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INTRODUCTION FOLITRAX LP GEL contains Methotrexate which belongs to the group of medicines called Antimetabolites. It is used to manage psoriasis. FOLITRAX LP GEL is also used to manage active rheumatoid arthritis in adults, which is a complex auto-immune disorde...
FOLITRAX LP GEL contains Methotrexate which belongs to the group of medicines called Antimetabolites. It is used to manage psoriasis. FOLITRAX LP GEL is also used to manage active rheumatoid arthritis in adults, which is a complex auto-immune disorder resulting in the inflammation of the bones leading to swelling and pain. This medicine may also be used for vitiligo.
Psoriasis is a skin condition characterized by itchy scales that is not responsive to conventional treatments such as phototherapy and retinoids. Vitiligo is a skin condition characterized by a loss of pigmentation, resulting in the appearance of discoloured patches on the skin.
Before using FOLITRAX LP GEL, it is recommended to inform the doctor about your medical and family history, including the list of medicines (prescription, non-prescription medicines, and herbal medicines) that are being used or taken.
FOLITRAX LP GEL is not recommended to be used by children less than 3 years of age, pregnant women, nursing women, or women planning to get pregnant. Consult your doctor before using the medicine.
It is used to manage:
FOLITRAX LP GEL contains methotrexate, which belongs to disease-modifying antirheumatic drugs (DMARDs). FOLITRAX LP GEL decreases the undesired reactions of the body’s own immune-defense mechanism, thereby working as an effective immunosuppressant. It also exhibits anti-inflammatory effects, thereby reducing pain, swelling, and redness. As a result, FOLITRAX LP GEL manages the symptoms associated with rheumatoid arthritis and psoriasis.
Always apply FOLITRAX LP GEL as directed by your physician. It is for external use only. Your doctor will decide your dose and duration of application according to your age and disease condition.
FOLITRAX LP GEL is not recommended for use if you are pregnant or are planning to become pregnant since it can be harmful to the fetus (growing baby) and lead to various malformations. Consult your doctor before applying FOLITRAX LP GEL.
FOLITRAX LP GEL is not recommended for use if you are a nursing mother. Consult your doctor before applying FOLITRAX LP GEL.
It should be used with caution if you are diagnosed with a liver disorder while using FOLITRAX LP GEL. Consult your doctor before using FOLITRAX LP GEL.
FOLITRAX LP GEL is not recommended if you are allergic to methotrexate and/or any other ingredients of this FOLITRAX LP GEL. Consult your doctor before applying FOLITRAX LP GEL.
It is recommended not to be used by children under the age of 3 years. Consult your doctor before giving FOLITRAX LP GEL to your child.
A. Drug-Drug Interactions:
Inform your doctor if you are using or taking any prescription, non-prescription medicines, ayurvedic, or herbal supplements.
Overdosage:
If you use too much of this medicine, consult your doctor immediately and visit any nearby hospital.
| Drug | : | Methotrexate |
| Pharmacological Category | : | Anti-metabolites |
| Therapeutic Indication | : | Rheumatoid Arthritis, Psoriasis |
| Dosage Forms | : | Injection, Gel, Capsule, Tablet |
A: FOLITRAX LP GEL is used to manage psoriasis. It is a skin condition characterized by itchy scales that is not responsive to conventional treatments such as phototherapy and retinoids. It is also used to manage active rheumatoid arthritis in adults, which is a complex auto-immune disorder resulting in the inflammation of the bones, leading to swelling and pain.
A: FOLITRAX LP GEL is not recommended for use in pregnant women and/or in women who are planning pregnancy because it can be harmful for the fetus (growing baby in the womb). Consult your doctor before using it.
A: FOLITRAX LP GEL is not recommended for use during breastfeeding due to a lack of safety data. Consult your doctor before applying it.
A: FOLITRAX LP GEL is not recommended for children less than 3 years of age. For children above the age of 3, it is recommended to closely monitor for side effects. It is recommended to consult a doctor before giving FOLITRAX LP GEL to your child.
1. KD. Tripathi. Antirheumatoid and Antigout Drugs, Anticancer Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page-210, 857.
2. Eskicirak, B., Zemheri, E. and Cerkezoglu, A., 2006. The treatment of psoriasis vulgaris: 1% topical methotrexate gel. International journal of dermatology. [Published in August 2006] [Accessed on 3rd February 2024] https://pubmed.ncbi.nlm.nih.gov/16911386/
3. Abdelmaksoud, A., Dave, D.D., Lotti, T. and Vestita, M., 2019. Topical methotrexate 1% gel for treatment of vitiligo: A case report and review of the literature. Dermatologic Therapy. [Published on 1st September 2019] [Accessed on 3rd February 2024] https://www.semanticscholar.org/paper/Topical-methotrexate-1-gel-for-treatment-of-A-case-Abdelmaksoud-Dave/0e38f07bfca67bdba9d7cbfe927122d0f136e134
4. DAS, S., Sharadha, M., Venkatesh, M.P., SAHOO, S., TRIPATHY, J. and Gowda, D.V., 2021. Formulation and evaluation of topical nanoemulgel of methotrexate for rheumatoid arthritis. International Journal of Applied Pharmaceutics. [Revised on 22nd June 2021] [Accessed on 3rd February 2024] https://innovareacademics.in/journals/index.php/ijap/article/view/41026/25364
5. Liver Tox: Clinical and Research Information on Drug-Induced Liver Injury [Internet]. Bethesda (MD): National Institute of Diabetes and Digestive and Kidney Diseases; 2012-. Methotrexate. [Updated on 19th February 2020] [Accessed on 3rd February 2024] https://www.ncbi.nlm.nih.gov/books/NBK548219/#:~:text=Methotrexate%20can%20lead%20to%20serious,regimens%20and%20in%20higher%20doses.
6. Drugs.com Methotrexate Pregnancy and Breastfeeding Warnings. [Updated on 8th June 2022] [Accessed on 3rd February 2024] https://www.drugs.com/pregnancy/methotrexate.html
7. Journal of the Turkish Academy of dermatology. Methotrexate in Psoriasis: From A to Z. Abdulla Saleh, Mohn’d Abuhilal, Bernard Cheung, MBChB, MRCP (UK), MSc Derm. [Published in 2010] [Accessed on 3rd February 2024] https://cms.galenos.com.tr/Uploads/Article_32345/jtad-4-0-En.pdf
8. Meth Gel. West Coast Pharmaceutical Works Ltd. [Accessed on 3rd February 2024] https://westcoastin.com/cosmetic/meth-gel/1642
Written By Dr. N. Sai Swaroop, Pharm.D
Last updated on 05 Feb 2024 | 04:24 PM(IST)