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INTRODUCTION ALFUGRESS D TABLET is a combination of Alfuzosin and Dutasteride which belongs to the group of medicines called Alpha-1 adrenergic blockers and 5-Alpha reductase inhibitors respectively. ALFUGRESS D TABLET is indicated for the treatment of signs and symptoms of benign prostatic hy...
ALFUGRESS D TABLET is a combination of Alfuzosin and Dutasteride which belongs to the group of medicines called Alpha-1 adrenergic blockers and 5-Alpha reductase inhibitors respectively. ALFUGRESS D TABLET is indicated for the treatment of signs and symptoms of benign prostatic hyperplasia (BPH) in adult men with an enlarged prostate.
Benign Prostatic Hyperplasia (also known as enlarged prostate) is a non-cancerous growth of prostate gland, which is predominantly caused by excessive production of a stress hormone called dihydrotestosterone (DHT) in men. Symptoms of BPH includes urinary problems such as difficulty in passing urine, urinary incontinence (unintentional passing of urine), frequent urination at night and sexual dysfunction or painful ejaculation.
Before taking ALFUGRESS D TABLET inform your doctor if you have low blood pressure, liver, kidney or heart disease as a precaution. During treatment with ALFUGRESS D TABLET, your doctor will regularly monitor your serum prostate-specific antigen (PSA) levels to rule out risk of prostate cancer.
Women who are pregnant or think they may be pregnant should not handle the leaked medicine or be exposed to the semen of men taking ALFUGRESS D TABLET, as it could cause serious abnormalities in the growing fetus. Usage of condom during sexual intercourse is recommended among fertile men to avoid conception.
Men being treated with ALFUGRESS D TABLET should not donate blood for at least 6 months after their last dose, in order to prevent the exposure of the medicine to pregnant women via blood transfusion. ALFUGRESS D TABLET should be used with caution in elderly patients (aged 65 years or above).
The most common side effects of taking ALFUGRESS D TABLET are dizziness, fainting, weakness and decreased sex drive or breast enlargement in men. Contact your doctor if any of the side effects worsen.
ALFUGRESS D TABLET effectively reduces the symptoms of BPH, where dutasteride acts by inhibiting the activity of an enzyme called 5-alpha reductase, which is responsible for the conversion of testosterone into dihydrotestosterone (a stress hormone that causes BPH) and alfuzosin acts by relaxing the muscles surrounding the bladder and prostate by inhibiting the alpha-1 adrenergic receptors of the lower urinary tract. As a result, ALFUGRESS D TABLET helps in shrinkage of an enlarged prostate, making it easier for the urine to pass through and provide relief from symptomatic BPH.
Take ALFUGRESS D TABLET as advised by your physician. Swallow the medicine as a whole and do not crush or chew the medicine. Try to take ALFUGRESS D TABLET at the same time each day immediately after meals. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and health condition.
Stop taking ALFUGRESS D TABLET and contact your doctor immediately if you experience any of the following side effects:
Nausea:
Try to take ALFUGRESS D TABLET with or just after a meal or a snack. Stick to simple meals. Avoid eating oil rich or spicy foods. Consult your doctor if the symptom did not improve.
Diarrhea:
Drink lot of fluids such as water or fruit juices to keep yourself hydrated. Avoid taking any medicine on your own for treating diarrhea. Consult your doctor if the symptom did not improve.
Headache:
Rest and relax. Drink lot of fluids such as water or electrolytes. Apply a pain-relieving balm on the forehead if required. Do not consume too much of alcohol. Consult your doctor if the symptom did not improve.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines while you are feeling dizzy. Do not consume too much of alcohol, as it can aggravate your dizziness. Consult your doctor if the symptom did not improve.
Skin rash:
Avoid hot showers because hot water can irritate your skin further. Do not scratch the affected area. Use protective clothing when going outdoors. Regularly moisturize your skin. Consult your doctor if the symptom did not improve.
Women who are pregnant or can become pregnant should not handle the leaked medicine or be exposed to the semen of men taking ALFUGRESS D TABLET, as it could cause serious abnormalities in the growing fetus. Usage of condom during sexual intercourse is therefore recommended in such population as a precaution. Contact your doctor for advice if a pregnant woman gets accidentally exposed to ALFUGRESS D TABLET.
ALFUGRESS D TABLET is not indicated to use in breast-feeding women as it is indicated to use only in men.
Do not drive or operate any heavy tools or machines if you experience dizziness, drowsiness, sleepiness, weakness or headache after taking ALFUGRESS D TABLET.
