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INTRODUCTION APIQUIS 2.5 TABLET contains Apixaban, which belongs to the group of medicines called Anticoagulants. It is used in adults to prevent blood clots from forming after hip or knee replacement operations and to prevent blood clots (clusters of blood) in patients with an irregular heart...
APIQUIS 2.5 TABLET contains Apixaban, which belongs to the group of medicines called Anticoagulants. It is used in adults to prevent blood clots from forming after hip or knee replacement operations and to prevent blood clots (clusters of blood) in patients with an irregular heartbeat (atrial fibrillation). It also helps in the treatment of blood clots in the legs (deep vein thrombosis) and the veins of the lungs (pulmonary embolism) and the prevention of their recurrence in either the legs or lungs.
GBNKEYWORD] is not recommended in patients who have liver disease, active bleeding, or a disease that can lead to active bleeding, such as an active ulcer or a recent bleed in the brain. If you are pregnant or breastfeeding, consult your doctor before taking APIQUIS 2.5 TABLET.
Patients who have kidney disease should use APIQUIS 2.5 TABLET with caution. APIQUIS 2.5 TABLET is not recommended for children and adolescents (under the age of 18). APIQUIS 2.5 TABLET should be used with caution in elderly patients over the age of 75.
The most common side effects of taking APIQUIS 2.5 TABLET are bleeding (eyes, nose, gums, urine, rectum, stomach, or bowel), bruising or swelling, anaemia, low blood pressure, and a quickened heart rate. If any of these symptoms worsen, contact your doctor immediately.
APIQUIS 2.5 TABLET helps to prevent the formation of blood clots by acting on the blood clotting mechanism of the body. It blocks clotting factor Xa which is an essential factor in the clotting mechanism.
Take APIQUIS 2.5 TABLET as advised by your physician. Swallow the medicine with a glass of water. If you have difficulty swallowing the medicine, talk to your doctor about other ways to take APIQUIS 2.5 TABLET. Your doctor will decide the correct dose and duration for you depending on your age, body weight and disease condition.
Stop taking APIQUIS 2.5 TABLET and contact your doctor immediately if you experience any of the following side effects:
Nausea:
Try and take the medicine with, or just after meals. Stick to simple meals. Avoid eating oily or spicy foods. Consult your doctor if your symptom gets worse.
The effects of APIQUIS 2.5 TABLET on pregnancy and the unborn child are not known. Hence it is not recommended during pregnancy. Consult your doctor before taking it.
It is not known if APIQUIS 2.5 TABLET passes into human breast milk. Consult your doctor for advice before taking this medicine during breastfeeding.
APIQUIS 2.5 TABLET does not impair the ability to drive or use machines. Consult your doctor.
APIQUIS 2.5 TABLET should be taken with caution in patients with severe kidney disease or who are on dialysis. Consult your doctor before taking it.
APIQUIS 2.5 TABLET is not recommended for use in patients with liver disease such as hepatic coagulopathy which may increase the risk of bleeding. Consult your doctor before taking it.
Do not take APIQUIS 2.5 TABLET if you are allergic to Apixaban.
APIQUIS 2.5 TABLET should be taken with caution in patients with prosthetic heart valves. Consult your doctor before taking it.
APIQUIS 2.5 TABLET is not recommended for use if you:
Before taking APIQUIS 2.5 TABLET, inform your doctor if you:
Use in pediatrics:
APIQUIS 2.5 TABLET is not recommended for use in children and adolescents (under 18 years of age). Consult your doctor before taking.
Use in geriatrics:
APIQUIS 2.5 TABLET should be used with caution in elderly patients (aged above 75 years). Consult your doctor before taking it.
A. Drug–Drug Interactions:
Overdosage:
If you or anyone else accidentally take too much of APIQUIS 2.5 TABLET, consult your doctor immediately or visit the nearby hospital. Overdose can result in increased bleeding.
| Drug | : | Apixaban |
| Pharmacological Category | : | Anti-coagulants |
| Therapeutic Indication | : | Prevention of blood clots in atrial fibrillation, Deep vein thrombosis, Pulmonary embolism, Deep vein thrombosis following hip or knee replacement |
| Dosage Forms | : | Tablet |
Is APIQUIS 2.5 TABLET a blood thinner?
Yes. [GBKEYWORD] is a blood thinner, also called an anticoagulant. It prevents blood clot formation and makes it easier for the blood to flow through the body. APIQUIS 2.5 TABLET blocks an essential factor of the clotting mechanism called factor Xa, which stops the blood from clotting.
What precautions should I take while taking APIQUIS 2.5 TABLET?
Patients taking APIQUIS 2.5 TABLET should inform their doctor about their pre-existing liver, heart, or kidney disease. As APIQUIS 2.5 TABLET is an anti-coagulant and helps in the prevention of blood clot formation, it is important to tell your doctor about any bleeding disorder or any active condition that can cause a bleed. Consult your doctor before taking it.
What if I forget to take a dose of APIQUIS 2.5 TABLET?
Take the dose as soon as you remember, then take the next dose of APIQUIS 2.5 TABLET at the usual time, and then continue as normal. Consult your doctor once.
Can APIQUIS 2.5 TABLET cause low blood pressure?
Yes. Low blood pressure is a common side effect of APIQUIS 2.5 TABLET. You may experience a faster heartbeat. Consult your doctor if the side effect worsens.
Is APIQUIS 2.5 TABLET safe during pregnancy?
The effects of APIQUIS 2.5 TABLET on pregnancy and the unborn child are not known. Hence, it is not recommended during pregnancy. Consult your doctor before taking it.
Can I suddenly stop taking APIQUIS 2.5 TABLET?
No. You should not stop taking APIQUIS 2.5 TABLET suddenly or alter its dose. Doing so can result in the reoccurrence of blood clots and can lead to serious side effects. Talk to your doctor if you notice any side effects.
1. Joseph T. DiPiro, Robert L. Talbert, Cardiovascular Diseases, Pharmacotherapy: A Pathophysiologic Approach, Eighth Edition. 2011. Page – 324.
2. Joseph P. Broderick, Jordan B. Bonomo, Brett M. Kissela, Jane C. Khoury, Charles J. Moomaw, Kathleen Alwell, Daniel Woo, Matthew L. Flaherty, Pooja Khatri, Opeolu Adeoye, Simona Ferioli, Dawn O. Kleindorfer. Withdrawal of Antithrombotic Agents and Its Impact on Ischemic Stroke Occurrence. NIH. National Library of Medicine. National Center for Biotechnology Information. PubMed Central. June 2011. [Accessed on 20th April 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3166233/
3. CATALENT ANAGNI S.R.L. Electronic Medicines Compendium (EMC). [Revised in September 2021]. [Accessed on 23rd April 2022] https://www.medicines.org.uk/emc/files/pil.4756.pdf
4. Bristol-Myers Squibb Company, Pfizer Inc. Bristol Myers Squib. [Revised in September 2021]. [Accessed on 20th April 2022] https://packageinserts.bms.com/pi/pi_eliquis.pdf
Written By Dr. Dhivakaran R, BDS
Last updated on 25 Nov 2022 | 03:12 PM(IST)