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INTRODUCTION CINCALTH 30 TABLET contains Cinacalcet which belongs to a group of medicines called Calcimimetic agent that increases the sensitivity of the calcium-sensing receptor to activation by extracellular calcium. It is used for secondary hyperparathyroidism (HPT) in patients with chronic...
CINCALTH 30 TABLET contains Cinacalcet which belongs to a group of medicines called Calcimimetic agent that increases the sensitivity of the calcium-sensing receptor to activation by extracellular calcium. It is used for secondary hyperparathyroidism (HPT) in patients with chronic kidney disease (CKD) on dialysis and for hypercalcemia in patients with parathyroid outgrowth.
Hyperparathyroidism (HPT) is a condition where the parathyroid gland may become overactive and make too much PTH. In this condition the calcium stored in the bones move into the blood leading to hypercalcemia (too much calcium in the blood). Secondary hyperparathyroidism (SHPT) describes an alteration in bone and mineral metabolism that occurs as a direct result of chronic kidney disease (CKD). The parathyroid gland is the central organ responsible for regulating these adaptive responses leading to secondary hyperparathyroidism. Parathyroid hormone helps in low calcium levels by acting on the bones, intestine, and kidneys. CINCALTH 30 TABLET works by controlling levels of the parathyroid hormone (PTH), calcium and phosphorous in body.
Do not drive or operate machines, if you experience side effects such as dizziness and seizures while taking this medicine. If you are pregnant or breast-feeding, think you may be pregnant or planning to have a baby, ask your doctor for advice before taking this medicine. The most common side effects are nausea, vomiting, dizziness, rash, muscle pain, loss of appetite, headache. Consult your doctor if you experience any of the above side effects persists for a longer duration.
It is used for:
CINCALTH 30 TABLET works by controlling levels of the parathyroid hormone (PTH), calcium and phosphorous in body.
Always take this medicine as advised by the physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition. Do not stop taking CINCALTH 30 TABLET unless your doctor advice you to stop.
Stop taking CINCALTH 30 TABLET and contact your doctor immediately if you experience any of the following side effects:
Eat fiber rich foods such as fresh fruit, vegetables and cereals, and drink plenty of water. Exercise more regularly.
Apply hot or cold-water bag on your head. Take rest in a quiet and dark room. Drink tea or coffee.
Keep taking this medicine with, or just after, a meal or snack and stick to simple meals and do not eat rich or spicy food.
CINCALTH 30 TABLET should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Consult your doctor before taking it.
It is not known whether CINCALTH 30 TABLET is excreted in human milk. Therefore, consult your doctor before taking the medicine.
Do not drive or operate any machinery while taking this medicine, it may make you feel dizziness.
Consumption of alcohol is not recommended while taking CINCALTH 30 TABLET.
CINCALTH 30 TABLET should be taken with caution in patients with severe kidney disease. Consult your doctor for advice.
CINCALTH 30 TABLET should be taken with caution in patients with severe liver disease. Consult your doctor for advice.
Do not take CINCALTH 30 TABLET if you are allergic to any of its ingredients of this medicine.
CINCALTH 30 TABLET should be taken with caution in patients with cardiac problems. Consult your doctor for advice.
The safety and efficacy of CINCALTH 30 TABLET in pediatric patients have not been established.
CINCALTH 30 TABLET should be used with caution in elderly patients above 65 years of age. Consult your doctor for advice.
It is not recommended CINCALTH 30 TABLET if you have low levels of calcium in your blood
A. Drug - Drug Interactions:
Before taking CINCALTH 30 TABLET, inform your doctor if you are taking any of the following medicines:
B. Drug - Food Interaction:
Overdosage:
|
Drug |
: |
Cinacalcet |
| Pharmacological Category | : | Calcimimetics |
| Therapeutic Indication | : | Hyperparathyroidism |
| Dosage Forms | : | Tablet |
A: No. It is not recommended for use in the pregnant women. Consult your doctor before taking.
A: Take CINCALTH 30 TABLET preferably after meals or as advised by your physician. Swallow the medicine with a glass of water. Do not cursh or chew the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition.
A: You need to take CINCALTH 30 TABLET as long as your doctor or physician prescribes you the medicine. Your doctor will decide the correct dose and duration of therapy for you depending upon your age, body weight and disease condition
A: CINCALTH 30 TABLET must be taken after meals to avoid gastrointestinal side effects. Consult your doctor for advice.
A: If you forgot to take a dose of CINCALTH 30 TABLET, take it as soon as you remember. However, if it is time for the next dose of CINCALTH 30 TABLET, skip the missed dose and take the next one regularly. Do not take a double dose of CINCALTH 30 TABLET to compensate the missed ones.
A: The most common side effects of CINCALTH 30 TABLET are nausea, vomiting, dizziness, rash, muscle pain, loss of appetite, headache. Consult your doctor if you experience any of the above side effects persists for a longer duration.
A: No. You should not stop taking CINCALTH 30 TABLET without consulting your doctor because it may lead to reversal of symptoms. If you feel better after using CINCALTH 30 TABLET, consult your doctor for advice.
1. K.D. Tripathi, Essentials of medical pharmacology, Cardiovascular drugs, Chapter 39 - Anti anginal and other ischaemic drugs, Page – 554.
2. Lionel H. Opie, Bernard J. Gersh, Drugs for the heart, Drugs Used in anti anginals, Eighth Edition, 2013. Page – 55-56.
3. Bharath M. Reddy, MD, Howard S. Weintraub, MD, and Arthur Z. Schwartzbard, MD, A New Approach to Treating an Old Problem. [Accessed on January 09th, 2024] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3014127/pdf/20101200s00004p641.pdf
4. Amgen Europe B.V; Electronic Medicines Compendium (EMC); [Revised on August, 2017] [Accessed on January 09th, 2024] https://www.medicines.org.uk/emc/files/pil.5599.pdf
5. Amgen Inc.; U.S. Food & Drug Administration; [Revised on August, 2011] [Accessed on January 09th, 2024] https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/021688s017lbl.pdf
Written By Dr. Janet.C, Pharm.D
Last updated on 16 Jan 2024 | 02:50 PM(IST)