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INTRODUCTION ADRIM 50MG INJECTION contains Doxorubicin which belongs to the group of medicines called Anti-cancer agents. It is used to treat certain types of cancers. It is used either alone or along with other anti-cancer medicines. Cancer is a disease in which some of t...
ADRIM 50MG INJECTION contains Doxorubicin which belongs to the group of medicines called Anti-cancer agents. It is used to treat certain types of cancers. It is used either alone or along with other anti-cancer medicines.
Cancer is a disease in which some of the cells of the body grow uncontrollably and spread to other parts of the body.
Before receiving ADRIM 50MG INJECTION, inform your doctor if you have or ever had heart disease, either before or during radiotherapy, had or having live or live-attenuated vaccinations, are currently taking or have recently taken Trastuzumab (used in the treatment of certain cancers).
There are no adequate and well-controlled studies in pregnant women. Consult your doctor during breast-feeding before starting treatment with this medicine as it may pass through the breast milk and possibly harm your child. Consult your doctor for advice before receiving the medicine.
The most common side effects of ADRIM 50MG INJECTION are infection, lack of appetite, inflammation in the mouth, diarrhea, nausea, vomiting, reddening, swelling, pain, numbness and tingling in the palms and feet may also occur whilst being treated with this medicine.
Hair loss is very common and may be quite severe, beard growth may stop in men, fever, feeling weak, chills, abnormal ECG (electrical trace of the heart) results, raised levels of liver enzymes (as detected by a blood test) can determine if the medicine is having an abnormal effect on your liver, weight increased in patients with early breast cancer.
ADRIM 50MG INJECTION works by suppressing the activity of an enzyme (topoisomerase II) involved in the DNA multiplication of the cancer cells. On the other hand, this also forms harmful chemicals (free radicals) which cause damage to the DNA. This slowdown the growth of cancer cells and eventually works against them.
ADRIM 50MG INJECTION will be administered intravenously (IV) into the vein by your doctor or nurse. Your doctor will administer the correct dose and duration for you depending upon your age, body weight and disease condition.
Stop receiving ADRIM 50MG INJECTION and contact your doctor immediately if you experience any of the following side effects:
There are no adequate and well-controlled studies in pregnant women. Consult your doctor before receiving ADRIM 50MG INJECTION.
ADRIM 50MG INJECTION is generally not recommended for use in breastfeeding women as it may pass through breast milk. Consult your doctor before receiving it.
There are no special precautions and can drive and operate machinery as long as you feel fully recovered after treatment with ADRIM 50MG INJECTION.
Avoid consumption of alcohol while receiving ADRIM 50MG INJECTION. Consult your doctor for advice.
ADRIM 50MG INJECTION is not recommended for use in patients having a hepatic impairment. Consult your doctor before receiving it.
Do not receive ADRIM 50MG INJECTION if you are allergic (hypersensitivity) to Doxorubicin or other similar medicines called anthracyclines or anthracenediones or any of the other ingredients of this medicine.
ADRIM 50MG INJECTION is not recommended in patients with a current or previous history of cardiac impairment (severe myocardial insufficiency, recent myocardial infarction, severe arrhythmia) Consult your doctor before receiving it.
ADRIM 50MG INJECTION is not recommended for use if you have:
Before receiving ADRIM 50MG INJECTION, inform your doctor if you have:
Use in pediatrics:
ADRIM 50MG INJECTION should be used with caution in children. Your doctor will administer the right dose depends on your child’s age, body weight and disease condition. Consult your doctor before receiving the medicine.
Use in geriatrics:
ADRIM 50MG INJECTION should be used with caution in elderly patients (aged 65 years and above). Consult your doctor before receiving the medicine.
A. Drug-Drug interactions:
Before receiving ADRIM 50MG INJECTION, inform your doctor if you are taking any of the following medicine:
Overdosage :
ADRIM 50MG INJECTION will be administered to you only by a doctor or a nurse in a hospital and it is so unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual problems.
| Drug | : | Doxorubicin |
| Pharmacological Category | : | Anthracyclin derivatives |
| Therapeutic Indication | : | Cancer |
| Dosage Forms | : | Injection |
Is ADRIM 50MG INJECTION can be used in pregnant women?
There are no adequate and well-controlled studies in pregnant women. Consult your doctor before receiving ADRIM 50MG INJECTION.
What for ADRIM 50MG INJECTION is used?
ADRIM 50MG INJECTION is used to treat cancer particularly useful in the treatment of cancers of the breast and lung. In addition, it can be given to treat cancers of the blood-forming tissues such as malignant lymphomas and leukemia.
Is there any food restriction while receiving ADRIM 50MG INJECTION?
No, there is no food restriction while receiving ADRIM 50MG INJECTION. Consult your doctor before undergoing treatment.
When do I need to seek medical help?
Contact your doctor or nurse immediately if you notice any of the following side effects feeling dizzy, feverish, short of breath with a tight chest or throat or have an itchy rash. This type of allergic reaction can be very serious. Your doctor will test your blood cell count during treatment. Doxorubicin may also cause decreased activity in your bone marrow.
What is the effect of ADRIM 50MG INJECTION on the heart?
ADRIM 50MG INJECTION should be used with caution in patients with a current or previous history of cardiac impairment (severe myocardial insufficiency, recent myocardial infarction, severe arrhythmia) Consult your doctor before receiving ADRIM 50MG INJECTION.
What precautions should take before receiving ADRIM 50MG INJECTION?
Before receiving ADRIM 50MG INJECTION, inform your doctor if you have heart problems, have had radiation treatment or currently receiving radiation therapy, are over the age of 50, have liver problems, plan to receive any vaccines, have any other medical conditions. Consult your doctor before receiving the medicine.
1. Anton Wellstein, Giuseppe Giaccone, Michael B. Atkins and Edward A. Sausville. Cytotoxic Drugs. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 13th Edition. New York McGraw Hill Medical 2018 Page – 1167-1201.
2. Caroline F. Thorn, Connie Oshiro, Sharon Marsh, Tina Hernandez-Boussard, Howard McLeod,d Teri E. Klein and Russ B. Altmana. Doxorubicin pathways: pharmacodynamics and adverse effects. Journal of Pharmacogenetic Genomics. July 2011. [Accessed on 10th May 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3116111/
3. Ekaterina Yu Podyacheva, Ekaterina A. Kushnareva, Andrei A. Karpov and Yana G. Toropova. Analysis of Models of Doxorubicin-Induced Cardiomyopathy in Rats and Mice. A Modern View From the Perspective of the Pathophysiologist and the Clinician. Journal of Frontiers Pharmacology. June 2021. [Accessed on 10th May] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8209419/
4. Claudia Christowitz, Tanja Davis, Ashwin Isaacs, Gustav van Niekerk, Suzel Hattingh & Anna-Mart Engelbrecht. Mechanisms of doxorubicin-induced drug resistance and drug resistant tumour growth in a murine breast tumour model. Journal of BMC cancer. August 2019. [Accessed on 10th May 2021] https://bmccancer.biomedcentral.com/articles/10.1186/s12885-019-5939-z
5. Pfizer Limited. Electronic Medicines Compendium (EMC). [Revised in February 2021] [Accessed 10th May 2022] https://www.medicines.org.uk/emc/files/pil.6184.pdf
6. Bedford Laboratories. Medicines Compendium (EMC). [Revised in April 2012] [Accessed 10th May 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/062921s022lbl.pdf
Written By Dr. Janet.C, Pharm.D
Last updated on 11 Nov 2022 | 03:27 PM(IST)