Avoid consumption of alcohol while taking ALFUGRESS D TABLET, as it could make you feel dizzier or weaker.
ALFUGRESS D TABLET should be taken with caution in patients with severe kidney impairment. Consult your doctor before taking ALFUGRESS D TABLET.
ALFUGRESS D TABLET is not recommended for use in patients with moderate to severe liver impairment and it should be used with caution in patients with mild liver impairment. Consult your doctor before taking ALFUGRESS D TABLET.
Talk to your doctor if you are allergic to Alfuzosin or Dutasteride.
ALFUGRESS D TABLET should be taken with caution in patients with heart disease (Ex. angina, prolong QT interval). Consult your doctor before taking ALFUGRESS D TABLET.
ALFUGRESS D TABLET is not recommended for use if you:
Before taking ALFUGRESS D TABLET, inform your physician if you:
Use in pediatrics:
ALFUGRESS D TABLET is not recommended for use in children and adolescents (aged below 18 years). Consult your child’s doctor for advice.
Use in geriatrics:
ALFUGRESS D TABLET should be used with caution in elderly patients (aged 65 years or above). Consult your doctor before taking ALFUGRESS D TABLET.
A. Drug-Drug interactions:
Before taking ALFUGRESS D TABLET inform to your doctor, if you are taking any of these medicines:
Overdosage:
If you or anyone else accidentally take too much of ALFUGRESS D TABLET, contact your doctor immediately or go to a hospital straight away. Symptoms of overdosage include severe hypotension (decrease in blood pressure causing severe dizziness and fainting).
| Drug | : | Alfuzosin, Dutasteride |
| Pharmacological Category | : | Alpha-1 adrenergic blockers, 5-Alpha reductase inhibitors |
| Therapeutic Indication | : | Benign Prostatic Hyperplasia |
| Dosage Forms | : | Tablet, Capsule |
Can the use of ALFUGRESS D TABLET cause long-lasting painful penile erection?
Yes, ALFUGRESS D TABLET can rarely cause a serious condition called priapism (persistent painful penile erection unrelated to sexual activity). Stop taking ALFUGRESS D TABLET and contact your doctor immediately if you experience persistent painful erections of the penis that is unrelated to sexual activity, because this condition can lead to permanent erectile dysfunction if not treated properly.
Can the use of ALFUGRESS D TABLET cause prostate cancer?
Yes, ALFUGRESS D TABLET can increase the risk of high-grade prostate cancer in men and so your doctor would regularly monitor your serum prostate specific antigen (PSA) levels. Current clinical findings show that men taking dutasteride develops a serious form of prostate cancer more often than men who are not relied on dutasteride therapy. However, the mechanism behind the incidence of prostate cancer is not clear.
Use of ALFUGRESS D TABLET by male individuals affects pregnancy?
Before taking ALFUGRESS D TABLET, inform your doctor if you are planning to have a baby, because this medicine can be found in the semen of men taking it. Both pregnant women and women of child-bearing potential must not be exposed to ALFUGRESS D TABLET either through direct handling or through semen, because it could cause serious abnormalities to the growing fetus. Usage of condom during sexual intercourse is recommended among fertile men to avoid conception.
Can ALFUGRESS D TABLET cause infertility?
Yes, ALFUGRESS D TABLET can cause sexual impotence, decreased sex drive or difficulty in ejaculation in men because it reduces the sperm count, semen volume and sperm movement. Consult your doctor if this bothers you.
Can the use of ALFUGRESS D TABLET make me feel dizzy?
Yes, ALFUGRESS D TABLET can cause dizziness in some people. Try to rest and relax. Get enough sleep. Avoid driving or operating any machines while you are feeling dizzy. Avoid consumption of alcohol as it can aggravate your dizziness. However, if you experience severe persistent dizziness and fainting while standing up, please consult your doctor.
What to do If I forget to take ALFUGRESS D TABLET?
You should take ALFUGRESS D TABLET immediately when you remember. If it is time for your next dose skip the dose and follow your regular dose schedule. Do not double the dose to match up your missed dose.
Is ALFUGRESS D TABLET safe to use in children?
ALFUGRESS D TABLET is not recommended for use in children and adolescents (aged below 18 years). Consult your doctor before taking ALFUGRESS D TABLET. If your child experiences any symptoms of difficulty in urination consult child’s doctor immediately.
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Written By Dr. R. Dinesh John Rajkumar, Pharm.D
Last updated on 03 Nov 2022 | 12:42 PM(IST)