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INTRODUCTION DIXIN contains Digoxin which belongs to the group of medicine called cardiac glycosides. It is indicated for the treatment of arrhythmias and heart failure. An arrhythmia is a heart rhythm disorder characterized by abnormal generation and conduction of cardiac impulses leading to...
DIXIN contains Digoxin which belongs to the group of medicine called cardiac glycosides. It is indicated for the treatment of arrhythmias and heart failure. An arrhythmia is a heart rhythm disorder characterized by abnormal generation and conduction of cardiac impulses leading to an irregular heartbeat. As a result, the heart beats at a wrong speed which causes chest pain, fluttering in the heart, fainting or dizziness. Heart failure is a chronic condition in which the heart does not pump adequate amount of blood required for the circulation. Symptoms includes fatigue, difficulty in breathing, shortness of breath, swollen legs and fast heartbeat.
Digoxin works by correcting the abnormal heart rhythm into a normal rhythm. It also improves cardiac contractility and ejection fraction which makes the heart pump more efficiently and increases blood circulation throughout the body. While taking this medicine, your doctor would periodically monitor your kidneys and concentration of digoxin in blood to avoid unwanted side effects. The most common side effects of taking this medicine are nausea, vomiting, palpitation, dizziness or blurred vision. Contact your doctor if any of the symptoms bothers you.
Before taking this medicine, inform your doctor if you have any heart disease apart from arrhythmia and heart failure. This medicine should be used with caution in patients having lung or kidney disease. If you are pregnant, or think you may be pregnant or breastfeeding, consult your doctor before taking this medicine. Your doctor would select an appropriate dose for you depending upon your condition.
Digoxin directly stimulates the parasympathetic nervous system through vagus nerve and slows the electrical conduction in the AV (atrioventricular) node, thus decreasing the heart rate. It also increases cardiac contractility by reversibly inhibiting the activity of an enzyme called Na-K ATPase pump (sodium-pump) which is responsible for controlling the movement of ions into the heart. This increases the influx of sodium and calcium in the myocardial cells, leading to an increase in the force of contraction, thus making the heart pump more efficiently.
This medicine will be given to you only by a doctor or a nurse into the vein as an intravenous infusion over a period of 10-20 minutes. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and health condition. Continue to take this medicine, as long as your doctor tells you to do so, to obtain better results.
Nausea or vomiting:
Stick to simple meals. Do not eat rich or spicy food.
Diarrhea:
Drink lots of fluids, such as water or juice, to avoid dehydration. Do not take any medicines without speaking to a doctor.
Skin rash:
Avoid hot showers because hot water can irritate the skin. Do not rub or scratch the affected area. Use sunscreen and protective clothing when outdoors. Regularly use moisturizers to soothe and hydrate the affected area. If the symptom persists, contact your doctor.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid traveling, driving or operating any tools or machines while you are feeling dizzy. If the symptom persists, contact your doctor for advice.
DIXIN should be used with caution in pregnant women. Consult your doctor before taking.
DIXIN should be used with caution in breastfeeding women. Consult your doctor before taking.
Do not drive or operate any machines while taking this medicine because it may cause dizziness or blurred vision.
Avoid consumption of alcohol while taking this medicine.
DIXIN should be taken with caution in patients with kidney problems. Consult your doctor for advice before taking.
Do not take this medicine if you are allergic to digoxin or other cardiac glycosides.
DIXIN should be taken with caution in patients with severe respiratory (lung) disease. Consult your doctor for advice before taking.
Before taking DIXIN, inform your doctor if you:
Talk to your doctor, if you are taking,
| Drug | : | Digoxin |
| Pharmacological Category | : | Cardiac glycosides, Antiarrhythmic agent |
| Therapeutic Indication | : | Arrhythmia, Heart failure |
| Dosage Forms | : | Tablet |
Store below 20-25°C and keep out of reach of children.
Can DIXIN and metoprolol be taken together?
No. Avoid concomitant use of this medicine with beta-blocker (e.g. atenolol, metoprolol) because it may increase the risk of irregular heartbeat.
Can you stop taking DIXIN abruptly?
No. Do not stop taking this medicine abruptly without consulting your doctor, because it may worsen your existing condition.
Can I drink alcohol while taking DIXIN?
No. Avoid consumption of alcohol while taking this medicine.
Is DIXIN a steroid?
No. This medicine is not a steroid. It is a cardiac glycoside used to treat arrhythmia (abnormal heartbeat) and heart failure.
1. KD. Tripathi. Cardiac Glycosides and Drugs for Heart Failure. Essentials of medical pharmacology. Seventh edition. 2013. Page – 512-519.
2. Kevin J. Sampson and Robert S. Kass. Anti-Arrhythmic Drugs. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 837-839.
3. Gerald G. Briggs and Roger K. Freeman. D. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 1172-1174.
4. National Heart, Lung, and Blood Institute (NHLBI). Digitalis Investigation Group (DIG). NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on July 2016] [Accessed 30th January 2021] https://clinicaltrials.gov/ct2/show/NCT00000476
5. R A Kelly and T W Smith. Digoxin in heart failure: implications of recent trials. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. October 1993. [Accessed 30th January 2021] https://pubmed.ncbi.nlm.nih.gov/8376681/
6. Sebastiano Virgadamo, Richard Charnigo, Yousef Darrat, Gustavo Morales and Claude S Elayi. Digoxin: A systematic review in atrial fibrillation, congestive heart failure and post myocardial infarction. NCBI; PMC US National Library of Medicine, National Institute of Health. November 2015. [Accessed 30th January 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4660476/
7. GlaxoSmithKline Manufacturing S.p.A. Electronic Medicines Compendium (EMC); [Revised on December 2019] [Accessed 30th January 2021] https://www.medicines.org.uk/emc/files/pil.5462.pdf
8. DSM Pharmaceuticals, Inc. U.S. Food & Drug Administration. November 2019. [Accessed 30th January 2021] https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/009330s026lbl.pdf