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INTRODUCTION ADILIP 135MG contains fenofibrate which belongs to the group of medicines called fibrates. It helps to reduce cholesterol (LDL; bad cholesterol) and triglycerides (fatty acids) in the blood. Increase in these types of fatty acids are often associated with cardiovascular risk facto...
ADILIP 135MG contains fenofibrate which belongs to the group of medicines called fibrates. It helps to reduce cholesterol (LDL; bad cholesterol) and triglycerides (fatty acids) in the blood. Increase in these types of fatty acids are often associated with cardiovascular risk factors like atherosclerosis, stroke, heart attack or chest pain. Additionally, fenofibrate also increases the amount of HDL cholesterol (good cholesterol) in the blood.
Fenofibrate increases lipid metabolism by activating peroxisome proliferator activated receptor alpha (PPARα) receptor. It can be used in addition with other medicines like statins in certain circumstances when levels of fats in blood are not controlled with a statin alone. Along with the therapy, your doctor might recommend you follow a low fat diet including fruits, greens, vegetables and sprouts. Other lifestyle changes may include exercising regularly, improving sleep at night, managing stress, quitting alcohol or smoking.
This medicine may rarely cause muscle pain or weakness or kidney damage. If you experience any unexplained muscle cramps or pain, stop taking this medicine and contact a doctor immediately. It should be used with caution in patients with pancreatitis, underactive thyroid, liver or kidney disease. This medicine is strictly not recommended for use in pregnant, or breastfeeding women and in children aged less than 18 years.
Fenofibrate enhances lipolysis and elimination of triglyceride-rich particles from plasma by activating lipoprotein lipase and by reducing the production of apoprotein C-III (an inhibitor of lipoprotein lipase activity).
It also activates peroxisome proliferator activated receptor alpha receptor, which generates peroxisomes filled with hydrogen peroxide, reactive oxygen species and few hydroxyl radicals that also induces lipolysis and enhance lipid metabolism.
Take ADILIP 135MG as directed by your physician. It should be taken only after meals. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose for you depending upon your condition. Continue to take this medicine, as long as your doctor tells you to do so, to obtain better results.
Feeling sick (nausea):
Try taking this medicine with, or just after meal. Stick to simple meals. Do not eat rich or spicy food.
Bloating or wind:
Eat smaller and frequent meals. Eat and drink slowly, and exercise regularly. If the symptoms get worse, contact your doctor straight away.
Diarrhea:
Drink lots of fluids, such as water or juice, to avoid dehydration. Do not take any medicines without speaking to a doctor.
Stomach pain:
Try to rest and relax. You can eat and drink slowly or have smaller and frequent meals. Keeping a heat pad on your stomach may also help. If still pain persists, speak to your doctor.
ADILIP 135MG is not recommended for use in pregnant women unless necessary. Discuss the risks and benefits with your doctor.
ADILIP 135MG is not recommended for use in breastfeeding women unless necessary. Discuss the risks and benefits with your doctor.
Do not drive or operate any machines if your ability is affected by this medicine.
Avoid consumption of alcohol while taking this medicine.
ADILIP 135MG should be taken with caution in patients with severe kidney disease. Consult your doctor for advice.
ADILIP 135MG should be taken with caution in patients with severe liver disease. Consult your doctor for advice.
Do not take this medicine if you are allergic (hypersensitive) to fenofibrate.
Do not take this medicine, if you have:
Talk to your doctor about all medicines you take, especially:
| Drug | : | Fenofibrate |
| Pharmacological Category | : | Fibrates |
| Therapeutic Indication | : | Hypercholesterolemia, Hypertriglyceridemia |
| Dosage Forms | : | Tablet, Capsule |
Store below 20-25°C and keep out of reach of children.
Can ADILIP 135MG cause weight loss?
No. Although this medicine can reduce LDL and triglyceride levels, it has no impact in reducing weight. Stay on a low-fat diet and exercise regularly for better results.
Can ADILIP 135MG reduce acne?
No. Currently, there is not enough data for understanding the effects of this medicine on acne.
Can ADILIP 135MG be used during pregnancy?
No. This medicine is strictly not recommended for use in pregnant women. Consult your doctor for advice.
1. KD. Tripathi. Hypolipidemic Drugs and Plasma Expanders. Essentials of medical pharmacology. Seventh edition. 2013. Page – 638-640.
2. Thomas B. Bersot. Drug Therapy for Hypercholesterolemia and Dyslipidemia. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 901-903.
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4. Ranbaxy Laboratories Limited. Bioequivalence Study of Fenofibrate 160mg Tablets Under Fed Conditions. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised on October 2008] [Accessed 26th November 2020] https://clinicaltrials.gov/ct2/show/NCT00775359
5. Russell Scott, Richard O'Brien, Greg Fulcher, Chris Pardy, Michael d'Emden, Dana Tse, Marja-Riitta Taskinen, Christian Ehnholm, Anthony Keech. Effects of Fenofibrate Treatment on Cardiovascular Disease Risk in 9,795 Individuals with Type 2 Diabetes and Various Components of the Metabolic Syndrome. NCBI; PMC US National Library of Medicine, National Institute of Health. March 2009. [Accessed 26th November 2020] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2646035/
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7. Genus Pharmaceuticals. Electronic Medicines Compendium (EMC); [Revised on August 2020] [Accessed 26th November 2020] https://www.medicines.org.uk/emc/files/pil.5267.pdf
8. Fournier Laboratories Ireland Limited. U.S. Food & Drug Administration. [Revised on August 2010] [Accessed 26th November 2020] https://www.accessdata.fda.gov/drugsatfda_docs/label/2010/021656s019lbl.pdf
9. Sciele Pharma, lnc. U.S. Food & Drug Administration. [Revised on April 2008] [Accessed 26th November 2020] https://www.accessdata.fda.gov/drugsatfda_docs/label/2008/021350s008lbl.pdf