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INTRODUCTION PROGRAF 1MG HARD CAPSULE contains Tacrolimus which belongs to the group of medicines called Immunosuppressants. It is used to prevent graft rejection in patients undergoing organ transplantation. It can also be used to treat an ongoing graft rejection of the newly transplanted org...
PROGRAF 1MG HARD CAPSULE contains Tacrolimus which belongs to the group of medicines called Immunosuppressants. It is used to prevent graft rejection in patients undergoing organ transplantation. It can also be used to treat an ongoing graft rejection of the newly transplanted organ. It is mostly used in combination with other immune suppressants to achieve maximum benefits.
Tacrolimus suppresses your body’s immune functions and enables your body to accept the transplanted organ. Take PROGRAF 1MG HARD CAPSULE regularly as instructed by your doctor. While undergoing therapy with PROGRAF 1MG HARD CAPSULE your doctor will periodically monitor your heart functions and nerve functions to avoid the risk of side effects.
Your doctor may also prescribe you blood tests and urine tests at regular intervals to access the improvement in your health conditions. During treatment with PROGRAF 1MG HARD CAPSULE, avoid exposing your skin towards direct sunlight. Wear protective loose-fitting clothes and apply sunscreen while going outdoors.
Before taking PROGRAF 1MG HARD CAPSULE inform your doctor if you have any liver, kidney or heart problems. Avoid consuming grapefruit or drinking grapefruit juice while taking PROGRAF 1MG HARD CAPSULE as it may increase the risk of side effects.
Do not take PROGRAF 1MG HARD CAPSULE without consulting your doctor if you are pregnant or breastfeeding. Both men and women taking PROGRAF 1MG HARD CAPSULE must use a suitable contraceptive method (such as condoms or oral contraceptive pills) to avoid pregnancy while undergoing therapy with PROGRAF 1MG HARD CAPSULE.
The most common side effects of taking PROGRAF 1MG HARD CAPSULE are an increase in blood sugar levels, increased blood cholesterol levels, difficulty in falling asleep, increased blood potassium levels, high blood pressure, headache, dizziness, indigestion, oedema and increased infections. Consult your doctor if any of these side effects worsen.
PROGRAF 1MG HARD CAPSULE is an immunosuppressive agent. It works by blocking the release of certain chemicals in the body (such as T-cells) that triggers the immune response. It suppresses your body’s immune functions and enables your body to accept the transplanted organ. As a result, it prevents the risk of graft rejection and increases the survival of the newly transplanted organ.
Take PROGRAF 1MG HARD CAPSULE 1 hour before meals or 2-3 hours after meals or as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.
Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight and disease condition. Do not stop taking PROGRAF 1MG HARD CAPSULE without consulting your doctor.
Stop taking PROGRAF 1MG HARD CAPSULE and contact your doctor immediately if you experience any of the following side effects such as:
Nausea or vomiting:
Try to take PROGRAF 1MG HARD CAPSULE with or just after meals. Stick to simple meals and avoid oil-rich or spicy foods. Consult your doctor if the nausea worsens.
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
Constipation:
Taking PROGRAF 1MG HARD CAPSULE with meals may reduce the chances of constipation. However, if you experience constipation, eat plenty of fiber-rich foods such as fresh fruits, vegetables and cereals. Drink plenty of fluids. Exercise more regularly. Consult your doctor if this side effect bothers you.
PROGRAF 1MG HARD CAPSULE should be used in pregnant women only if it is considered necessary by the physician. Therefore, inform your doctor before taking it. Women of childbearing potential must use a suitable contraceptive method to avoid pregnancy while undergoing therapy with PROGRAF 1MG HARD CAPSULE.
PROGRAF 1MG HARD CAPSULE may pass through breast milk. Therefore, it is not recommended for use in breastfeeding woman. However, consult your doctor before taking it.
Do not drive or operate any heavy tools or machines if you experience dizziness or sleepiness after taking PROGRAF 1MG HARD CAPSULE.
Avoid consumption of alcohol while taking PROGRAF 1MG HARD CAPSULE as it might make you feel dizzier or sleepy.
PROGRAF 1MG HARD CAPSULE should be used with caution in patients with kidney problems. Therefore, consult your doctor before taking it.
PROGRAF 1MG HARD CAPSULE should be used with caution in patients with liver problems. Therefore, consult your doctor before taking it.
