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INTRODUCTION CYPZEST SYRUP is a combination of Cyproheptadine and Tricholine Citrate, which belong to the groups of medicines called antihistamines and bile acid-binding agents, respectively. It is used to treat loss of appetite, weight loss and anorexia nervosa (an eating disorder). It is als...
CYPZEST SYRUP is a combination of Cyproheptadine and Tricholine Citrate, which belong to the groups of medicines called antihistamines and bile acid-binding agents, respectively. It is used to treat loss of appetite, weight loss and anorexia nervosa (an eating disorder). It is also used to treat weight gain in anti-tubercular and antiretroviral regimens.
In children, it is used for gaining weight, having an inadequate dietary intake or loss of appetite or suffering from anaemia, liver disease or digestive disorders. It is also used to treat allergic rhinitis and conjunctivitis, migraine, asthma and hepatic disorders. Appetite loss is a state in which an individual has no desire to eat food, which leads to a deficiency of essential and non-essential nutrients that are required for the proper metabolism and growth of the body.
CYPZEST SYRUP is not recommended for use in patients who have or had angle-closure glaucoma, stenosing peptic ulcer, symptomatic prostatic hypertrophy, bladder neck obstruction or pyloroduodenal obstruction. Alcohol should be avoided during CYPZEST SYRUP treatment because it may increase the CYPZEST SYRUP's action.
Before taking this medicine, tell your physician if you have a history of bronchial asthma, increased intraocular pressure, hyperthyroidism, cardiovascular disease, liver problems, kidney problems or hypertension. CYPZEST SYRUP is not recommended for use by pregnant or breastfeeding women. It should be recommended for use in children and adolescents (below 18 years of age).
The most common side effects of taking this medicine are drowsiness, dizziness, insomnia, blurred vision, loss of coordination, skin rash, gastrointestinal upset, nausea or vomiting. Contact your physician if the symptoms worsen.
CYPZEST SYRUP is used to treat the following:
CYPZEST SYRUP contain Cyproheptadine and Tricholine Citrate, where Cyproheptadine prevents weight loss by reducing the effect of serotonin (a chemical messenger) in the hypothalamus that helps in regulating appetite and Tricholine Citrate is a bile acid-binding agent that works by removing the bile acids from the body, which results in the liver using cholesterol, leading to more production of bile acids, which causes a decreased cholesterol level in the body, resulting in weight gain.
Take CYPZEST SYRUP as advised by your physician. Shake well before use. Your physician will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Stop taking CYPZEST SYRUP and contact your physician immediately if you experience any of the following side effects:
Dizziness:
Try to rest and get enough sleep. Try to avoid driving or operating any tools or machines while you feel dizzy. Limit your consumption of alcohol, as it can aggravate dizziness. Consult and inform your doctor if the symptom worsens.
Nausea or vomiting:
Take this medicine with meals or just after meals. Stick to simple meals. Avoid eating rich or spicy foods.
Constipation:
Try to eat high-fiber foods such as vegetables, cereals and fresh fruit and drink plenty of water. Engage in regular exercise (going for a daily walk or run) and if this does not help, consult and inform your doctor about receiving alternate treatments for constipation.
Dry mouth:
Try to drink plenty of cold water and sip on cold unsweetened drinks and use lip balm if your lips are dry. Brush your teeth twice a day and try to use mouthwash. Consult and inform your doctor if the symptom worsens.
CYPZEST SYRUP is not recommended for use in pregnant women. Consult your physician for advice.
CYPZEST SYRUP is not recommended for use in breastfeeding women. Consult your physician for advice.
Do not drive or operate any machines if you feel dizziness or drowsiness after taking CYPZEST SYRUP.
Avoid consumption of alcohol while taking CYPZEST SYRUP since it may increase the risk of stomach problems.
CYPZEST SYRUP should be used with caution if you have any kidney disease such as renal failure. Consult your physician for advice.
CYPZEST SYRUP should be used with caution in patients with liver problems such as liver impairment. If you have any liver problems. Consult your physician for advice.
Talk to your physician if you are allergic to Cyproheptadine, Tricholine citrate or any of the other ingredients in this medicine.
CYPZEST SYRUP should be used with caution in patients with a history of bronchial asthma. Consult your doctor before taking CYPZEST SYRUP.
CYPZEST SYRUP should be used with caution in patients with cardiovascular disease. Consult your physician for advice.
