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INTRODUCTION ABOUT CREMAGEL 2% GEL CREMAGEL 2% GEL contains Diltiazem which belongs to the group of medicines called Calcium Channel Blockers. It is used to treat anal fissures (a cut or tear in the back passage). It reduces pain and promotes the healing of the tear that has occurred in the sk...
CREMAGEL 2% GEL contains Diltiazem which belongs to the group of medicines called Calcium Channel Blockers. It is used to treat anal fissures (a cut or tear in the back passage). It reduces pain and promotes the healing of the tear that has occurred in the skin of the anus.
Apply CREMAGEL 2% GEL regularly as instructed by your doctor. It is for external use only. Wash your hands before and after application. Use a finger covering, such as cling film or a disposable glove to apply the medicine. Discard the finger covering after use. Avoid contact of CREMAGEL 2% GEL with your eyes, ears, nose, mouth or vagina.
Before using CREMAGEL 2% GEL inform your doctor if you have any heart problems. You must also inform your doctor if you have low blood pressure, anemia, increased pressure in the brain or severe dehydration as a precaution.
If you are a pregnant or breast-feeding women, consult your doctor for advice before using CREMAGEL 2% GEL. The most common side effects of applying CREMAGEL 2% GEL are headache, feeling dizzy while changing position and local itching or burning sensation. Contact your doctor if any of these side effect worsens.
CREMAGEL 2% GEL effectively heals anal fissures, where diltiazem acts by relaxing the muscle around the anus (back passage). This action reduces pressure around the anal regions and increases blood flow which promotes healing of cuts and tears in the anus.
Take a small amount of CREMAGEL 2% GEL on your finger (approximately 2.5 cm) and gently apply the medicine inside and around the anus or as directed by your physician. CREMAGEL 2% GEL is for external use only. Wash your hands before and after application. Use a finger covering, such as cling film or a disposable glove to apply the medicine.
Discard the finger covering after use. Avoid contact of CREMAGEL 2% GEL with your eyes, ears, nose, mouth or vagina. Your doctor will decide the correct dose and duration of treatment for you depending upon your age, body weight and the severity of the disease condition.
Continue to use CREMAGEL 2% GEL for the duration recommended by your doctor without any interruption to achieve better results.
Stop using CREMAGEL 2% GEL and contact your doctor immediately if you experience any of the following side effects:
Headache:
Rest and relax. Keep yourself hydrated by drinking plenty of fluids such as water or electrolytes. Applying a pain-relieving balm on your forehead can be beneficial. Do not consume excessive alcohol, as it could aggravate your headache. Consult your doctor if your headache worsens.
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any tools or machines completely while you are feeling dizzy. Do not consume excessive alcohol, as it could aggravate your dizziness. Consult your doctor if your dizziness worsens.
There is no proper information regarding the use of CREMAGEL 2% GEL in pregnant women. Therefore, it should be used in pregnant women only if considered necessary by the physician.
CREMAGEL 2% GEL should be used in breastfeeding women only if considered necessary by the physician. Therefore, consult your doctor before using it.
Do not drive or operate any heavy tools or machines if you experience dizziness or tiredness after using CREMAGEL 2% GEL.
Avoid or limit the consumption of alcohol while using CREMAGEL 2% GEL.
Before using CREMAGEL 2% GEL, inform your doctor if you are allergic to diltiazem.
CREMAGEL 2% GEL should be used with caution in patients with heart problems (such as heart failure, cardiomyopathy (a disease of heart muscles) or a recent heart attack). Therefore, consult your doctor before using it.
Before using CREMAGEL 2% GEL, inform your doctor if you have:
Use in Pediatrics:
CREMAGEL 2% GEL should be used in children and adolescents (aged below 18 years) only if prescribed by the physician. Therefore, consult your doctor before using it.
Use in Geriatrics:
CREMAGEL 2% GEL should be used with caution in the elderly patients. Therefore, consult your doctor before using it.
