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INTRODUCTION CLOSTOP SRX TABLET contains a combination of Mefenamic acid and Tranexamic acid, which belongs to the group of medicines called Non-Steroidal Anti-inflammatory Drugs (NSAIDs) and antifibrinolytics. It helps to stop/arrest bleeding and relieve pain and swelling from various parts o...
CLOSTOP SRX TABLET contains a combination of Mefenamic acid and Tranexamic acid, which belongs to the group of medicines called Non-Steroidal Anti-inflammatory Drugs (NSAIDs) and antifibrinolytics. It helps to stop/arrest bleeding and relieve pain and swelling from various parts of the body. It is used to treat, control and prevent heavy menstrual bleeding (menorrhagia) and menstrual pain, bleeding from the nose or eyes, following a tooth extraction, prostate surgery etc.
Tranexamic acid works by preventing the breakdown of blood clots by blocking the interaction of plasminogen with fibrin. Mefenamic acid works by preventing the release of a chemical messenger called prostaglandin by inhibiting an enzyme called cyclooxygenase that causes fever, pain and inflammation in the body (redness and swelling). Your doctor may suggest you take relevant medical tests to understand your existing condition.
CLOSTOP SRX TABLET is not recommended for use if you have severe kidney disease or failure, blood clots (thrombosis), abnormal body movements such as fits or seizures, an abnormal or excessive bleeding disorder (consumptive coagulopathy), etc. CLOSTOP SRX TABLET should be used with caution. Inform your doctor if you have blood in the urine, uncontrolled bleeding, blood clots throughout your body, irregular menstruation, mild to moderate kidney or liver disease, angioneurotic oedema (HANO), etc.
CLOSTOP SRX TABLET should be used with caution in pregnant women and nursing mothers and only if prescribed by a doctor. The most common side effects of CLOSTOP SRX TABLET are feeling sick, vomiting, having a headache, having an abnormal heartbeat, having changes in blood pressure, having difficulty urinating, having urine leaks, etc. Contact your doctor if the symptoms worsen.
Tranexamic acid works by preventing the breakdown of blood clots by blocking the interaction of plasminogen with fibrin. Mefenamic acid works by preventing the release of a chemical messenger called prostaglandin by inhibiting an enzyme called cyclooxygenase that causes fever, pain and inflammation in the body (redness and swelling). As a result, CLOSTOP SRX TABLET treatment controls and prevents severe loss of blood and pain.
Take CLOSTOP SRX TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose, frequency and duration for you depending on your age, body weight and disease condition.
Stop taking CLOSTOP SRX TABLET and contact your doctor immediately if you experience any of the following side effects:
Nausea (feeling sick) or vomiting:
Take CLOSTOP SRX TABLET with or just after meals. Stick to simple meals. Avoid eating rich or spicy food.
Headache:
Take rest and get adequate sleep and stay hydrated. Consult your doctor immediately if the symptoms persist or worsen.
Diarrhea:
Drink lots of fluids, such as water or fruit juices to keep yourself hydrated. Consult your doctor immediately if the symptom did not improve.
CLOSTOP SRX TABLET should be used with caution in pregnant women, only if recommended by your doctor. Consult your doctor before taking it.
CLOSTOP SRX TABLET should be used with caution in breastfeeding mothers, only if recommended by your doctor. Consult your doctor before taking it.
Do not drive or operate any heavy tools or machines. If you are experiencing improper vision, dizziness etc.
Avoid consuming alcohol while using CLOSTOP SRX TABLET, as it may worsen your existing condition and increases the risk of bleeding in the stomach. Consult your doctor before taking it.
CLOSTOP SRX TABLET is not recommended for use if are having severe kidney disease such as kidney failure etc. Consult your doctor before taking it.
CLOSTOP SRX TABLET should be used with caution if you are having liver disease. Consult your doctor before taking it.
Do not take CLOSTOP SRX TABLET if you are allergic to Tranexamic acid and Mefenamic acid.
CLOSTOP SRX TABLET is not recommended for use if you have:
Before taking CLOSTOP SRX TABLET, inform your physician if you have:
Use in Pediatrics:
The safety of the usage of CLOSTOP SRX TABLET in children is not known. Consult your doctor for advice.
Use in Geriatrics:
CLOSTOP SRX TABLET should be used with caution in an elderly patient. Consult your doctor before taking this medicine.
