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INTRODUCTION AGOPREX 25MG TABLET contains Agomelatine which belongs to a group of medicines called Antidepressants. AGOPREX 25MG TABLET is used in adults to manage depression and reduce and gradually remove the symptoms related to depression. Depression is a continuing disturbance of mood that...
AGOPREX 25MG TABLET contains Agomelatine which belongs to a group of medicines called Antidepressants. AGOPREX 25MG TABLET is used in adults to manage depression and reduce and gradually remove the symptoms related to depression. Depression is a continuing disturbance of mood that causes interference with everyday life, which is characterized by symptoms such as deep sadness, feeling worthless, loss of interest, sleep disturbances, feeling of being low, feeling anxious and changes in weight.
Prior to the management, your doctor may want you to take a liver function test to understand the functioning of the liver and may advise you for a follow-up liver function test to decide whether you should receive or continue taking AGOPREX 25MG TABLET.
Before taking AGOPREX 25MG TABLET, inform your doctor if you are overweight, diabetic, and/or have bipolar disorder with manic symptoms such as emotional highs and depression (including thoughts of killing or harming yourself) and suffering from dementia (a state of loss of thinking, remembering and thinking).
AGOPREX 25MG TABLET is not recommended for use if you are allergic to Agomelatine and or have serious liver problems that affect proper functioning of your liver. Pregnant women or women with childbearing potential are not recommended to take AGOPREX 25MG TABLET as a precautionary measure and are advised to consult their doctor before use if there is a need to take the medicine. AGOPREX 25MG TABLET is not recommended for use in breastfeeding women and also children and adolescents (less than 18 years of age).
The most common side effects of taking AGOPREX 25MG TABLET are headache, dizziness, sleepiness, increase in weight, difficulty in sleeping, nausea, diarrhea, constipation, abdominal pain, back pain, tiredness, anxiety, abnormal dreams, and vomiting. Consult your doctor if any of these symptoms gets worse.
AGOPREX 25MG TABLET is an antidepressant which works in two ways, by stimulating the MT1, MT2 receptors (a protein that binds melatonin (a hormone responsible for sleep-wake cycle) in brain) and by blocking the 5-HT2C receptors (a protein that regulates mood, anxiety, feeding, and reproductive behavior) in the brain that leads to an increase in the levels of the neurotransmitters (chemicals that allow nerve cells in the brain to communicate with each other) mainly dopamine and noradrenaline. As dopamine and noradrenaline are involved in the control of mood, their increase between nerve cells in the brain due to Agomelatine is believed to help relieve the symptoms of depression which also help to normalize sleep patterns.
Take AGOPREX 25MG TABLET as advised by your physician. Swallow AGOPREX 25MG TABLET with a glass of water and do not chew or crush the medicine. AGOPREX 25MG TABLET can be taken with or without food. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition. Do not stop taking your medicine without the advice of your doctor even if you feel better.
Stop taking AGOPREX 25MG TABLET and contact your doctor if you experience any of the following side effects :
Try to eat more high-fiber foods such as fresh fruit, vegetables, cereals, and drink plenty of water. Try doing exercise regularly (going for a daily walk or run). If this does not help, inform your doctor for receiving alternate treatments for constipation.
Drink lots of fluids, such as water to keep yourself hydrated. Try to avoid taking any medicine on your own to treat diarrhea and consult your doctor if the symptom gets worse.
Try to rest and relax. Get enough sleep. Try to avoid driving or operating any tools or machines while you are feeling dizzy. Do not consume alcohol, as it can aggravate your dizziness. Consult your doctor if the symptom did not improve.
Rest and relax. Drink plenty of fluids such as water or electrolytes. Apply a pain-relieving balm on the head if required. Do not consume alcohol. Consult your doctor if the symptom did not improve.
Try to take AGOPREX 25MG TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating rich or spicy food. Consult your doctor if the symptom gets worse.
AGOPREX 25MG TABLET is not recommended for use in pregnant women and in women who think they might get pregnant. If there is a need to take this medicine, consult your doctor before taking AGOPREX 25MG TABLET.
AGOPREX 25MG TABLET is not recommended for use in breastfeeding women. Consult your doctor before taking AGOPREX 25MG TABLET.
Do not drive or operate any machines if you feel dizziness or sleepiness after taking AGOPREX 25MG TABLET.
Avoid consumption of alcohol while taking AGOPREX 25MG TABLET.
AGOPREX 25MG TABLET should be used with caution in patients with severe or moderate kidney impairment. Consult your doctor before taking AGOPREX 25MG TABLET.
AGOPREX 25MG TABLET is not recommended for use in patients with liver impairment (such as cirrhosis or active liver disease) and it should be used with caution in patients with increased levels of liver enzymes (before treatment). Consult your doctor for advice before taking AGOPREX 25MG TABLET.
