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INTRODUCTION ACUCLAV 1.2GM INJECTION contains Amoxicillin and Clavulanic acid, which belong to the group of medicines called Penicillins and Beta-Lactamase Inhibitors. It is used in the treatment of various bacterial infections such as respiratory tract infections (pneumonia, acute exacerbatio...
ACUCLAV 1.2GM INJECTION contains Amoxicillin and Clavulanic acid, which belong to the group of medicines called Penicillins and Beta-Lactamase Inhibitors. It is used in the treatment of various bacterial infections such as respiratory tract infections (pneumonia, acute exacerbation of chronic bronchitis), urinary tract infections (cystitis, urethritis, pyelonephritis), bone and joint infections (osteomyelitis), middle ear infections (otitis media), tonsillitis, sinusitis, skin and soft tissue infections such as cellulitis, boils, wound infections, intra-abdominal sepsis, dental infections, infections of genital organs in females.
ACUCLAV 1.2GM INJECTION is also used as prophylaxis against various bacterial infections associated with major surgeries of the heart, joints, kidney, head and neck, stomach, biliary tract, intestine and pelvic region. Along with treatment with ACUCLAV 1.2GM INJECTION your doctor might order bacterial culture tests to enhance the outcomes of the treatment.
ACUCLAV 1.2GM INJECTION is not recommended for use in patients with severe kidney impairment, who had a history of liver problems or jaundice after taking penicillin antibiotics. Consult your doctor before receiving it. ACUCLAV 1.2GM INJECTION should be used with caution in patients suffering from glandular fever (a viral infection causing sore throat, high fever, swelling of salivary glands etc.), liver disease, kidney disease, who are not passing urine daily, convulsions (fits) or large intestine inflammation.
ACUCLAV 1.2GM INJECTION is not recommended for use in pregnant women unless necessary. ACUCLAV 1.2GM INJECTION should be used with caution in breastfeeding women as it may pass through breast milk. ACUCLAV 1.2GM INJECTION should be used with caution in children as it may require dose modification. Consult your doctor before receiving ACUCLAV 1.2GM INJECTION. The most common side effects after receiving ACUCLAV 1.2GM INJECTION are diarrhoea, thrush (fungal infection), etc. Consult your doctor immediately if any of your symptoms get worse or persist.
ACUCLAV 1.2GM INJECTION helps in treating bacterial infection where Amoxicillin works by inhibiting penicillin-binding proteins (which are involved in the synthesis of the bacterial cell wall) leading to the activation of autolytic enzymes in the bacterial cell wall. Therefore, leading to lysis of the cell wall and death of the bacterial cell and Clavulanic acid inhibits the activity of bacterial enzymes known as beta-lactamases and hence enhances the antibacterial activity of amoxicillin.
ACUCLAV 1.2GM INJECTION will be given to you only by a doctor or a nurse into a vein as an intravenous infusion or intravenous injection. Your doctor will decide the exact dose and duration of treatment for you depending on your age, body weight and disease condition.
Stop receiving ACUCLAV 1.2GM INJECTION and consult your doctor immediately in case you experience:
Nausea, vomiting:
Receive the medicine, before meals. Stick to simple meals. Avoid eating oily or spicy food however, contact your doctor if nausea or vomiting gets worse or persists.
Itchy skin:
Avoid hot showers because hot water can irritate the skin and do not scratch the affected area. Apply moisturizing cream, Sunscreen and use protective clothing. Contact your doctor in case the itching gets worse or persists.
Diarrhoea:
Drink plenty of water or fruit juices to keep you hydrated. Don’t take any medicine on your own for treating diarrhoea however contact your doctor if diarrhoea gets worse or persists.
Headache:
Rest and relax. Drink plenty of water and electrolytes. Apply a pain-relieving balm on the head if required. Do not consume alcohol however, contact your doctor if your headache gets worse or persists.
ACUCLAV 1.2GM INJECTION is not recommended for use in pregnant women unless necessary. Consult your doctor before receiving ACUCLAV 1.2GM INJECTION.
ACUCLAV 1.2GM INJECTION should be used with caution in breastfeeding women as it may pass through breast milk. Consult your doctor before receiving ACUCLAV 1.2GM INJECTION.
Do not drive or operate machinery after receiving ACUCLAV 1.2GM INJECTION.
ACUCLAV 1.2GM INJECTION is not recommended for use in patients with severe kidney impairment. Consult your doctor before receiving ACUCLAV 1.2GM INJECTION.
ACUCLAV 1.2GM INJECTION should be used with caution in patients suffering from kidney problems. Consult your doctor before receiving ACUCLAV 1.2GM INJECTION.
ACUCLAV 1.2GM INJECTION is not recommended for use in patients who had a history of liver problems or jaundice after taking penicillin antibiotics. Consult your doctor before receiving ACUCLAV 1.2GM INJECTION.
ACUCLAV 1.2GM INJECTION should be used with caution in patients suffering from, liver disease. consult your doctor before receiving ACUCLAV 1.2GM INJECTION.
Do not receive ACUCLAV 1.2GM INJECTION if you are allergic to Amoxicillin, Clavulanic acid or any other ingredients in this medicine.
Before receiving ACUCLAV 1.2GM INJECTION inform your doctor if you have:
Use in paediatrics:
ACUCLAV 1.2GM INJECTION should be used with caution children as it may requires dose modification. Consult your doctor before administration of ACUCLAV 1.2GM INJECTION to your child.
