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INTRODUCTION AMNURITE 25MG TABLET is a combination of Amitriptyline and Methylcobalamin, which belong to a group of medicines called Tricyclic antidepressants and Vitamins, respectively. It is used in the management of neuropathic pain which is a type of pain caused by damage or injury to the...
AMNURITE 25MG TABLET is a combination of Amitriptyline and Methylcobalamin, which belong to a group of medicines called Tricyclic antidepressants and Vitamins, respectively. It is used in the management of neuropathic pain which is a type of pain caused by damage or injury to the nerves that transfer information between the brain and spinal cord from the skin, muscles and other parts of the body which is generally characterized by symptoms such as spontaneous pain which may be of shooting, burning, stabbing or electric shock-like pain, with tingling and numbness feeling.
Avoid taking AMNURITE 25MG TABLET if you are allergic to Amitriptyline and Methylcobalamin or have a history of urinary retention due to enlargement of the prostate gland (benign prostatic hypertrophy), myocardial infarction (heart attack), congestive heart failure and/or impaired liver function.
Before taking AMNURITE 25MG TABLET, inform your doctor if you have a history of seizures, blood dyscrasias, urinary retention, narrow-angle glaucoma (an eye disorder), increased intraocular (eye) pressure, an overactive thyroid, suicidal thoughts or kidney problems.
AMNURITE 25MG TABLET is not recommended for use during pregnancy and in breastfeeding women; it is also not recommended for use in children and adolescents (below 18 years). The most common symptoms of taking AMNURITE 25MG TABLET are sleepiness, drowsiness, shakiness of hands or other body parts, dizziness, headache, dry mouth and constipation. Consult your doctor if any of your symptoms get worse.
AMNURITE 25MG TABLET helps to manage neuropathic pain, where amitriptyline increases the levels of certain chemical messengers (serotonin and noradrenaline) that stop the movement of pain signals in the brain and methylcobalamin helps in the production of myelin, a substance that protects the nerve fibres and rejuvenates damaged nerve cells, which together acting with amitriptyline provides relief from neuropathic pain due to damaged nerves.
Take AMNURITE 25MG TABLET as advised by your physician. Swallow AMNURITE 25MG TABLET with a glass of water and do not chew or crush the medicine. Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition.
Stop taking AMNURITE 25MG TABLET and contact your doctor if you experience any of the following side effects:
Dizziness:
Try to rest, relax and get enough sleep. Try to avoid driving or operating any tools or machines while you are feeling dizzy. Limit your consumption of alcohol, as it can aggravate your dizziness. Consult and inform your doctor if the symptom does not improve.
Headache:
If AMNURITE 25MG TABLET causes a headache, then take rest and drink plenty of fluids. Try to avoid drinking alcohol. Ask your doctor to recommend a painkiller. Paracetamol is safe to be taken with these medicines. Headaches should usually go away after the first week of taking AMNURITE 25MG TABLET. If headaches last more than a week or are severe, inform your doctor.
Nausea and vomiting:
Try to take AMNURITE 25MG TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if the symptom gets worse.
Constipation:
Try to eat more high-fiber foods, such as fresh fruit, vegetables and cereals and drink plenty of water. Try doing exercise regularly (going for a daily walk or run). If this does not help, inform your doctor about receiving alternate treatments for constipation.
Diarrhea:
Drink lots of fluids, such as water, to keep yourself hydrated. Try to avoid taking any medicine to treat diarrhoea. Consult your doctor if the symptom worsens.
AMNURITE 25MG TABLET is not recommended for use during pregnancy or in women with childbearing potential. Consult your doctor before taking AMNURITE 25MG TABLET.
AMNURITE 25MG TABLET is not recommended for use in breastfeeding women. Consult your doctor before taking AMNURITE 25MG TABLET.
AMNURITE 25MG TABLET might cause dizziness or drowsiness. If you experience these side effects, try to avoid driving or operating heavy machines. Consult your doctor before taking AMNURITE 25MG TABLET.
Avoid consumption of alcohol while taking AMNURITE 25MG TABLET since it increases the sedative effect.
AMNURITE 25MG TABLET should be used with caution in patients with kidney problems such as renal failure. Consult your doctor before taking AMNURITE 25MG TABLET.
AMNURITE 25MG TABLET is not recommended for use in patients with impaired liver function. Consult your doctor before taking AMNURITE 25MG TABLET.
AMNURITE 25MG TABLET is not recommended for use if you are allergic to Amitriptyline, Methylcobalamin or any other ingredients of this medicine.
