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INTRODUCTION ABURA 500MG TABLET contains Abiraterone, which belongs to a group of medicines called Androgen biosynthesis inhibitors. ABURA 500MG TABLET is used with prednisone or prednisolone in adult men to manage prostate cancer that has spread to other parts of the body....
ABURA 500MG TABLET contains Abiraterone, which belongs to a group of medicines called Androgen biosynthesis inhibitors. ABURA 500MG TABLET is used with prednisone or prednisolone in adult men to manage prostate cancer that has spread to other parts of the body.
ABURA 500MG TABLET is also used to manage early stages of prostate cancer when used with androgen deprivation therapy (treatment that lowers testosterone hormone) and prednisone/prednisolone (medication) in affected individuals. ABURA 500MG TABLET is not recommended for use in patients allergic to abiraterone. It is also not recommended for use in patients suffering from severe liver disease.
Before taking ABURA 500MG TABLET, inform your doctor if you have high blood pressure, any other blood vessel problems (such as blood pressure, stroke), swelling in the feet, ankles, or legs, diabetes, lung problems (such as shortness of breath), heart problems (such as heart failure, irregular or rapid heart rate), kidney, and/or liver problems.
ABURA 500MG TABLET is not recommended for use in pregnant and breastfeeding women since it is intended to be used only in male patients.While taking ABURA 500MG TABLET, male patients must use a suitable contraceptive method to avoid exposure of this medicine to their female partners.
ABURA 500MG TABLET is also not recommended for use in children and adolescents (aged below 18 years) and is advised to be used with caution in elderly patients (aged 75 years or older) after consulting the doctor.
The most common side effects of taking ABURA 500MG TABLET are swelling in the legs or feet, high blood pressure, urinary tract infection, diarrhea, indigestion, chest pain, an irregular heartbeat, and/or a rash. Contact your doctor if any of the symptoms worsen.
ABURA 500MG TABLET is used with prednisone/prednisolone:
ABURA 500MG TABLET is an androgen biosynthesis inhibitor that works by inhibiting the production of the 17α-hydroxylase (CYP17) enzyme needed to produce testosterone (male sex hormone), which enables the growth of cancer cells in the prostate gland. Since ABURA 500MG TABLET suppresses the production of testosterone, the cancer cells in the prostate gland won't be able to grow, thus preventing its effects on the gland in affected individuals.
Take ABURA 500MG TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Avoid taking medicine with food. Your doctor will decide the correct dose and duration for you depending on your age, body weight, and disease condition.
Stop taking ABURA 500MG TABLET and contact your doctor if you experience any of the following side effects:
Drink lots of fluids, such as water, to keep yourself hydrated. Try to avoid taking any medicine on your own to treat diarrhea and consult your doctor if the symptom gets worse.
Try to reduce your consumption of tea, coffee, cola, or alcohol and lose weight if you are obese. Avoid smoking, and do not eat for three to four hours before going to bed. Consult your doctor if the symptoms get worse.
Do not scratch the affected area. Wear protective clothing while going outdoors. Regularly moisturize your skin. Consult and inform your doctor if the symptom gets worse.
ABURA 500MG TABLET is not intended for use in women.
ABURA 500MG TABLET is not recommended for use in breastfeeding women since it is intended to be used only in male patients.
ABURA 500MG TABLET is unlikely to affect your ability to drive or operate machines. Consult your doctor before taking ABURA 500MG TABLET.
ABURA 500MG TABLET should be used with caution in patients with kidney problems. Consult your doctor before taking ABURA 500MG TABLET.
ABURA 500MG TABLET is not recommended for use in patients with severe liver damage. It should be used with caution in patients with other liver diseases. Consult your doctor before taking ABURA 500MG TABLET.
Do not take ABURA 500MG TABLET if you are allergic to abiraterone and/or any other ingredients in this medicine.
ABURA 500MG TABLET should be used with caution in patients with lung problems such as shortness of breath. Consult your doctor before taking ABURA 500MG TABLET.
ABURA 500MG TABLET should be used with caution in patients with heart problems such as heart failure, irregular or rapid heart rate, and/or heart rhythm problems. Consult your doctor before taking ABURA 500MG TABLET.
ABURA 500MG TABLET is not recommended for use in children and adolescents (aged below 18 years). Consult your doctor before taking ABURA 500MG TABLET.
