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INTRODUCTION APRESOL PLUS TABLET is a combination of Hydralazine and Isosorbide dinitrate which belongs to the group of medicines called Vasodilators. It is used to treat heart failure along with standard therapy in patients to improve survival, delay hospitalization for heart failure and to i...
APRESOL PLUS TABLET is a combination of Hydralazine and Isosorbide dinitrate which belongs to the group of medicines called Vasodilators. It is used to treat heart failure along with standard therapy in patients to improve survival, delay hospitalization for heart failure and to improve patient-reported functional status.
Heart failure is defined as a progressive clinical disorder where your heart is unable to pump sufficient blood to meet the body’s metabolic needs, characterized by shortness of breath and extreme tiredness.
During course of the treatment your doctor might regularly monitor your blood pressure to avoid any untoward side effects. The safety and effectiveness of APRESOL PLUS TABLET in children have not been established.
Before taking APRESOL PLUS TABLET, inform your doctor if you have any kidney, heart, lung or liver problems, too much sweating, fluid loss, vomiting or diarrhea or if you consume alcohol.
APRESOL PLUS TABLET is not studied in pregnant and breastfeeding women, so consult your doctor before taking it. The most common side effects of taking APRESOL PLUS TABLET are headache and dizziness. Consult your doctor if any of the side effects worsen.
APRESOL PLUS TABLET helps in the treatment of heart failure, where hydralazine relaxes the smooth muscles of arteries and isosorbide dinitrate acts by releasing nitric oxide and subsequently activating guanylyl cyclase and ultimately relaxes smooth muscles of both arteries and veins.
Take APRESOL PLUS TABLET as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Stop taking APRESOL PLUS TABLET and consult your doctor immediately if you experience any of the following side effects:
Headache:
Drink ample amount of water. Get adequate rest. Try to be relaxed and stress free. Ask your doctor before taking any medicine for headache.
Dizziness:
When you start taking APRESOL PLUS TABLET, you may feel dizzy. If this happens, resting or lying down for some time can help. Rise slowly after sitting or lying down. Be careful while going up and down stairs. Consult your doctor if you experience persistent dizziness.
APRESOL PLUS TABLET is not studied in pregnant women. Consult your doctor before taking it.
APRESOL PLUS TABLET is not studied in breastfeeding women. Consult your doctor before taking this medicine as it is not known if it passes into breast milk.
Do not drive or use any machines until you see how APRESOL PLUS TABLET affects you.
Avoid consumption of alcohol during treatment with APRESOL PLUS TABLET as it may increase the risk of vasodilating effects of this medicine.
APRESOL PLUS TABLET is not studied in patients with kidney impairment. Consult your doctor before taking it.
APRESOL PLUS TABLET is not studied in patients with liver impairment. Consult your doctor before taking it.
Do not take APRESOL PLUS TABLET if you are allergic to Hydralazine or Isosorbide dinitrate.
APRESOL PLUS TABLET should be used with caution in patients with hypertrophic cardiomyopathy. Consult your doctor before taking it.
Before taking APRESOL PLUS TABLET, inform your doctor if you:
Use in pediatrics:
Safety and effectiveness of APRESOL PLUS TABLET in children and adolescents (aged less than 18 years) have not been established. Consult your child’s doctor for advice.
Use in geriatrics:
APRESOL PLUS TABLET should be used with caution in elderly patients. Consult your doctor before taking it.
A. Drug - Drug interactions:
Before taking APRESOL PLUS TABLET, inform your doctor if you are taking any of the following medicines:
Overdosage:
If you or anyone else accidentally took too much of APRESOL PLUS TABLET, contact your doctor immediately. Symptoms of overdose include headache, confusion, fast heartbeat, generalized skin flushing, reduced cardiac output, low blood pressure, irregular heartbeat and shock.
| Drug | : | Hydralazine, Isosorbide dinitrate |
| Pharmacological Category | : | Vasodilators |
| Therapeutic Indication | : | As adjunct to standard treatment in heart failure |
| Dosage Forms | : | Tablet |
Q: What do I need to inform my doctor before taking APRESOL PLUS TABLET?
A: Before taking APRESOL PLUS TABLET, inform your doctor about all the medicines that you are taking (prescription or OTC, herbal products, vitamins) and your health problems. This is necessary to make sure that it is safe for you to take this medicine with all your other medicines and health problems. Do not start, stop or change the dose of any medicine without consulting your doctor.
Q: How does APRESOL PLUS TABLET work?
A: APRESOL PLUS TABLET helps in the treatment of heart failure, where hydralazine relaxes the smooth muscles of arteries and isosorbide dinitrate acts by releasing nitric oxide and subsequently activating guanylyl cyclase and ultimately relaxes smooth muscles of both arteries and veins.
Q: Can APRESOL PLUS TABLET make me feel dizzy?
A: APRESOL PLUS TABLET may cause a drop in your blood pressure that may make you feel dizzy. If this happens, resting or lying down for some time can help. Rise slowly after sitting or lying down. Be careful while going up and down stairs. Consult your doctor if you experience persistent dizziness.
Q: Does APRESOL PLUS TABLET cause headache?
A: Yes, headache is a side effect of APRESOL PLUS TABLET. Drink ample amount of water. Get adequate rest. Try to be relaxed and stress free. Ask your doctor before taking any medicine for headache.
Q: Can APRESOL PLUS TABLET be used in children?
A: The safety and effectiveness of APRESOL PLUS TABLET in children and adolescents (aged less than 18 years) have not been established. Your child’s doctor will select a suitable alternative therapy for your child to treat the condition.
1. Barbara G. Wells, Joseph T. DiPiro, Terry L. Shwinghammer, Cecily V. DiPiro. Heart Failure. Pharmacotherapy Handbook. Ninth edition. Page- 75
2. Anne L Taylor, Susan Ziesche, Clyde Yancy, Peter Carson, Ralph D'Agostino Jr, Keith Ferdinand, Malcolm Taylor, Kirkwood Adams, Michael Sabolinski, Manuel Worcel, Jay N Cohn; African-American Heart Failure Trial Investigators. Combination of isosorbide dinitrate and hydralazine in blacks with heart failure. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. November 2004. [Accessed on 30th May 2022] https://pubmed.ncbi.nlm.nih.gov/15533851/
3. Arbor Pharmaceuticals. LLC. U.S. Food & Drug Administration. [Revised in April 2015] [Accessed on 30th May 2022] https://www.accessdata.fda.gov/drugsatfda_docs/label/2015/020727s005lbl.pdf
4. Memorial Sloan Kettering Cancer Centre. Hydralazine + Isosorbide dinitrate. [Revised in September 2020] [Accessed on 30th May 2022] https://www.mskcc.org/pdf/cancer-care/patient-education/isosorbide-dinitrate-and-hydralazine
Written By Dr. R. Dinesh John Rajkumar, Pharm.D
Last updated on 19 Jan 2023 | 05:49 PM(IST)