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INTRODUCTION DM LEF 10 TABLET contains Leflunomide which belongs to the group of medicines called Anti-rheumatics. It is indicated in adults for the treatment of active rheumatoid arthritis. Rheumatoid arthritis is an auto-immune chronic inflammatory disorder which affects many joints includin...
DM LEF 10 TABLET contains Leflunomide which belongs to the group of medicines called Anti-rheumatics. It is indicated in adults for the treatment of active rheumatoid arthritis. Rheumatoid arthritis is an auto-immune chronic inflammatory disorder which affects many joints including those in the hands and feet. Symptoms include inflammation of joints, swelling, difficulty moving and pain, loss of appetite, fever, loss of energy and anaemia (lack of red blood cells).
DM LEF 10 TABLET is also used in adults to treat active psoriatic arthritis. Active psoriatic arthritis refers to a condition where psoriasis, a skin condition is present along with arthritis. Symptoms include inflammation of joints, swelling, difficulty in moving, pain and patches of red and scaly skin (skin lesions).
Before starting treatment with DM LEF 10 TABLET, your doctor might ask you to take a few blood tests to understand the existing condition and to use this medicine safely.
DM LEF 10 TABLET is not recommended for use in patients having liver or moderate to severe kidney disease, any problem which affects the immune system (like AIDS), bone marrow problems, serious infections, severely low levels of proteins in the blood (hypoproteinaemia) and reduced levels of white or red blood cells and platelet count.
DM LEF 10 TABLET should be used with caution in patients who have interstitial lung disease, tuberculosis and if you are a male who wishes to father a child and chronic diarrhoea. Avoid consumption of alcohol during treatment with this medicine as it may increase the risk of liver damage.
DM LEF 10 TABLET is not recommended for use in pregnant women or women who become pregnant during treatment with this medicine and it is not recommended for use in breastfeeding women. DM LEF 10 TABLET is not recommended for use in children and adolescents (below 18 years of age).
The most common side effects of taking DM LEF 10 TABLET are loss of appetite, tiredness, headache, dizziness, diarrhoea, nausea, vomiting, inflammation of the mouth or mouth ulcers, abdominal pain and increased hair loss. Consult your doctor if any of the side effects worsen.
Treats,
DM LEF 10 TABLET acts by inhibiting an enzyme which results in stopping the activated and autoimmune white blood cells. This inhibition leads to anti-inflammatory and immunomodulatory effects, reducing inflammation due to arthritis.
Take DM LEF 10 TABLET as advised by your doctor. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Stop taking DM LEF 10 TABLET and contact your doctor immediately if you experience any of the following side effects:
Nausea or vomiting:
Stick to simple meals while taking this medicine. Avoid eating oily rich, fried or spicy foods. Do not lie down or sleep immediately after eating. Consult your doctor if the symptom does not improve.
Diarrhoea:
Drink lot of fluids, such as water to keep yourself hydrated. Avoid eating high-fat or spicy foods. Try to avoid taking any medicine on your own to treat diarrhoea and consult your doctor if the symptom gets worse.
Stomach pain:
Try to rest and relax. Eat and drink slowly or try to have smaller meals more frequently. Keep a heating pad on your stomach. If the symptom does not improve, consult your doctor.
Headache:
Drink ample amount of water and avoid skipping meals. Get adequate rest. Try to be relaxed and stress-free. Apply pain relieving balm on your forehead if necessary. Consult your doctor if the symptom does not improve.
Loss of appetite:
Eat when you feel hungry. Eat smaller meals frequently than usual. Snack only when you're hungry. Eat a nutritious snack which is rich in calories and protein, such as dried fruits and nuts. Consult your doctor if the symptom does not improve.
DM LEF 10 TABLET is not recommended for use in pregnant women or women who become pregnant during treatment with this medicine, as it may increase the risk of serious birth defects in the baby. Women of childbearing potential should not take DM LEF 10 TABLET without using reliable contraceptive measures. If you plan to become pregnant after stopping treatment with this medicine and it is necessary to ensure that all traces of the medicine have left your body, this may take up to 2 years. Consult your doctor before taking DM LEF 10 TABLET.
DM LEF 10 TABLET is not recommended for use in breastfeeding women as it passes through the breast milk. Consult your doctor before taking DM LEF 10 TABLET.
Do not drive or operate any machines if you feel dizzy after taking DM LEF 10 TABLET.
Avoid consumption of alcohol while taking DM LEF 10 TABLET as it may increase the chances of liver damage.
