INTRODUCTION

COGNISTAR 30MG contains Cerebroprotein Hydrolysate which belongs to the group of medicines called Neurotrophic agents. It is used to treat cranial injury (trauma to scalp, skull, and/or brain), inability to sustain concentration in dementia (group of disease or illness that affects your ability to think, memorize and reason), cerebrovascular disease that includes stroke (brain damage due to interruption of blood flow), and alzheimer's disease (progressive neurologic disorder that causes brain to shrink and brain cells to die).

Cerebroprotein hydrolysate is a neurotrophic agent which works by protecting the nerve cells from toxins and lack of oxygen thus improving its survival rate. It also helps in the formation of new nerve cells by increasing nutrition supply to the brain cells and reducing the inflammatory reaction of the brain tissues which results in preventing damage to the brain cells.

COGNISTAR 30MG is not recommended for use in patients with severe kidney dysfunction, status epilepticus (life threatening neurological disorder), and or major epilepsia (seizure that causes loss of consciousness). It should be used with caution in patients with epilepsy (fits or seizures) and or allergic diathesis (condition that causes group of allergic reaction such as hay fever, allergic rhinitis, bronchial asthma, or atopic dermatitis).

COGNISTAR 30MG should be used with caution in pregnant and breastfeeding women only if it is clearly advised by your doctor. It should be used with caution in elderly patients (above 65 years). Consult your doctor before receiving. The common side effects associated with the use of COGNISTAR 30MG are headache, nausea, vertigo (sensation of spinning), increased sweating, agitation, fever, and hallucinations. Inform your doctor if any of the symptom worsens.

USES OF COGNISTAR 30MG

It is used to treat:

• cranial injury (head injury)
• cerebrovascular disease that includes stroke (lack of blood supply in the brain)
• aprosexia (inability to concentrate) in dementia
• alzheimer’s disease (disease caused due to degeneration of brain cells)

HOW COGNISTAR 30MG WORKS

COGNISTAR 30MG helps in restoring brain functions, where cerebroprotein hydrolysate works by protecting the nerve cells from toxins and lack of oxygen thus improving its survival rate. It also helps in the formation of new nerve cells by increasing nutrition supply to the brain cells and reducing the inflammatory reaction on the brain tissues which results in preventing damage to the brain cells.

DIRECTIONS FOR USE

COGNISTAR 30MG will be given to you only by a doctor or a nurse into the vein. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

SIDE EFFECTS OF COGNISTAR 30MG

HOW TO MANAGE SIDE EFFECTS

Headache:

Take rest and drink plenty of water. Do not strain your eyes by watching screen for long time. Inform your doctor if the condition persists for long or gets worsened.

Diarrhoea:

Drink lot of fluids, such as water to keep yourself hydrated, consult your doctor if the symptom gets worse.

Constipation:

Try to eat more high-fibre foods such as fresh fruit, vegetables, cereals, and drink plenty of water. If this does not help, inform your doctor for receiving alternate treatments for constipation.

Nausea and vomiting:

Eat light and bland foods. Avoid eating foods which are hard to digest and eat less when you feel nauseated. Drink clear or ice-cold drinks. Rest after eating with the head elevated. Consult your doctor if the symptom gets worse.

WARNING & PRECAUTIONS

INTERACTIONS

A. Drug-Drug Interactions

Before receiving COGNISTAR 30MG, inform your doctor, if you are taking any of the following medicine:

• medicines used to treat depression such as mono-amine oxidase inhibitors (MAOIs) Ex. phenelzine or selegiline

Overdosage:

COGNISTAR 30MG will be given to you only by a doctor or nurse in a hospital setting, and so it is unlikely to receive an overdose. However, if you experience any unusual symptoms, consult your doctor immediately.

SYNOPSIS

MORE INFORMATION

• Keep COGNISTAR 30MG out of reach of children
• Store COGNISTAR 30MG at room temperature

FAQs ABOUT COGNISTAR 30MG

What is COGNISTAR 30MG used for?

