), abdominal discomfort, and/or diarrhea.

REFERENCES

1. KD Tripathi. Insulin, Oral Hypoglycaemic Drugs and Glucagon. Essentials of Medical Pharmacology. Seventh Edition. 2019. Page – 270, 275, 277.

2. Kalra S, Das AK, Priya G, Ghosh S, Mehrotra RN, Das S, Shah P, Bajaj S, Deshmukh V, Sanyal D, Chandrasekaran S, Khandelwal D, Joshi A, Nair T, Eliana F, Permana H, Fariduddin MD, Shrestha PK, Shrestha D, Kahandawa S, Sumanathilaka M, Shaheed A, Rahim AA, Orabi A, Al-Ani A, Hussein W, Kumar D, Shaikh K. Fixed-dose combination in management of type 2 diabetes mellitus. NIH National Library of Medicine. National center for biotechnology information. PMC PubMed Central. [Revised in November 2020] [Accessed on 26th November 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7842427/

3. Windlas Biotech Private Limited. Amaryl MV 1mg, Amaryl MV 2mg. [Revised in March 2021] [ [Accessed on 26th November 2022] https://www.sanofi.in/dam/jcr:99ce79b7-f940-4c0e-ae78-225fbf7b45b3/Amaryl%20MV%20PI.pdf

4. Primus Remedies Pvt. Ltd. Voglow GM1 Fort. [Accessed on 26th November 2022] https://primusremedies.com/Products_list_26-10-2022.pdf

5. Eris Lifesciences. Glimisave MV 1.3 F, Glimisave MV 2 forte, Glimisave MV 3.3, Glimisave MV 3.3 F.  [Accessed on 26th November 2022] https://eris.co.in/all-brands/

6. Leeford Healthcare Ltd. VOGLIMET-GM FORTE. [Accessed on 26th November 2022] https://www.leeford.in/product/843/voglimet-gm-forte

7. Ikon Remedies Pvt. Ltd. Voglicon-GM Tablets. [Accessed on 26th November 2022] https://www.ikonremedies.com/product/voglicon-gm-tablets/

USEFUL DIAGNOSTIC TESTS

• HbA1C, Also known as Glycated Hemoglobin, Glycosylated Hemoglobin
• Blood Glucose Fasting (FBS)
• Random Blood Sugar (RBS)
• Post Prandial Blood Sugar (PPBS)
• Insulin-Fasting
• Insulin Postprandial (PP)
• Vital Diabetes Care
• Extended Diabetes Care
• Advance Diabetes Care
• Comprehensive Diabetes Care

AUTHOR DETAILS

Written By Dr. N. Sai Swaroop, Pharm.D
Last updated on 06 Jan 2024 | 04:54 PM(IST)