A. Drug-Drug interactions:
Before taking CLOSTOP SRX TABLET, inform your doctor if you are taking any of the following medicine.
B. Drug - Food interaction:
The possible interaction of CLOSTOP SRX TABLET with foods is not known. Consult your doctor for advice.
Overdosage:
If you or anyone else accidentally take too much of CLOSTOP SRX TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are feeling sick, vomiting, dizziness or lightheadedness, fits or seizure etc
| Drug | : | Mefenamic acid, Tranexamic acid |
| Pharmacological Category | : | Non-steroidal Anti-inflammatory Drugs (NSAIDs), Anti-fibrinolytics |
| Therapeutic Indication | : | To treat, prevent and control bleeding and relieve pain |
| Dosage Forms | : | Tablet, Capsule, Injection |
Q: Can CLOSTOP SRX TABLET be used for treating heavy menstrual bleeding?
A: Heavy menstrual bleeding is caused by several conditions, such as a fibroid in the uterus, the unusual shape of the womb, the irregular or abnormal lining of the uterus, a clotting disorder, etc. They present with bleeding and pain. CLOSTOP SRX TABLET helps to stop bleeding and relieve pain.
Q: Who is not recommended for using CLOSTOP SRX TABLET?
A: CLOSTOP SRX TABLET is not recommended for use in patients with active diseases such as severe kidney disease, fits or seizures, excessive bleeding, blood clots in blood vessels (thrombosis), etc.
Q: What to do if CLOSTOP SRX TABLET is taken in excess
A: If you or anyone else accidentally takes too much CLOSTOP SRX TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are feeling sick, vomiting, dizziness or light-headedness, stomach pain, etc.
Q: Is CLOSTOP SRX TABLET safe to use in a kidney disease patient?
A: CLOSTOP SRX TABLET should be used with caution if you have mild to moderate kidney disease. It is not recommended for use if you have severe kidney disease, such as kidney failure. Consult your doctor for advice.
Q: Is it safe to use CLOSTOP SRX TABLET while taking birth control oral contraceptive pills?
A: The use of birth control medicine such as desogestrel, estradiol, dienogest, drospirenone, etc. may interact when used with CLOSTOP SRX TABLET, which results in worsening side effects.
1. KD. Tripathi. Drugs affecting blood and blood formation. Essentials of medical pharmacology. 8th edition. 2019. Page - 672.
2. Laurence Brunton, Bruce Chabner, Bjorn Knollman. Anti-inflammatory, antipyretic and anti-analgesic agents. Goodman & Gilman’s The Pharmacological Basis of Therapeutics. 12th Edition. 2006. Page-989.
3. Damadari Bai, Purna Chandrakala. International Journal of Health Research and Medico-Legal Practice (IJHRMLP). Efficacy of Mefenamic Acid and Tranexamic Acid in the Management of Dysfunctional Uterine Bleeding. [Revised on 14th October 2016] [Accessed on 24th May 2022] http://www.ijhrmlp.org/pdfs/177.pdf
4. Waymade Plc. Tranexamic acid 500 mg tablet. [Revised on May 2018] [Accessed on 24th May 2022] https://www.waymade.co.uk/wp-content/uploads/2019/05/Tranexamic-Acid-Tablets-500-mg-Rev-May-2018.pdf
5. Rivopharm UK Ltd. Electronic medicines Compendium (EMC)Tranexamic Acid 500 mg film-coated tablets. [Revised on June 2018] [Accessed on 24th May 2022] https://www.medicines.org.uk/emc/files/pil.2359.pdf
6. Psychotropics India Ltd. Genericure. Gynae Pil Forte 500 mg/250 mg Tablet, Tranexamic Acid (500 mg), Mefenamic Acid (250 mg). [Accessed on 24th May 2022] https://www.genericure.in/gynae-pil-forte-500-mg-250-mg-tablet
7 . Alpha drug. Colinyl-t Tab, Mefenamic Acid 250 mg + Tranexamic Acid 500 mg Tablet. [Accessed on 24th May 2022] https://www.alphadrug.in/product/colinyl-t-tab
8. Wellona Pharma. Trapic MF, Mefenamic Acid 250 mg + Tranexamic Acid 500 mg Tablet. [Accessed on 24th May 2022] https://wellonapharma.com/product/finished/tranexamic-acid-and-mefenamic-tablets
Written By Dr. Dhivakaran R, BDS
Last updated on 11 Jan 2023 | 05:36 PM(IST)