Do not take AGOPREX 25MG TABLET if you are allergic to Agomelatine or any of the other ingredients of this medicine.
AGOPREX 25MG TABLET is generally not recommended for use in children and adolescents (below 18 years). Consult your doctor before taking AGOPREX 25MG TABLET.
AGOPREX 25MG TABLET is not recommended for use in elderly patients (aged 75 years or above). Consult your doctor before taking AGOPREX 25MG TABLET.
Before taking AGOPREX 25MG TABLET, inform your doctor if you:
A. Drug-Drug Interactions:
Before taking AGOPREX 25MG TABLET, inform your doctor, if you are taking any of the following medicine:
Overdosage:
If you or anyone else accidentally takes too much of AGOPREX 25MG TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are pain in the upper part of the stomach, sleepiness, fatigue, agitation, anxiety, tension, dizziness, cyanosis (abnormal blue discoloration of the skin) or malaise (state of discomfort, illness, or uneasiness).
| Drug | : | Agomelatine |
| Pharmacological Category | : | Melatonin receptor agonist |
| Therapeutic Indication | : | Depression |
| Dosage Forms | : | Tablet |
Q: What AGOPREX 25MG TABLET is used for?
A: AGOPREX 25MG TABLET is used in adults to manage depression and reduce and gradually remove the symptoms related to depression which is characterized by symptoms such as deep sadness, feeling worthless, loss of interest, sleep disturbances, feeling of being low, feeling anxious and changes in weight.
Q: How AGOPREX 25MG TABLET works in your body?
A: AGOPREX 25MG TABLET works in two ways, by stimulating the MT1, MT2 receptors (a protein that binds melatonin (a hormone responsible for sleep-wake cycle) in brain) and by blocking the 5-HT2C receptors (a protein that regulates mood, anxiety, feeding, and reproductive behavior) in the brain that leads to an increase in the levels of the neurotransmitters (chemicals that allow nerve cells in the brain to communicate with each other) mainly dopamine and noradrenaline. As dopamine and noradrenaline are involved in the control of mood, their increase between nerve cells in the brain due to Agomelatine is believed to help relieve the symptoms of depression which also help to normalize sleep patterns.
Q: What side effects are seen with AGOPREX 25MG TABLET?
A: The most common side effects of taking AGOPREX 25MG TABLET are as deep sadness, feeling worthless, loss of interest, sleep disturbances, feeling of being low, feeling anxious and changes in weight. Consult your doctor if any of these symptoms gets worse.
Q: Is AGOPREX 25MG TABLET safe to use in children?
A: No. AGOPREX 25MG TABLET is not recommended for use in children and adolescents (less than 18 years of age). If AGOPREX 25MG TABLET is accidentally ingested by a child or adolescent, go to the hospital immediately and consult the doctor for further management.
Q: Can AGOPREX 25MG TABLET be taken by a diabetes patient?
A: AGOPREX 25MG TABLET should be used with caution in patients with high blood sugar. Consult your doctor before taking AGOPREX 25MG TABLET who may advise you to check your blood sugar level before AGOPREX 25MG TABLET is advised to be taken.
Q: Can AGOPREX 25MG TABLET be taken by pregnant or breastfeeding women?
A: AGOPREX 25MG TABLET is not recommended for use as a precautionary measure in pregnant women and in women who think they might get pregnant. If there is a need to take this medicine, consult your doctor before taking AGOPREX 25MG TABLET. GBNKEYWORD] is not recommended for use in breastfeeding women who should consult a doctor before taking AGOPREX 25MG TABLET.
1. Paul Harrison, Philip Cowen, Tom Burns, Mina Fazel. The acute treatment of depression. Shorter Oxford Textbook Of Psychiatry. Seventh edition. 2018. Page – 219.
2. Novartis.Efficacy, Safety and Tolerability of Agomelatine in the Treatment of Major Depressive Disorder. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in December 2020] [Accessed on 25th April 2022] https://clinicaltrials.gov/ct2/show/NCT00411099
3. B Guardiola-Lemaitre, C De Bodinat, P Delagrange, M J Millan, C Munoz, and E Mocaër.Agomelatine: mechanism of action and pharmacological profile in relation to antidepressant properties. NIH National Library of Medicine, National center for biotechnology information. PMC Pubmed Central. [Revised in July 2014] [Accessed on 25th April 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4128060/
4. Les Laboratoires Servier. European Medicines Agency (EMA). [Revised in December 2018] [Accessed on 25th April 2022] https://www.ema.europa.eu/en/documents/product-information/valdoxan-epar-product-information_en.pdf
5. Accord Healthcare Limited. Electronic Medicines Compendium (EMC) [Revised in February 2021] [Accessed on 25th April 2022] https://www.medicines.org.uk/emc/files/pil.9887.pdf
Written By Dr. R. Dinesh John Rajkumar, Pharm.D
Last updated on 21 Oct 2023 | 04:18 PM(IST)