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INTRODUCTION NATZOLD 5MG INFUSION contains Zoledronic Acid which belongs to the group of medicines called Bisphosphonates. NATZOLD 5MG INFUSION is used in post-menopausal women and adult men to manage osteoporosis, or osteoporosis caused by treatment with cortico...
NATZOLD 5MG INFUSION contains Zoledronic Acid which belongs to the group of medicines called Bisphosphonates. NATZOLD 5MG INFUSION is used in post-menopausal women and adult men to manage osteoporosis, or osteoporosis caused by treatment with corticosteroids, and Paget’s disease of the bone in adults.
Osteoporosis is a bone disease that develops when bone mineral density and bone mass decrease or when the quality or structure of the bone changes. It usually occurs in women after the menopause and also occurs in adult men.
Paget's disease of bone is a chronic bone disorder that disrupts the normal cycle of bone renewal, causing bones to become weakened and possibly deformed.
Along with treatment with NATZOLD 5MG INFUSION, your doctor might ask you to make some lifestyle changes, such as eating a balanced diet rich in calcium and vitamin D. Prior to starting treatment with NATZOLD 5MG INFUSION, your doctor might want you to take some diagnostic tests to understand the existing condition.
NATZOLD 5MG INFUSION is not recommended for use in patients with severe kidney problems and hypocalcemia (low levels of calcium in the blood). NATZOLD 5MG INFUSION is not recommended for use by pregnant and breastfeeding women. Consult your doctor before receiving NATZOLD 5MG INFUSION.
NATZOLD 5MG INFUSION is not recommended for use in children and adolescents (under 18 years of age) and should be used with caution in elderly patients.
The most common side effects of receiving NATZOLD 5MG INFUSION are headache, dizziness, vomiting, diarrhea, fever, chills, pain in muscles, joints, or bones, and pain in the back, arms, or legs. Inform your doctor if any of the symptoms worsen.
To manage:
NATZOLD 5MG INFUSION works by suppressing the activity of osteoclasts, cells that cause the destruction of bones. This strengthens the bones and minimizes the risk of fractures.
NATZOLD 5MG INFUSION will be given to you only by a doctor or a nurse into a vein (intravenously). Your doctor will decide the correct dose and duration of NATZOLD 5MG INFUSION for you depending upon your age, body weight, and disease condition.
Consult your doctor if you experience any of the following side effects after receiving NATZOLD 5MG INFUSION:
Try to eat more high-fiber foods, such as fresh fruit, vegetables, and cereals, and drink plenty of water. If this does not help, inform your doctor about receiving alternate treatment for constipation.
Drink a lot of fluids, such as water, to keep yourself hydrated. Avoid eating high-fat or spicy foods. Inform your doctor if the symptom gets worse.
Lie down until the dizziness is gone, then get up slowly. Move slowly and carefully, do not hurry. Get adequate rest. Drink plenty of water and other fluids. Inform your doctor if the symptom gets worse.
Drink an ample amount of water and avoid skipping meals. Get adequate rest. Try to be relaxed and stress-free. Apply a pain-relieving balm to your forehead if necessary. Inform your doctor if the symptom does not improve.
Stick to simple meals. Avoid eating oily, fried, or spicy foods. Do not lie down or go to sleep immediately after eating. Inform your doctor if the symptom does not improve.
Try to rest and relax. Eat and drink slowly or try to have smaller and more frequent meals. Keep a heat pad on your stomach. If the symptoms do not improve, inform your doctor.
NATZOLD 5MG INFUSION is not recommended for use by pregnant women. Consult your doctor before receiving NATZOLD 5MG INFUSION.
NATZOLD 5MG INFUSION is not recommended for use by breastfeeding women. Consult your doctor before receiving NATZOLD 5MG INFUSION.
Do not drive or operate any machines if you feel dizziness after receiving NATZOLD 5MG INFUSION.
NATZOLD 5MG INFUSION is not recommended for use in patients with severe kidney disease, and it should be used with caution in patients with other kidney problems. Consult your doctor before receiving NATZOLD 5MG INFUSION.