ABURA 500MG TABLET should be used with caution in elderly patients (aged 75 years or older). Consult your doctor before taking ABURA 500MG TABLET.
Before taking ABURA 500MG TABLET, inform your doctor if you :
A. Drug-Drug Interactions:
Before taking ABURA 500MG TABLET, inform your doctor if you are taking any of the following medicines:
B. Drug-Food Interactions:
ABURA 500MG TABLET should not be taken with grapefruit juice since it may increase the risk of side effects.
Overdosage:
If you or anyone else accidentally takes too much of ABURA 500MG TABLET, contact your doctor immediately or go to a hospital right away.
| Drug | : | Abiraterone |
| Pharmacological Category | : | Androgen biosynthesis inhibitors |
| Therapeutic Indication | : | Prostate cancer |
| Dosage Forms | : | Tablet, Injection |
Q: What is ABURA 500MG TABLET used for?
A: ABURA 500MG TABLET is used with prednisone or prednisolone in adult men to manage prostate cancer that has spread to other parts of the body. It is also used to manage early stages of prostate cancer when used with androgen deprivation therapy (a treatment that lowers testosterone hormone) and prednisone/prednisolone (a medication) in affected individuals.
Q: Can ABURA 500MG TABLET be taken along with food?
A: No. ABURA 500MG TABLET should not be taken along with food since it may increase the absorption of this medicine and can increase the risk of side effects. Take this medicine one hour before or after two hours of eating the food. Consult your doctor before taking the medicine.
Q: What are the side effects of ABURA 500MG TABLET?
A: The most common side effects of taking ABURA 500MG TABLET are swelling in the legs or feet, high blood pressure, urinary tract infection, diarrhea, indigestion, chest pain, an irregular heartbeat, and/or a rash. Contact your doctor if any of the symptoms worsen.
Q: Is ABURA 500MG TABLET safe to use with children?
A: No, ABURA 500MG TABLET is not recommended for use in children and adolescents (aged below 18 years). If ABURA 500MG TABLET is accidentally ingested by a child or adolescent, go to the hospital immediately and consult the doctor for further management.
Q: Can ABURA 500MG TABLET be taken by a diabetic patient?
A: ABURA 500MG TABLET should be used with caution in patients with high blood sugar. Consult your doctor before taking ABURA 500MG TABLET, who may advise you to check your blood sugar level before ABURA 500MG TABLET is advised to be taken.
1. Beverly Moy, Richard J. Lee and Mathew Smith. Natural products in cancer chemotherapy: Hormones and related drugs. Goodman & Gilman’s: The pharmacological basics of therapeutics. 12th Edition. New York MC Graw Hill Medical 2011. Page – 1767.
2. Yasser Rehman, Jonathan E Rosenberg. Abiraterone acetate: oral androgen biosynthesis inhibitor for treatment of castration-resistant prostate cancer. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. 2012. [Accessed on 26th April 2022] https://pubmed.ncbi.nlm.nih.gov/22291466/
3. Matthew R Smith, Dana E Rathkopf, Peter F A Mulders, Joan Carles, Hendrik Van Poppel, Jinhui Li, Thian Kheoh, Thomas W Griffin, Arturo Molina, Charles J Ryan. Efficacy and Safety of Abiraterone Acetate in Elderly (75 Years or Older) Chemotherapy Naïve Patients with Metastatic Castration Resistant Prostate Cancer. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. November 2015. [Accessed on 26th April 2022] https://pubmed.ncbi.nlm.nih.gov/26151676/
4. Merckle GmbH. Health Products Regulatory Authority (HPRA). [Revised in May 2022] [Accessed on 26th April 2022] http://www.hpra.ie/img/uploaded/swedocuments/80fd6aa1-a8b2-4f60-92bf-ac7a2e96c6a4.pdf
5. Biocon Biologics India Limited. ABSTET. [Revised in July 2019] [Accessed on 26th April 2022] https://www.biocon.com/docs/domestic-market-pi/onco/ABSTET%20PI.pdf
6. Azista Industries Private Limited. Abiraterone acetate 250mg tablets. [Accessed on 26th April 2022] https://www.azistaindustries.com/abiraterone-acetate-tablets-exporters/
Written By Dr. N. Sai Swaroop, Pharm.D
Last updated on 28 Nov 2023 | 04:17 PM(IST)