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INTRODUCTION HEPATREAT contains l-ornithine-l-aspartate which belongs to the group of medicines called hepatoprotective agent. It is used in the treatment of various liver disorders such as acute or chronic hepatitis, liver cirrhosis, fatty liver with hyperammonemia or hepatic encephalopathy (...
HEPATREAT contains l-ornithine-l-aspartate which belongs to the group of medicines called hepatoprotective agent. It is used in the treatment of various liver disorders such as acute or chronic hepatitis, liver cirrhosis, fatty liver with hyperammonemia or hepatic encephalopathy (a series of neuropsychiatric abnormalities in patients with liver dysfunction, after exclusion of brain disease). It can also be used as an adjuvant therapy with all hepatotoxic drugs.
L-ornithine-l-aspartate is made up of two amino acids called ornithine and aspartic acid. Both l-ornithine and l-aspartic acid, ensures hepatoprotective effect by decreasing the toxic load on liver, and by providing metabolic support for hepatic cells. Before taking this medicine, inform your doctor if you have severe liver disease, because your doctor might adjust the dose on an individual basis to avoid nausea and vomiting.
Always take this medicine as directed by your physician. Swallow the medicine as a whole with a glass of water. Do not crush or chew the medicine. It is well tolerated with minimal side effects. However, if you experience any unusual symptoms after taking this medicine, inform your doctor. Do not take this medicine if you have severe renal impairment. Ask your doctor for advice. Ask your doctor for advice before taking this medicine, if you are pregnant or breastfeeding.
L-ornithine converts the toxic ammonia into non-toxic urea which is eliminated via kidneys. By doing this, it lowers the elevated level of toxic load (ammonia) in blood and helps the diseased liver to carry out its normal function smoothly (detoxification). L-Aspartate is an important component of citric acid cycle which liberates energy in the form of ATP, which helps in regeneration of damaged liver cells.
Always take HEPATREAT as directed by your physician. Swallow the medicine as a whole with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose for you depending upon your condition. Continue to take this medicine, as long as your doctor tells you to do so, to obtain better results.
HEPATREAT is generally safe and does not cause any side effects. However, if you experience any unusual symptoms after taking this medicine, inform your doctor.
HEPATREAT should be used with caution in pregnant women. Consult your doctor before taking this medicine.
HEPATREAT should be used with caution in breastfeeding women. Consult your doctor before taking this medicine.
Do not drive or operate any machines if your ability is affected by this medicine.
Avoid consumption of alcohol while taking this medicine, because alcohol can reduce the chances of healing and worsens the liver damage.
Do not take HEPATREAT, if you suffer from renal insufficiency (severely impaired kidney function). Consult your doctor for advice.
HEPATREAT should be taken with caution in patients with severe liver disease. Consult your doctor for advice.
Do not take this medicine if you are allergic (hypersensitive) to l-ornithine-l-aspartate.
Tell your doctor about all the medicines you use, including prescription and non-prescription medicines, and herbal supplements.
Drug | : | L-ornithine-L-aspartate |
Pharmacological Category | : | Hepatoprotective agent |
Therapeutic Indication | : | Liver Disease , Hepatic Encephalopathy, Hyperammonemia |
Dosage Forms | : | Tablet, Granules, Infusion, Syrup |
Store below 20-25°C and keep out of reach of children.
How to take HEPATREAT?
Always take this medicine as directed by your physician. Swallow the medicine as a whole with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose for you depending upon your condition. Continue to take this medicine, as long as your doctor tells you to do so, to obtain better results.
Can HEPATREAT be taken by pregnant women?
This medicine should be used with caution in pregnant women. Consult your doctor before taking.
Can we consume alcohol while taking HEPATREAT?
No. Avoid consumption of alcohol while taking this medicine, because alcohol can reduce the chances of healing and worsens the liver damage.
1. James M. Ritter, Lionel D. Lewis, Timothy GK Mant & Albert Ferro. The Alimentary system. Alimentary system and liver. A Textbook of Clinical Pharmacology and Therapeutics. Fifth edition. Hodder Arnold, an imprint of Hodden Education, part of Hachette Livre UK 2008. Page 260-264.
2. Centro Regional para el Estudio de las Enfermedades Digestivas. Efficacy of L-Ornithine L-Aspartate in Acute Hepatic Encephalopathy. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on September 2014] [Accessed 25th November 2020] https://clinicaltrials.gov/ct2/show/NCT01041755
3. Aga Khan University. Efficacy of L-Ornithine-L-Aspartate in Cirrhotics with Hepatic Encephalopathy. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on February 2007] [Accessed 25th November 2020] https://clinicaltrials.gov/ct2/show/NCT00433368
4. Gerald Kircheis and Stefan Lüth. Pharmacokinetic and Pharmacodynamic Properties of l-Ornithine l-Aspartate (LOLA) in Hepatic Encephalopathy. NCBI; PMC US National Library of Medicine, National Institute of Health. January 2019. [Accessed 25th November 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6416235/
5. Ee Teng Goh, Caroline S Stokes, Sandeep S Sidhu, Hendrik Vilstrup, Lise Lotte Gluud and Marsha Y Morgan. L-ornithine L-aspartate for prevention and treatment of hepatic encephalopathy in people with cirrhosis. NCBI; PMC US National Library of Medicine, National Institute of Health. May 2018. [Accessed 25th November 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494563/