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INTRODUCTION ACMEGLIM M 2 TABLET is a combination of Glimepiride and Metformin which belongs to a group of medicines called Antidiabetic agents. ACMEGLIM M 2 TABLET is used to manage type 2 diabetes mellitus when diet, exercise and the single agent does not result in adequate glycemic control....
ACMEGLIM M 2 TABLET is a combination of Glimepiride and Metformin which belongs to a group of medicines called Antidiabetic agents. ACMEGLIM M 2 TABLET is used to manage type 2 diabetes mellitus when diet, exercise and the single agent does not result in adequate glycemic control. Type 2 diabetes is a medical condition in which the body does not make enough insulin, or the produced insulin does not work well. Symptoms include excessive urination, excessive thirst, hunger, fatigue, and blurred vision.
Glimepiride lowers blood sugar by causing the pancreas to produce more insulin and helps the body to use insulin efficiently. Metformin is a biguanide which effectively reduces the total amount of sugar released into the blood by the liver. Along treatment with ACMEGLIM M 2 TABLET follow regular exercise and diet plan as advised by your doctor to achieve better results.
Before taking ACMEGLIM M 2 TABLET inform your doctor if you have type 1 diabetes mellitus, diabetic ketoacidosis, severe liver or kidney disease, acute heart problems. Inform your doctor if you are pregnant or breastfeeding. It is not suitable for use in children and adolescents under 18 years of age. Avoid consumption of alcohol during treatment with ACMEGLIM M 2 TABLET as it may increase or decrease the blood sugar lowering action of ACMEGLIM M 2 TABLET and increases the risk of lactic acidosis. The most common side effects of taking ACMEGLIM M 2 TABLET are taste disturbance, nausea, diarrhea, stomach ache, and vomiting. Contact your doctor if any of the symptoms worsen.
ACMEGLIM M 2 TABLET controls blood glucose levels, where glimepiride works by increasing the amount of insulin released by the pancreas in order to lower the blood glucose. Metformin works by lowering glucose production in the liver, delaying glucose absorption from intestine, and increasing the body's sensitivity to insulin.
Take ACMEGLIM M 2 TABLET as advised by your physician. Swallow ACMEGLIM M 2 TABLET with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition. Do not stop taking ACMEGLIM M 2 TABLET without informing your doctor.
Stop taking ACMEGLIM M 2 TABLET and contact your doctor immediately if you experience any of the following side effects:
Drink lots of fluids, such as water or fruit juices to keep yourself hydrated. Avoid taking any medicine on your own for treating diarrhea. Consult your doctor if the symptom did not improve.
Eat when you feel hungry. Eat smaller meals frequently than usual. Snack only when you're hungry. Consult your doctor if the symptom did not improve.
Stick to simple meals. Avoid eating oily, fried, and spicy foods. Do not perform any strenuous activities immediately after eating. Consult your doctor if the symptom did not improve.
Rest and relax. Eat and drink slowly or try to have smaller and frequent meals. Keep a heat pad on your stomach. Consult your doctor if the symptom did not improve.
ACMEGLIM M 2 TABLET should not be taken during pregnancy. Consult your doctor before taking ACMEGLIM M 2 TABLET if you are planning to become pregnant.
ACMEGLIM M 2 TABLET should not be taken during breastfeeding as it may pass through breast milk. Consult your doctor before taking ACMEGLIM M 2 TABLET for advice.
Do not drive or handle any machines if you experience low or high blood sugar levels (symptoms include dizziness, tiredness, shaking or trembling) or if you develop visual problems due to altered blood sugar levels.
Avoid consumption of alcohol during treatment with ACMEGLIM M 2 TABLET as it may increase or decrease the blood sugar lowering action of ACMEGLIM M 2 TABLET and increases the risk of lactic acidosis. Consult your doctor for advice before taking ACMEGLIM M 2 TABLET.
ACMEGLIM M 2 TABLET is not recommended for use in patients with severe kidney disease and it should be used with caution in patients with kidney disease and your dose will be adjusted if needed depending upon kidney function. Consult your doctor before taking ACMEGLIM M 2 TABLET.
ACMEGLIM M 2 TABLET is not recommended if you have severe liver disease and it should be used with caution in patients with liver disease and your dose will be adjusted if needed depending upon liver function. Consult your doctor before taking ACMEGLIM M 2 TABLET.
Do not take ACMEGLIM M 2 TABLET if you are allergic (hypersensitive) to Glimepiride or Metformin or other sulfonylureas (such as glipizide, glibenclamide) or sulfonamides (such as sulfamethoxazole).
ACMEGLIM M 2 TABLET is not recommended for use in patients with acute heart problems or recently had a heart attack or have severe circulatory problems or breathing difficulties (signs of heart failure). Consult your doctor before taking ACMEGLIM M 2 TABLET.