Talk to your doctor before taking PROGRAF 1MG HARD CAPSULE if you are allergic to Tacrolimus or to any macrolide antibiotics (such as erythromycin, azithromycin).
PROGRAF 1MG HARD CAPSULE should be used with caution in patients with heart problems (such as prolonged QT interval). Therefore, consult your doctor before taking it.
Before taking PROGRAF 1MG HARD CAPSULE inform your doctor if you:
Use in pediatrics:
The safety and effectiveness of PROGRAF 1MG HARD CAPSULE have not been established in children and adolescents (aged below 18 years) undergoing transplantation. Therefore, consult your doctor before taking it.
Use in geriatrics:
PROGRAF 1MG HARD CAPSULE should be used with caution in elderly patients. Therefore, consult your doctor before taking it.
A. Drug-Drug interactions :
Before taking PROGRAF 1MG HARD CAPSULE inform your doctor if you are taking the following medicines such as:
B. Drug-food interactions :
PROGRAF 1MG HARD CAPSULE may interact with food. To avoid this, take PROGRAF 1MG HARD CAPSULE 1 hour before meals or 2-3 hours after meals. Avoid consuming grapes or grapefruit juice while taking PROGRAF 1MG HARD CAPSULE as it may increase the risk of side effects.
Overdosage:
If you or anyone else accidentally took more PROGRAF 1MG HARD CAPSULE, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose might include tremors, abnormal kidney function results in less or no urine output, increased blood pressure, leg swelling and lack of energy.
| Drug | : | Tacrolimus |
| Pharmacological Category | : | Calcineurin Inhibitors |
| Therapeutic Indication | : | Prevents graft rejection |
| Dosage Forms | : | Capsules, Tablets, Ointment, Lotion, solution, Topical Solution, Oral gel, eye ointment |
What is the use of PROGRAF 1MG HARD CAPSULE?
PROGRAF 1MG HARD CAPSULE is used to prevent graft rejection in patients undergoing organ transplantation. It can also be used to treat an ongoing graft rejection of the newly transplanted organ.
How PROGRAF 1MG HARD CAPSULE works?
PROGRAF 1MG HARD CAPSULE is an immunosuppressive agent. It works by blocking the release of certain chemicals in the body (such as T-cells) that triggers the immune response. It suppresses your body’s immune functions and enables your body to accept the transplanted organ. As a result, it prevents the risk of graft rejection and increases the survival of the newly transplanted organ.
How to take PROGRAF 1MG HARD CAPSULE?
Take PROGRAF 1MG HARD CAPSULE 1 hour before meals or 2-3 hour after meals or as directed by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine.
What is the best time to take PROGRAF 1MG HARD CAPSULE?
Take PROGRAF 1MG HARD CAPSULE 1 hour before meals or 2-3 hours after meals or as directed by your physician. It is usually taken twice daily. However, your doctor will decide the correct dose, duration of therapy and time of administration for you depending on your age, body weight and disease condition.
Is PROGRAF 1MG HARD CAPSULE an antibiotic?
No. PROGRAF 1MG HARD CAPSULE is an immunosuppressive agent. It suppresses your body’s immune functions and enables your body to accept the transplanted organ.
What precautions must be followed while taking PROGRAF 1MG HARD CAPSULE?
PROGRAF 1MG HARD CAPSULE must be taken 1 hour before meals or 2-3 hour after meals. Avoid drinking grapefruit juice while taking PROGRAF 1MG HARD CAPSULE. During treatment with PROGRAF 1MG HARD CAPSULE, avoid exposing your skin towards direct sunlight. Wear protective loose-fitting clothes and apply sunscreen while going outdoors. Before taking PROGRAF 1MG HARD CAPSULE inform your doctor if you have any liver, kidney or heart problems or if you are pregnant or breastfeeding. Both men and women taking PROGRAF 1MG HARD CAPSULE must use a suitable contraceptive method (such as condoms or oral contraceptive pills) to avoid pregnancy while undergoing therapy with PROGRAF 1MG HARD CAPSULE.
How long should I take PROGRAF 1MG HARD CAPSULE?
You need to take PROGRAF 1MG HARD CAPSULE for the stipulated duration prescribed by your doctor. Your doctor will decide the correct dose and duration of therapy for you depending on your age, body weight and disease condition.
What to do if I forgot to take a dose of PROGRAF 1MG HARD CAPSULE?