Use in geriatrics:
ACUCLAV 1.2GM INJECTION should be used with caution in the elderly. Consult your doctor for advice.
A. Drug-Drug interactions:
Before receiving ACUCLAV 1.2GM INJECTION, inform your doctor if you are taking any of the following medicine:
Overdosage:
ACUCLAV 1.2GM INJECTION will be administered to you only by a doctor or a nurse in a hospital and so it is unlikely to receive an overdose. However, consult your doctor or nurse immediately if you experience any unusual symptoms. Symptoms of overdose of ACUCLAV 1.2GM INJECTION are nausea, diarrhoea, fits, upset stomach.
| Drug | : | Amoxicillin + Clavulanic acid |
| Pharmacological Category | : | Penicillins and Beta-Lactamase Inhibitors |
| Therapeutic Indication | : | Bacterial Infections |
| Dosage Forms | : | Tablets, Syrup, Oral Drops, Eye Drops, Ear Drops, Oral Suspension, Injection, Dispersible Tablet, Dry Suspension, Dry Syrup, Sachet |
What are the uses of ACUCLAV 1.2GM INJECTION?
ACUCLAV 1.2GM INJECTION is used in adults and children for the treatment of various bacterial infections such as respiratory tract infections which includes pneumonia, acute exacerbation of chronic bronchitis, urinary tract infections (cystitis, urethritis, pyelonephritis), bone and joint infections (osteomyelitis), middle ear infections (otitis media), tonsillitis, sinusitis, skin and soft tissue infections such as cellulitis, boils, wound infections, intra-abdominal sepsis, dental infections, infections of genital organs in females. ACUCLAV 1.2GM INJECTION is also used as prophylaxis against various bacterial infections associated with major surgeries of the heart, joints, kidney, head and neck, stomach, biliary tract, intestine and pelvic region.
What are the side effects of ACUCLAV 1.2GM INJECTION?
The most common side effects after receiving ACUCLAV 1.2GM INJECTION are vomiting, diarrhoea, thrush (fungal infection), etc. Consult your doctor immediately in case any of the side effects worsen.
How does ACUCLAV 1.2GM INJECTION work?
ACUCLAV 1.2GM INJECTION helps in treating bacterial infection where Amoxicillin works by inhibiting penicillin-binding proteins (which are involved in the synthesis of the bacterial cell wall), leading to the activation of autolytic enzymes in the bacterial cell wall. Therefore, leading to lysis of the cell wall and death of the bacterial cell and Clavulanic acid inhibits the activity of bacterial enzymes known as beta-lactamases, hence enhancing the antibacterial activity of amoxicillin.
Is ACUCLAV 1.2GM INJECTION safe for use in pregnant and breastfeeding women?
No, ACUCLAV 1.2GM INJECTION is not recommended for use in pregnant women unless necessary and ACUCLAV 1.2GM INJECTION should be used with caution in breastfeeding women as it may pass through breastmilk. Consult your doctor before receiving ACUCLAV 1.2GM INJECTION.
1. KD Tripathi. Antimicrobial Drugs. Essentials of Medical Pharmacology. 7th edition. 2013. Page-723, 724.
2. Justin Evans, Maryam Hannoodee, Micah Wittler. Amoxicillin Clavulanate. National Centre for Biotechnology. NLM. National Institute of Health. Statpearls. December 2021. [Accessed on 21st October 2022] https://www.ncbi.nlm.nih.gov/books/NBK538164/#article-17475.s5
3. Pharmachemie B.V. Human Products and Regulatory Authority (HPRA). [Revised in October 2021] [Accessed on 21st October 2022] https://www.hpra.ie/img/uploaded/swedocuments/8b431234-1c37-4f42-b962-f92da83d33ef.pdf
4. Antibiotice SA. Electronic Medicines Compendium (EMC). [Revised in March 2022] [Accessed on 21st October 2022] https://www.medicines.org.uk/emc/files/pil.11108.pdf
5. Fresensius Kabi Limited . Human Products and Regulatory Authority (HPRA). [Revised in March 2022] [Accessed on 21st October 2022] https://www.hpra.ie/img/uploaded/swedocuments/71865a06-c147-4ab6-8563-5db6ce566a30.pdf
6. GlaxoSmithKline Pharmaceuticals Limited. Amoxicillin + Clavulanic acid. [Revised in July 2022] [Accessed on 21st October 2022] https://india-pharma.gsk.com/media/6337/augmentin-i-v.pdf
7. Medreich Limited. Amoxicillin + Clavulanic acid. [Revised in June 2015] [Accessed on 21st October 2022] http://www.paradigmpharma.com/CMS/IMAGES/pdfuploads/1503656556_Fleming%20(Co-Amoxiclav).pdf
8. Cipla Limited. Amoxicillin + Clavulanic acid. [Revised in September 2019] [Accessed on 21st October 2022] https://www.ciplamed.com/content/advent-iv-injection
9. Augpen Injection (Amoxicillin + Clavulanic acid). Zuventus Healthcare Limited. [Accessed on 21st October 2022] http://www.zuventus.co.in/doctor_wise_products_selected.aspx?Medi_Id=65
Written By Dr. Dhivakaran R, BDS
Last updated on 14 Nov 2022 | 05:05 PM(IST)