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INTRODUCTION PANGRAF 0.03% OINTMENT contains Tacrolimus which belongs to the group of medicines called Immunosuppressants. It is used to treat and prevent moderate to severe atopic dermatitis (eczema) when other conventional therapies fail to provide adequate results. Atop...
PANGRAF 0.03% OINTMENT contains Tacrolimus which belongs to the group of medicines called Immunosuppressants. It is used to treat and prevent moderate to severe atopic dermatitis (eczema) when other conventional therapies fail to provide adequate results.
Atopic dermatitis is an allergic skin condition that makes your skin itchy, red, dry and irritated. It is characterized by small, raised bumps on the skin with pus accompanied by severe skin itching, redness and inflammation.
PANGRAF 0.03% OINTMENT is suitable for use both in adults and in children (aged 2 years or older). Apply a thin layer of PANGRAF 0.03% OINTMENT on the affected skin areas. You may use your regular skin moisturizer and/or other skin lotions along with PANGRAF 0.03% OINTMENT, but make sure to apply them after 2 hours of applying PANGRAF 0.03% OINTMENT.
Do not use PANGRAF 0.03% OINTMENT for more than the stipulated duration recommended by your doctor. Regularly visit your doctor (once a year or as instructed) for reviewing your condition even if your condition remains under control.
Before using PANGRAF 0.03% OINTMENT inform your doctor if you have any other skin disease apart from eczema such as skin cancer, skin infections or lesions at the application site, any inherited skin barrier disease or generalised erythroderma (severe skin redness and scaling).
You must also inform your doctor if you have a weak immune system, liver problems or any autoimmune disease conditions. Consult your doctor before using PANGRAF 0.03% OINTMENT if you are pregnant or breastfeeding.
While undergoing therapy with PANGRAF 0.03% OINTMENT, avoid exposing your skin towards direct sunlight or towards any artificial light sources. Wear protective loose-fitting clothes and apply sunscreen while going outdoors. Also, avoid consumption of alcohol as it may make your skin look more flushed.
The most common side effects of applying PANGRAF 0.03% OINTMENT are skin irritation, burning sensation, redness or warmth at the site of application. Consult your doctor if this side effect troubles you.
It is used in adults and in children (aged 2 years or older) to treat and prevent:
PANGRAF 0.03% OINTMENT is an immunosuppressive agent. It works by blocking the release of certain chemicals in the body (such as T-cells) that cause allergic and inflammatory reactions. When applied topically, it suppresses the immune system and prevents the abnormal immune response towards allergens. This reduces skin dryness, redness, itching and inflammation associated with auto-immune skin conditions.
Apply a small amount of PANGRAF 0.03% OINTMENT into the affected skin areas or directed by the physician . It is for topical use only. Wash your hands before and after application unless your hands are also treated.
Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight and health condition. Do not stop using or overuse PANGRAF 0.03% OINTMENT without consulting your doctor.
Avoid contact of PANGRAF 0.03% OINTMENT with your eyes, mouth, ears, nose or with open wounds. Do not cover the application site with bandages, dressings or clothes.
Stop using PANGRAF 0.03% OINTMENT and contact your doctor immediately if you experience any of the following side effects such as:
Application Site Reactions:
Place an icepack on the affected skin areas to ease the irritation. Avoid using harsh chemicals or soaps on the affected areas. Wear protective loose-fitting clothes while going outdoors. Regularly moisturize your skin. Avoid exposing your skin towards direct sunlight. If the condition did not improve, contact your doctor.
PANGRAF 0.03% OINTMENT should be used in pregnant women only if considered necessary by the physician. Therefore, consult your doctor before using it.
PANGRAF 0.03% OINTMENT should be used in breastfeeding women only if considered necessary by the physician. Therefore, consult your doctor before using it.
PANGRAF 0.03% OINTMENT is unlikely to affect your ability for driving and using machinery. However, do not drive or handle any heavy tools or machines if your ability is affected by PANGRAF 0.03% OINTMENT.
Avoid consumption of alcohol while using PANGRAF 0.03% OINTMENT as it may make your skin look more flushed.
PANGRAF 0.03% OINTMENT should be used with caution in patients with liver problems (such as liver failure). Therefore, consult your doctor before using it.
Talk to your doctor before using PANGRAF 0.03% OINTMENT if you are allergic to Tacrolimus or to any macrolide antibiotics (such as erythromycin, azithromycin).
Before using PANGRAF 0.03% OINTMENT inform your doctor if you:
Use in pediatrics:
PANGRAF 0.03% OINTMENT should be used in children and adolescents (aged 2 years or older) only if prescribed by the physician. It is not recommended for use in children aged below 2 years. Therefore, consult your doctor before using it.
Use in geriatrics:
PANGRAF 0.03% OINTMENT should be used with caution in the elderly patients. Therefore, consult your doctor before taking it.
