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INTRODUCTION DURAJOINT 50MG CAPSULE contains Diacerein which belongs to the group of medicines called Anthraquinones. It is used for the symptomatic treatment of functional symptoms of osteoarthritis. Osteoarthritis is a common progressive disorder affecting primarily weig...
DURAJOINT 50MG CAPSULE contains Diacerein which belongs to the group of medicines called Anthraquinones. It is used for the symptomatic treatment of functional symptoms of osteoarthritis.
Osteoarthritis is a common progressive disorder affecting primarily weight bearing joints (knee, hip), characterised by progressive destruction of cartilage causing pain, limitation of motion, stiffness, deformity and disability.
Prior to the treatment, your doctor may want you to take several blood tests to understand your existing condition like liver disease.
Avoid taking alcohol with DURAJOINT 50MG CAPSULE as it may increase the risk of liver damage. DURAJOINT 50MG CAPSULE is not recommended for use in patients having liver or kidney disease, colitis or crohn’s disease, partial or complete intestinal obstruction or abdominal pain with an unknown cause.
Inform your doctor, if you have kidney or urinary problems, history of diarrhea, irritable bowel disease, rare hereditary diseases such as congenital galactosemia, glucose or galactose malabsorption syndrome or lactase deficiency.
DURAJOINT 50MG CAPSULE is not recommended for use in pregnant and breastfeeding women. Contact your doctor before taking.
DURAJOINT 50MG CAPSULE is not recommended for use in children and adolescents under 15 years of age. Contact your doctor before taking.
DURAJOINT 50MG CAPSULE should be used with caution in elderly aged above 65 years. Contact your doctor before taking.
The most common side effects of taking DURAJOINT 50MG CAPSULE are diarrhea, soft stools, pain in abdomen, frequent bowel movements, flatulence, skin rash, itching, and eczema. Contact your doctor if any of the side effects worsen.
DURAJOINT 50MG CAPSULE works by blocking the chemicals (interleukin-1) causing inflammation and destruction of cartilage in the body. It also stimulates the production of certain chemicals called transforming growth factor-β (TGF-β) which triggers chondrocyte proliferation and stimulates the production of collagen and proteoglycan, glycosaminoglycans and hyaluronic acid. Therefore DURAJOINT 50MG CAPSULE prevents the cartilage destruction and improves symptoms in patients with osteoarthritis.
Take DURAJOINT 50MG CAPSULE as advised by your physician. Swallow the medicines with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Stop taking DURAJOINT 50MG CAPSULE and contact your doctor immediately if you experience any of the following side effects:
Diarrhoea:
Drink lots of fluids, such as water or fruit juices to keep you hydrated. Do not take any medicine on your own for treating diarrhea. Contact your doctor if the symptom did not improve.
Stomach pain:
Rest and relax. Try to have smaller meals but take frequently. Keep a heat pad on your stomach. Do not self-treat and contact your doctor if the symptom did not improve.
Flatulence:
Eat smaller meals but take frequently and exercise regularly. If the symptom does not improve, contact your doctor.
Itchy skin:
Avoid hot showers because hot water can irritate the skin. Do not scratch the affected area. Use sunscreen and protective clothing when outdoors. Regularly use unscented moisturizers to soothe and hydrate the affected area. If the symptom does not improve, contact your doctor.
DURAJOINT 50MG CAPSULE is generally not recommended for use in pregnant women. Consult your doctor before taking.
DURAJOINT 50MG CAPSULE is generally not recommended for use in breastfeeding women as it is not known if this medicine passes into breast milk. Consult your doctor before taking.
Avoid consumption of alcohol while taking DURAJOINT 50MG CAPSULE as it increases the risk of liver damage.
DURAJOINT 50MG CAPSULE is not recommended for use in patients with severe kidney disease. Consult your doctor before taking.
DURAJOINT 50MG CAPSULE is not recommended for use in patients with liver disease. Consult your doctor before taking.
Do not take DURAJOINT 50MG CAPSULE if you are allergic to Diacerein or any of the other ingredients of this medicine.
DURAJOINT 50MG CAPSULE is not recommended for use if you have:
Before taking DURAJOINT 50MG CAPSULE, inform your doctor if you have:
Use in pediatrics:
DURAJOINT 50MG CAPSULE is generally not recommended for use in children and adolescents under 15 years of age. Consult your doctor before taking.