Do not receive NATZOLD 5MG INFUSION if you are allergic to Zoledronic Acid, other bisphosphonates (such as alendronate), or any of the other ingredients of this medicine.
NATZOLD 5MG INFUSION is not recommended for use in children and adolescents (under 18 years of age). Consult the child’s doctor for advice.
NATZOLD 5MG INFUSION should be used with caution in elderly patients (aged 65 years and above). Consult your doctor before receiving NATZOLD 5MG INFUSION.
NATZOLD 5MG INFUSION is not recommended for use if you:
Before receiving NATZOLD 5MG INFUSION, inform your doctor if you:
A. Drug-Drug Interactions:
Before receiving NATZOLD 5MG INFUSION, inform your doctor if you are taking any of the following medicines:
Overdosage:
NATZOLD 5MG INFUSION will be administered to you only by a doctor or a nurse in a hospital, and so you are unlikely to receive an overdose. However, consult your doctor or nurse if you experience any unusual symptoms after receiving NATZOLD 5MG INFUSION.
Drug | : | Zoledronic Acid |
Pharmacological Category | : | Bisphosphonates |
Therapeutic Indication | : | Osteoporosis, Paget’s disease of the bone |
Dosage Forms | : | Injection, Infusion |
A: NATZOLD 5MG INFUSION should be received in the dose and duration as advised by your doctor. The medicine takes around 6 months to show its maximum benefits for bones. However, in some cases, the doctor may suggest NATZOLD 5MG INFUSION for a longer duration. The exact duration will depend on the condition you are being treated for.
A: NATZOLD 5MG INFUSION will be given to you only by a doctor or a nurse into a vein (intravenously). Your doctor will decide the correct dose and duration of NATZOLD 5MG INFUSION for you depending upon your age, body weight, and disease condition.
A: To get maximum benefit from this medicine, there are certain lifestyle changes that you must adhere to. Include some calcium- or vitamin-D-rich foods for bone strength. Try to spend more time in sunlight to get natural vitamin D. Quit smoking and reduce alcohol consumption, as they may harm your bones. You can take up an exercise regime such as walking and low-impact aerobics, as they are good for your bones. Similarly, you can try strength-training exercises where you use your own body weight, which in turn improves bone health.
A: Yes, NATZOLD 5MG INFUSION may cause constipation in some individuals. To manage this effect, try to eat more high-fiber foods such as fresh fruit, vegetables, and cereals, and drink plenty of water. If this does not help, inform your doctor about receiving alternate treatment for constipation.
A: NATZOLD 5MG INFUSION is not recommended for use in pregnant and breast-feeding women. Consult your doctor before receiving NATZOLD 5MG INFUSION if you are pregnant, planning to be pregnant, or breast-feeding.
1. Briggs GG, Freeman RK, editors. A Reference Guide to Fetal and Neonatal Risk: Drugs in Pregnancy and Lactation. 10th ed. Philadelphia, PA: Wolters Kluwer Health; 2015. Page - 4229-4231.
2. Ma Chao, Qin Hua, Zhou Yingfeng, Wan Guang, Shi Shufeng, Dong Yuzhen, Wang Wei, and Tan Haifeng. Study on the role of zoledronic acid in treatment of postmenopausal osteoporosis women. NIH: National Library of Medicine, National center of biotechnology Information, PMC PubMed Central. December 2013 [Accessed on 5th February 2024] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3905367/
3. Margaret Seton and Stephen M Krane. Use of zoledronic acid in the treatment of Paget’s disease. NIH: National Library of Medicine, National center of biotechnology Information, PMC, PubMed Central. October 2007 [Accessed on 5th February 2024] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2376069/
4. Sun Pharmaceutical Industries Europe B.V. Electronic Medicines Compendium (EMC). [Revised in October 2020] [Accessed on 5th February 2024] https://www.medicines.org.uk/emc/files/pil.5242.pdf
Written By Dr. N. Sai Swaroop, Pharm.D
Last updated on 06 Feb 2024 | 04:50 PM(IST)