A. Drug-Drug Interactions:
Before using CREMAGEL 2% GEL, inform your doctor, if you are taking any of the following medicines such as:
Overdosage:
If you or anyone else accidentally applied excessive amount of CREMAGEL 2% GEL, consult your doctor immediately or visit the nearby hospital.
| Drug | : |
Diltiazem |
| Pharmacological Category | : |
Calcium channel blocker |
| Therapeutic Indication | : |
Anal fissures |
| Dosage Forms | : |
Tablet, Capsule, Injection, Topical gel |
A: CREMAGEL 2% GEL is used to manage anal fissures (a cut or tear in the back passage). It reduces pain and promotes the healing of the tear that has occurred in the skin of the anus.
A: CREMAGEL 2% GEL effectively heals anal fissures, where diltiazem acts by relaxing the muscle around the anus (back passage). This action reduces pressure around the anal regions and increases blood flow which promotes healing of cuts and tears in the anus.
A: The most common side effects of applying CREMAGEL 2% GEL are headache, feeling dizzy while changing position and local itching or burning sensation. Contact your doctor if any of these side effect worsens.
A: CREMAGEL 2% GEL should be used in children and adolescents (aged below 18 years) only if prescribed by the physician. Therefore, consult your doctor before using the medicine.
A: There is no proper information regarding the use of CREMAGEL 2% GEL in pregnant women. Therefore, it should be used in pregnant women only if considered necessary by the physician.
A: If you forgot to apply a dose of CREMAGEL 2% GEL, apply it as soon as you remember. However, if it is time for the next dose of CREMAGEL 2% GEL, skip the missed dose and apply the next one regularly. Do not apply more of CREMAGEL 2% GEL to compensate the missed ones.
A: No, using a higher dose of CREMAGEL 2% GEL will not be effective rather it can lead to toxicity. Always use the dose prescribed by your doctor. If the prescribed dose is not effective for you, consult your doctor for advice. Your doctor might change the dose or suggest an alternative therapy.
A: Do not stop using CREMAGEL 2% GEL without consulting your doctor as your symptom may reappear once again. Make sure to take CREMAGEL 2% GEL for the stipulated duration recommended by your doctor to achieve maximum results.
A: No. Do not stop using CREMAGEL 2% GEL without consulting your doctor. Apply CREMAGEL 2% GEL as advised by your doctor for the stipulated duration to achieve better results.
A: No, do not stop using the medicine suddenly, as it may worsen your condition. Instead, you should consult the doctor and he/she may adjust your dose as per your needs.
1. Gerald G. Briggs and Roger K. Freeman. D. A reference guide to fetal and neonatal risk: Drugs in Pregnancy and Lactation. Tenth Edition. 2015. Page – 1184-1186.
2. Akira Tsunoda, Yasuharu Kashiwagura, Ken-ichi Hirose, Tadanori Sasaki and Nobuyasu Kano. Quality of life in patients with chronic anal fissure after topical treatment with diltiazem. NIH National Library of Medicine. National center for Biotechnology Information. PMC PubMed Central. November 2012 [Accessed on 28th April 2022] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3596506/
3. St. Mark’s Hospital. National Health Service (NHS). London Northwest University Healthcare. NHS trust. [Revised in December 2019]. [Accessed on 28th April 2022] https://www.stmarkshospital.nhs.uk/wp-content/uploads/2020/02/2112-diltiazem-2162009.pdf
4. Chesterfield Royal Hospital. NHS foundation trust. Diltiazem 2% hydrochloride cream. [Revised in August 2019] [Accessed 28th April 2022] https://www.chesterfieldroyal.nhs.uk/application/files/8815/4142/8195/Diltiazem_2_Hydrochloride_Cream.pdf
5. Diltiazem Hydrochloride 2% Cream. GIG CYMRU NHS Wales. Sian Elin Jones, Clinical Pharmacist. NHS.Uk. [Revised in September 2011]. [Accessed on 3rd November 2022] https://www.wmic.wales.nhs.uk/wp-content/uploads/2016/09/diltiazem_eng_PIL.pdf
6. Hemorrhoid Centers of America. Alan L. Goldman, MD, FACS. Patient Drug Education for Diltiazem Ointment. March 2014. [Accessed on 3rd November 2022] https://hemorrhoidcentersamerica.com/wp-content/uploads/diltiazemointment.pdf
Written By Dr. Janet.C, Pharm.D
Last updated on 23 Mar 2024 | 10:16 PM(IST)