ACMEGLIM M 2 TABLET is generally not recommended for use in children and adolescents (under 18 years of age). Consult child’s doctor for advice.
ACMEGLIM M 2 TABLET is not recommended for use in elderly patients (aged 75 years or above) and it should be used with caution in elderly patients (aged 65 years or above), especially in patients with impaired kidney function. Your doctor may assess your kidney function more frequently during treatment with ACMEGLIM M 2 TABLET. Consult your doctor before taking ACMEGLIM M 2 TABLET.
ACMEGLIM M 2 TABLET is not recommended for use, if you have:
Before taking ACMEGLIM M 2 TABLET inform your doctor if you:
A. Drug-Drug interactions:
Before taking ACMEGLIM M 2 TABLET inform to your doctor, if you are taking any of these medicines:
Overdosage:
If you or anyone else take too much of ACMEGLIM M 2 TABLET, contact your doctor immediately or go to a nearest hospital straight away. Overdosage symptoms of ACMEGLIM M 2 TABLET includes risk of low blood sugar levels, and it may cause life-threatening lactic acidosis. Symptoms of lactic acidosis include vomiting, bellyache with muscle cramps, general feeling of not being well with severe tiredness, reduced body temperature, low heartbeat, and difficulty in breathing.
| Drug | : | Glimepiride, Metformin |
| Pharmacological Category | : | Sulfonylureas, Biguanides |
| Therapeutic Indication | : | Type 2 Diabetes mellitus |
| Dosage Forms | : | Tablet |
Q: What is ACMEGLIM M 2 TABLET used for?
A: ACMEGLIM M 2 TABLET is used to manage type 2 diabetes mellitus when diet, exercise and the single agent alone does not result in adequate glycemic control. Along treatment with ACMEGLIM M 2 TABLET follow regular exercise and diet plan as advised by your doctor to achieve better results.
Q: Can I drive or handle machines after taking ACMEGLIM M 2 TABLET?
A: Do not drive or handle any machines if you experience low or high blood sugar levels (symptoms include dizziness, tiredness, shaking or trembling) or if you develop visual problems due to altered blood sugar levels. Consult your doctor before taking ACMEGLIM M 2 TABLET.
Q: Can I consume alcohol while taking ACMEGLIM M 2 TABLET?
A: Avoid consumption of alcohol during treatment with ACMEGLIM M 2 TABLET, as it may increase or decrease the blood sugar lowering action of ACMEGLIM M 2 TABLET and increases the risk of lactic acidosis. Consult your doctor for advice before taking ACMEGLIM M 2 TABLET.
Q: Is ACMEGLIM M 2 TABLET safe to use in patients with kidney problems?
A: ACMEGLIM M 2 TABLET is not recommended for use in patients with severe kidney disease and it should be used with caution in patients with kidney disease and your dose will be adjusted if needed depending upon kidney function. Consult your doctor before taking ACMEGLIM M 2 TABLET.
Q: What are the common side effects of ACMEGLIM M 2 TABLET?
A: The most common side effects of taking ACMEGLIM M 2 TABLET are taste disturbance, nausea, vomiting, diarrhea, loss of appetite, and stomach pain. Contact your doctor if any of the symptoms worsen.
1. KD Tripathi MD. Hormones and related drugs. Essentials of medical pharmacology. Seventh edition. New Delhi, May 2013. Page – 274.
2. Rakesh Kumar Sahay, Vinod Mittal, G Raja Gopal, Sunil Kota, Ghanshyam Goyal, Mahesh Abhyankar, Santosh Revenkar. Glimepiride and Metformin Combinations in Diabetes Comorbidities and Complications: Real-World Evidence. September 2020. [Accessed on July 24th 2021] https://www.cureus.com/articles/37779-glimepiride-and-metformin-combinations-in-diabetes-comorbidities-and-complications-real-world-evidence
3. Sanofi. Efficacy and Safety Comparison of Metformin/Glimepiride Combination Versus Each Compound Alone in New Diagnosed Type 2 Diabetes Patients (RECOMMEND). NIH U.S. National Library of Medicine. ClinicalTrials.gov. [Revised in January 2015] [Accessed on July 24th 2021] https://clinicaltrials.gov/ct2/show/NCT01459809
4. Torrent pharmaceuticals Ltd. Azulix MF. Metformin Hydrochloride Prolonged Release and Glimepiride Tablets I.P. [Revised in July 2019] [Accessed on July 24th 2021] https://www.torrentian.com/pisheet/Upload/PI_Sheet/2642.pdf
5. Sanofi-aventis group. Amaryl M. Glimepiride + Metformin. [Revised in May 2015] [Accessed on July 24th 2021] http://pharm.cals.am/pharm/data/drug_124396/1470300364248.pdf
Written By Dr. Janet.C, Pharm.D
Last updated on 29 Dec 2023 | 02:43 PM(IST)