COGNISTAR 30MG contains Cerebroprotein hydrolysate (that belongs to group of medicines called neurotrophic agents) which is used to treat cranial injury, aprosexia (inability to concentrate) in dementia, stroke (lack of blood supply in the brain), and alzheimer's disease (disease caused due to degeneration of brain cells) in affected individuals.

What side effects are seen with COGNISTAR 30MG?

The common side effects associated with the use of COGNISTAR 30MG are headache, nausea, vertigo (sensation of spinning), increased sweating, agitation, fever, and hallucinations. Inform your doctor if any of the symptom worsens.

Who should avoid receiving COGNISTAR 30MG?

COGNISTAR 30MG is not recommended for use in patients who are allergic to cerebroprotein hydrolysate, and in patients suffering from severe kidney dysfunction, status epilepticus (life threatening neurological disorder), or major epilepsia (seizure that causes loss of consciousness and violent muscle contractions). Consult your doctor before receiving COGNISTAR 30MG.

Is COGNISTAR 30MG safe to use in elderly patients?

COGNISTAR 30MG should be used with caution in elderly patients (aged 65 years and above) especially those who do not respond to anticholinesterases (such as neostigmine or pyridostigmine). Consult your doctor before receiving COGNISTAR 30MG.

How does COGNISTAR 30MG work?

COGNISTAR 30MG helps in restoring brain functions where cerebroprotein hydrolysate works by protecting the nerve cells from toxins and lack of oxygen thus improving its survival rate. It also helps in the formation of new nerve cells by increasing nutrition supply to the brain cells and reducing the inflammatory reaction on the brain tissues which results in preventing damage to the brain cells.

What is method of receiving COGNISTAR 30MG?

COGNISTAR 30MG will be given to you only by a doctor or a nurse into the vein. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.

Can COGNISTAR 30MG cause flu?

Yes, COGNISTAR 30MG may cause flu like symptoms such as fever, chills, sore throat, and cough in some patients which is generally temporary and resolves with time. However, inform your doctor if the symptom worsens over the time.

Is COGNISTAR 30MG safe to use in patients with kidney problems?

COGNISTAR 30MG is not recommended for use in patients with severe kidney dysfunction. It should be used with caution in patients with other kidney problems. Consult your doctor before receiving COGNISTAR 30MG.

REFERENCES

1. Perry B. Molinoff. Neurotransmission and the Central Nervous System. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. Twelfth Edition. 2011. Page – 375.

2. Mosam Phirke, Avinash Desousa, Nilesh Shah, Sushma Sonavane, Anup Bharati. The use of cerebroprotein hydrolysate in dementia: A case series of 25 cases seen in a tertiary general hospital. Journal of geriatric mental health. 2014. [Accessed on 7th July 2022] https://www.jgmh.org/article.asp?issn=2348-9995;year=2014;volume=1;issue=2;spage=106;epage=109;aulast=Phirke

3. Fanbing Kong, Hujie Song. Progress in Treatment of Spastic Cerebral Palsy with Integrated Traditional Chinese and Western Medicine. Clausius Scientific Press. MEDS Clinical Medicine. 2021. [Accessed on 7th July 2022] http://clausiuspress.com/assets/default/article/2021/11/24/article_1637736393.pdf

4. Ciplamed. Cerebrocip Injection (Cerebroprotein hydrolysate). [Revised in August 2017] [Accessed on 7th July 2022] https://www.ciplamed.com/content/cerebrocip-injection

5. Medicrit Biotech Private Limited. Cerbocin 60 mg Injection. [Accessed on 7th July 2022] https://www.medicrit.co.in/product/cerbocin-60mg-injection/

USEFUL DIAGNOSTIC TESTS

• Computerized tomography (CT) scan
• Magnetic resonance imaging (MRI)
• Positron emission tomography (PET)
• Psychiatric evaluation