DM LEF 10 TABLET is not recommended for use in patients with moderate to severe kidney problems. Consult your doctor before taking DM LEF 10 TABLET.
DM LEF 10 TABLET is not recommended for use in patients with any liver problems. Consult your doctor before taking DM LEF 10 TABLET.
Do not take DM LEF 10 TABLET if you are allergic to Leflunomide or any other ingredients of this medicine.
DM LEF 10 TABLET should be used with caution in patients who have suffered with interstitial lung disease or if you ever had tuberculosis. Consult your doctor before taking DM LEF 10 TABLET.
DM LEF 10 TABLET is not recommended for use if you:
Before taking DM LEF 10 TABLET, inform your doctor if you:
Use in paediatrics:
DM LEF 10 TABLET is not recommended for use in children and adolescents (below 18 years of age). Consult your child’s doctor for advice.
A. Drug – Drug Interactions:
Before taking DM LEF 10 TABLET, inform your doctor if you are taking any of the following medicines:
Overdosage:
If you or anyone else accidentally takes too much of DM LEF 10 TABLET, consult your doctor immediately or visit the nearby hospital.
| Drug | : | Leflunomide |
| Pharmacological Category | : | Disease-Modifying Antirheumatic Drug (DMARD) |
| Therapeutic Indication | : | Rheumatoid Arthritis, Active psoriatic arthritis |
| Dosage Forms | : | Tablet |
What is DM LEF 10 TABLET and why is it given?
DM LEF 10 TABLET contains leflunomide which belongs to the group of medicines called Anti-rheumatic medicines. It is used to treat active rheumatoid arthritis and active psoriatic arthritis. Consult your doctor before taking DM LEF 10 TABLET.
What type of drug is DM LEF 10 TABLET?
DM LEF 10 TABLET has leflunomide as the active agent which is a disease-modifying antirheumatic drug (DMARDs). It acts by slowing the progression of the condition and decreasing the inflammation which aids in improving the physical activity of the people affected with rheumatoid arthritis.
Can DM LEF 10 TABLET be taken by pregnant women?
DM LEF 10 TABLET is not recommended for use in pregnant women or women who become pregnant during treatment with this medicine, as it may increase the risk of serious birth defects in the baby. Women of childbearing potential should not take DM LEF 10 TABLET without using reliable contraceptive measures. If you plan to become pregnant after stopping treatment with this medicine and it is necessary to ensure that all traces of the medicine have left your body, this may take up to 2 years. Consult your doctor before taking DM LEF 10 TABLET.
Does DM LEF 10 TABLET affects the liver?
DM LEF 10 TABLET is not recommended for use in patients who have liver diseases. Inform your doctor if you notice any signs of liver injury (which includes itching, yellowing of eyes or skin, loss of appetite, dark urine or light-coloured stools). Your doctor may monitor your liver function test before and during treatment with DM LEF 10 TABLET to prevent the risk of liver damage. Consult your doctor before taking DM LEF 10 TABLET.
Does DM LEF 10 TABLET has any effect on male fertility?
DM LEF 10 TABLET should be used with caution in a male who wishes to father a child because it may pass into the semen. Effective contraception must be exercised while on the course of DM LEF 10 TABLET. If you wish to father a child and you are taking DM LEF 10 TABLET, ask for your doctor’s advice as he may advise you to stop taking this medicine and take certain medications to remove this medicine rapidly from the body. Consult your doctor for advice.
1. KD. Tripathi. Autacoids and Related Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 212.
2. Inderbir S. Padda; Amandeep Goyal. Leflunomide. NIH National Library of Medicine, National center for biotechnology information. Bookshelf. [Revised in May 2022] [Accessed on 17th June 2022] https://www.ncbi.nlm.nih.gov/books/NBK557799/
3. Muhammad Ishaq, Salma Razzaque, Fadieleh Shohail, Ajeet Kumar, Jibran Sualeh Muhammad. Onset of Hypertension in Leflunamide Treated Low Socioeconomic Rheumatoid Arthritis Patients: An Unseen Iceberg. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. 2019. [Accessed on 17th June 2022] https://pubmed.ncbi.nlm.nih.gov/29283072/
4. Pharmathen SA. Electronic Medicines Compendium (EMC). [Revised in February 2021] [Accessed on 17th June 2022] https://www.medicines.org.uk/emc/files/pil.5399.pdf
Written By Dr. R. Dinesh John Rajkumar, Pharm.D
Last updated on 27 Sep 2022 | 10:47 AM(IST)