AMNURITE 25MG TABLET is not recommended for use if you have heart diseases such as myocardial infarction (heart attack) and congestive heart failure. Consult your doctor before taking AMNURITE 25MG TABLET.
AMNURITE 25MG TABLET is not recommended for use if you:
Before taking AMNURITE 25MG TABLET, inform your doctor if you:
Use in Pediatrics:
AMNURITE 25MG TABLET should be used with caution in children and adolescents (below 18 years). Consult your doctor before taking AMNURITE 25MG TABLET.
Use in Geriatrics:
AMNURITE 25MG TABLET should be used with caution in elderly patients (aged 65 years or above). Consult your doctor before taking AMNURITE 25MG TABLET.
A. Drug-Drug Interactions:
Before taking AMNURITE 25MG TABLET, inform your doctor, if you are taking any of the following medicine:
Overdosage:
If you or anyone else accidentally takes too much of AMNURITE 25MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are temporary confusion, disturbed concentration or transient visual hallucinations, hypothermia (a dangerous drop in temperature), drowsiness, fast heart rate, bundle branch block, congestive heart failure, dilated pupils, disorders of ocular motility (eye movement), convulsions, severe low blood pressure, stupor (state of unconsciousness), coma, polyradiculoneuropathy (autoimmune disorder); constipation, agitation, muscle rigidity, overactive reflexes, high fever and vomiting.
| Drug | : | Amitriptyline, Methylcobalamin |
| Pharmacological Category | : | Tricyclic antidepressants and Vitamins |
| Therapeutic Indication | : | Neuropathic pain |
| Dosage Forms | : | Tablet |
Q: What is the function of AMNURITE 25MG TABLET?
AMNURITE 25MG TABLET is used in the management of neuropathic pain, which is a type of pain caused by damage or injury to the nerves that transfer information between the brain and spinal cord from the skin, muscles and other parts of the body.
Q: Who should avoid taking AMNURITE 25MG TABLET?
A: AMNURITE 25MG TABLET is not recommended for use in patients who are allergic to Amitriptyline and Methylcobalamin, have a history of urinary retention due to enlargement of the prostate gland (benign prostatic hypertrophy), myocardial infarction (heart attack), congestive heart failure, impaired liver function or are pregnant or breastfeeding women.
Q: What side effects are seen with AMNURITE 25MG TABLET?
A: The most common symptoms of taking AMNURITE 25MG TABLET are sleepiness, drowsiness, shakiness of hands or other body parts, dizziness, headache, dry mouth and constipation. Consult your doctor if any of these symptoms get worse.
Q: Is it safe to drive after taking AMNURITE 25MG TABLET?
A: AMNURITE 25MG TABLET might cause dizziness or drowsiness. If you experience these side effects, try to avoid driving or operating heavy machines. Consult your doctor before taking AMNURITE 25MG TABLET.
Q: What happens if you take more AMNURITE 25MG TABLET than your required dose?
A: If you or anyone else accidentally takes too much AMNURITE 25MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are temporary confusion, disturbed concentration, visual hallucinations, hypothermia (a dangerous drop in temperature), drowsiness, a fast heart rate, congestive heart failure, dilated pupils, convulsions, severe low blood pressure, stupor (state of unconsciousness), coma, constipation, agitation, muscle rigidity, overactive reflexes, a high fever and vomiting.
1. KD Tripathi. Drugs Used in Mental Illness: Antidepressant and Antianxiety Drugs & Haematinics and Erythropoietin. Essentials of medical pharmacology. Seventh edition. 2013. Page – 464 & 608.
2. EpiCept Corporation.A Study of the Efficacy and Safety of Amitriptyline/Ketamine Topical Cream in Patients With Diabetic Peripheral Neuropathy. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in May 2011] [Accessed on 7th June 2022] https://clinicaltrials.gov/ct2/show/NCT00476151
3. Clair Haslam and Turo Nurmikk. Pharmacological treatment of neuropathic pain in older persons. NIH National Library of Medicine, National center for biotechnology information. PMC PubMed Central. March 2008. [Accessed on 7th June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2544357/
4. Brown & Burk UK Ltd. Electronic medicines compendium (EMC). [Revised in January 2022] [Accessed on 7th June 2022] https://www.medicines.org.uk/emc/files/pil.10850.pdf
5. The madras pharmaceuticals. Am Nursing Tablets. [Revised in January 2022] [Accessed on 7th June 2022] https://www.centaurpharma.com/downloads/2022/neurology/Am-Nuring.pdf
Written By Dr. Dhivakaran R, BDS
Last updated on 27 Dec 2022 | 10:02 AM(IST)