Use in geriatrics:
DURAJOINT 50MG CAPSULE is not recommended for use in elderly patients aged above 65 years. Consult your doctor before taking.
A. Drug - Drug interactions:
Before taking DURAJOINT 50MG CAPSULE, inform your doctor if you are taking any of the following medicine:
Overdosage:
If you or anyone else accidentally takes too much of DURAJOINT 50MG CAPSULE, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are diarrhea.
| Drug | : | Diacerein |
| Pharmacological Category | : | Anthraquinones |
| Therapeutic Indication | : | Osteoarthritis |
| Dosage Forms | : | Tablet, Capsule |
Is DURAJOINT 50MG CAPSULE a painkiller?
No. DURAJOINT 50MG CAPSULE belongs to a group of medicines called Anthraquinones with mild anti-inflammatory and anti-catabolic properties. Contact your doctor before taking.
What is DURAJOINT 50MG CAPSULE is used for?
DURAJOINT 50MG CAPSULE is used for the symptomatic treatment of functional symptoms of osteoarthritis.
Who should avoid taking DURAJOINT 50MG CAPSULE?
DURAJOINT 50MG CAPSULE is avoided in patients with liver or kidney disease, colitis or crohn’s disease, partial or complete intestinal obstruction or abdominal pain with an unknown cause, rapidly progressive osteoarthritis of hip, allergic to DURAJOINT 50MG CAPSULE or rhein, pregnant or lactating women, children and elderly patients. Consult your doctor before taking.
Can I take alcohol while using DURAJOINT 50MG CAPSULE?
No. Do not take alcohol with DURAJOINT 50MG CAPSULE as it may increases the risk of liver damage. Contact your doctor before taking.
What are the side effects of DURAJOINT 50MG CAPSULE?
The most common side effects of taking DURAJOINT 50MG CAPSULE are diarrhea, soft stools, pain in abdomen, frequent bowel movements, flatulence, skin rash, itching, and eczema.
How DURAJOINT 50MG CAPSULE works?
DURAJOINT 50MG CAPSULE belongs to proteoglycan synthesis stimulator which works by building cartilage (soft connective tissue around the joints) leading to joint repair. It also lowers pain and inflammation (swelling).
Does DURAJOINT 50MG CAPSULE cause liver damage?
Yes. DURAJOINT 50MG CAPSULE may increase the risk of liver injury. If you experience any unusual symptoms like tiredness, anorexia, yellowish discoloration of skin and white of eyes (jaundice), abdominal pain, nausea, vomiting, change in stool and urine colour, itchy skin. Stop taking DURAJOINT 50MG CAPSULE and immediately consult your doctor.
1. Pavelka K, Bruyere O, Cooper C, Kanis JA, Leeb BF, Maheu E, Martel-Pelletier J, Monfort J, Pelletier JP, Rizzoli R, Reginster JY. Uses and mechanism of Diacerein. National Institute of Health. National Library of Medicine. National Center for Biotechnology Information. Pubmed.gov. February 2016. [Accessed on 7th May 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4756045/
2. Solignac M. Les. Mechanism of action of Diacerein. National Institute of Health. National Library of Medicine. National Center for Biotechnology Information. Pubmed.gov. May 2004. [Accessed on 7th May 2022] https://pubmed.ncbi.nlm.nih.gov/15226683/
3. Diacerein. European Medical Agency. [Accessed on 7th May 2022] https://www.ema.europa.eu/en/documents/referral/diacerein-article-31-referral-annex-iii_en.pdf
4. Diacerein. Mims.com. [Accessed on 7th May 2022] https://www.mims.com/india/drug/info/diacerein?type=full&mtype=generic#special-precautions
5. Israel pharmaceutical products. Diacerein. [Accessed on 7th May 2022] https://mohpublic.z6.web.core.windows.net/IsraelDrugs/ArcRishum01_1_158963216.pdf
6. Trima Israel Pharmaceutical Products Ltd. Diacerein. [Accessed on 7th May 2022] https://mohpublic.z6.web.core.windows.net/IsraelDrugs/ArcRishum01_6_164528016.pdf
7. Wellona pharma. Diacerein. [Accessed on 7th May 2022] https://wellonapharma.com/product/finished/diacerein-capsules
8. Diacerein. CDSCO. [Accessed on 6th May 2022] https://cdscoonline.gov.in/CDSCO/Drugs
Written By Dr. Janet.C, Pharm.D
Last updated on 30 Nov 2022 | 12:46 PM(IST)