A. Drug – drug interaction:
Before using PANGRAF 0.03% OINTMENT inform your doctor if you are taking following medicines such as:
Overdosage:
If you or anyone else accidentally swallowed PANGRAF 0.03% OINTMENT, consult your doctor for advice or visit the nearby hospital.
| Drug | : | Tacrolimus |
| Pharmacological Category | : | Calcineurin Inhibitors |
| Therapeutic Indication | : | Atopic dermatitis |
| Dosage Forms | : | Capsules, Tablets, Ointment, Lotion, solution, Topical Solution, Oral gel, eye ointment |
What is the use of PANGRAF 0.03% OINTMENT?
PANGRAF 0.03% OINTMENT is used to treat and prevent moderate to severe atopic dermatitis (eczema) when other conventional therapies fail to provide adequate results.
How PANGRAF 0.03% OINTMENT works?
PANGRAF 0.03% OINTMENT is an immunosuppressive agent. It works by blocking the release of certain chemicals in the body (such as T-cells) that cause allergic and inflammatory reactions. When applied topically, it suppresses the immune system and prevents the abnormal immune response towards allergens. This reduces skin dryness, redness, itching and inflammation associated with auto-immune skin conditions.
How to use PANGRAF 0.03% OINTMENT?
Apply a small amount of PANGRAF 0.03% OINTMENT into the affected skin areas or directed by the physician . It is for topical use only. Wash your hands before and after application unless your hands are also treated.
What precautions must be followed while using PANGRAF 0.03% OINTMENT?
PANGRAF 0.03% OINTMENT is for topical use only. Avoid contact of PANGRAF 0.03% OINTMENT with your eyes, mouth, ears, nose or with open wounds. Do not cover the application site with bandages, dressings or clothes. Wash your hands before and after application. Before using PANGRAF 0.03% OINTMENT inform your doctor if you have any other skin disease apart from eczema such as skin cancer, skin infections or any inherited skin barrier disease. Consult your doctor before using PANGRAF 0.03% OINTMENT if you are pregnant or breastfeeding. Avoid exposing your skin towards direct sunlight and wear protective loose-fitting clothes and sunscreen while going outdoors.
Is PANGRAF 0.03% OINTMENT safe?
PANGRAF 0.03% OINTMENT may cause skin irritation, burning sensation, redness and warmth at the site of application. Consult your doctor if this bothers you.
What are the common side effects of using PANGRAF 0.03% OINTMENT?
The most common side effects of applying PANGRAF 0.03% OINTMENT are skin irritation, burning sensation, redness or warmth at the site of application. Consult your doctor if this side effect troubles you.
What to do if I forgot to apply PANGRAF 0.03% OINTMENT?
If you forgot to apply a dose of PANGRAF 0.03% OINTMENT, apply it as soon as you remember. However, if it is time for the next dose of PANGRAF 0.03% OINTMENT, skip the missed dose and apply the next one regularly. Do not apply a double dose of PANGRAF 0.03% OINTMENT to compensate for the missed ones.
How long will it take for PANGRAF 0.03% OINTMENT to heal my condition?
You need to apply PANGRAF 0.03% OINTMENT as long as your doctor prescribes you the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
Can I use other topical medicines while using PANGRAF 0.03% OINTMENT?
Avoid using any other topical medicines along with PANGRAF 0.03% OINTMENT without consulting your doctor.
Can PANGRAF 0.03% OINTMENT be used in pregnant women?
PANGRAF 0.03% OINTMENT should be used in pregnant women only if considered necessary by the physician. Therefore, consult your doctor before using it.
Can PANGRAF 0.03% OINTMENT be used in children?
PANGRAF 0.03% OINTMENT should be used in children and adolescents (aged between 2-18 years) only if prescribed by the physician. It is not recommended for use in children aged below 2 years. However, consult your doctor for advice.
Can I use PANGRAF 0.03% OINTMENT for psoriasis?
PANGRAF 0.03% OINTMENT is usually prescribed for the treatment of eczema. Consult your doctor for advice if you are wishing to use this medicine to treat psoriasis.
Can I use PANGRAF 0.03% OINTMENT for my 4-year-old son?
PANGRAF 0.03% OINTMENT can be used in children aged 2 years or older. However, consult your paediatrician before using them in young children.
1. KD Tripathi. Autocoids and related drugs. Essentials of Medical Pharmacology. 8th edition. 2019. Page – 940-941.
2. Mamitaro Ohtsuki, Hiroshi Morimoto and Hidemi Nakagawa. Tacrolimus ointment for the treatment of adult and pediatric atopic dermatitis: Review on safety and benefits. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. August 2018. [Accessed on 25th October 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6099320/
3. Astellas Ireland Co. Ltd. Electronic Medicines Compendium (EMC). [Revised in June 2021] [Accessed on 25th October 2022] https://www.medicines.org.uk/emc/files/pil.1612.pdf
4. Astellas Toyama Co., Ltd. U.S. Food and Drug Administration. [Revised in November 2011]. [Accessed on 26th October 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/050777s018lbl.pdf
Written By Srilekha. R, B.Pharm
Last updated on 27 Oct 2022 | 10:32 AM(IST)