If you forgot to take a dose of PROGRAF 1MG HARD CAPSULE, take it as soon as you remember. However, if it is time for the next dose of PROGRAF 1MG HARD CAPSULE, skip the missed dose and take the next one regularly. Do not take a double dose of PROGRAF 1MG HARD CAPSULE to compensate for the missed ones.
Is PROGRAF 1MG HARD CAPSULE safe?
The most common side effects of taking PROGRAF 1MG HARD CAPSULE are an increase in blood sugar levels, increased blood cholesterol levels, difficulty in falling asleep, increased blood potassium levels, high blood pressure, headache, dizziness, indigestion, oedema and increased infections. Consult your doctor if any of these side effects worsen.
Can I stop taking PROGRAF 1MG HARD CAPSULE without consulting your doctor?
No. You should not stop taking PROGRAF 1MG HARD CAPSULE without consulting your doctor because your body’s immune system may once again attempt to reject the newly transplanted organ. Therefore, take PROGRAF 1MG HARD CAPSULE for the stipulated duration recommended by your doctor to achieve maximum results.
What happens if I take too more of PROGRAF 1MG HARD CAPSULE?
If you or anyone else accidentally took more PROGRAF 1MG HARD CAPSULE, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose might include tremors, abnormal kidney function results in less or no urine output, increased blood pressure, leg swelling and lack of energy.
Can I use PROGRAF 1MG HARD CAPSULE if I suffer from kidney diseases?
PROGRAF 1MG HARD CAPSULE should be used with caution in patients with kidney problems. Therefore, consult your doctor before taking it.
Will taking a higher dose of PROGRAF 1MG HARD CAPSULE be more effective?
No, taking a higher dose of PROGRAF 1MG HARD CAPSULE will not be effective rather it can lead to toxicity. Always take the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might increase the dose or suggest an alternative therapy.
Can I take medication for high blood pressure along with PROGRAF 1MG HARD CAPSULE?
It is not advisable to take medicines to control blood pressure while taking PROGRAF 1MG HARD CAPSULE without consulting your doctor as they have known interactions with PROGRAF 1MG HARD CAPSULE.
Can PROGRAF 1MG HARD CAPSULE be used in pregnant women?
PROGRAF 1MG HARD CAPSULE should be used in pregnant women only if it is considered necessary by the physician. Therefore, consult your doctor before taking it.
How much PROGRAF 1MG HARD CAPSULE should I take?
PROGRAF 1MG HARD CAPSULE should be used only under medical supervision. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body condition and severity of the disease condition.
Can PROGRAF 1MG HARD CAPSULE cause constipation?
Yes. Constipation is a common side effect of using PROGRAF 1MG HARD CAPSULE. Eat plenty of fiber-rich foods such as fresh fruits, vegetables, cereals as well as drink plenty of water and exercise more regularly when taking this medicine. Contact your doctor if this side effect bothers you.
Can the use of PROGRAF 1MG HARD CAPSULE affect fertility?
PROGRAF 1MG HARD CAPSULE may affect fertility in both men and women. Therefore, try to avoid pregnancy while undergoing therapy with PROGRAF 1MG HARD CAPSULE. Both men and women must use a suitable contraceptive method (such as condoms or oral contraceptive pills) to avoid pregnancy while undergoing therapy with [GBNKEYWORD.
1. KD. Tripathi. Autocoids and related drugs. Essentials of Medical Pharmacology. 8th edition. 2019. Page – 940-941.
2. Mahmoud Kamel, Manish Kadian, Titte Srinivas, David Taber, and Maria Aurora Posadas Salas. Tacrolimus confers lower acute rejection rates and better renal allograft survival compared to cyclosporine. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. December 2016. [Accessed on 26th October 2022]. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5175228/
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5. Astellas Pharma Tech Co. Ltd. Tacrolimus [Revised in July 2021] [Accessed on 26th October 2022] https://www.astellas.com/us/system/files/prografwpi_3.pdf
6. Biocon Ltd. Tacrolimus Capsules. Tacrograf – 0.25/0.5/1/2/3/5mg. [Accessed on 26th October 2022] https://biocon.com/docs/prescribing_informatio/nephrology/tacrograf_pi.pdf
Written By Srilekha. R, B.Pharm
Last updated on 27 Oct 2022 | 06:21 PM(IST)