CYPZEST SYRUP is not recommended for use if you:
Before taking CYPZEST SYRUP, inform your doctor if you:
Use in Pediatrics:
CYPZEST SYRUP is recommended for use in children and adolescents (below 18 years of age). Consult your physician before taking it.
Use in Geriatrics:
CYPZEST SYRUP is generally not recommended for use in elderly patients unless it is indicated necessary for use. Consult your physician before taking.
A. Drug-Drug interactions:
Before taking CYPZEST SYRUP, inform your doctor, if you are taking any of the following medicine:
Overdosage:
If you or anyone else accidentally took too much of this medicine, consult your physician immediately. The symptoms of overdosage are hallucinations, depression and fits.
| Drug | : | Cyproheptadine, Tricholine Citrate |
| Pharmacological Category | : | Antihistamine, Bile acid-binding agent |
| Therapeutic Indication | : |
Loss of appetite, weight loss, anorexia nervosa, adjunct to anti-tubercular and antiretroviral regimens for weight gain, allergic rhinitis and conjunctivitis, migraine, asthma and hepatic disorders, in children suffering from anemia, liver or digestive disorder |
| Dosage Forms | : | Drops, Syrup, Liquid |
Is it safe to consume alcohol along with CYPZEST SYRUP?
Avoid consuming alcohol while taking CYPZEST SYRUP as it has additive effects and may increase the risk of stomach problems. Consult your physician before taking it.
Does CYPZEST SYRUP cause dry mouth?
The most common side effect of CYPZEST SYRUP is dry mouth. When dry mouth occurs, try to manage it by drinking plenty of cold water, sipping on cold unsweetened drinks and using lip balm if lips are dry. Brush your teeth twice a day and try to use mouthwash. If the symptoms do not improve or get worse, consult your doctor immediately.
Can I use CYPZEST SYRUP with children?
CYPZEST SYRUP can be given to children and adolescents (below 18 years of age) if prescribed by the physician. The dose may vary depending on the child’s age, body weight and disease condition.
Can I take CYPZEST SYRUP along with antidepressants?
No, CYPZEST SYRUP should not be taken along with antidepressants, especially monoamine oxidase inhibitors (MAOI), as it may prolong and increase the effects of CYPZEST SYRUP. Consult your physician before taking CYPZEST SYRUP with other medicines to avoid unpleasant side effects.
Can I drive after taking CYPZEST SYRUP?
Avoid driving and do not operate any machine after taking CYPZEST SYRUP because CYPZEST SYRUP may cause drowsiness and dizziness. Patients should be warned about engaging in activities requiring mental alertness and motor coordination. So, please consult your physician before taking CYPZEST SYRUP.
1. KD Tripathi. 5-Hydroxytryptamine, its Antagonists and Drug Therapy of Migraine. Essentials of medical pharmacology. 7th edition. 2013. Page – 174.
2. Randal A. Skidgel. Histamine, Bradykinin and Their Antagonists. Goodman & Gilman’s The Pharmacological basics of Therapeutics. 13th Edition. New York McGraw Hill Medical 2018. Page – 711-726.
3. Mayuresh Dilip Kiran, Shaheen Naseem Sheikh, Lalit Jeevan Pawaskar. Safety and Efficacy of a Combination of Cyproheptadine and Tricholine Citrate: Phase IV Study. Annals of International Medical and Dental Research. December 2017. [Accessed on 17th June 2022] https://www.readcube.com/articles/10.21276%2Faimdr.2018.4.2.pe1
4. Khadijehsadat Najib, MD, Mozhgan Moghtaderi, MD, Zohreh Karamizadeh, MD and Ebrahim Fallahzadeh, MD. Beneficial Effect of Cyproheptadine on Body Mass Index in Undernourished Children: A Randomized Controlled Trial. Iranian Journal of Pediatrics. December 2014. [Accessed on 17th June 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4442838/
5. Centaur Pharmaceutical Pvt. Ltd. Oraxin syrup and drop. [Revised on January 2021] [Accessed on 17th June 2022] https://www.centaurpharma.com/downloads/2021/pediatrics/nutritional-and-vitamins/Oraxin%20syrup%20and%20drop.pdf
6. Alaina Pharma. Cyproheptadine and Tricholine citrate syrup. [Accessed on 17th June 2022] http://alainapharma.com/Cyproheptadine%20and%20Tricholine%20Citrate%20Syrup.html
Written By Dr. Dhivakaran R, BDS
Last updated on 10 Dec 2022 | 02:52 PM(IST)